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Cited by 46BRCA gene mutations in cancerCancer-related cognitive impairment studiesNeural and Behavioral Psychology Studies

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Executive function after risk-reducing salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: does current mood and early life adversity matter?

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Shanmugan, Sheila, Sammel, Mary D., Loughead, James, Ruparel, Kosha, Gur, Ruben C., Brown, Thomas E., Faust, Jessica, Domchek, Susan, Epperson, C. Neill·2020·Menopause
DOI 10.1097/gme.0000000000001535PMC PMC7473450
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Abstract

Objective: Despite the fact that negative mood and executive dysfunction are common after risk-reducing salpingo-oophorectomy (RRSO), occurring in up to a third of women, little is known about risk factors predicting these negative outcomes. Adverse childhood experiences (ACE) predict poorer health in adulthood and may be a risk factor for negative outcomes after RRSO. Given the complex relationship between early life stress, affective disorders, and cognitive dysfunction, we hypothesized that ACE would be associated with poorer executive function and that mood symptoms would partially mediate this relationship. Methods: Women who had undergone RRSO were included in the study (N = 552; age 30-73 y). We measured executive function (continuous performance task, letter n-back task, and Brown Attention Deficit Disorder Scale Score), exposure to early life stress (ACE questionnaire), and mood symptoms (Hospital Anxiety and Depression Scale). Generalized estimating equations were used to evaluate the association between ACE and executive dysfunction and the role of mood symptoms as a mediator in this relationship. Results: ACE was associated with greater severity of subjective executive dysfunction (adjusted mean difference [aMD] = 7.1, P = 0.0005) and worse performance on both cognitive tasks (continuous performance task: aMD = –0.1, P = 0.03; n-back: aMD = –0.17, P = 0.007). Mood symptoms partially mediated ACE associations with sustained attention (21.3% mediated; 95% CI: 9.3%-100%) and subjective report of executive dysfunction (62.8% mediated; 95% CI: 42.3%-100%). Conclusions: The relationship between childhood adversity and executive dysfunction is partially mediated by mood symptoms. These data indicate that assessing history of childhood adversity and current anxiety and depression symptoms may play a role in treating women who report cognitive complaints after RRSO. Video Summary: http://links.lww.com/MENO/A571.

