Cited by 262Enzyme Structure and FunctionProtein Structure and DynamicsDrug Transport and Resistance Mechanisms

An updated structural classification of substrate-binding proteins.

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Scheepers, Giel H., Lycklama a Nijeholt, Jelger A., Poolman, Bert·2016·FEBS Letters

Abstract

Substrate-binding proteins (SBPs) play an important role in solute uptake and signal transduction. In 2010, Berntsson et al. classified the 114 organism-specific SBP structures available at that time and defined six protein clusters, based on their structural similarity. Since then, the number of unique SBP structures has increased almost fivefold, whereas the number of protein entries in the Protein Data Bank (PDB) nearly doubled. On the basis of the much larger dataset, we now subclassify the SBPs within the original clusters. Moreover, we propose a 7th cluster based on a small group of SBPs with structural features significantly different from those observed in the other proteins.

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Crossref · 10.1002/1873-3468.12445

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Authors
Scheepers, G. H., Lycklama a Nijeholt, J. A., & Poolman, B.
Affiliations
  • University of Groningen (NL)
  • Department of Biochemistry Groningen Biomolecular Sciences and Biotechnology Institute Zernike Institute for Advanced Materials University of Groningen The Netherlands
Corresponding author
Poolman, Bert
Venue
FEBS Letters
Publisher
Wiley
Published
2016-10-23
Volume
590
Issue
23
Pages
4393-4401
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2528162531
Cited by
260
References
47
Citations by year
2026: 7 · 2025: 24 · 2024: 26 · 2023: 29 · 2022: 31 · 2021: 51 · 2020: 28 · 2019: 28 · 2018: 22 · 2017: 13 · 2016: 1
FWCI
9.79
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders
European Research Council (670578)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
substrate-binding protein, structural classification, protein clusters, solute uptake, signal transduction, protein structure, Protein Data Bank
MeSH terms
Protein Conformation, alpha-Helical, Models, Molecular, Protein Binding, Proteins, Computational Biology, Databases, Protein

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