Effects of Four-Week Supplementation with a Multi-Vitamin/Mineral Preparation on Mood and Blood Biomarkers in Young Adults: A Randomised, Double-Blind, Placebo-Controlled Trial
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This study explored the effects of four-week multi-vitamin and mineral (MVM) supplementation on mood and neurocognitive function in healthy, young adults. Fifty-eight healthy adults, 18-40 years of age (M = 25.82 years, SD = 4.87) participated in this randomised, double-blind, placebo-controlled trial, in which mood and blood biomarkers were assessed at baseline and after four weeks of supplementation. Compared to placebo, MVM supplementation was associated with significantly lowered homocysteine and increased blood B-vitamin levels (p < 0.01). MVM treatment was also associated with significantly improved mood, as measured by reduced scores on the "depression-dejection" subscale of the Profile of Mood States (p = 0.018). These findings suggest that the four weeks of MVM supplementation may have beneficial effects on mood, underpinned by elevated B-vitamins and lowered homocysteine in healthy young adults.
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In one trial, compared with placebo, a 4-week supplementation (B vitamins, vitamin C, zinc, calcium and magnesium) in 58 healthy adults was associated with a significant improvement of mood, in relation to increased levels of B vitamins and lowered homocysteine in blood.
“one trial has shown that, compared with placebo, a 4 week supplementation (B vitamins, vitamin C, zinc, calcium and magnesium) in 58 healthy adults was associated with a significant improvement of mood, in relation to increased levels of B vitamins and lowered homocysteine in blood [220].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [220]
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- Authors
- White, D., Cox, K., Peters, R., Pipingas, A., & Scholey, A.
- Affiliations
- Swinburne University of Technology (AU)
- Corresponding author
- Scholey, Andrew
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2015-10-30
- Volume
- 7
- Issue
- 11
- Pages
- 9005-9017
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC4663579
- OpenAlex
- W1958192686
- Cited by
- 48
- References
- 50
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 4
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (cc-by)
- Funders
- Bayer
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- mood, depression, homocysteine, B vitamins, blood biomarkers, neurocognitive function, young adults, Profile of Mood States
- MeSH terms
- Adolescent, Adult, Affect, Cognition, Depression, Double-Blind Method, Female, Homocysteine, Humans, Male, Minerals, Reference Values, Trace Elements, Vitamin B Complex, Vitamins, Biomarkers, Dietary Supplements, Young Adult
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