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Cited by 38Treatment of Major DepressionChild and Adolescent Psychosocial and Emotional DevelopmentMental Health Treatment and Access

Efficacy of antidepressants in child and adolescent depression: a meta-analytic study

Papanikolaou, K., Richardson, C., Pehlivanidis, A., Papadopoulou-Daifoti, Z.·2006·Journal of Neural Transmission
DOI 10.1007/s00702-005-0340-2
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Abstract

Objectives To examine whether antidepressant drugs are superior to placebo in the treatment of juvenile depression.Method Extensive literature search was done to retrieve all randomised controlled and all uncontrolled trials describing children and adolescents with a diagnosis of depression who underwent any antidepressant drug treatment. In order to combine results, separate analyses using random effect models were conducted first for controlled and then for both controlled and open studies.Results 18 controlled and 23 open trials were submitted to meta-analysis. Tricyclics showed no significant benefit over placebo. Odds ratios for SSRIs were 1.84 (95% CI 1.35-2.50) for controlled and 1.83 (95% CI 1.40-2.40) for controlled and uncontrolled studies suggesting a significant benefit over placebo. Combining all antidepressants also gave confidence interval excluding the value one.Conclusions Despite some promising data concerning the use of SSRIs in the treatment of adolescent depression, caution is warranted until the long-term safety of these agents can be demonstrated. Insufficient data are available to judge even the short term merits of these agents in prepubertal children. There is no evidence to support the use of tricyclics in this population.

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Crossref · 10.1007/s00702-005-0340-2

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Authors
Papanikolaou, K., Richardson, C., Pehlivanidis, A., & Papadopoulou-Daifoti, Z.
Affiliations
  • Panteion University (GR)
  • National and Kapodistrian University of Athens (GR)
ORCID
Venue
Journal of Neural Transmission
Publisher
Springer Science and Business Media LLC
Published
2005-08-03
Volume
113
Issue
3
Pages
399-415
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
DOI
10.1007/s00702-005-0340-2
OpenAlex
W1964395326
Cited by
38
References
106
Citations by year
2023: 3 · 2019: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 7 · 2013: 1 · 2012: 3
FWCI
2.13
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
antidepressants, adolescent depression, children, selective serotonin reuptake inhibitors, tricyclic antidepressants, placebo comparison, treatment efficacy, long-term safety, prepubertal children
MeSH terms
Adolescent, Age Factors, Antidepressive Agents, Antidepressive Agents, Tricyclic, Child, Clinical Trials as Topic, Depressive Disorder, Female, Humans, Male, Placebo Effect, Treatment Outcome, Selective Serotonin Reuptake Inhibitors

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