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Cited by 111Psychopathy, Forensic Psychiatry, Sexual OffendingGenetic Associations and EpidemiologyChild and Adolescent Psychosocial and Emotional Development

Genome-wide association study of conduct disorder symptomatology

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Dick, D M, Aliev, F, Krueger, R F, Edwards, A, Agrawal, A, Lynskey, M, Lin, P, Schuckit, M +10 more·2011·Molecular Psychiatry
DOI 10.1038/mp.2010.73PMC PMC3580835
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Abstract

Conduct disorder (CD) is one of the most prevalent childhood psychiatric conditions, and is associated with a number of serious concomitant and future problems. CD symptomatology is known to have a considerable genetic component, with heritability estimates in the range of 50%. Despite this, there is a relative paucity of studies aimed at identifying genes involved in the susceptibility to CD. In this study, we report results from a genome-wide association study of CD symptoms. CD symptoms were retrospectively reported by a psychiatric interview among a sample of cases and controls, in which cases met the criteria for alcohol dependence. Our primary phenotype was the natural log transformation of the number of CD symptoms that were endorsed, with data available for 3963 individuals who were genotyped on the Illumina Human 1M beadchip array. Secondary analyses are presented for case versus control status, in which caseness was established as endorsing three or more CD symptoms (N = 872 with CD and N = 3091 without CD). We find four markers that meet the criteria for genome-wide significance (P<5 × 10(-8)) with the CD symptom count, two of which are located in the gene C1QTNF7 (C1q and tumor necrosis factor-related protein 7). There were six additional SNPs in the gene that yielded converging evidence of association. These data provide the first evidence of a specific gene that is associated with CD symptomatology. None of the top signals resided in traditional candidate genes, underscoring the importance of a genome-wide approach for identifying novel variants involved in this serious childhood disorder.

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  • One genome-wide association study of childhood conduct disorder in an American sample detected three genome-wide significant loci.

    “One study, carried out on childhood conduct disorder in an American sample (N=3963, including 872 cases and 3091 controls), detected three genome-wide significant loci”

    From Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior (2017) · cites this paper as D. M. Dick et al., 2011

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Authors
Dick, D. M., Aliev, F., Krueger, R. F., Edwards, A., Agrawal, A., Lynskey, M., Lin, P., Schuckit, M., Hesselbrock, V, Nurnberger, J., Almasy, L., Porjesz, B., Edenberg, H. J., Bucholz, K., Kramer, J., Kuperman, S., Bierut, L., & Consortia, A. P. O. T. S. A. G.
Affiliations
  • Virginia Commonwealth University (US)
  • Washington University in St. Louis (US)
  • University of California San Diego (US)
  • University of Connecticut (US)
  • Texas Biomedical Research Institute (US)
  • Indiana University School of Medicine (US)
  • University of Iowa (US)
Corresponding author
Dick, D M
ORCID
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2010-06-29
Volume
16
Issue
8
Pages
800-808
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/mp.2010.73
PMC
PMC3580835
OpenAlex
W1979290553
Cited by
111
References
3
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 18 · 2019: 12 · 2018: 9 · 2017: 8 · 2016: 13 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 8
FWCI
6.69
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • SUNY Digital Repository Support (State University of New York System) (submittedVersion, cc-by-nc-nd)
  • IUScholarWorks (Indiana University) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute on Alcohol Abuse and Alcoholism (K02AA018755, U10AA008401)
  • National Institute on Drug Abuse (R01DA019963, R01DA013423, R01DA025888)
  • National Human Genome Research Institute (U01HG004422, U01HG004446, U01HG004438, HHSN268200782096C)
  • National Cancer Institute (P01CA089392)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
conduct disorder, genetic susceptibility, single nucleotide polymorphisms, alcoholism, child psychopathology, heritability, genetic association
MeSH terms
Adolescent, Adult, Aged, Alcoholism, Female, Genotype, Humans, Male, Middle Aged, Retrospective Studies, Case-Control Studies, Diagnosis, Dual (Psychiatry), Conduct Disorder, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study

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