CoChat
Sign Up
Cited by 58Free Radicals and AntioxidantsRedox biology and oxidative stressChemical Reaction Mechanisms

Reaction Rates of Superoxide Radicals with the Essential Amino Acids

Bielski, Benon H. J., Shiue, Grace G.·2008·Novartis Foundation Symposia
DOI 10.1002/9780470715413.ch4
Open this paper in CoChat — free account

Abstract

Upper limits for the rates of reaction of amino acids with superoxide radicals have been determined spectrophotometrically by the stopped flow method. Rate measurements at 23 degrees C for the reaction of HO2 with amino acids were made in the pH range between 1 and 2; similar measurements for O2- were taken near pH 10. The results show that, overall, amino acids are relatively unreactive toward both HO2 and O2-. Computed second-order rate constants for their interaction with HO2 range from 101 mol-1s-1 for aliphatic amino acids to about 600 1 mol-1s-1. The second-order rate constants for the interaction of amino acids with O2- are smaller and range from 0.1 to about 20 1 mol-1s-1.

Integrity signals

Registry

Crossref · 10.1002/9780470715413.ch4

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Second-order rate constants for HO2• reactions with aliphatic amino acids are reported in the range of 1 × 10 M−1s−1 and about 6 × 10^2 M−1s−1 for Cys; O2•− reactions are lower, ranging from 1.0 × 10−1 M−1s−1 to about 2 × 10 M−1s−1.

    “Second order rate constant values for HO2• reactions for aliphatic amino acids are reported in the literature in the range of 1 × 10 M−1s−1 and a value of about 6 × 102 M−1s−1 for Cys, these values are even lower for O2•− reactions of these amino acids, with values ranging from 1.0 × 10−1 M−1s−1 to about 2 × 10 M−1s−1 [131].”

    From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [131]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Bielski, B. H. J., & Shiue, G. G.
Affiliations
Brookhaven National Laboratory (US)
Venue
Novartis Foundation Symposia
Publisher
John Wiley & Sons, Ltd.
Published
2008-05-27
Issue
65
Pages
43-56
ISSN
  • 1528-2511 (ISSN-L)
  • 1935-4657
DOI
10.1002/9780470715413.ch4
OpenAlex
W1592794698
Cited by
58
References
17
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2014: 1 · 2013: 3 · 2012: 1
FWCI
22.44
Type
book chapter
Language
en
Open access
closed
Locations
  • Novartis Foundation symposium (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
Keywords
superoxide, amino acids, reaction rate, second-order rate constants, hydroxyl radicals, radical reactivity, pH dependence, aliphatic amino acids, essential amino acids
MeSH terms
Amino Acids, Essential, Chemistry, Cysteine, Free Radicals, Hydrogen-Ion Concentration, Kinetics, Oxygen, Superoxides, Chemical Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review