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  1. Domchek, 2010, Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality, JAMA, 304, 967, 10.1001/jama.2010.1237 · DOI · Paper page
  2. Finch, 2014, Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation, J Clin Oncol, 32, 1547, 10.1200/JCO.2013.53.2820 · DOI
  3. Shanmugan, 2014, Estrogen and the prefrontal cortex: towards a new understanding of estrogen's effects on executive functions in the menopause transition, Hum Brain Mapp, 35, 847, 10.1002/hbm.22218 · DOI · Paper page
  4. Rocca, 2007, Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause, Neurology, 69, 1074, 10.1212/01.wnl.0000276984.19542.e6 · DOI · Paper page
  5. Ryan, 2014, Impact of a premature menopause on cognitive function in later life, BJOG, 121, 1729, 10.1111/1471-0528.12828 · DOI · Paper page
  6. Kurita, 2016, Association of bilateral oophorectomy with cognitive function in healthy, postmenopausal women, Fertil Steril, 106, 749, 10.1016/j.fertnstert.2016.04.033 · DOI · Paper page
  7. Shanmugan, 2017, Impact of tryptophan depletion on executive system function during menopause is moderated by childhood adversity, Neuropsychopharmacology, 42, 2398, 10.1038/npp.2017.64 · DOI
  8. Shanmugan, 2017, Impact of early life adversity and tryptophan depletion on functional connectivity in menopausal women: a double-blind, placebo-controlled crossover study, Psychoneuroendocrinology, 84, 197, 10.1016/j.psyneuen.2017.07.239 · DOI
  9. Douglas, 2010, Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders, Addict Behav, 35, 7, 10.1016/j.addbeh.2009.07.004 · DOI · Paper page
  10. Giovanelli, 2016, Adverse childhood experiences and adult well-being in a low-income, urban cohort, Pediatrics, 137, e20154016, 10.1542/peds.2015-4016 · DOI · Paper page
  11. Mersky, 2013, Impacts of adverse childhood experiences on health, mental health, and substance use in early adulthood: a cohort study of an urban, minority sample in the U.S, Child Abuse Negl, 37, 917, 10.1016/j.chiabu.2013.07.011 · DOI · Paper page
  12. Sachs-Ericsson, 2017, When emotional pain becomes physical: adverse childhood experiences, pain, and the role of mood and anxiety disorders, J Clin Psychol, 2, 917
  13. Schilling, 2007, Adverse childhood experiences and mental health in young adults: a longitudinal survey, BMC Public Health, 7, 30, 10.1186/1471-2458-7-30 · DOI
  14. Epperson, 2017, Adverse childhood experiences and risk for first-episode major depression during the menopause transition, J Clin Psychiatry, 78, e298, 10.4088/JCP.16m10662 · DOI
  15. Salinas-Miranda, 2015, Adverse childhood experiences and health-related quality of life in adulthood: revelations from a community needs assessment, Health Qual Life Outcomes, 13, 123, 10.1186/s12955-015-0323-4 · DOI
  16. Walsh, 2014, The mediating role of depressive symptoms in the relationship between adverse childhood experiences and smoking, Addict Behav, 39, 1471, 10.1016/j.addbeh.2014.05.020 · DOI
  17. Shanmugan, 2016, Common and dissociable mechanisms of executive system dysfunction across psychiatric disorders in youth, Am J Psychiatry, 173, 517, 10.1176/appi.ajp.2015.15060725 · DOI · Paper page
  18. Castellon, 2004, Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen, J Clin Exp Neuropsychol, 26, 955, 10.1080/13803390490510905 · DOI
  19. Van Dyk, 2017, Evaluating cognitive complaints in breast cancer survivors with the FACT-Cog and quantitative electroencephalography, Breast Cancer Res Treat, 166, 157, 10.1007/s10549-017-4390-6 · DOI
  20. Ganz, 2013, Cognitive complaints after breast cancer treatments: examining the relationship with neuropsychological test performance, J Natl Cancer Inst, 105, 791, 10.1093/jnci/djt073 · DOI
  21. Sandra Kooij, 2008, Reliability, validity, and utility of instruments for self-report and informant report concerning symptoms of ADHD in adult patients, J Atten Disord, 11, 445, 10.1177/1087054707299367 · DOI · Paper page
  22. Gur, 2010, A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: standardization and initial construct validation, J Neurosci Methods, 187, 254, 10.1016/j.jneumeth.2009.11.017 · DOI · Paper page
  23. Shanmugan, 2016, Neural markers of the development of executive function: relevance for education, Curr Opin Behav Sci, 10, 7, 10.1016/j.cobeha.2016.04.007 · DOI
  24. Kurtz, 2001, Comparison of the continuous performance test with and without working memory demands in healthy controls and patients with schizophrenia, Schizophr Res, 48, 307, 10.1016/S0920-9964(00)00060-8 · DOI · Paper page
  25. Snodgrass, 1988, Pragmatics of measuring recognition memory: applications to dementia and amnesia, J Exp Psychol Gen, 117, 34, 10.1037/0096-3445.117.1.34 · DOI
  26. Ragland, 2002, Working memory for complex figures: an fMRI comparison of letter and fractal n-back tasks, Neuropsychology, 16, 370, 10.1037/0894-4105.16.3.370 · DOI · Paper page
  27. Chapman, 2004, Adverse childhood experiences and the risk of depressive disorders in adulthood, J Affect Disord, 82, 217, 10.1016/j.jad.2003.12.013 · DOI · Paper page
  28. Højsgaard, 2006, The R package geepack for generalized estimating equations, J Stat Softw, 15, 1
  29. Freeman, 2012, Anti-mullerian hormone as a predictor of time to menopause in late reproductive age women, J Clin Endocrinol Metab, 97, 1673, 10.1210/jc.2011-3032 · DOI
  30. Korten, 2014, Adverse childhood and recent negative life events: contrasting associations with cognitive decline in older persons, J Geriatr Psychiatry Neurol, 27, 128, 10.1177/0891988714522696 · DOI
  31. Radford, 2017, Childhood stress and adversity is associated with late-life dementia in Aboriginal Australians, Am J Geriatr Psychiatry, 25, 1097, 10.1016/j.jagp.2017.05.008 · DOI
  32. Almanza-Sepulveda, 2018, Executive function in teen and adult women: association with maternal status and early adversity, Dev Psychobiol, 60, 849, 10.1002/dev.21766 · DOI
  33. Philip, 2016, Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task, Brain Imaging Behav, 10, 124, 10.1007/s11682-015-9373-9 · DOI
  34. Hostinar, 2012, Associations between early life adversity and executive function in children adopted internationally from orphanages, Proc Natl Acad Sci USA, 109, 17208, 10.1073/pnas.1121246109 · DOI · Paper page
  35. Loman, 2013, The effect of early deprivation on executive attention in middle childhood, J Child Psychol Psychiatry, 54, 37, 10.1111/j.1469-7610.2012.02602.x · DOI · Paper page
  36. Heyman, 2015, Negative life events predict performance on an executive function task in young adults with developmental disabilities, J Intellect Disabil Res, 59, 746, 10.1111/jir.12181 · DOI
  37. Epperson, 2011, Impact of atomoxetine on subjective attention and memory difficulties in perimenopausal and postmenopausal women, Menopause, 18, 542, 10.1097/gme.0b013e3181fcafd6 · DOI · Paper page
  38. Epperson, 2015, New onset executive function difficulties at menopause: a possible role for lisdexamfetamine, Psychopharmacology (Berl), 232, 3091, 10.1007/s00213-015-3953-7 · DOI · Paper page
  39. Freeman, 2014, Longitudinal pattern of depressive symptoms around natural menopause, JAMA Psychiatry, 71, 36, 10.1001/jamapsychiatry.2013.2819 · DOI
  40. Klojcnik, 2017, Relationship of depression with executive functions and visuospatial memory in elderly, Int J Aging Hum Dev, 85, 490, 10.1177/0091415017712186 · DOI
  41. Bjelland, 2002, The validity of the Hospital Anxiety and Depression Scale. An updated literature review, J Psychosom Res, 52, 69, 10.1016/S0022-3999(01)00296-3 · DOI · Paper page
  42. Madalinska, 2005, Quality-of-life effects of prophylactic salpingo-oophorectomy versus gynecologic screening among women at increased risk of hereditary ovarian cancer, J Clin Oncol, 23, 6890, 10.1200/JCO.2005.02.626 · DOI
  43. Tolman, 2012, Neurocognitive predictors of objective and subjective quality of life in individuals with schizophrenia: a meta-analytic investigation, Schizophr Bull, 38, 304, 10.1093/schbul/sbq077 · DOI
  44. Wehmeier, 2010, Social and emotional impairment in children and adolescents with ADHD and the impact on quality of life, J Adolesc Health, 46, 209, 10.1016/j.jadohealth.2009.09.009 · DOI · Paper page
  45. Nelson, 2006, Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis, JAMA, 295, 2057, 10.1001/jama.295.17.2057 · DOI · Paper page

