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Shared Neural Phenotypes for Mood and Anxiety Disorders: A Meta-analysis of 226 Task-Related Functional Imaging Studies
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Importance: Major depressive disorder, bipolar disorder, posttraumatic stress disorder, and anxiety disorders are highly comorbid and have shared clinical features. It is not yet known whether their clinical overlap is reflected at the neurobiological level. Objective: To detect transdiagnostic convergence in abnormalities in task-related brain activation. Data Source: Task-related functional magnetic resonance imaging articles published in PubMed, Web of Science, and Google Scholar during the last decade comparing control individuals with patients with mood, posttraumatic stress, and anxiety disorders were examined. Study Selection: Following Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guidelines, articles were selected if they reported stereotactic coordinates of whole-brain-based activation differences between adult patients and control individuals. Data Extraction and Synthesis: Coordinates of case-control differences coded by diagnosis and by cognitive domain based on the research domain criteria were analyzed using activation likelihood estimation. Main Outcomes and Measures: Identification of transdiagnostic clusters of aberrant activation and quantification of the contribution of diagnosis and cognitive domain to each cluster. Results: A total of 367 experiments (major depressive disorder, 149; bipolar disorder, 103; posttraumatic stress disorder, 55; and anxiety disorders, 60) were included comprising observations from 4507 patients and 4755 control individuals. Three right-sided clusters of hypoactivation were identified centered in the inferior prefrontal cortex/insula (volume, 2120 mm3), the inferior parietal lobule (volume, 1224 mm3), and the putamen (volume, 888 mm3); diagnostic differences were noted only in the putamen (χ23 = 8.66; P = .03), where hypoactivation was more likely in bipolar disorder (percentage contribution = 72.17%). Tasks associated with cognitive systems made the largest contribution to each cluster (percentage contributions >29%). Clusters of hyperactivation could only be detected using a less stringent threshold. These were centered in the perigenual/dorsal anterior cingulate cortex (volume, 2208 mm3), the left amygdala/parahippocampal gyrus (volume, 2008 mm3), and the left thalamus (volume, 1904 mm3). No diagnostic differences were observed (χ23 < 3.06; P > .38), while tasks associated with negative valence systems made the largest contribution to each cluster (percentage contributions >49%). All findings were robust to the moderator effects of age, sex, and magnetic field strength of the scanner and medication. Conclusions and Relevance: In mood disorders, posttraumatic stress disorder, and anxiety disorders, the most consistent transdiagnostic abnormalities in task-related brain activity converge in regions that are primarily associated with inhibitory control and salience processing. Targeting these shared neural phenotypes could potentially mitigate the risk of affective morbidity in the general population and improve outcomes in clinical populations.
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“Since its inception, support for this model has been rapidly mounting within the ID-domain (e.g. [56–59]).”
From Infraslow closed-loop brain training for anxiety and depression (ISAD): a protocol for a randomized, double-blind, sham-controlled pilot trial in adult females with internalizing disorders (2022) · cites this paper as [56]
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Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657
Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., Charlson, F. J., Norman, R. E., Flaxman, A. D., Johns, N., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61611-6 · Cited by 6,006
Saliency, switching, attention and control: a network model of insula function
Menon, V., & Uddin, L. Q. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0262-0 · Cited by 5,592
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406
Inhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059
