The DOI matches its Crossref record; 52 of the 56 references it cites were found in a registry or an index; 5 of the 23 sources its claims cite were checked for support.
Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior
Open accessAbstract
Importance Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not been identified.
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25 Own result · 9 Own method · 9 Own interpretation · 5 Sources not found · 5 No full text of the sources · 2 Supported · 2 Supported so far · 2 No basis given · 1 Not checked yet
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Specific causal genetic variants have, however, not been identified.”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Abstract > Importance
What the sources say
- Supportedcites Vassos, Collier, & Fazel, 2014 source
The Discussion says the review found no gene of major effect for aggression and that candidate-gene studies had not identified genes consistently associated with aggression or violence. It also describes the few markers reported for conduct disorder as having modest effects, not as established causal variants. (LLM, conf=0.86)
- Not checked — no full text of the sourcecites Kendler, 2013 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“a systematic review and meta-analysis of the majority of published genetic association studies on aggression and violence failed to reveal a significant overall association between any of the previously reported candidate genes and aggression”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Introduction
What the sources say
- Supportedcites Vassos, Collier, & Fazel, 2014 source
The Abstract reports that the primary meta-analyses found no association between any analyzed polymorphism and aggression at the 5% significance level. The Discussion likewise reports no significant associations in the primary analyses, while noting a few findings in sensitivity analyses. (LLM, conf=0.92)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“none of the other published GWAS studies Tielbeek et al. 2012(Tielbeek et al., 2012) (QIMR, N=4816, continuous measure of adult antisocial behaviour), Salvatore et al. 2015(Salvatore et al., 2015) (COGA, N=1379, continuous measure of adult antisocial behaviour, part of the present meta-analysis), Viding et al. 2010(Viding et al., 2010) (TEDS, N=1186 (Ncases=593), psychopathic tendencies) and Derr”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Introduction
What the sources say
- Supportedcites Tielbeek et al., 2012 source
The Results report that no associations reached genome-wide significance in either the case-status analysis or the adult antisocial-behavior symptom-count analysis. The Abstract gives the sample size as 4,816. This supports the claim as it pertains to Tielbeek et al.; it does not establish the results of the other cited studies. (LLM, conf=0.94)
- Supportedcites Salvatore et al., 2015 source
The Discussion (page not provided) states that no SNP reached strict genome-wide significance in this study of adult antisocial behavior. That supports the claim as it applies to the cited Salvatore et al. GWAS; it does not need to establish the results of the other studies listed alongside it. (LLM, conf=0.93)
- Not checked — no full text of the sourcecites Viding et al., 2010 source
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“One study, carried out on childhood conduct disorder in an American sample (N=3963, including 872 cases and 3091 controls), detected three genome-wide significant loci”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Introduction
What the sources say
- Supportedcites D. M. Dick et al., 2011 source
The Results report four genome-wide-significant SNPs: two in C1QTNF7, and the Discussion locates the other two on chromosomes 11 and 13. That amounts to three distinct loci, despite there being four significant markers. Materials and methods (Measure) gives N=3963, including 872 CD cases and 3091 controls; the study assessed childhood conduct-disorder symptoms retrospectively in adults. (LLM, conf=0.92)
plaincorrelationaln = 872- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Top signals were located differently across sex, which is illustrated by the Miami plot in Figure 1 and Table S5.”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results > Meta-analysis of GWAS
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Age of First Birth (r=-.43, p=.008)”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results > SNP heritability and genetic correlation of ASB with other traits
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the meta-analysis for males (N=7772, Table S2c) identified a near genome-wide signal on chromosome X (rs41456347, p= 2.0 x 10-8, R2=.41%)”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results > Meta-analysis of GWAS
plaincorrelationaln = 7,772 ·- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The BroadABC antisocial genetic risk scores could predict case-control status of antisocial personality disorder in the Finnish Crime Study (sex-combined, p=.031; male-specific, p=.05, in the most optimal model”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results > Polygenic risk scores
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We found no evidence for heterogeneity (I2=0) across discovery samples in the association of rs2764450 (p=.45), rs11215217 (p=.54) and rs41456347 (p=.60) with ASB”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results > Meta-analysis of GWAS
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“None of the traditional candidate genes on antisocial behaviour were significantly associated with ASB (top gene=TH, pcorr=.0841, Table S4a-c).”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results > Meta-analysis of GWAS
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- It may state two separate claims as one. 17
- Probably not a substantial claim. 7
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“No significant genetic overlap was found with conduct disorder in YalePenn, although a nominal significant effect (p=.04, R2=.0022) in the expected direction was found in the males-only analysis”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results > Polygenic risk scores
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Gene-based and gene-set analyses yielded no significant genes (top gene= CENPI, p= 3.2 × 10-5, Table S3a-c, Figure S3) or gene-sets (top gene-set=‘Reactome cell communication’, p= 3.6 × 10-4, Table S3d).”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results > Meta-analysis of GWAS
