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Cited by 167Treatment of Major DepressionChild and Adolescent Psychosocial and Emotional DevelopmentMental Health Treatment and Access

Tricyclic drugs for depression in children and adolescents

Hazell, Philip, O'Connell, Dianne, Heathcote, Diane, Henry, David A·2002·Cochrane Database of Systematic Reviews
DOI 10.1002/14651858.cd002317
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Abstract

Background There is a need to identify effective and safe treatments for depression in children and adolescents. While tricyclic drugs are effective in treating depression in adults, individual studies involving children and adolescents have been equivocal. Objectives To assess the effects of oral tricyclic antidepressants compared to placebo in the treatment of child and adolescent depression. Search strategy We searched MEDLINE (1966-1997), EMBASE, Excerpta Medica (June 1974-1997), the Cochrane Collaboration Depression, Anxiety and Neurosis Group trials register (most recent search 25/1/2000) and bibliographies of previously published reviews and papers describing original research were cross-checked. Current Contents was screened for recent publications. We contacted authors of relevant abstracts in conference proceedings of the American Academy of Child and Adolescent Psychiatry, and we hand searched the Journal of the American Academy of Child and Adolescent Psychiatry (1978-1999). Selection criteria Randomised controlled trials comparing the efficacy of orally administered tricyclic medication with placebo in depressed people aged 6-18 years. Data collection and analysis Most studies reported multiple outcome measures including depression scales and clinical global impression scales. For each study the best available depression measure was taken as the index measure of depression outcome. Predetermined criteria were established to assist in the ranking of measures. Wher…

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Authors
Hazell, P., O'Connell, D., Heathcote, D., & Henry, D. A.
Affiliations
  • Hunter New England Local Health District (AU)
  • Institute for Clinical Evaluative Sciences (CA)
ORCID
Venue
Cochrane Database of Systematic Reviews
Publisher
John Wiley & Sons, Ltd
Published
2002-04-22
Issue
2
Pages
CD002317-CD002317
ISSN
1361-6137 (ISSN-L)
DOI
10.1002/14651858.cd002317
OpenAlex
W4232604357
Cited by
167
References
33
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 8 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 9 · 2014: 4 · 2013: 7 · 2012: 15
Type
reference entry
Language
en
Update notices
new_version (2013-06-18)
Open access
closed
Locations
  • Cochrane Database of Systematic Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
tricyclic antidepressants, childhood depression, adolescent depression, children, antidepressant efficacy, antidepressant safety, adverse effects, placebo comparison, treatment response, subgroup analysis, Clinical Global Impression Scale, depression rating scales, treatment discontinuation, remission, treatment-emergent mania
MeSH terms
Administration, Oral, Adolescent, Antidepressive Agents, Tricyclic, Child, Depression, Humans, Confidence Intervals, Odds Ratio, Randomized Controlled Trials as Topic, Outcome Assessment, Health Care

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