Sridharan, D., Levitin, D. J., & Menon, V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800005105 · Cited by 2,892
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Penninx, B. W., Pine, D. S., Holmes, E. A., & Reif, A. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00359-7 · Cited by 740
Understanding Emotions: Origins and Roles of the Amygdala
Šimić, G., Tkalčić, M., Vukić, V., Mulc, D., Španić, E., Šagud, M., Olucha-Bordonau, F. E., Vukšić, M., & Hof, P. R. (2021) · Biomolecules · doi:10.3390/biom11060823 · Cited by 631
Chavanne, A. V., & Robinson, O. J. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19111153 · Cited by 249
Air pollution, depressive and anxiety disorders, and brain effects: A systematic review
Zundel, C. G., Ryan, P., Brokamp, C., Heeter, A., Huang, Y., Strawn, J. R., & Marusak, H. A. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.10.011 · Cited by 236
Ali, A. M., Alkhamees, A. A., Hori, H., Kim, Y., & Kunugi, H. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph181910142 · Cited by 193
Ali, A. M., Hori, H., Kim, Y., & Kunugi, H. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.799769 · Cited by 122
Neurobiology and systems biology of stress resilience
Kalisch, R., Russo, S. J., & Müller, M. B. (2024) · Physiological Reviews · doi:10.1152/physrev.00042.2023 · Cited by 149
Doucet, G. E., Janiri, D., Howard, R., O’Brien, M., Andrews‐Hanna, J. R., & Frangou, S. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2020.57 · Cited by 118
Self-citationSerra-Blasco, M., Raduà, J., Soriano‐Mas, C., Gómez‐Benlloch, A., Casteràs, D. P., Carulla‐Roig, M., Albajes‐Eizagirre, A., Arnone, D., Klauser, P., Canales-Rodríguez, E. J., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.002 · Cited by 105
An insula hierarchical network architecture for active interoceptive inference
Fermin, A. S. R., Friston, K., & Yamawaki, S. (2022) · Royal Society Open Science · doi:10.1098/rsos.220226 · Cited by 101
Sydnor, V. J., Cieslak, M., Duprat, R., Deluisi, J. A., Flounders, M. W., Long, H., Scully, M., Balderston, N. L., Sheline, Y. I., Bassett, D. S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn5803 · Cited by 103
The Amygdala and Depression: A Sober Reconsideration
Grogans, S. E., Fox, A. S., & Shackman, A. J. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20220412 · Cited by 86
A triple-network organization for the mouse brain
Mandino, F., Vrooman, R. M., Foo, H. E., Yeow, L. Y., Bolton, T. A. W., Salvan, P., Teoh, C. L., Lee, C. Y., Beauchamp, A., Luo, S. X., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01298-5 · Cited by 87
A network model of depressive and anxiety symptoms: a statistical evaluation
Cai, H. X., Chen, M., Li, X.-H., Zhang, L., Su, Z., Cheung, T. C. C., Tang, Y., Malgaroli, M., Jackson, T., Zhang, Q., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02369-5 · Cited by 79
Psychedelic therapy's transdiagnostic effects: A research domain criteria (RDoC) perspective
Kelly, J. R., Gillan, C. M., Prenderville, J., Kelly, C., Harkin, A., Clarke, G., & O'Keane, V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.800072 · Cited by 69
Transdiagnostic neuroimaging markers of psychiatric risk: A narrative review
Vanes, L. D., & Dolan, R. J. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102634 · Cited by 73
Balogh, L., Tanaka, M., Török, N., Vécsei, L., & Taguchi, S. (2021) · Biomedicines · doi:10.3390/biomedicines9040340 · Cited by 57
Klugah‐Brown, B., Zhou, X., Pradhan, B., Zweerings, J., Mathiak, K., Biswal, B. B., & Becker, B. (2021) · Addiction Biology · doi:10.1111/adb.12997 · Cited by 59
Bas‐Hoogendam, J. M., Groenewold, N. A., Aghajani, M., Freitag, G. F., Harrewijn, A., Hilbert, K., Jahanshad, N., Thomopoulos, S. I., Thompson, P. M., Veltman, D. J., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25100 · Cited by 57
Zhou, Z., Gao, Y., Bao, W., Liang, K., Cao, L., Tang, M., Li, H., Hu, X., Zhang, L., Sun, H., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105583 · Cited by 53
Shanmugan, S., Sammel, M. D., Loughead, J., Ruparel, K., Gur, R. C., Brown, T. E., Faust, J., Domchek, S., & Epperson, C. N. (2020) · Menopause · doi:10.1097/gme.0000000000001535 · Cited by 46
Parsing variability in borderline personality disorder: a meta-analysis of neuroimaging studies
