Cited by 193Lipoproteins and Cardiovascular HealthDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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Statins for the prevention of dementia

McGuinness, Bernadette, Craig, David, Bullock, Roger, Passmore, Peter·2009·Cochrane Database of Systematic Reviews

DOI 10.1002/14651858.cd003160.pub2

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Abstract

Background This is an update of a Cochrane review first published in 2001. At that stage there was insufficient evidence to recommend statins for the prevention of Alzheimer's disease (AD). The scope of this review has been expanded to include all forms of dementia. Objectives To assess the effects of statins in the prevention of dementia. Search strategy The Specialized Register of the Cochrane Dementia and Cognitive Improvement Group, The Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL and LILACS were searched on 10 October 2007 using the terms statin*, lovastatin*, pravastatin*, simvastatin*, fluvastatin*, atorvastatin* and rosuvastatin*. The CDCIG Register contains records from many healthcare databases, SIGLE, LILACS as well as many trials databases and is updated regularly. Selection criteria Double-blind randomized placebo-controlled trials of statins in people at risk of AD and dementia. Data collection and analysis Two independent reviewers extracted and assessed data independently and agreement was reached after discussion. Adverse effects were noted. Main results Two trials were identified with 26,340 participants; HPS 2002 and PROSPER 2002. Age range was 40-82 years across the two studies, PROSPER 2002 included 5804 patients aged 70-82 years and HPS included 20,536 patients with 5806 at least 70 years old at study entry. Mean total cholesterol 5.9 mmol/l, LDL cholesterol 3.4 mmol/l at study entry with mean reduction in LDL cholesterol of 1.0 mmol/l in simvasta…

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Authors: McGuinness, B., Craig, D., Bullock, R., & Passmore, P.
Affiliations: Queen's University Belfast (GB)
Victoria Hospital (CA)
ORCID: McGuinness, Bernadette
Craig, David
Passmore, Peter
Venue: Cochrane Database of Systematic Reviews
Publisher: John Wiley & Sons, Ltd
Published: 2009-04-15
Issue: 2
Pages: CD003160-CD003160
ISSN: 1361-6137 (ISSN-L)
DOI: 10.1002/14651858.cd003160.pub2
OpenAlex: W4210956788
Cited by: 193
References: 105
Citations by year: 2025: 3 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 9 · 2016: 17 · 2015: 18 · 2014: 17 · 2013: 18 · 2012: 22
Type: reference entry
Language: en
Update notices: new_version (2016-01-04)
Open access: closed
Locations: Cochrane Database of Systematic Reviews (publishedVersion)
PubMed (publishedVersion)
Research Portal (Queen's University Belfast) (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: statins, dementia prevention, Alzheimer's disease, simvastatin, pravastatin, cognitive function, LDL cholesterol lowering, adverse effects, statin safety, older adults, hypercholesterolemia, dementia incidence, cholesterol-lowering drugs
MeSH terms: Alzheimer Disease, Anticholesteremic Agents, Cognition, Dementia, Humans, Randomized Controlled Trials as Topic, Pravastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Simvastatin

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