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Metadata

Authors
Shanmugan, S., Sammel, M. D., Loughead, J., Ruparel, K., Gur, R. C., Brown, T. E., Faust, J., Domchek, S., & Epperson, C. N.
Affiliations
  • University of Pennsylvania (US)
  • University of Southern California (US)
  • University of Colorado Anschutz (US)
Corresponding author
Epperson, C. Neill
ORCID
Venue
Menopause
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2020-03-16
Volume
27
Issue
7
Pages
746-755
ISSN
  • 1072-3714 (ISSN-L)
  • 1530-0374
DOI
10.1097/gme.0000000000001535
PMC
PMC7473450
OpenAlex
W3011525283
Cited by
46
References
3
Citations by year
2025: 4 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 31 · 2020: 2
FWCI
5.72
Type
journal article
Language
en
Open access
Locations
  • Menopause The Journal of The North American Menopause Society (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01AG048839, F30AG055256)
  • National Institute of Mental Health (P50MH099910, R25MH119043)
  • National Institute on Drug Abuse (K24DA030301)
  • National Cancer Institute (R01CA215587)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD085848)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
risk-reducing salpingo-oophorectomy, BRCA1 mutation carriers, BRCA2 mutation carriers, executive function, adverse childhood experiences, childhood adversity, mood symptoms, anxiety, depression, sustained attention, cognitive impairment, mediation
MeSH terms
Salpingo-oophorectomy, Adverse Childhood Experiences, Adult, Aged, Anxiety, Child, Female, Humans, Middle Aged, Mutation, Ovarian Neoplasms, Ovariectomy, BRCA1 Protein, BRCA2 Protein, Executive Function

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