Degasperi, G., Cristea, I., Rosa, E. D., Costa, C., & Gentili, C. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01446-z · Cited by 40
Κωνσταντοπούλου, Γ., Iliou, T., Karaivazoglou, K., Iconomou, G., Assimakopoulos, K., & Alexopoulos, P. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02836-1 · Cited by 53
Two Decades of Anxiety Neuroimaging Research: New Insights and a Look to the Future
Shackman, A. J., & Fox, A. S. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20121733 · Cited by 46
Gray matter alterations in adolescent major depressive disorder and adolescent bipolar disorder
Long, X., Li, L., Wang, X., Cao, Y., Wu, B., Roberts, N., Gong, Q., Kemp, G. J., & Jia, Z. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.01.049 · Cited by 43
Cena, L., Gigantesco, A., Mirabella, F., Palumbo, G., Camoni, L., Trainini, A., & Stefana, A. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.015 · Cited by 40
Resting-state functional connectivity in anxiety disorders: a multicenter fMRI study
Langhammer, T., Hilbert, K., Adolph, D., Arolt, V., Bischoff, S., Böhnlein, J., Cwik, J. C., Dannlowski, U., Deckert, J., Domschke, K., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02768-2 · Cited by 34
Ketamine Normalizes the Structural Alterations of Inferior Frontal Gyrus in Depression
Dai, D., Lacadie, C. M., Holmes, S. E., Cool, R., Anticevic, A., Averill, C., Abdallah, C., & Esterlis, I. (2020) · Chronic Stress · doi:10.1177/2470547020980681 · Cited by 34
Pan, N., Wang, S., Qin, K., Li, L., Chen, Y., Zhang, X., Lai, H., Suo, X., Long, Y., Yu, Y., et al. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.06.003 · Cited by 34
FAAH polymorphism (rs324420) modulates extinction recall in healthy humans: an fMRI study
Spohrs, J., Martin, U., Grön, G., Plener, P. L., & Abler, B. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01367-4 · Cited by 32
Amidfar, M., Quevedo, J., Réus, G. Z., & Kim, Y. (2020) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2020.1861632 · Cited by 33
Kühn, S., Düzel, S., Mascherek, A., Eibich, P., Krekel, C., Kolbe, J., Goebel, J., Gallinat, J., Wagner, G. G., & Lindenberger, U. (2021) · Landscape and Urban Planning · doi:10.1016/j.landurbplan.2021.104196 · Cited by 33
Linking cerebellar functional gradients to transdiagnostic behavioral dimensions of psychopathology
Dong, D., Guell, X., Genon, S., Wang, Y., Ji, C., Eickhoff, S. B., Yao, D., & Luo, C. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103176 · Cited by 29
Self-citationAn Honest Reckoning With the Amygdala and Mental Illness
Fox, A. S., & Shackman, A. J. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240941 · Cited by 32
Dugre, J. R., & Potvin, S. (2021) · Psychological Medicine · doi:10.1017/s0033291721001525 · Cited by 34
Paulus, M. P., & Khalsa, S. S. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2021.21060622 · Cited by 27
Xie, H., Cao, Y., Li, J., Lyu, Y., Roberts, N., & Jia, Z. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.03.082 · Cited by 30
Chen, Z., Tang, Y., Liu, X., Li, W., Hu, Y., Hu, B., Xu, T., Zhang, R., Xia, L., Zhang, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-55008-0 · Cited by 27
Haynos, A. F., Widge, A. S., Anderson, L. M., & Redish, A. D. (2022) · Current Psychiatry Reports · doi:10.1007/s11920-022-01320-9 · Cited by 25
Nawijn, L., Dinga, R., Aghajani, M., van Tol, M., van der Wee, N. J. A., Wunder, A., Veltman, D. J., & Penninx, B. W. J. H. (2022) · Depression and Anxiety · doi:10.1002/da.23264 · Cited by 23
Ge, R., Sassi, R. B., Yatham, L. N., & Frangou, S. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01925-9 · Cited by 24
Self-citationLi, B.-Z., Cao, Y., Zhang, Y., Chen, Y., Gao, Y., Peng, J., Shao, Y., & Zhang, X. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.642411 · Cited by 24
Tamm, S., Harmer, C. J., Schiel, J., Holub, F., Rutter, M. K., Spiegelhalder, K., & Kyle, S. D. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21050466 · Cited by 22
Emotion regulation: From neural circuits to a transdiagnostic perspective
Morawetz, C., Hemetsberger, F. J., Laird, A. R., & Kohn, N. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105960 · Cited by 27
Chow, M. W., Noorthoorn, E. O., Wierdsma, A. I., van der Horst, M. Z., de Boer, N., Gülöksüz, S., & Luykx, J. J. (2021) · BJPsych Open · doi:10.1192/bjo.2021.1049 · Cited by 22