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Nevertheless, the analyses revealed low Nagelkerke’s R2 estimates (R2=.0019 in the most optimal model) not exceeding the Bonferroni corrected threshold for significance.”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results > Polygenic risk scores
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In total, BroadABC has genotypic and phenotypic data from 25,781 individuals across eight unique samples, making it the largest collective sample available to estimate the effects of genome wide genetic variants for ASB”
- Also stated in: § Conclusions and Relevance · plain
“The Broad Antisocial Behaviour Consortium entails the largest collaboration to date (total N=25,781) on the genetic architecture of antisocial behaviour”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Introduction
plainn = 25,781- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § Conclusions and Relevance · plain
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The genomic inflation factors for the combined, male and female meta-analyses were 1.015, 1.012 and 1.001, respectively, which are as expected under a polygenic model given the current sample size, prevalence, and heritability of ASB”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“we found that the genetic effect from the females-only ASB analysis significantly overlapped with genetic effects in the expected direction on conduct problems in MSUTR (p= .004, R2=.021 for the most optimal model, see Figure 2E), but not with the sex-combined and males-only analyses”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results > Polygenic risk scores
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The genome-wide significance threshold was set at 1.67 x 10-8 as we performed three meta-analyses”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Materials and methods > Statistical analyses
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Polygenic risk score analysis, based on a broad conceptualization of ASB, could reliably predict some of the variation in antisocial personality disorder in a forensic cohort, demonstrating that population-based genetic association studies can also be informative for samples that are at-risk.”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Discussion
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no discrepancies between the results files of the two analysts at either the cohort level or the meta-analysis level.”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“although we cannot rule out that most of the genetic variance in ASB is due to rare alleles”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Discussion
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“previous meta-analytical GWAS studies have successfully applied this joint analysis approach, by identifying additional loci associated with depressive symptoms and neuroticism”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Introduction
What the sources say
- Not matchedcites Okbay, Baselmans, et al., 2016
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Not matched
In the paper
“Strikingly, ASB also correlates with reproductive traits, thus fitting to the unified evolutionary theory that Boutwell and others proposed”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Discussion
What the sources say
- Not checked — no full text of the sourcecites Boutwell et al., 2015 source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Quality control (QC) and meta-analysis of the GWA summary results were performed by two independent analysts (J.J.T. & A.J.), following a strict analysis protocol.”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Materials and methods > Statistical analyses
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“SNP heritability analyses demonstrated that the collective effect of the measured SNPs accounted for 5% of the variance, or 10% of the heritability of ˜50%, as estimated from family-based studies.”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Discussion
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Our meta-analyses of diverse continuous measures of ASB showed that ASB is heritable and highly polygenic and suggests that part of the genetic architecture is sex specific.”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Discussion
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“We only reported and interpreted the results of polymorphisms with a total sample size greater than 10,000 (across all samples) and 5000 (sex-specific).”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Materials and methods > Statistical analyses
plainn = 10,000- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“We removed 2,134,049 SNPs due to insufficient total sample size (N < 10 000), resulting in 7,392,849 SNPs available for analyses.”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Results
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“All participants were recruited from different regions, thus making sample overlap highly unlikely.”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Materials and methods > Cohorts and phenotypes
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Nevertheless, effect sizes were very small, indicating limited prediction accuracy and clinical utility for the current GWAS outcomes.”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Discussion
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Given the substantial differences in prevalence, age of onset, and severity of ASB between males and females (Cale & Lilienfeld, 2002)”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Discussion
What the sources say
- Not checked — no full text of the sourcecites Cale & Lilienfeld, 2002 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Genome-wide association analyses (GWA) were performed at the cohort level according to a pre-specified analysis plan (Standard Operating Procedures; SOP).”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Materials and methods > Statistical analyses
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Our genetic correlation analyses revealed a suggestive positive genetic correlation of ASB with neuroticism, which is concordant with previous twin research demonstrating a shared genetic etiology of externalizing behaviour and negative emotionality”
§ Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior > Discussion
What the sources say
- Not checked — no full text of the sourcecites Singh & Waldman, 2010 source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper relies on this without support.
