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Cited by 519Posttraumatic Stress Disorder ResearchSleep and related disordersTraumatic Brain Injury Research

The DOI matches its Crossref record; 284 of the 288 references it cites were found in a registry or an index.

Pharmacotherapy for post traumatic stress disorder (PTSD)

Open access
Stein, Dan J, Ipser, Jonathan C, Seedat, Soraya, Sager, Carli, Amos, Taryn·2006·Cochrane Database of Systematic Reviews
DOI 10.1002/14651858.cd002795.pub2PMC PMC6993948
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Abstract

BACKGROUND: Post traumatic stress disorder (PTSD) is a prevalent and disabling disorder. Evidence that PTSD is characterised by specific psychobiological dysfunctions has contributed to a growing interest in the use of medication in its treatment. OBJECTIVES: To assess the effects of medication for post traumatic stress disorder. SEARCH STRATEGY: We searched the Cochrane Depression, Anxiety and Neurosis Group specialised register (CCDANCTR-Studies) on 18 August 2005, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library issue 4, 2004), MEDLINE (January 1966 to December 2004), PsycINFO (1966 to 2004), and the National PTSD Center Pilots database. Reference lists of retrieved articles were searched for additional studies. SELECTION CRITERIA: All randomised controlled trials (RCTs) of pharmacotherapy for PTSD. DATA COLLECTION AND ANALYSIS: Two raters independently assessed RCTs for inclusion in the review, collated trial data, and assessed trial quality. Investigators were contacted to obtain missing data. Summary statistics were stratified by medication class, and by medication agent for the selective serotonin reuptake inhibitors (SSRIs). Dichotomous and continuous measures were calculated using a random effects model, heterogeneity was assessed, and subgroup/sensitivity analyses were undertaken. MAIN RESULTS: 35 short-term (14 weeks or less) RCTs were included in the analysis (4597 participants). Symptom severity for 17 trials was significantly reduced in the medication groups, relative to placebo (weighted mean difference -5.76, 95% confidence intervals (CI) -8.16 to -3.36, number of participants (N) = 2507). Similarly, summary statistics for responder status from 13 trials demonstrated overall superiority of a variety of medication agents to placebo (relative risk 1.49, 95% CI 1.28 to 1.73, number needed to treat = 4.85, 95% CI 3.85 to 6.25, N = 1272). Medication and placebo response occurred in 59.1% (N = 644) and 38.5% (628) of patients, respectively. Of the medication classes, evidence of treatment efficacy was most convincing for the SSRIs. Medication was superior to placebo in reducing the severity of PTSD symptom clusters, comorbid depression and disability. Medication was also less well tolerated than placebo. A narrative review of 3 maintenance trials suggested that long term medication may be required in treating PTSD. AUTHORS' CONCLUSIONS: Medication treatments can be effective in treating PTSD, acting to reduce its core symptoms, as well as associated depression and disability. The findings of this review support the status of SSRIs as first line agents in the pharmacotherapy of PTSD, as well as their value in long-term treatment. However, there remain important gaps in the evidence base, and a continued need for more effective agents in the management of PTSD.

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Research works printed but not linked: 25

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  5. Rapaport, 2002, Posttraumatic stress disorder and quality of life: Results across 64 weeks of sertraline treatment, Journal of Clinical Psychiatry, 63, 59, 10.4088/JCP.v63n0112 · DOI
  6. Davidson, 2004, Treatment of PTSD: A comparison of venlafaxine extended release, sertraline, and placebo [abstract NR521], 157th Annual Meeting of the American Psychiatric Association; 2004 May 1-6; New York, NY, 195
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  14. Hertzberg, 1999, A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder, Biological Psychiatry, 45, 1226, 10.1016/S0006-3223(99)00011-6 · DOI
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Metadata

Authors
Stein, D. J., Ipser, J. C., Seedat, S., Sager, C., & Amos, T.
Affiliations
  • University of Cape Town (ZA)
  • Stellenbosch University (ZA)
ORCID
Venue
Cochrane Database of Systematic Reviews
Publisher
Wiley
Published
2006-01-25
Issue
1
Pages
CD002795-CD002795
ISSN
  • 1361-6137 (ISSN-L)
  • 1465-1858
DOI
10.1002/14651858.cd002795.pub2
PMC
PMC6993948
OpenAlex
W1530873853
Cited by
519
References
288
Citations by year
2026: 5 · 2025: 12 · 2024: 20 · 2023: 21 · 2022: 23 · 2021: 25 · 2020: 24 · 2019: 26 · 2018: 20 · 2017: 22 · 2016: 54 · 2015: 29 · 2014: 31 · 2013: 33 · 2012: 27
FWCI
3.43
Type
journal article
Language
en
Update notices
new_version (2022-03-02)
Open access
Locations
  • Cochrane Database of Systematic Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Medical Research Council
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Keywords
post-traumatic stress disorder, pharmacotherapy, selective serotonin reuptake inhibitors, antidepressants, symptom severity, comorbid depression, anxiety comorbidity, treatment response, placebo response, adverse drug reactions, treatment discontinuation, PTSD symptom clusters
MeSH terms
Antidepressive Agents, Humans, Psychotropic Drugs, Stress Disorders, Post-Traumatic, Randomized Controlled Trials as Topic

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