Recurrence Risk for Autism Spectrum Disorders: A Baby Siblings Research Consortium Study
Open accessAbstract
OBJECTIVE: The recurrence risk of autism spectrum disorders (ASD) is estimated to be between 3% and 10%, but previous research was limited by small sample sizes and biases related to ascertainment, reporting, and stoppage factors. This study used prospective methods to obtain an updated estimate of sibling recurrence risk for ASD. METHODS: A prospective longitudinal study of infants at risk for ASD was conducted by a multisite international network, the Baby Siblings Research Consortium. Infants (n = 664) with an older biological sibling with ASD were followed from early in life to 36 months, when they were classified as having or not having ASD. An ASD classification required surpassing the cutoff of the Autism Diagnostic Observation Schedule and receiving a clinical diagnosis from an expert clinician. RESULTS: A total of 18.7% of the infants developed ASD. Infant gender and the presence of >1 older affected sibling were significant predictors of ASD outcome, and there was an almost threefold increase in risk for male subjects and an additional twofold increase in risk if there was >1 older affected sibling. The age of the infant at study enrollment, the gender and functioning level of the infant's older sibling, and other demographic factors did not predict ASD outcome. CONCLUSIONS: The sibling recurrence rate of ASD is higher than suggested by previous estimates. The size of the current sample and prospective nature of data collection minimized many limitations of previous studies of sibling recurrence. Clinical implications, including genetic counseling, are discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Understanding of onset patterns of ASD has dramatically expanded over the past 10 years through work on infants with a first degree relative with ASD, who due to the high heritability of the condition have a 20% chance of developing ASD themselves.
“Understanding of onset patterns of ASD has dramatically expanded over the past 10 years, through work on infants with a first degree relative with ASD, who due to the high heritability of the condition have a 20% chance of developing ASD themselves 25”
From Autism spectrum disorder (2020) · cites this paper as [25]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredSeveral earlier studies have reported absolute sibling recurrence risk, but absolute risk is a cumulative measure that depends on length of follow-up and differs between populations.
“Several earlier studies have reported absolute sibling recurrence risk28–34 but absolute risk is a cumulative measure which depends on the length of follow up (higher at age 15 years than at age 5 year) and will differ between populations.”
From The Familial Risk of Autism (2014) · cites this paper as [34]
Infants who develop ASD later in childhood have substantially typical profiles of interest in faces and eyes at 6 months of age.
“For example, infants who develop ASD later in childhood have substantially typical profiles of interest in faces 25 and eyes 26 at 6 months of age”
From Autism spectrum disorder (2020) · cites this paper as [25]
The Discussion says behavioral signs and parental concerns about ASD are rare before 6 months, but it does not address infants’ interest in faces or eyes. Searches for face and eye interest at 6 months found no passage establishing the claimed typical profiles. (LLM, conf=0.76)
Experimental — accuracy not yet measuredMany factors (including age at reporting and birth order) affect parent reports of language milestones, earlier social skills, and children's loss of social and language skills.
“In addition, studies of the accuracy of parent reports of language milestones, earlier social skills, and children's loss of social and language skills suggest that many factors (including age at reporting and birth order) affect these data (Hus et al. 2011, Jones et al. 2014, Ozonoff et al. 2011a).”
From Recent Advances in Autism Research as Reflected in DSM-5 Criteria for Autism Spectrum Disorder (2015) · cites this paper as Ozonoff et al. 2011a
The Discussion (page not available) says parent reports of whether older children had ASD can inflate sibling recurrence estimates, while Patients and Methods records birth order as a study variable. Neither passage addresses whether age at reporting or birth order affects parent reports of language milestones, earlier social skills, or loss of skills. Searches for those reports and for parental recall found no passage addressing the claim. (LLM, conf=0.75)
Experimental — accuracy not yet measuredASD recurrence in families is about 20%.
“recurrence in families is ~20%8,9”
From Genome-wide detection of tandem DNA repeats that are expanded in autism (2020) · cites this paper as [8]
Genetic factors contribute to ASD etiology.
“Genetic factors contribute to the etiology of ASD; twin studies estimate heritability in the 50–90% range, and recurrence in families is ~20%8,9.”
From Genome-wide detection of tandem DNA repeats that are expanded in autism (2020) · cites this paper as [8]
Twin studies estimate ASD heritability at 50-90%.
“twin studies estimate heritability in the 50–90% range”
From Genome-wide detection of tandem DNA repeats that are expanded in autism (2020) · cites this paper as [8]
Infant siblings of children with ASD have a nearly 20% chance of developing ASD.
“Infant siblings of children with ASD have a nearly 20% chance of developing ASD [2]”
From EEG power at 3 months in infants at high familial risk for autism (2017) · cites this paper as [2]
Infants with an older sibling with ASD have close to a 20% risk of developing ASD themselves.
“Since infants with an older sibling with ASD have close to a 20 % risk of developing ASD themselves [7], researchers can examine the neural and cognitive precursors to symptom emergence by following a cohort of “infant siblings” from early infancy to early childhood.”
A previous Baby Siblings Research Consortium report indicated that 18.7% of 3-year-old high-risk siblings will themselves develop an autism spectrum disorder.
“A recent report4 from the Baby Siblings Research Consortium (BSRC) indicated that 18.7% of 3-year-old HR siblings will themselves develop an ASD.”
From Beyond Autism: A Baby Siblings Research Consortium Study of High-Risk Children at Three Years of Age (2013) · cites this paper as [4]
Boys exhibited higher autism spectrum disorder severity scores than girls at 3 years independent of risk group.