Recent genome-wide association studies of other complex traits demonstrate that SNP heritability increases with greater sample sizes.
“Recent GWAs on other complex traits such as height, BMI, and schizophrenia clearly demonstrated that with greater sample sizes the SNP h2 increases.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, the EAGLE GWAS meta-analysis of children’s aggression [13] and the Tielbeek’s GWAS of antisocial behavior (64% adult) [47] do not show genetic correlation.”
From An integrated analysis of genes and functional pathways for aggression in human and rodent models (2019) · cites this paper as [47]
Citations
Cites
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bulik-Sullivan, B. K., Loh, P.-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., & Neale, B. M. (2015) · Nature Genetics · doi:10.1038/ng.3211 · Cited by 5,559
METAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205 · cited 2×
“The meta-analysis across discovery cohorts was run for the pooled male-female GWAS results (N = 16 400), as well as separately for the sexes (8535 female individuals and 7772 male individuals), using a fixed-effects model with z scores weighted by sample size as implemented in the software METAL.31 We only reported an…”
MethodCommon polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821
An atlas of genetic correlations across human diseases and traits
ReproGen Consortium, Bulik-Sullivan, B., Psychiatric Genomics Consortium, Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3, Finucane, H. K., Anttila, V., Gusev, A., Day, F. R., Loh, P.-R., Duncan, L., et al. (2015) · Nature Genetics · doi:10.1038/ng.3406 · Cited by 4,255 · cited 1×
“This method is particularly useful because it only requires GWAS summary statistics and is not biased by sample overlap.(33) Genetic correlations of ASB were calculated with cognitive and psychiatric traits previously reported to be comorbid with ASB using summary results from attentiondeficit/hyperactivity disorder (…”
MethodSelf-citationHowie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928
Partitioning heritability by functional annotation using genome-wide association summary statistics
ReproGen Consortium, Finucane, H. K., Schizophrenia Working Group of the Psychiatric Genomics Consortium, The RACI Consortium, Bulik-Sullivan, B., Gusev, A., Trynka, G., Reshef, Y., Loh, P.-R., Anttila, V., et al. (2015) · Nature Genetics · doi:10.1038/ng.3404 · Cited by 2,604
Self-citationMeta-analysis of the heritability of human traits based on fifty years of twin studies
Polderman, T. J. C., Benyamin, B., de Leeuw, C. A., Sullivan, P. F., van Bochoven, A., Visscher, P. M., & Posthuma, D. (2015) · Nature Genetics · doi:10.1038/ng.3285 · Cited by 2,467
Self-citationVisscher, P. M., Brown, M. A., McCarthy, M. I., & Yang, J. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.029 · Cited by 2,425 · cited 1×
“This lack of positive results fromGWASs ismost likely attributable to lowstatistical power todetect small effects.(20)For example, recentwork of the SchizophreniaWorkingGroup of the Psychiatric Genomics Consortium revealed the direct association between sample size and success in detecting genetic variants.”
BackgroundMaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
Li, Y., Willer, C. J., Ding, J., Scheet, P., & Abecasis, G. R. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20533 · Cited by 1,843
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Behavioral Genetics of Aggression and Intermittent Explosive Disorder
Tuvblad, C., Sild, M., Frogner, L., & Booij, L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813858-8.00002-4 · Cited by 6
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“For example, recent studies showed that parents with higher genome-wide PRS showed more warmth, sensitivity, and stimulating caregiving to their children(28) and that PRS predicted antisocial phenotypes in a sample of 2536 men and 3684 women.(29) Thus, future research may benefit specifically from incorporating PRS in…”
ResultA Study on the Effects of Responsive Outpatient Aggression Regulation Therapy for Juveniles
Hoogsteder, L. M., Oomen, P., Sweers, N., & Hendriks, J. (2022) · International Journal of Forensic Mental Health · doi:10.1080/14999013.2022.2129524 · Cited by 6
“An increasing amount of research suggests that stress influences the development and continuation of externalized problem behavior, including aggressive behavior (e.g., Lee & DiGiuseppe, 2018; Tielbeek et al., 2017).”
