The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Models of Nociception: Hot‐Plate, Tail‐Flick, and Formalin Tests in Rodents
Abstract
Experimental models of pain include tests of response thesholds to high intensity stimuli (acute pain tests) and changes in spontaneous or evoked behavioral responses in animals with peripheral injury or inflammation (persistent pain models). Acute thermal pain is modeled by the hot‐plate and tail‐flick test, while persistent pain can be modeled by the formalin test. This unit presents protocols for all three of these tests, including preparation of animals (rats or mice), administration of a compound being tested for its analgesic properties and data collection. Curr. Protoc. Neurosci. 41:8.9.1‐8.9.16. © 2007 by John Wiley & Sons, Inc.
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Cites
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R., Brown, F., Flores, C., & Joris, J. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,135
A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
D'AMOUR, F. E., & SMITH, D. L. (1941) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)03823-6 · Cited by 3,231
Dubuisson, D., & Dennis, S. G. (1977) · Pain · doi:10.1016/0304-3959(77)90130-0 · Cited by 2,524
Formalin test in mice, a useful technique for evaluating mild analgesics
Hunskaar, S., Fasmer, O. B., & Hole, K. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90116-5 · Cited by 821
Standardization of the rat paw formalin test for the evaluation of analgesics
Wheeler-Aceto, H., & Cowan, A. (1991) · Psychopharmacology · doi:10.1007/bf02244551 · Cited by 367
Dickenson, A. H., & Sullivan, A. F. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90242-4 · Cited by 264
Methodological refinements to the mouse paw formalin test
Murray, C. W., Porreca, F., & Cowan, A. (1988) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(88)90078-2 · Cited by 209
Response latencies in the tail-flick test depend on tail skin temperature
Berge, O.-G., Garcia-Cabrera, I., & Hole, K. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90497-1 · Cited by 168
Mogil, J. S., Kest, B., Sadowski, B., & Belknap, J. K. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12304-5 · Cited by 153
An automated flinch detecting system for use in the formalin nociceptive bioassay
Yaksh, T. L., Ozaki, G. T., McCumber, D., Rathbun, M. L., Svensson, C. I., Malkmus, S. A., & Yaksh, M. C. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2386 · Cited by 144
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Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review
Uritu, C. M., Mihai, C. T., Stanciu, G.-D., Dodi, G., Alexa-Stratulat, T., Luca, A., Leon-Constantin, M.-M., Stefanescu, R., Bild, V., Melnic, S., et al. (2018) · Pain Research and Management · doi:10.1155/2018/7801543 · Cited by 367
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Sarkar, S., Engler-Chiurazzi, E. B., Cavendish, J. Z., Povroznik, J. M., Russell, A. E., Quintana, D. D., Mathers, P. H., & Simpkins, J. W. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146327 · Cited by 91
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Metadata
- Authors
- Bannon, A. W., & Malmberg, A. B.
- Venue
- Current Protocols in Neuroscience
- Publisher
- Wiley
- Published
- 2007-10
- Volume
- 41
- Issue
- 1
- Pages
- Unit 8.9-Unit 8.9
- ISSN
- 1934-8576 (ISSN-L)
- 1934-8584
- OpenAlex
- W2132187713
- Cited by
- 316
- References
- 16
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bannon, A. W., & Malmberg, A. B. (2007). Models of Nociception: Hot‐Plate, Tail‐Flick, and Formalin Tests in Rodents. Current Protocols in Neuroscience. https://doi.org/10.1002/0471142301.ns0809s41
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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