“Independent of risk group, boys exhibited higher ASD severity scores than girls at 3 years, which extends similar findings based on parent report19 and parallels the higher rate of ASD diagnosis among boys in epidemiologic and prospective high-risk samples.4,35”
From Beyond Autism: A Baby Siblings Research Consortium Study of High-Risk Children at Three Years of Age (2013) · cites this paper as [4]
The recurrence rate of ASD in siblings is 18.7%, nearly 20-fold greater than in the general population.
“The recurrence rate of ASD in siblings is 18.7% (Ozonoff et al ., 2011), a nearly 20-fold greater risk than in the general population.”
From Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder (2013) · cites this paper as Ozonoff et al., 2011
Around 20% of younger siblings of children with autism spectrum disorder are diagnosed with autism themselves.
“Around 20% of younger siblings are diagnosed with autism themselves [8]”
From Enhanced Visual Search in Infancy Predicts Emerging Autism Symptoms (2015) · cites this paper as [8]
Around 20% of high-risk infants receive an autism diagnosis by their third birthday.
“Around 20% of high-risk infants receive an autism diagnosis by their third birthday (Ozonoff et al., 2011).”
From From early markers to neuro-developmental mechanisms of autism (2014) · cites this paper as Ozonoff et al., 2011
Studies of younger siblings of children with autism are motivated by a twentyfold increase in autism incidence in these groups compared with the general population.
“Studies of younger siblings of children with autism are motivated by the twentyfold increase in autism incidence in these groups with respect to the general population (Baird, Simonoff, Pickles, Chandler, & Loucas, 2006; Ozonoff, Young, Carter, & Messinger, 2011), making prospective studies feasible (Zwaigenbaum et al., 2007).”
From From early markers to neuro-developmental mechanisms of autism (2014) · cites this paper as Ozonoff, Young, Carter, & Messinger, 2011
Proband sex did not affect this recurrence risk.
“but no effect of proband sex on this recurrence risk”
From Sex differences in autism spectrum disorders (2013) · cites this paper as [34]
Sibling recurrence rates were 26.2% for males and 9.1% for females, independent of the older autistic sibling's sex.
“recurrence rate in siblings is 26.2% for males and 9.1% for females, regardless of the sex of their older autistic sibling”
From Sex differences in autism spectrum disorders (2013) · cites this paper as [34]
A prospective study reported an 18.7% recurrence risk among siblings of autistic probands.
“Prospective study finds a recurrence risk of 18.7% for siblings of autistic probands”
From Sex differences in autism spectrum disorders (2013) · cites this paper as [34]
ASD recurrence risk for siblings of children with ASD is as high as 18.7%, with population-based estimates around 10%.
“Current research indicates that ASD recurrence risk for siblings of children with ASD is as high as 18.7 % [38], with population-based estimates around 10 % [44].”
From Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life (2015) · cites this paper as [38]
The recurrence rate in the current study was 32.1%, higher than the 18.7% reported by Ozonoff et al. (2011).
“It is worth noting that the recurrence rate reported in the current study (32.1%) is higher than that reported in the large consortium paper published by Ozonoff and colleagues (18.7%; Ozonoff et al., 2011).”
From Behavioural markers for autism in infancy: Scores on the Autism Observational Scale for Infants in a prospective study of at-risk siblings (2015) · cites this paper as Ozonoff et al., 2011
A previous BSRC report utilizing 664 high-risk infants yielded an 18.7% risk of ASD recurrence, which was elevated among males and among siblings from multiplex families.
“A previous report from the Baby Siblings Research Consortium (BSRC) utilizing slightly more than half (664) of the current sample of 1241 high-risk infants yielded an 18.7 % risk of ASD recurrence, which was elevated among males and among siblings from multiplex families [10].”
From Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study (2015) · cites this paper as [10]
Male:female ratios in prospectively followed high-risk sibling samples were 2.8:1 and 1.65:1.
“Variable male:female ratios in prospectively followed high-risk sibling samples (2.8:1 [10] and 1.65:1 [11])”
From Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study (2015) · cites this paper as [10]
The 3.18:1 increased odds of ASD in males in the current sample (95% CI = 2.31 to 4.39) is similar to estimates from community-based ascertainment of children (2.5:1-2.6:1) and to a previous report on approximately half of the current high-risk sample.
“The 3.18:1 increased odds of ASD in males in the current sample (95 % CI = 2.31 to 4.39) is similar to estimates from community-based ascertainment of children (2.5:1–2.6:1) [5–7], as well as to a previous report on approximately half of the current high-risk sample [10].”
From Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study (2015) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520 · see citing works
Miller, D. T., Adam, M. P., Aradhya, S., Biesecker, L. G., Brothman, A. R., Carter, N. P., Church, D. M., Crolla, J. A., Eichler, E. E., Epstein, C. J., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.04.006 · Cited by 2,882 · see citing works
Dawson, G., Rogers, S., Munson, J., Smith, M., Winter, J., Greenson, J., Donaldson, A., & Varley, J. (2010) · Pediatrics · doi:10.1542/peds.2009-0958 · Cited by 2,621 · see citing works
Self-citationAutism as a strongly genetic disorder: evidence from a British twin study
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461 · see citing works
Mullen Scales of Early Learning
Bradley‐Johnson, S. (1997) · Psychology in the Schools · doi:10.1002/(sici)1520-6807(199710)34:4 · Cited by 2,329 · see citing works
Functional impact of global rare copy number variation in autism spectrum disorders
Pinto, D., Pagnamenta, A. T., Klei, L., Anney, R., Merico, D., Regan, R., Conroy, J., Magalhaes, T. R., Correia, C., Abrahams, B. S., et al. (2010) · Nature · doi:10.1038/nature09146 · Cited by 2,013 · see citing works
Self-citationBehavioral manifestations of autism in the first year of life
Zwaigenbaum, L., Bryson, S., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.001 · Cited by 1,602 · see citing works
Self-citationRobins, D. L., Fein, D., Barton, M. L., & Green, J. A. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1010738829569 · Cited by 1,563 · see citing works
Pervasive Developmental Disorders in preschool children
Chakrabarti, S. (2001) · JAMA · doi:10.1001/jama.285.24.3093 · Cited by 1,132 · see citing works
A Prospective Study of the Emergence of Early Behavioral Signs of Autism
Ozonoff, S., Iosif, A.-M., Baguio, F., Cook, I. C., Hill, M. M., Hutman, T., Rogers, S. J., Rozga, A., Sangha, S., Sigman, M., et al. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2009.11.009 · Cited by 1,011 · see citing works
Self-citationEvidence-Based Comprehensive Treatments for Early Autism
Rogers, S. J., & Vismara, L. A. (2008) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374410701817808 · Cited by 984 · see citing works
Self-citationRice, C. E. (2009) · PsycEXTRA Dataset · doi:10.1037/e562722010-001 · Cited by 760 · see citing works
Development in infants with autism spectrum disorders: a prospective study
Landa, R., & Garrett‐Mayer, E. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01531.x · Cited by 730 · see citing works
Self-citationCopy-number variations associated with neuropsychiatric conditions
Cook Jr, E. H., & Scherer, S. W. (2008) · Nature · doi:10.1038/nature07458 · Cited by 659 · see citing works
Mack, A. H. (2011) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/j.ypsy.2010.11.009 · Cited by 500 · see citing works
Sibling Recurrence and the Genetic Epidemiology of Autism
Constantino, J. N., Zhang, Y., Frazier, T., Abbacchi, A. M., & Law, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101470 · Cited by 481 · see citing works
Self-citationCharman, T., Taylor, E., Drew, A., Cockerill, H., Brown, J., & Baird, G. (2005) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00377.x · Cited by 469 · see citing works
Zwaigenbaum, L., Bryson, S., Lord, C., Rogers, S., Carter, A., Carver, L., Chawarska, K., Constantino, J., Dawson, G., Dobkins, K., et al. (2009) · Pediatrics · doi:10.1542/peds.2008-1606 · Cited by 444 · see citing works
Self-citationA Prospective Study of the Emergence of Early Behavioral Signs of Autism
Ozonoff, S. J., Iosif, A., Baguio, F., et al. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-201003000-00009 · Cited by 406 · see citing works
Self-citationKleinman, J. M., Robins, D. L., Ventola, P. E., Pandey, J., Boorstein, H., Esser, E. L., Wilson, L. B., ROSENTHAL, M. A., Sutera, S., Verbalis, A. D., et al. (2007) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0450-9 · Cited by 395 · see citing works
Lauritsen, M. B., Pedersen, C. B., & Mortensen, P. B. (2005) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00391.x · Cited by 359 · see citing works
Yirmiya, N., Seidman, I., Pilowsky, T., Feldman, R., Baron‐Cohen, S., & Sigman, M. (2005) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01528.x · Cited by 328 · see citing works
Self-citationA unified genetic theory for sporadic and inherited autism
Zhao, X., Leotta, A., Kustanovich, V., Lajonchere, C., Geschwind, D. H., Law, K., Law, P., Qiu, S., Lord, C., Sebat, J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705803104 · Cited by 319 · see citing works
Wetherby, A. M., Brosnan-Maddox, S., Peace, V., & Newton, L. (2008) · Autism · doi:10.1177/1362361308094501 · Cited by 287 · see citing works
(1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.8.1032 · Cited by 255 · see citing works
Epidemiological trends in rates of autism
Fombonne, E. J. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001162 · Cited by 231 · see citing works
Reznick, J. S., Baranek, G. T., Reavis, S., Watson, L. R., & Crais, E. R. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0303-y · Cited by 217 · see citing works
Mullen Scales of Early Learning
(2012) · Springer eBooks · doi:10.1007/springerreference_184265 · Cited by 212 · see citing works
How early do parent concerns predict later autism diagnosis?
Ozonoff, S., Young, G. S., Steinfeld, M. B., Hill, M. M., Cook, I., Hutman, T., Macari, S., Rogers, S. J., & Sigman, M. (2009) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e3181ba0fcf · Cited by 210 · see citing works
Self-citationVariability in outcome for children with an ASD diagnosis at age 2
Turner, L. M., & Stone, W. L. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01744.x · Cited by 192 · see citing works
Self-citationComplex segregation analysis of autism.
Jorde, L. B., Hasstedt, S. J., RITVO, E. R., MASON-BROTHERS, A., Freeman, B. J., Pingree, C., McMahon, W. M., Petersen, B., Jenson, W. R., & Mo, A. (1991) · PubMed · Cited by 191 · see citing works
Surveillance for violent deaths--national violent death reporting system, 16 States, 2006.
