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Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

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Radiosensitizing Effects of Temozolomide Observed in vivo only in a Subset of O6-Methylguanine-DNA Methyltransferase Methylated Glioblastoma Multiforme Xenografts

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Combination of Measles Virus Virotherapy and Radiation Therapy Has Synergistic Activity in the Treatment of Glioblastoma Multiforme

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Interleukin-13 Displaying Retargeted Oncolytic Measles Virus Strains Have Significant Activity Against Gliomas With Improved Specificity

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Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy

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PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel

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p53 Small-Molecule Inhibitor Enhances Temozolomide Cytotoxic Activity against Intracranial Glioblastoma Xenografts

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Increased Sensitivity of Transforming Growth Factor (TGF) β1 Null Cells to Alkylating Agents Reveals a Novel Link between TGFβ Signaling and O 6-Methylguanine Methyltransferase Promoter Hypermethylation

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Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma

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A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

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Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization

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p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

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Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance

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Redox-Responsive Magnetic Nanoparticle for Targeted Convection-Enhanced Delivery of O 6-Benzylguanine to Brain Tumors

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Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations

Zhang, D. Y., Dmello, C., Chen, L., Arrieta, V. A., González-Buendía, E., KANE, J. R., Magnusson, L. P., Baran, A. H., James, C. D., Horbinski, C., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2182 · Cited by 176 · see citing works

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

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A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles

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BET bromodomain proteins are required for glioblastoma cell proliferation

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Immunovirotherapy with measles virus strains in combination with anti–PD-1 antibody blockade enhances antitumor activity in glioblastoma treatment

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Improving drug delivery to primary and metastatic brain tumors: Strategies to overcome the blood–brain barrier

Parrish, K., Sarkaria, J. N., & Elmquist, W. F. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.71 · Cited by 126 · see citing works

Delineation of MGMT Hypermethylation as a Biomarker for Veliparib-Mediated Temozolomide-Sensitizing Therapy of Glioblastoma

Gupta, S. K., Kizilbash, S. H., Carlson, B. L., Mladek, A. C., Boakye‐Agyeman, F., Bakken, K. K., Pokorny, J. L., Schroeder, M. A., Decker, P. A., Cen, L., et al. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv369 · Cited by 125 · see citing works

Oncolytic measles virus strains have significant antitumor activity against glioma stem cells

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Drug and disease signature integration identifies synergistic combinations in glioblastoma

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Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Zhou, D., Alver, B., Li, S., Hlady, R. A., Thompson, J. J., Schroeder, M. A., Lee, J., Qiu, J., Schwartz, P. H., Sarkaria, J. N., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1420-6 · Cited by 97 · see citing works

Efflux Transporters at the Blood-Brain Barrier Limit Delivery and Efficacy of Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib (PD-0332991) in an Orthotopic Brain Tumor Model

Parrish, K. E., Pokorny, J. L., Mittapalli, R. K., Bakken, K. K., Sarkaria, J. N., & Elmquist, W. F. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.228213 · Cited by 97 · see citing works

Preclinical Evidence of STAT3 Inhibitor Pacritinib Overcoming Temozolomide Resistance via Downregulating miR-21-Enriched Exosomes from M2 Glioblastoma-Associated Macrophages

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Molecular Characterization of EGFR and EGFRvIII Signaling Networks in Human Glioblastoma Tumor Xenografts

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Active Efflux of Dasatinib from the Brain Limits Efficacy against Murine Glioblastoma: Broad Implications for the Clinical Use of Molecularly Targeted Agents

Agarwal, S., Mittapalli, R. K., Zellmer, D. M., Gallardo, J. L., Donelson, R., Seiler, C., Decker, S. A., SantaCruz, K. S., Pokorny, J. L., Sarkaria, J. N., et al. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0552 · Cited by 92 · see citing works

The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood–Brain Barrier in Glioblastoma

Pokorny, J. L., Calligaris, D., Gupta, S. K., Iyekegbe, D. O., Mueller, D. J., Bakken, K. K., Carlson, B. L., Schroeder, M. A., Evans, D. L., Lou, Z., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2588 · Cited by 91 · see citing works

Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System

Parrish, K. E., Cen, L., Murray, J., Calligaris, D., Kizilbash, S. H., Mittapalli, R. K., Carlson, B. L., Schroeder, M. A., Sludden, J., Boddy, A. V., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0553 · Cited by 91 · see citing works

Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma

Marin, B. M., Porath, K. A., Jain, S., Kim, M., Conage‐Pough, J. E., Oh, J., Miller, C. L., Talele, S., Kitange, G. J., Tian, S., et al. (2021) · Neuro-Oncology · doi:10.1093/neuonc/noab133 · Cited by 84 · see citing works

InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma

Ma, Y., Tang, N., Thompson, R. C., Mobley, B. C., Clark, S. W., Sarkaria, J. N., & Wang, J. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1677 · Cited by 83 · see citing works

PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity

Gupta, S. K., Smith, E. J., Mladek, A. C., Tian, S., Decker, P. A., Kizilbash, S. H., Kitange, G. J., & Sarkaria, J. N. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2018.00670 · Cited by 81 · see citing works

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion

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Culture on 3D Chitosan‐Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells

Wang, K., Kievit, F. M., Erickson, A. E., Silber, J. R., Ellenbogen, R. G., & Zhang, M. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600684 · Cited by 78 · see citing works

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Randall, E. C., Emdal, K. B., Laramy, J. K., Kim, M., Roos, A., Calligaris, D., Regan, M. S., Gupta, S. K., Mladek, A. C., Carlson, B. L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07334-3 · Cited by 77 · see citing works

Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma

Miklja, Z., Yadav, V. N., Cartaxo, R. T., Siada, R. G., Thomas, C., Cummings, J. R., Mullan, B. P., Stallard, S., Paul, A., Bruzek, A. K., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133310 · Cited by 75 · see citing works

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

Kushwaha, D. S., Ramakrishnan, V., Ng, K., Steed, T., Nguyen, T. P., Futalan, D., Akers, J. C., Sarkaria, J. N., Jiang, T., Chowdhury, D., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1974 · Cited by 74 · see citing works

Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Kitange, G. J., Mladek, A. C., Schroeder, M. A., Pokorny, J. C., Carlson, B. L., Zhang, Y., Nair, A., Lee, J., Yan, H., Decker, P. A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.045 · Cited by 73 · see citing works

Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier

Salphati, L., Heffron, T. P., Alicke, B., Nishimura, M. C., Barck, K. H., Carano, R. A. D., Cheong, J., Edgar, K. A., Greve, J. M., Kharbanda, S., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0720 · Cited by 70 · see citing works

EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma

An, Z., Knobbe-Thomsen, C. B., Wan, X., Fan, Q. W., Reifenberger, G., & Weiss, W. A. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3551 · Cited by 66 · see citing works

Three-dimensional microscale hanging drop arrays with geometric control for drug screening and live tissue imaging

Ganguli, A., Mostafa, A., Saavedra, C., Kim, Y., Le, P., Faramarzi, V., Feathers, R. W., Berger, J., Ramos-Cruz, K. P., Adeniba, O. O., et al. (2021) · Science Advances · doi:10.1126/sciadv.abc1323 · Cited by 66 · see citing works

The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival

Thompson, E. M., Keir, S. T., Venkatraman, T. N., Lascola, C. D., Yeom, K. W., Nixon, A. B., Liu, Y., Picard, D. J., Remke, M., Bigner, D. D., et al. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox033 · Cited by 65 · see citing works

The antibiotic clofoctol suppresses glioma stem cell proliferation by activating KLF13

Hu, Y., Zhang, M., Tian, N., Li, D., Wu, F., Hu, P., Wang, Z., Wang, L., Hao, W., Kang, J., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124979 · Cited by 66 · see citing works

Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens

Pedrón, S., Wolter, G. L., Chen, J.-W. E., Laken, S. E., Sarkaria, J. N., & Harley, B. A. C. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119371 · Cited by 65 · see citing works

RNA interference for glioblastoma therapy: Innovation ladder from the bench to clinical trials

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Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas

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Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition

Rahman, M., Olson, I., Mansour, M. A., Carlstrom, L. P., Sutiwisesak, R., Saber, R., Rajani, K. R., Warrington, A. E., Howard, A., Schroeder, M. A., et al. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0029 · Cited by 63 · see citing works

Src family kinases differentially influence glioma growth and motility

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Automatic 3D Nonlinear Registration of Mass Spectrometry Imaging and Magnetic Resonance Imaging Data

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Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

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Identification of Global DNA Methylation Signatures in Glioblastoma-Derived Cancer Stem Cells

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Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma

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IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling

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Carbenoxolone Enhances TRAIL -Induced Apoptosis Through the Upregulation of Death Receptor 5 and Inhibition of Gap Junction Intercellular Communication in Human Glioma

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Quantitative Phosphoproteomics Reveals Wee1 Kinase as a Therapeutic Target in a Model of Proneural Glioblastoma

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Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma

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Bystander Effects, Pharmacokinetics, and Linker-Payload Stability of EGFR-Targeting Antibody-Drug Conjugates Losatuxizumab Vedotin and Depatux-M in Glioblastoma Models

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Patient-Derived Xenografts as a Model System for Radiation Research

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Microtubule actin cross-linking factor 1, a novel target in glioblastoma

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A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem Cells

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Dominant Effects of Δ40p53 on p53 Function and Melanoma Cell Fate

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Perivascular Stromal Cells Instruct Glioblastoma Invasion, Proliferation, and Therapeutic Response within an Engineered Brain Perivascular Niche Model

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Crizotinib and erlotinib inhibits growth of c-Met+/EGFRvIII+ primary human glioblastoma xenografts

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Network Modeling Identifies Patient-specific Pathways in Glioblastoma

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A reproducible brain tumour model established from human glioblastoma biopsies

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