BackgroundCallousness, exploitativeness, and tracking of cooperation incentives in the human default network
Allen, T. A., Hallquist, M. N., & Dombrovski, A. Y. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2307221121 · Cited by 4
Tielbeek, J. J., & Boutwell, B. B. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00539 · Cited by 4
“Items included in these types of composite scores can vary considerably, with some examples including: ‘hit others when provoked’, ‘blamed others’ and ‘had trouble keeping a job’, yet all of them load on the broader construct of antisocial behavior (22).”
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“Contemporary research has shifted toward polygenic frameworks, identifying loci associated with risk-taking, mood instability, and antisocial behavior (Karlsson Linnér et al., 2019; Ward et al., 2020; Tielbeek et al., 2017), and links to risks of justice involvement (Tielbeek et al., 2022).”
Challenges Faced by Behavioral Genetic Studies: Researchers Perspective from the MENA Region
Khabour, O. F., Abu-Siniyeh, A. A., Alzoubi, K. H., & Al-Sheyab, N. (2021) · Current Genomics · doi:10.2174/1389202923666211216162141 · Cited by 3
“In a genome-wide study of antisocial behavior in a large combined sample, it has been shown that a large number of genetic variants play a role in antisocial behavior and several variants show gender-specific effects on antisocial behavior in males and females [18].”
BackgroundKazantseva, A. V., Davydova, Y. D., Enikeeva, R. F., Yakovleva, D. V., Mustafin, R. N., Lobaskova, M. M., Malykh, S. B., & Хуснутдинова, Э. К. (2023) · Russian Journal of Genetics · doi:10.1134/s1022795423140065 · Cited by 3
“From another side, various studies have checked a predictive difference for a set of SNPs within a p -value range of 0.1–0.5 [14].”
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Incarceration, polygenic risk, and depressive symptoms among males in late adulthood
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Shared genomic architectures of COVID-19 and antisocial behavior
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“The impulsive behavior of APD is closely related to crime (Piotrowska et al., 2015; Tielbeek et al., 2017), and therefore high-risk antisocial groups have aroused widespread concern among researchers (Fellmeth et al.”
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“Notably, whereas genomic association studies have identified genotypes that are associated with antisocial behavior (Bentley et al., 2013; Rautiainen et al., 2016; Tielbeek et al., 2017), we argue that most manifestations of the criminality tested here are the result of interactions between addictive genotypes and cer…”
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“Previous studies found that the explanation by polymorphism of monogenic loci accoutned for only 1%, while genome-wide association studies found that 13 SNPs accounted for 5.2% of antisocial behavior (single nucleotide polymorphisms) (Harden & Koellinger, 2020; Tielbeek et al., 2017).”
InfluentialNeurodevelopmental Disorders: Attention Deficit Hyperactivity Disorder (ADHD)
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Disentangling differing relationships between internalizing disorders and alcohol use
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Antisocial personality disorder:Failure to balance excitation/inhibition?
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Een tweelingstudie naar indicatoren van genetische en culturele transmissie
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Evolutionary psychology and social work
Silberberg, P. J., & Thyer, B. A. (2023) · Journal of Human Behavior in the Social Environment · doi:10.1080/10911359.2023.2168817 · Cited by 2
“…led to the conclusion that those with ASPD tend to have children earlier and more of them, which contributes to a kind of evolutionary fitness in part through adaptive learning by being “superficially charming”—a term often used to describe sociopaths (Murphy & Stich, 2000; Tielbeek et al., 2017).”
BackgroundInfluentialCounterproductive Work Behaviors in a Saudi Tertiary Healthcare Organization
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“Apart from chronic diseases, high neuroticism shares a genetic correlation with anti-social behavioral disorders (Tielbeek et al., 2017) and can also increase mortality risk (Jokela et al., 2020).”
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Tielbeek, J., Barnes, J. C., Popma, A., Polderman, T., Lee, J. J., Perry, J. R. B., Posthuma, D., & Boutwell, B. (2018) · bioRxiv · doi:10.1101/247411 · Cited by 21
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Self-citationNeurogenetics, Genome-Wide Association and Candidate Gene Studies
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Psychiatric genomics: brain pathophysiology and genetic factors
Qian, J., Al-Chalabi, N., Wang, Y., Igblom, A., Fatemi, A. B., & Luca, V. D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819602-1.00016-4 · Cited by 1
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The Role of Epigenetics in the Formation of Serial Killers: Nature vs. Nurture
Lin, J. S., Bose, J. K., & Roy, T.-A. (2024) · Journal of Student Research · doi:10.47611/jsr.v13i1.2394 · Cited by 1
“…for coding enzyme breaking down neurotransmitters such as serotonin and norepinephrine; COMT gene, which is involved in the breakdown of dopamine; and CADM2 gene, which is associated with aggressive actions in males (Bevilacqua et al., 2010; Bortolato et al., 2013; Tielbeek et al., 2017).”