Karch, D. L., Dahlberg, L. L., Patel, N., Davis, T. W., Logan, J. E., Hill, H. A., & Ortega, L. (2009) · PubMed · Cited by 152 · see citing works
Cumulative incidence of childhood autism: a total population study of better accuracy and precision
Honda, H., Shimizu, Y., Imai, M., & Nitto, Y. (2005) · Developmental Medicine & Child Neurology · doi:10.1017/s0012162205000034 · Cited by 143 · see citing works
Stoppage rules and genetic studies of autism
Jones, M. B., & Szatmári, P. (1988) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02211816 · Cited by 129 · see citing works
Selkirk, C. G., McCarthy Veach, P., Lian, F., Schimmenti, L., & LeRoy, B. S. (2009) · Journal of Genetic Counseling · doi:10.1007/s10897-009-9233-0 · Cited by 118 · see citing works
Sumi, S., Taniai, H., Miyachi, T., & Tanemura, M. (2006) · Journal of Human Genetics · doi:10.1007/s10038-006-0392-7 · Cited by 117 · see citing works
Inflation of Sibling Recurrence-Risk Ratio, Due to Ascertainment Bias and/or Overreporting
Guo, S. (1998) · The American Journal of Human Genetics · doi:10.1086/301928 · Cited by 106 · see citing works
Current Developments in the Genetics of Autism: From Phenome to Genome
Losh, M. C., Sullivan, P. F., Trembath, D. G., & Piven, J. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318184482d · Cited by 106 · see citing works
Oosterling, I. J., Wensing, M., Willemsen‐Swinkels, S. H. N., van der Gaag, R. J., Visser, J. C., Woudenberg, T., Minderaa, R. B., Steenhuis, M., & Buitelaar, J. K. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02150.x · Cited by 105 · see citing works
Cumulative incidence of childhood autism: a total population study of better accuracy and precision
Honda, H., Shimizu, Y., Imai, M., & Nitto, Y. (2007) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2005.tb01034.x · Cited by 102 · see citing works
PGD gender selection for non-Mendelian disorders with unequal sex incidence
Amor, D. J., & Cameron, C. (2008) · Human Reproduction · doi:10.1093/humrep/dem433 · Cited by 89 · see citing works
Genetic Counseling in Autism and Pervasive Developmental Disorders
Simonoff, E. A. (1998) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1026060623511 · Cited by 83 · see citing works
Childhood autism spectrum disorder in the Barwon region: A community based study
Icasiano, F., Hewson, P. H., Machet, P., Cooper, C., & Marshall, A. (2004) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2004.00513.x · Cited by 82 · see citing works
McConachie, H., Couteur, A. S. L., & Honey, E. J. (2005) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-004-1995-5 · Cited by 60 · see citing works
Goin-Kochel, R. P., Abbacchi, A., Constantino, J. N., & Autism Genetic Resource Exchange Consortium (2007) · Autism · doi:10.1177/1362361307076857 · Cited by 47 · see citing works
Self-citationGenetic counseling and ethical issues for autism
McMahon, W. M., Baty, B. J., & Botkin, J. R. (2006) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30082 · Cited by 41 · see citing works
Recurrence risk in Autism Spectrum Disorder: A study of parental knowledge
Whitelaw, C., Flett, P. J., & Amor, D. J. (2007) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2007.01156.x · Cited by 15 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Chakrabarti S, Fombonne E. Pervasive de- velopmental disorders in preschool chil- dren. JAMA. 2001;285(24):3093-3099
- Zhao X, Leotta A, Kustanovich V, et al. A uni- fied genetic theory for sporadic and inher- ited autism. Proc Natl Acad Sci USA. 2007; 104(31):12831-12836
Cited by
Sorted by citations
Lord, C., Elsabbagh, M., Baird, G., & Veenstra-Vanderweele, J. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31129-2 · Cited by 2,819 · see citing works
Lord, C., Brugha, T. S., Charman, T., Cusack, J., Dumas, G., Frazier, T., Jones, E. J. H., Jones, R. M., Pickles, A., State, M. W., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0138-4 · Cited by 1,859 · see citing works
Identification, Evaluation, and Management of Children With Autism Spectrum Disorder
Hyman, S. L., Levy, S. E., Myers, S. M., COUNCIL ON CHILDREN WITH DISABILITIES, S. O. D. A. B. P., Kuo, D. Z., Apkon, S., Davidson, L. F., Ellerbeck, K. A., Foster, J. E. A., Noritz, G. H., et al. (2020) · Pediatrics · doi:10.1542/peds.2019-3447 · Cited by 1,548 · see citing works
Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism
Jones, W., & Klin, A. (2013) · Nature · doi:10.1038/nature12715 · Cited by 1,293 · see citing works
Sex differences in autism spectrum disorders
Werling, D. M., & Geschwind, D. H. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32835ee548 · Cited by 1,245 · see citing works
Sex/Gender Differences and Autism: Setting the Scene for Future Research
Lai, M.-C., Lombardo, M. V., Auyeung, B., Chakrabarti, B., & Baron-Cohen, S. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.10.003 · Cited by 1,120 · see citing works
Sandin, S., Lichtenstein, P., Kuja-Halkola, R., Larsson, H., Hultman, C. M., & Reichenberg, A. (2014) · JAMA · doi:10.1001/jama.2014.4144 · Cited by 1,073 · see citing works
An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options
Masi, A., DeMayo, M. M., Glozier, N., & Guastella, A. J. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0100-y · Cited by 987 · see citing works
Genetics of autism spectrum disorders
Geschwind, D. H. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.003 · Cited by 696 · see citing works
Wolff, J. J., Gu, H., Gerig, G., Elison, J. T., Styner, M., Gouttard, S., Botteron, K. N., Dager, S. R., Dawson, G., Estes, A. M., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11091447 · Cited by 671 · see citing works
Self-citationDisentangling the heterogeneity of autism spectrum disorder through genetic findings
Jeste, S. S., & Geschwind, D. H. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.278 · Cited by 644 · see citing works
Lipkin, P. H., Macias, M. M., COUNCIL ON CHILDREN WITH DISABILITIES, S. O. D. A. B. P., Norwood, K. W., Brei, T. J., Davidson, L. F., Davis, B. E., Ellerbeck, K. A., Houtrow, A. J., Hyman, S. L., et al. (2020) · Pediatrics · doi:10.1542/peds.2019-3449 · Cited by 676 · see citing works