Dunlop, B. W., Cha, J., Choi, K. S., Nemeroff, C. B., Craighead, W. E., & Mayberg, H. S. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01653-w · Cited by 22
khodadadifar, T., Soltaninejad, Z., Ebneabbasi, A., Eickhoff, C. R., Sorg, C., van Eimeren, T., Vogeley, K. T., Zarei, M., Eickhoff, S. B., & Tahmasian, M. (2021) · Human Brain Mapping · doi:10.1002/hbm.25722 · Cited by 21
Self-citationTu, P., Chen, M., Chang, W.-C., Kao, Z.-K., Hsu, J.-W., Lin, W.-C., Li, C., Su, T., & Bai, Y. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2020.106 · Cited by 21
Chase, H. W., Auerbach, R. P., Brent, D. A., Posner, J. E., Weissman, M. M., & Talati, A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01022-5 · Cited by 21
Multiscale neural signatures of major depressive, anxiety, and stress-related disorders
Zhukovsky, P., Wainberg, M., Milic, M. S., Tripathy, S. J., Mulsant, B. H., Felsky, D., & Voineskos, A. N. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204433119 · Cited by 23
Hardi, F. A., Goetschius, L. G., McLoyd, V. C., Lopez‐Duran, N. L., Mitchell, C. M., Hyde, L. W., Beltz, A. M., & Monk, C. S. (2022) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13749 · Cited by 20
Jiang, J., Ferraro, S., Zhao, Y., Wu, B., Lin, J., Chen, T., Gao, J., & Li, L. (2024) · Psychoradiology · doi:10.1093/psyrad/kkae022 · Cited by 22
Sreeraj, V. S., Holla, B., Ithal, D., Nadella, R. K., Mahadevan, J., Balachander, S., Ali, F., Sheth, S., Narayanaswamy, J. C., Venkatasubramanian, G., et al. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113647 · Cited by 18
Gewirtz‐Meydan, A. (2022) · Child Maltreatment · doi:10.1177/10775595221148425 · Cited by 19
Böttger, S. J., Förstner, B. R., Szalek, L., Koller-Schlaud, K., Rapp, M. A., & Tschorn, M. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1184978 · Cited by 24
Ge, R., Hassel, S., Arnott, S. R., Davis, A. D., Harris, J. K., Zamyadi, M., Milev, R. V., Frey, B. N., Strother, S. C., Müller, D. J., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110194 · Cited by 19
Person-based similarity in brain structure and functional connectivity in bipolar disorder
Doucet, G. E., Glahn, D. C., & Frangou, S. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.06.041 · Cited by 18
Self-citationWang, Z., He, D., Yang, L., Wang, P., Zou, Z., Xiao, J. F., Min, W., He, Y., & Zhu, H. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105284 · Cited by 16
The Role of Gut Microbiota in the High-Risk Construct of Severe Mental Disorders: A Mini Review
Sani, G., Manchia, M., Simonetti, A., Janiri, D., Paribello, P., Pinna, F., & Carpiniello, B. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.585769 · Cited by 18
Self-citationSympathetic Neural Control in Humans with Anxiety‐Related Disorders
Bigalke, J. A., & Carter, J. R. (2021) · Comprehensive physiology · doi:10.1002/cphy.c210027 · Cited by 29
Iron deficiency and internalizing symptom severity in unmedicated adolescents: a pilot study
Abbas, M., Gandy, K., Salas, R., Devaraj, S., & Calarge, C. A. (2021) · Psychological Medicine · doi:10.1017/s0033291721004098 · Cited by 18
McDermott, T. J., Berg, H. E., Touthang, J., Akeman, E., Cannon, M. J., Santiago, J., Cosgrove, K. T., Clausen, A. N., Kirlić, N., Smith, R. S., et al. (2022) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.220083 · Cited by 16
Lee, H., Rhee, S. J., Kim, J., Lee, Y., Kim, H.-Y., Lee, J., Lee, K., Shin, H., Kim, H., Lee, T. Y., et al. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.07.041 · Cited by 16
Toward Coordinate-based Cognition Dictionaries: A BrainMap and Neurosynth Demo
Lu, Q., Towne, J. M., Lock, M., Jiang, C., Cheng, Z., Habes, M., Zuo, X., & Zang, Y. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.02.016 · Cited by 15
Carsten, H. P., Härpfer, K., Nelson, B. D., Kathmann, N., & Riesel, A. (2023) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-023-01094-4 · Cited by 15
Meta-analytical transdiagnostic neural correlates in common pediatric psychiatric disorders
Dugre, J. R., Eickhoff, S. B., & Potvin, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-08909-3 · Cited by 15
Self-citationLabel-based meta-analysis of functional brain dysconnectivity across mood and psychotic disorders
