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Cited by 161Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Antidepressants plus benzodiazepines for major depression

Furukawa, Toshi A, Streiner, David, Young, L. Trevor, Kinoshita, Yoshihiro·2001·Cochrane Database of Systematic Reviews
DOI 10.1002/14651858.cd001026
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Abstract

Background Anxiety frequently coexists with depression. Adding benzodiazepines to antidepressants is commonly used to treat people with depression, although there has been no convincing evidence to show that such a combination is more effective than antidepressants alone and that there are suggestions that benzodiazepines may lose their efficacy with long-term administration and that their chronic use carries risks of dependence. Objectives To determine whether, among adult patients with major depression, adding benzodiazepines to antidepressants brings about any benefit in terms of symptomatic recovery or side-effects in the short term (less than 8 weeks) and long term (more than 2 months), in comparison with treatment by antidepressants alone. Search strategy We searched MEDLINE (1972 to September 1997), EMBASE (1980 to September 1997), International Pharmaceutical Abstracts (1972 to September 1997), Biological Abstracts (1984 to September 1997), LILACS (1980 to September 1997), PsycLIT (1974 to September 1997), the Cochrane Library (issue 3, 1997) and the trial register of the Cochrane Depression, Anxiety and Neurosis Group (last searched March 1999), combined with hand searching, reference searching, SciSearch and personal contacts. Selection criteria All randomised controlled trials that compared combined antidepressant-benzodiazepine treatment with antidepressant alone for adult patients with major depression. Exclusion criteria are: antidepressant dosage lower than 100…

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  • There is a risk that a patient with depression and insomnia will not be able to stop combination treatment with benzodiazepines and SSRI/SNRI after 14-28 days and will develop dependence.

    “However, there is a related risk that the patient suffering from depression and insomnia will not be able to stop such treatment after 14 -28 days of therapy and will develop a dependence [21, 22].”

    From Effects of Antidepressants on Sleep (2017) · cites this paper as [22]

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Metadata

Authors
Furukawa, T. A., Streiner, D., Young, L. T., & Kinoshita, Y.
Affiliations
  • Nagoya City University (JP)
  • Baycrest Centre for Geriatric Care (CA)
  • McMaster University (CA)
ORCID
Venue
Cochrane Database of Systematic Reviews
Publisher
Wiley
Published
2001-07-23
Issue
1
Pages
CD001026-CD001026
ISSN
  • 1361-6137 (ISSN-L)
  • 1465-1858
DOI
10.1002/14651858.cd001026
OpenAlex
W1504483181
Cited by
161
References
11
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 1 · 2020: 5 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 12 · 2015: 11 · 2014: 8 · 2013: 8 · 2012: 8
FWCI
0.75
Type
journal article
Language
en
Update notices
new_version (2019-06-03)
Open access
closed
Locations
  • Cochrane Database of Systematic Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords
major depressive disorder, antidepressants, benzodiazepines, combination therapy, anxiety comorbidity, treatment discontinuation, antidepressant side effects, benzodiazepine dependence, long-term efficacy, relapse prevention
MeSH terms
Adult, Antidepressive Agents, Benzodiazepines, Depression, Drug Therapy, Combination, Humans, Anti-Anxiety Agents, Randomized Controlled Trials as Topic

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