Jacquemont, S., Coe, B. P., Hersch, M., Duyzend, M. H., Krumm, N., Bergmann, S., Beckmann, J. S., Rosenfeld, J. A., & Eichler, E. E. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.02.001 · Cited by 605 · see citing works
Chawarska, K., Macari, S., & Shic, F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.022 · Cited by 623 · see citing works
The Female Autism Phenotype and Camouflaging: a Narrative Review
Hull, L., Petrides, K. V., & Mandy, W. (2020) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-020-00197-9 · Cited by 614 · see citing works
Developmental pathways to autism: A review of prospective studies of infants at risk
Jones, E. J. H., Gliga, T., Bedford, R., Charman, T., & Johnson, M. H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.001 · Cited by 607 · see citing works
The Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium (2017) · Molecular Autism · doi:10.1186/s13229-017-0137-9 · Cited by 587 · see citing works
Examining and interpreting the female protective effect against autistic behavior
Robinson, E. B., Lichtenstein, P., Anckarsäter, H., Happé, F., & Ronald, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211070110 · Cited by 531 · see citing works
Genetic architecture in autism spectrum disorder
Devlin, B., & Scherer, S. W. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.03.002 · Cited by 545 · see citing works
Whole-genome sequencing of quartet families with autism spectrum disorder
Yuen, R. K. C., Thiruvahindrapuram, B., Merico, D., Walker, S., Tammimies, K., Hoang, N., Chrysler, C., Nalpathamkalam, T., Pellecchia, G., Liu, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3792 · Cited by 514 · see citing works
Self-citationSchaefer, G. B., & Mendelsohn, N. J. (2013) · Genetics in Medicine · doi:10.1038/gim.2013.32 · Cited by 537 · see citing works
Inherited and de novo genetic risk for autism impacts shared networks
Ruzzo, E. K., Pérez-Cano, L., Jung, J.-Y., Wang, L.-K., Kashef-Haghighi, D., Hartl, C., Singh, C., Xu, J., Hoekstra, J. N., Leventhal, O., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.015 · Cited by 457 · see citing works
Autism Spectrum Disorders and the Gut Microbiota
Fattorusso, A., Di Genova, L., Dell’Isola, G., Mencaroni, E., & Esposito, S. (2019) · Nutrients · doi:10.3390/nu11030521 · Cited by 484 · see citing works
Disengagement of Visual Attention in Infancy is Associated with Emerging Autism in Toddlerhood
Elsabbagh, M., Fernandes, J., Jane Webb, S., Dawson, G., Charman, T., & Johnson, M. H. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.030 · Cited by 431 · see citing works
Common genetic variants, acting additively, are a major source of risk for autism
Klei, L., Sanders, S. J., Murtha, M. T., Hus, V., Lowe, J. K., Willsey, A. J., Moreno-De-Luca, D., Yu, T. W., Fombonne, E., Geschwind, D., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-9 · Cited by 418 · see citing works
The role of de novo mutations in the genetics of autism spectrum disorders
Ronemus, M., Iossifov, I., Levy, D., & Wigler, M. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3585 · Cited by 390 · see citing works
Ozonoff, S., Young, G. S., Landa, R. J., Brian, J., Bryson, S., Charman, T., Chawarska, K., Macari, S. L., Messinger, D., Stone, W. L., et al. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12421 · Cited by 377 · see citing works
Self-citationIBIS network, Estes, A., Zwaigenbaum, L., Gu, H., St. John, T., Paterson, S., Elison, J. T., Hazlett, H., Botteron, K., Dager, S. R., et al. (2015) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-015-9117-6 · Cited by 363 · see citing works
Self-citationEmerson, R. W., Adams, C., Nishino, T., Hazlett, H. C., Wolff, J. J., Zwaigenbaum, L., Constantino, J. N., Shen, M. D., Swanson, M. R., Elison, J. T., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aag2882 · Cited by 359 · see citing works
Self-citationShen, M. D., Nordahl, C. W., Young, G. S., Wootton-Gorges, S. L., Lee, A., Liston, S. E., Harrington, K. R., Ozonoff, S., & Amaral, D. G. (2013) · Brain · doi:10.1093/brain/awt166 · Cited by 345 · see citing works
Self-citationGene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders
Werling, D. M., Parikshak, N. N., & Geschwind, D. H. (2016) · Nature Communications · doi:10.1038/ncomms10717 · Cited by 296 · see citing works
Head Lag in Infants at Risk for Autism: A Preliminary Study
Flanagan, J. E., Landa, R., Bhat, A., & Bauman, M. (2012) · American Journal of Occupational Therapy · doi:10.5014/ajot.2012.004192 · Cited by 321 · see citing works
Self-citationDevelopmental Trajectories in Children With and Without Autism Spectrum Disorders: The First 3 Years
Landa, R. J., Gross, A. L., Stuart, E. A., & Faherty, A. (2013) · Child Development · doi:10.1111/j.1467-8624.2012.01870.x · Cited by 316 · see citing works
Self-citationTackling healthcare access barriers for individuals with autism from diagnosis to adulthood
Malik-Soni, N., Shaker, A., Luck, H., Mullin, A. E., Wiley, R. E., Lewis, M. E. S., Fuentes, J., & Frazier, T. W. (2022) · Pediatric Research · doi:10.1038/s41390-021-01465-y · Cited by 309 · see citing works
Constantino, J. N., & Charman, T. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00151-9 · Cited by 294 · see citing works
Self-citationBeyond Autism: A Baby Siblings Research Consortium Study of High-Risk Children at Three Years of Age
Messinger, D., Young, G. S., Ozonoff, S., Dobkins, K., Carter, A., Zwaigenbaum, L., Landa, R. J., Charman, T., Stone, W. L., Constantino, J. N., et al. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.12.011 · Cited by 290 · see citing works
Self-citationAnnual research review: re-thinking the classification of autism spectrum disorders
Lord, C., & Jones, R. M. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02547.x · Cited by 290 · see citing works
Wan, M. W., Green, J., Elsabbagh, M., Johnson, M., Charman, T., Plummer, F., & the BASIS Team (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12032 · Cited by 266 · see citing works