Grot, S., Smine, S., Potvin, S., Darcey, M., Pavlov, V., Genon, S., Nguyen, H. D., & Orban, P. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.110950 · Cited by 17
Not Only Mania or Depression: Mixed States/Mixed Features in Paediatric Bipolar Disorders
Janiri, D., Conte, E., Luca, I. D., Simone, M. V., Moccia, L., Simonetti, A., Mazza, M., Marconi, E., Monti, L., Chieffo, D. P. R., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11040434 · Cited by 15
Self-citationBed nucleus of the stria terminalis and amygdala responses to unpredictable threat in children
Feola, B., Melancon, S. N. T., Clauss, J. A., Noall, M. P., Mgboh, A., Flook, E. A., Benningfield, M. M., & Blackford, J. U. (2021) · Developmental Psychobiology · doi:10.1002/dev.22206 · Cited by 13
Wang, Z., Zou, Z., Xiao, J. F., Wang, P., Luo, Y., Min, W., He, Y., Yuan, C., Su, Y., Yang, C., et al. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104929 · Cited by 12
Maywald, M., Paolini, M., Rauchmann, B., Christian, G., Heppe, J. L., Wolf, A., Lerchenberger, L., Tominschek, I., Stoecklein, S., Reidler, P., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12121714 · Cited by 12
Trait anxiety and corresponding neuromarkers predict internet addiction: A longitudinal study
He, M., Mao, Y., & Qiu, J. (2024) · Journal of Behavioral Addictions · doi:10.1556/2006.2023.00086 · Cited by 14
Breuer, F., Meyhöfer, I., Lencer, R., Sprenger, A., Roesmann, K., Schag, K., Dannlowski, U., & Leehr, E. J. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105840 · Cited by 15
BNST and amygdala connectivity are altered during threat anticipation in schizophrenia
Feola, B., McHugo, M., Armstrong, K., Noall, M. P., Flook, E. A., Woodward, N. D., Heckers, S., & Blackford, J. U. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113428 · Cited by 12
Alper, H., Tuly, R., Seil, K., & Brite, J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17197330 · Cited by 11
Arasappan, D., Eickhoff, S. B., Nemeroff, C. B., Hofmann, H. A., & Jabbi, M. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02195-8 · Cited by 12
Self-citationBauer, E., Wilson, K. A., Phan, K. L., Shankman, S. A., & MacNamara, A. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.08.009 · Cited by 12
Roebuck, G., Mazzolini, M., Mohebbi, M., Pasco, J. A., Stuart, A. L., Forbes, M., Berk, M., & Williams, L. J. (2023) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13563 · Cited by 10
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Liu, J., Wang, H., & Li, L. (2025) · Meta-Radiology · doi:10.1016/j.metrad.2025.100135 · Cited by 9
de Lange, S. C., Tissink, E., Bresser, T., Savage, J. E., Posthuma, D., van den Heuvel, M. P., & Someren, E. J. W. V. (2025) · Nature Mental Health · doi:10.1038/s44220-025-00412-8 · Cited by 12
The influence of sex steroid treatment on insular connectivity in gender dysphoria
Reed, M. B., Handschuh, P. A., Klöbl, M., Konadu, M. E., Kaufmann, U., Hahn, A., Kranz, G. S., Spies, M., & Lanzenberger, R. R. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106336 · Cited by 11
Perez, T. M., Glue, P., Adhia, D. B., Navid, M. S., Zeng, J., Dillingham, P., Smith, M., Niazi, I. K., Young, C. K., & De Ridder, D. (2022) · Trials · doi:10.1186/s13063-022-06863-z · Cited by 8
Chen, V. C., Kao, C. C., Tsai, Y., Cheok, M. T., McIntyre, R. S., & Weng, J. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.711731 · Cited by 10
Genetic influences on central and peripheral nervous system activity during fear conditioning
Kastrati, G., Rosén, J., Fredrikson, M., Chen, X., Kuja‐Halkola, R., Larsson, H., Jensen, K. B., & Åhs, F. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01861-w · Cited by 9
Chaudhary, S., Hu, S., Hu, K., Dominguez, J. C., Chao, H. H., & Li, C. R. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100646 · Cited by 14
Genetic neuroimaging of bipolar disorder: a systematic 2017–2020 update
Janiri, D., Kotzalidis, G. D., Luzio, M. D., Giuseppin, G., Simonetti, A., Janiri, L., & Sani, G. (2021) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000274 · Cited by 10
Self-citationWu, S., Feng, F., Ren-jian, Z., Fu, H., Sun, J.-W., Jia, X., Yin, Y.-F., & Wang, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.595933 · Cited by 9
