The DOI matches its Crossref record; 104 of the 105 references it cites were found in a registry or an index.
Statins for the prevention of dementia
Abstract
Background This is an update of a Cochrane review first published in 2001. At that stage there was insufficient evidence to recommend statins for the prevention of Alzheimer's disease (AD). The scope of this review has been expanded to include all forms of dementia. Objectives To assess the effects of statins in the prevention of dementia. Search strategy The Specialized Register of the Cochrane Dementia and Cognitive Improvement Group, The Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL and LILACS were searched on 10 October 2007 using the terms statin*, lovastatin*, pravastatin*, simvastatin*, fluvastatin*, atorvastatin* and rosuvastatin*. The CDCIG Register contains records from many healthcare databases, SIGLE, LILACS as well as many trials databases and is updated regularly. Selection criteria Double-blind randomized placebo-controlled trials of statins in people at risk of AD and dementia. Data collection and analysis Two independent reviewers extracted and assessed data independently and agreement was reached after discussion. Adverse effects were noted. Main results Two trials were identified with 26,340 participants; HPS 2002 and PROSPER 2002. Age range was 40-82 years across the two studies, PROSPER 2002 included 5804 patients aged 70-82 years and HPS included 20,536 patients with 5806 at least 70 years old at study entry. Mean total cholesterol 5.9 mmol/l, LDL cholesterol 3.4 mmol/l at study entry with mean reduction in LDL cholesterol of 1.0 mmol/l in simvasta…
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“Some observational studies have suggested a beneficial effect of aspirin on cognition,465,466 although this was not confirmed in others.467,468”
Citations
Cites
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
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High-Dose Atorvastatin after Stroke or Transient Ischemic Attack
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Statins and the risk of dementia
Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S. S., & Drachman, D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03155-x · Cited by 1,764
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711
Research works printed but not linked: 2
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- Refolo, 2001, A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of alzheimer's disease, Neurobiological Disorders, 8, 890
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Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811
Ballard, C., Gauthier, S., Corbett, A., Brayne, C., Aarsland, D., & Jones, E. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61349-9 · Cited by 2,336
Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.016 · Cited by 1,660
A commentary on studies presenting projections of the future prevalence of dementia
Norton, S., Matthews, F. E., & Brayne, C. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-1 · Cited by 634
Andrade, J. G., Aguilar, M., Atzema, C. L., Bell, A., Cairns, J. A., Cheung, C. C., Cox, J. L., Dorian, P., Gladstone, D. J., Healey, J. S., et al. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.09.001 · Cited by 593
Metadata
- Authors
- McGuinness, B., Craig, D., Bullock, R., & Passmore, P.
- Affiliations
- Queen's University Belfast (GB)
- Victoria Hospital (CA)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- John Wiley & Sons, Ltd
- Published
- 2009-04-15
- Issue
- 2
- Pages
- CD003160-CD003160
- ISSN
- 1361-6137 (ISSN-L)
- OpenAlex
- W4210956788
- Cited by
- 193
- References
- 105
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 9 · 2016: 17 · 2015: 18 · 2014: 17 · 2013: 18 · 2012: 22
- Type
- reference entry
- Language
- en
- Update notices
- new_version (2016-01-04)
- Open access
- closed
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- statins, dementia prevention, Alzheimer's disease, simvastatin, pravastatin, cognitive function, LDL cholesterol lowering, adverse effects, statin safety, older adults, hypercholesterolemia, dementia incidence, cholesterol-lowering drugs
- MeSH terms
- Alzheimer Disease, Anticholesteremic Agents, Cognition, Dementia, Humans, Randomized Controlled Trials as Topic, Pravastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Simvastatin
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