The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology
Chen, J. A., Peñagarikano, O., Belgard, T. G., Swarup, V., & Geschwind, D. H. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040405 · Cited by 254 · see citing works
The development of face orienting mechanisms in infants at-risk for autism
Elsabbagh, M., Gliga, T., Pickles, A., Hudry, K., Charman, T., & Johnson, M. H. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.030 · Cited by 257 · see citing works
the BASIS team, Bedford, R., Elsabbagh, M., Gliga, T., Pickles, A., Senju, A., Charman, T., & Johnson, M. H. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1450-y · Cited by 248 · see citing works
Genome-wide characteristics of de novo mutations in autism
Yuen, R. K., Merico, D., Cao, H., Pellecchia, G., Alipanahi, B., Thiruvahindrapuram, B., Tong, X., Sun, Y., Cao, D., Zhang, T., et al. (2016) · npj Genomic Medicine · doi:10.1038/npjgenmed.2016.27 · Cited by 216 · see citing works
Self-citationGenome-wide detection of tandem DNA repeats that are expanded in autism
Trost, B., Engchuan, W., Nguyen, C. M., Thiruvahindrapuram, B., Dolzhenko, E., Backstrom, I., Mirceta, M., Mojarad, B. A., Yin, Y., Dov, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2579-z · Cited by 238 · see citing works
Self-citationRecent Advances in Autism Research as Reflected in DSM-5 Criteria for Autism Spectrum Disorder
Lord, C., & Bishop, S. L. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032814-112745 · Cited by 224 · see citing works
The role of sex-differential biology in risk for autism spectrum disorder
Werling, D. M. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0112-8 · Cited by 208 · see citing works
Speech Disturbs Face Scanning in 6-Month-Old Infants Who Develop Autism Spectrum Disorder
Shic, F., Macari, S., & Chawarska, K. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.009 · Cited by 221 · see citing works
Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study
Messinger, D. S., Young, G. S., Webb, S. J., Ozonoff, S., Bryson, S. E., Carter, A., Carver, L., Charman, T., Chawarska, K., Curtin, S., et al. (2015) · Molecular Autism · doi:10.1186/s13229-015-0027-y · Cited by 207 · see citing works
Self-citationTemperament in the First 2 Years of Life in Infants at High-Risk for Autism Spectrum Disorders
The BASIS Team, Clifford, S. M., Hudry, K., Elsabbagh, M., Charman, T., & Johnson, M. H. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1612-y · Cited by 198 · see citing works
Bolton, P. F., Golding, J., Emond, A., & Steer, C. D. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2011.12.009 · Cited by 193 · see citing works
Autism genetics: searching for specificity and convergence
Berg, J. M., & Geschwind, D. H. (2012) · Genome Biology · doi:10.1186/gb-2012-13-7-247 · Cited by 192 · see citing works
Limited Fine Motor and Grasping Skills in 6-Month-Old Infants at High Risk for Autism
Libertus, K., Sheperd, K. A., Ross, S. W., & Landa, R. J. (2014) · Child Development · doi:10.1111/cdev.12262 · Cited by 181 · see citing works
Self-citationGrønborg, T. K., Schendel, D. E., & Parner, E. T. (2013) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2013.2259 · Cited by 180 · see citing works
Zwaigenbaum, L., Bryson, S. E., Szatmari, P., Brian, J., Smith, I. M., Roberts, W., Vaillancourt, T., & Roncadin, C. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1515-y · Cited by 178 · see citing works
Self-citationEnhanced Visual Search in Infancy Predicts Emerging Autism Symptoms
Gliga, T., Bedford, R., Charman, T., Johnson, M. H., Baron-Cohen, S., Bolton, P., Cheung, C., Davies, K., Liew, M., Fernandes, J., et al. (2015) · Current Biology · doi:10.1016/j.cub.2015.05.011 · Cited by 163 · see citing works
Jones, E. J. H., Venema, K., Earl, R., Lowy, R., Barnes, K., Estes, A., Dawson, G., & Webb, S. J. (2016) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-016-9139-8 · Cited by 164 · see citing works
“Since infants with an older sibling with ASD have close to a 20 % risk of developing ASD themselves [7], researchers can examine the neural and cognitive precursors to * Correspondence: e.”
BackgroundDeneault, E., White, S. H., Rodrigues, D. C., Ross, P. J., Faheem, M., Zaslavsky, K., Wang, Z., Alexandrova, R., Pellecchia, G., Wei, W., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.10.003 · Cited by 145 · see citing works
Service Needs Across the Lifespan for Individuals with Autism
Turcotte, P., Mathew, M., Shea, L. L., Brusilovskiy, E., & Nonnemacher, S. L. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2787-4 · Cited by 167 · see citing works
Schendel, D. E., DiGuiseppi, C., Croen, L. A., Fallin, M. D., Reed, P. L., Schieve, L. A., Wiggins, L. D., Daniels, J., Grether, J., Levy, S. E., et al. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1461-8 · Cited by 154 · see citing works
Self-citationFrom early markers to neuro-developmental mechanisms of autism
Gliga, T., Jones, E. J. H., Bedford, R., Charman, T., & Johnson, M. H. (2014) · Developmental Review · doi:10.1016/j.dr.2014.05.003 · Cited by 150 · see citing works
Robinson, E. B., Samocha, K. E., Kosmicki, J. A., McGrath, L., Neale, B. M., Perlis, R. H., & Daly, M. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409204111 · Cited by 142 · see citing works
Ozonoff, S., & Iosif, A.-M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.012 · Cited by 146 · see citing works
Self-citationCharman, T., Young, G. S., Brian, J., Carter, A., Carver, L. J., Chawarska, K., Curtin, S., Dobkins, K., Elsabbagh, M., Georgiades, S., et al. (2017) · Autism Research · doi:10.1002/aur.1669 · Cited by 147 · see citing works
Self-citationFamilial Recurrence of Autism Spectrum Disorder: Evaluating Genetic and Environmental Contributions
Risch, N., Hoffmann, T. J., Anderson, M., Croen, L. A., Grether, J. K., & Windham, G. C. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13101359 · Cited by 144 · see citing works
Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice?