Wang, Z., He, D., Yang, L., Wang, P., Xiao, J. F., Zou, Z., Min, W., He, Y., Yuan, C., Zhu, H., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.06.095 · Cited by 10
Precision neuroimaging biomarkers for bipolar disorder
Janiri, D., & Frangou, S. (2022) · International Review of Psychiatry · doi:10.1080/09540261.2022.2106121 · Cited by 8
Self-citationAlexopoulos, P., Papanastasiou, A. D., Εconomou, P., Beis, P., Niforas, M., Dassios, T. G., Kormpaki, A., Zarkadis, I. K., Reichel, M., Kornhuber, J., et al. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-020-02280-1 · Cited by 9
Chen, V. C., Kao, C. C., Tsai, Y., McIntyre, R. S., & Weng, J. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030174 · Cited by 8
The Attentional Boost Effect in Young and Adult Euthymic Bipolar Patients and Healthy Controls
Gabrielli, G. B., Rossi‐Arnaud, C., Spataro, P., Doricchi, F., Costanzi, M., Santirocchi, A., Angeletti, G., Sani, G., & Cestari, V. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030185 · Cited by 9
Self-citationShamabadi, A., Karimi, H., Cattarinussi, G., Moghaddam, H. S., Akhondzadeh, S., Sambataro, F., Schiena, G., & Delvecchio, G. (2023) · Brain Sciences · doi:10.3390/brainsci13050801 · Cited by 9
Pan, N., Ma, T., Liu, Y., Zhang, S., Hu, S., Shekara, A., Cao, H., Gong, Q., & Chen, Y. (2024) · Psychological Medicine · doi:10.1017/s003329172400285x · Cited by 7
“The task and corresponding Research Domain Criteria (RDoC) construct and domain were labeled for each included fMRI study (Cuthbert, 2014; Janiri et al., 2020; Pan et al., 2022) (approach to coding task experiments in Online Supplementary Appendix 2).”
Zhou, Z., Zhang, L., Hu, X., Cao, L., Gao, Y., Li, H., Bao, W., Tang, M., Sun, H., Kuang, W., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03758-w · Cited by 7
Braak, S., Bakker, G., Su, T., Osinga, C., Nawijn, L., van Tol, M., van der Wee, N. J. A., Pijnenburg, Y. A. L., & Penninx, B. W. J. H. (2024) · Depression and Anxiety · doi:10.1155/2024/8564344 · Cited by 6
Boisvert, M., Dugre, J. R., & Potvin, S. (2024) · Psychological Medicine · doi:10.1017/s003329172400165x · Cited by 9
Treating anxiety comorbidity: Lessons from exposure generalization studies
Zlomuzica, A., Kodzaga, I., Piovesan, K., & Lipp, A. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115409 · Cited by 7
Insights from a methylome-wide association study of antidepressant exposure
Davyson, E., Shen, X., Huider, F., Adams, M. J., Borges, K., McCartney, D. L., Barker, L., van Dongen, J., Boomsma, D. I., Weihs, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55356-x · Cited by 10
Sympathetic Neural Control in Humans with Anxiety‐Related Disorders
Bigalke, J. A., & Carter, J. R. (2021) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00206.x · Cited by 6
Metadata
- Authors
- Janiri, D., Moser, D. A., Doucet, G. E., Luber, M. J., Rasgon, A., Lee, W. H., Murrough, J. W., Sani, G., Eickhoff, S. B., & Frangou, S.
- Affiliations
- Sapienza University of Rome (IT)
- Icahn School of Medicine at Mount Sinai (US)
- Azienda Ospedaliera Sant'Andrea (IT)
- Forschungszentrum Jülich (DE)
- Corresponding author
- Frangou, Sophia
- ORCID
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2020-02-01
- Volume
- 77
- Issue
- 2
- Pages
- 172
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC6822098
- OpenAlex
- W2982542860
- Cited by
- 173
- References
- 47
- Citations by year
- 2026: 20 · 2025: 25 · 2024: 25 · 2023: 16 · 2022: 31 · 2021: 41 · 2020: 14
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- JAMA Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, other-oa)
- Funders
- European Commission
- National Institutes of Health (1s10od018522-01)
- National Institute of Mental Health (R01MH116147, R01MH074457, R01MH104284)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- mood disorders, anxiety disorders, post-traumatic stress disorder, major depressive disorder, bipolar disorder, task-related brain activation, hypoactivation, hyperactivation, inferior prefrontal cortex, insula, inferior parietal lobule, putamen, anterior cingulate cortex, amygdala, thalamus, Research Domain Criteria, cognitive domain, negative valence
- MeSH terms
- Anxiety Disorders, Brain, Humans, Mood Disorders, Functional Neuroimaging
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