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Indefensible Spaces: Policing and the Struggle for Housing
Kurwa, R. (2025) · University of California Press eBooks · doi:10.1525/luminos.235 · Cited by 1
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Genetics of personality disorders
Ramoz, N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819602-1.00005-x · Cited by 2
Rodríguez-López, M. L., Pol, H. E. H., Franke, B., & Klein, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/750091 · Cited by 4
“These studies had been approved by local ethics committees and had obtained the required informed consents (as described in earlier publications (Demontis et al., 2019; Pappa et al., 2016; Tielbeek et al., 2017)).”
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Using polygenic scores to assess liability to antisocial behavior
Kazantseva, A. V., Yakovleva, D. V., Davydova, Y. D., & Khusnutdinova, E. K. (2025) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-25-91
Gay Genes? Genetics and Sexual Orientation
Alexander, D. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108566520.011
On oxytocin and social behavior
Hovey, D. (2018) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Partitioning the genetic architecture of amyotrophic lateral sclerosisPreprint
Broce, I., Fan, C. C., Olney, N. T., Lomen‐Hoerth, C., Finkbeiner, S. M., Atassi, N., Cudkowicz, M., Paganoni, S., Yokoyama, J. S., Kao, A. W., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/505693 · Cited by 1
“6 Antisocial behavior ASB 16,400 9,545,468 [61]”
Rabinowitz, J. A., Musci, R. J., Reboussin, B. A., Milam, A. J., Benke, K. S., Uhl, G. R., Sisto, D. Y., Ialongo, N. S., & Maher, B. S. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000701
“Discovery sample for antisocial behavior The antisocial behavior PRS was created based on a GWAS for antisocial behavior conducted by Tielbeek et al. (2017).”
BackgroundMethodInfluentialTesting gene by community disadvantage moderation of sexual health outcomes among urban women
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Definitions of Technical Terms
Alexander, D. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108566520.015
Alexander, D. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108566520.005
Genetic Information and How It Flows
Alexander, D. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108566520.003 · Cited by 1
Genes and Environments in Human Development
Alexander, D. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108566520.004
Genes, Personality and Personality Disorders
Alexander, D. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108566520.008
Alexander, D. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108566520.006
Alexander, D. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108566520.013
Developmental Factors in Violence Propensity
Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.005
Building Causal Knowledge in Behavior GeneticsPreprint
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Media violance and how it`s impact on audience
Nazarova, I. V. (2021) · Век информации (сетевое издание) · doi:10.33941/age-info.com54(17)1
Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.009
Genes, Religiosity and Political Commitment
Alexander, D. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108566520.010
Major UN Initiatives to Address Violence, 1986–2018
Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.013
Genes, Education and Intelligence
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Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.015
Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.001
The Prospect of Human Violence
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Alexander, D. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108566520.012
Advancing a Global Public Health Response to Violence
Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.007
Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.012
Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.011
Genes, Food, Exercise and Weight
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Whittington, R., McGuire, J., & Peres, M. F. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139086486.008
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Alexander, D. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108566520.002
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Genetische Studien an forensisch Untergebrachten?
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Introduction: DNA, Race, and Reproduction in the Twenty-First Century
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“…GWASs targeting more largely antisocial behaviors (e.g., criminality, rule-breaking) likely capture signals encompassing more heterogeneous expressions of individual and environmental difficulties (e.g., poverty, systemic discrimination) (Karlsson Linner et al., 2021; Tielbeek et al., 2012, 2017).”
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Genetic Characterization of MAOA and OXTR in Western Lowland Gorillas ( Gorilla gorilla gorilla )
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“Consistent with this, large‐scale genome‐wide association studies have not identified MAOA as a major stan-dalone predictor of behavioral traits, indicating that its effects are modest and contingent on developmental and environmental context (Tielbeek et al. 2017).”