Haker, H., Schneebeli, M., & Stephan, K. E. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00107 · Cited by 130 · see citing works
Maternal verbal responses to communication of infants at low and heightened risk of autism
Leezenbaum, N. B., Campbell, S. B., Butler, D., & Iverson, J. M. (2014) · Autism · doi:10.1177/1362361313491327 · Cited by 140 · see citing works
Self-citationUnderstanding sex bias in autism spectrum disorder
Werling, D. M., & Geschwind, D. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301602110 · Cited by 135 · see citing works
Differential habituation to repeated sounds in infants at high risk for autism
Guiraud, J. A., Kushnerenko, E., Tomalski, P., Davies, K., Ribeiro, H., & Johnson, M. H. (2011) · NeuroReport · doi:10.1097/wnr.0b013e32834c0bec · Cited by 130 · see citing works
Autism and the Social Brain: The First-Year Puzzle
Elsabbagh, M., & Johnson, M. H. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.019 · Cited by 136 · see citing works
Georgiades, S., Szatmari, P., Zwaigenbaum, L., Bryson, S., Brian, J., Roberts, W., Smith, I., Vaillancourt, T., Roncadin, C., & Garon, N. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.1 · Cited by 130 · see citing works
Self-citationSantini, E., & Klann, E. (2014) · Science Signaling · doi:10.1126/scisignal.2005832 · Cited by 118 · see citing works
Epigenetics of Autism Spectrum Disorder
Siu, M. T., & Weksberg, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-53889-1_4 · Cited by 121 · see citing works
Maternal Autoantibodies in Autism
Braunschweig, D., & Van de Water, J. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.2506 · Cited by 122 · see citing works
Standards of diagnostic assessment for autism spectrum disorder
Brian, J. A., Zwaigenbaum, L., & Ip, A. (2019) · Paediatrics & Child Health · doi:10.1093/pch/pxz117 · Cited by 126 · see citing works
Self-citationA twin study of heritable and shared environmental contributions to autism
Frazier, T. W., Thompson, L., Youngstrom, E. A., Law, P., Hardan, A. Y., Eng, C., & Morris, N. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2081-2 · Cited by 120 · see citing works
Gammer, I., Bedford, R., Elsabbagh, M., Garwood, H., Pasco, G., Tucker, L., Volein, A., Johnson, M. H., & Charman, T. (2015) · Infant Behavior and Development · doi:10.1016/j.infbeh.2014.12.017 · Cited by 118 · see citing works
Macari, S. L., Campbell, D., Gengoux, G. W., Saulnier, C. A., Klin, A. J., & Chawarska, K. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1521-0 · Cited by 116 · see citing works
EEG power at 3 months in infants at high familial risk for autism
Levin, A. R., Varcin, K. J., O’Leary, H. M., Tager-Flusberg, H., & Nelson, C. A. (2017) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9214-9 · Cited by 107 · see citing works
Psychosocial deprivation, executive functions and the emergence of socio-emotional behavior problems
McDermott, J. M., Troller-Renfree, S., Vanderwert, R., Nelson, C. A., Zeanah, C. H., & Fox, N. A. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00167 · Cited by 113 · see citing works
Brain Volume Findings in 6-Month-Old Infants at High Familial Risk for Autism
Hazlett, H. C., Gu, H., McKinstry, R. C., Shaw, D. W. W., Botteron, K. N., Dager, S. R., Styner, M., Vachet, C., Gerig, G., Paterson, S. J., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11091425 · Cited by 108 · see citing works
Righi, G., Tierney, A. L., Tager-Flusberg, H., & Nelson, C. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105176 · Cited by 105 · see citing works
“These infants are termed ‘‘high-risk’’ for ASD because they have an increased predisposition to develop ASD, estimated to be around fifteen to twenty times higher than infants with no family history of ASD [10,11].”
BackgroundStubbs, G., Henley, K., & Green, J. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.01.015 · Cited by 107 · see citing works
Maternal vitamin D levels and the autism phenotype among offspring
Whitehouse, A. J. O., Holt, B. J., Serralha, M., Holt, P. G., Hart, P. H., & Kusel, M. M. H. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1676-8 · Cited by 100 · see citing works
Edmunds, S. R., Kover, S. T., & Stone, W. L. (2019) · Autism Research · doi:10.1002/aur.2100 · Cited by 93 · see citing works
Self-citationDargenio, V. N., Dargenio, C., Castellaneta, S., De Giacomo, A., Laguardia, M., Schettini, F., Francavilla, R., & Cristofori, F. (2023) · Nutrients · doi:10.3390/nu15071620 · Cited by 98 · see citing works
Motor development in children at risk of autism: A follow-up study of infant siblings
Leonard, H. C., Bedford, R., Charman, T., Elsabbagh, M., Johnson, M. H., Hill, E. L., The BASIS team, Baron-Cohen, S., Bolton, P., Chandler, S., et al. (2014) · Autism · doi:10.1177/1362361312470037 · Cited by 94 · see citing works
Association of Sex With Recurrence of Autism Spectrum Disorder Among Siblings
Palmer, N., Beam, A., Agniel, D., Eran, A., Manrai, A., Spettell, C., Steinberg, G., Mandl, K., Fox, K., Nelson, S. F., et al. (2017) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2017.2832 · Cited by 89 · see citing works
Alpha Asymmetry in Infants at Risk for Autism Spectrum Disorders
Gabard-Durnam, L., Tierney, A. L., Vogel-Farley, V., Tager-Flusberg, H., & Nelson, C. A. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1926-4 · Cited by 85 · see citing works
Seery, A. M., Vogel-Farley, V., Tager-Flusberg, H., & Nelson, C. A. (2013) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2012.11.007 · Cited by 84 · see citing works
Hypersensitive pupillary light reflex in infants at risk for autism
Nyström, P., Gredebäck, G., Bölte, S., Falck-Ytter, T., & EASE team (2015) · Molecular Autism · doi:10.1186/s13229-015-0011-6 · Cited by 79 · see citing works
Increased cortical reactivity to repeated tones at 8 months in infants with later ASD
Kolesnik, A., Begum Ali, J., Gliga, T., Guiraud, J., Charman, T., Johnson, M. H., Jones, E. J. H., & The BASIS Team (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0393-x · Cited by 75 · see citing works
Pearson, N., Charman, T., Happé, F., Bolton, P. F., & McEwen, F. S. (2018) · Autism Research · doi:10.1002/aur.2035 · Cited by 75 · see citing works
Bedford, R., Pickles, A., Gliga, T., Elsabbagh, M., Charman, T., Johnson, M. H., & the BASIS Team (2014) · Developmental Science · doi:10.1111/desc.12139 · Cited by 70 · see citing works
Atypical social referencing in infant siblings of children with autism spectrum disorders
Cornew, L., Dobkins, K. R., Akshoomoff, N., McCleery, J. P., & Carver, L. J. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1518-8 · Cited by 71 · see citing works
Self-citationEquivalence of symptom dimensions in females and males with autism
Frazier, T. W., & Hardan, A. Y. (2017) · Autism · doi:10.1177/1362361316660066 · Cited by 71 · see citing works
Atypical Hemispheric Specialization for Faces in Infants at Risk for Autism Spectrum Disorder
Keehn, B., Vogel‐Farley, V., Tager‐Flusberg, H., & Nelson, C. A. (2015) · Autism Research · doi:10.1002/aur.1438 · Cited by 63 · see citing works
Genetic research in autism spectrum disorders
Robinson, E. B., Neale, B. M., & Hyman, S. E. (2015) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000278 · Cited by 60 · see citing works
The female protective effect in autism spectrum disorder is not mediated by a single genetic locus
Gockley, J., Willsey, A. J., Dong, S., Dougherty, J. D., Constantino, J. N., & Sanders, S. J. (2015) · Molecular Autism · doi:10.1186/s13229-015-0014-3 · Cited by 61 · see citing works
Jones-Davis, D. M., Yang, M., Rider, E., Osbun, N. C., da Gente, G. J., Li, J., Katz, A. M., Weber, M. D., Sen, S., Crawley, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061829 · Cited by 61 · see citing works
Wilson, R. B., Vangala, S., Elashoff, D., Safari, T., & Smith, B. A. (2021) · Sensors · doi:10.3390/s21020616 · Cited by 59 · see citing works
Clinical practice guidelines for autism spectrum disorders
Subramanyam, A., Mukherjee, A., Dave, M., & Chavda, K. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_542_18 · Cited by 59 · see citing works
- Authors
- Ozonoff, S., Young, G. S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., Bryson, S., Carver, L. J., Constantino, J. N., Dobkins, K., Hutman, T., Iverson, J. M., Landa, R., Rogers, S. J., Sigman, M., & Stone, W. L.
- Affiliations
- University of California, Davis (US)
- University of Massachusetts Boston (US)
- University of Miami (US)
- Hebrew University of Jerusalem (IL)
- University of Alberta (CA)
- Dalhousie University (CA)
- University of California San Diego (US)
- Washington University in St. Louis (US)
- University of California, Los Angeles (US)
- University of Pittsburgh (US)
- Kennedy Krieger Institute (US)
- University of Washington (US)
- ORCID
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2011-09-01
- Volume
- 128
- Issue
- 3
- Pages
- e488-e495
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- PMC
- PMC3164092
- OpenAlex
- W2133978628
- Cited by
- 1,429
- References
- 48
- Citations by year
- 2026: 25 · 2025: 51 · 2024: 106 · 2023: 68 · 2022: 98 · 2021: 113 · 2020: 143 · 2019: 94 · 2018: 112 · 2017: 116 · 2016: 105 · 2015: 115 · 2014: 95 · 2013: 102 · 2012: 71
- FWCI
- 45.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- PEDIATRICS (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Canadian Institutes of Health Research (102665, 62924)
- National Institute of Mental Health (U54MH066417, R01MH068398, R01MH059630, U54MH068172)
- National Institute on Deafness and Other Communication Disorders (R01 DC10290, R01DC010290)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD54979, R01HD057284, R01HD047417, R01HD042541, R01HD043292, R01HD052804, R01HD054979)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
- Keywords
- autism spectrum disorder, sibling recurrence risk, genetic counseling
- MeSH terms
- Child Development Disorders, Pervasive, Family Health, Female, Humans, Infant, Male, Recurrence, Linear Models, Siblings
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