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Metadata
- Authors
- Tielbeek, J. J., Johansson, A., Polderman, T. J. C., Rautiainen, M.-R., Jansen, P., Taylor, M., Tong, X., Lu, Q., Burt, A. S., Tiemeier, H., Viding, E., Plomin, R., Martin, N. G., Heath, A. C., Madden, P. A. F., Montgomery, G., Beaver, K. M., Waldman, I., Gelernter, J., Kranzler, H. R., Farrer, L. A., Perry, J. R. B., Munafò, M., LoParo, D., Paunio, T., Tiihonen, J., Mous, S. E., Pappa, I., de Leeuw, C., Watanabe, K., Hammerschlag, A. R., Salvatore, J. E., Aliev, F., Bigdeli, T. B., Dick, D., Faraone, S. V., Popma, A., Medland, S. E., Posthuma, D., & for the Broad Antisocial Behavior Consortium collaborators
- Affiliations
- QIMR Berghofer Medical Research Institute (AU)
- Åbo Akademi University (FI)
- Amsterdam Neuroscience (NL)
- University of Helsinki (FI)
- Erasmus MC (NL)
- University of Bristol (GB)
- Michigan State University (US)
- Department of Psychology, Michigan State University, East Lansing
- University College London (GB)
- Washington University in St. Louis (US)
- Florida State University (US)
- Emory University (US)
- Veterans Health Administration (US)
- Philadelphia VA Medical Center (US)
- Boston University (US)
- University of Cambridge (GB)
- Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, England
- University of Eastern Finland (FI)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
- Virginia Commonwealth University (US)
- Department of African American Studies, Virginia Commonwealth University, Richmond
- SUNY Upstate Medical University (US)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Tielbeek, Jorim J.
- ORCID
- Tielbeek, Jorim J.
- Johansson, Ada
- Polderman, Tinca J. C.
- Jansen, Philip
- Taylor, Michelle
- Tong, Xiaoran
- Lu, Qing
- Tiemeier, Henning
- Viding, Essi
- Plomin, Robert
- Martin, Nicholas G.
- Heath, Andrew C.
- Madden, Pamela A. F.
- Montgomery, Grant
- Beaver, Kevin M.
- Waldman, Irwin
- Gelernter, Joel
- Kranzler, Henry R.
- Farrer, Lindsay A.
- Perry, John R. B.
- LoParo, Devon
- Paunio, Tiina
- Tiihonen, Jari
- Mous, Sabine E.
- Pappa, Irene
- Watanabe, Kyoko
- Hammerschlag, Anke R.
- Salvatore, Jessica E.
- Bigdeli, Tim B.
- Dick, Danielle
- Faraone, Stephen V.
- Popma, Arne
- Medland, Sarah E.
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2017-12-01
- Volume
- 74
- Issue
- 12
- Pages
- 1242
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC6309228
- OpenAlex
- W2762265603
- Cited by
- 194
- References
- 56
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 14 · 2023: 19 · 2022: 17 · 2021: 28 · 2020: 57 · 2019: 24 · 2018: 20
- FWCI
- 34.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Explore Bristol Research (publishedVersion, other-oa)
- VU Research Portal (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UEF eRepo (University of Eastern Finland) (acceptedVersion)
- Bristol Research (University of Bristol) (submittedVersion, other-oa)
- UTUPub (University of Turku) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Åbo Akademi University Research Portal (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- WOS
- Funders
- Suomen Kulttuurirahasto
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO 480‐05‐003, 480- 05-003, VICI 453-14-005, 406-12-131, NWO VICI 453-14-005, 453-14-005)
- Waldemar von Frenckells Stiftelse
- National Institutes of Health
- Medical Research Council (MC_UU_12015/2, MR/M021475/1, MC_PC_15018)
- National Health and Medical Research Council (1103623)
- National Institute on Alcohol Abuse and Alcoholism (F32AA022269, K01AA024152)
- National Institute on Drug Abuse (K01DA033346)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Sociology and Political Science › Crime Patterns and Interventions
- Keywords
- antisocial behavior, genetic architecture, heritability, single nucleotide polymorphisms, genetic risk variants, pleiotropy, polygenic risk score, conduct problems, conduct disorder, substance dependence, educational attainment, European ancestry, psychiatric traits, candidate genes
- MeSH terms
- Adolescent, Adult, Antisocial Personality Disorder, Child, Environment, Female, Finland, Humans, Male, Middle Aged, Sex Factors, Genetic Variation, Conduct Disorder, Multifactorial Inheritance, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-09-28, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-09-28 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Cited sources are checked with a language model’s help (gpt-6-sol).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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