The reaction of superoxide radical with N-acetylcysteine

Tissue sulfhydryl groups

Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,824 · see citing works

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works

Handbook of Chemistry and Physics

(1937) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/20.1.142a · Cited by 4,759 · see citing works

Reactivity of HO2/O− 2 radicals in aqueous solution

Bielski, B. H. J., Cabelli, D. E., Arudi, R. L., & Ross, A. B. (1985) · Journal of Physical and Chemical Reference Data · doi:10.1063/1.555739 · Cited by 2,169 · see citing works

The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid

Aruoma, O. I., Halliwell, B. B., Hoey, B. M., & Butler, J. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90066-x · Cited by 1,774 · see citing works

The chemical basis of radiation biology

von Sonntag, C. (1987) · Medical Entomology and Zoology · Cited by 1,748 · see citing works

Colorimetric Determination of Hydrogen Peroxide

Eisenberg, G. M. (1943) · Industrial & Engineering Chemistry Analytical Edition · doi:10.1021/i560117a011 · Cited by 1,305 · see citing works

A colorimetric method for determining low concentrations of mercaptans

Ellman, G. L. (1958) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(58)90014-6 · Cited by 1,085 · see citing works

Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide

Winterbourn, C. C., & Metodiewa, D. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00051-9 · Cited by 799 · see citing works

Glutathione: Toxicological Implications

Reed, D. J. (1990) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.30.040190.003131 · Cited by 748 · see citing works

Mechanism of the disproportionation of superoxide radicals

Bielski, B. H. J., & Allen, A. O. (1977) · The Journal of Physical Chemistry · doi:10.1021/j100526a005 · Cited by 485 · see citing works

Glutathione Deficiency and Human Immunodeficiency Virus Infection

Staal, F. J. T., Ela, S. W., Roederer, M., Anderson, M. T., Herzenberg, L. A., & Herzenberg, L. A. (1992) · The Lancet · doi:10.1016/0140-6736(92)90939-z · Cited by 404 · see citing works

Sulfur-Centered Reactive Intermediates in Chemistry and Biology

Chatgilialoglu, C., & Asmus, K. (1990) · Springer eBooks · doi:10.1007/978-1-4684-5874-9 · Cited by 337 · see citing works

Stabilization of oxidized sulfur centers in organic sulfides. Radical cations and odd-electron sulfur-sulfur bonds

Asmus, K. D. (1979) · Accounts of Chemical Research · doi:10.1021/ar50144a003 · Cited by 314 · see citing works

The Reaction of Superoxide with Reduced Glutathione

Winterbourn, C. C., & Metodiewa, D. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1444 · Cited by 269 · see citing works

Lung Protection by a Thiol-Containing Antioxidant: N-Acetylcysteine

Moldéus, P., Cotgreave, I. A., & Berggren, M. M. (2009) · Respiration · doi:10.1159/000195086 · Cited by 262 · see citing works

Pulse radiolysis study of sulfhydryl compounds in aqueous solution

Hoffman, M. Z., & Hayon, E. (1973) · The Journal of Physical Chemistry · doi:10.1021/j100627a005 · Cited by 200 · see citing works

Biothiols in Health and Disease

Packer, L., & Cadenas, E. (1995) · Medical Entomology and Zoology · Cited by 198 · see citing works

Pulse Radiolytic Study of the Interaction of Thiols and Ascorbate with OH Adducts of dGMP and dG: Implications for DNA Repair Processes

O'Neill, P. (1983) · Radiation Research · doi:10.2307/3576178 · Cited by 188 · see citing works

The Formation and Structure of the Sulfoxyl Radicals RSO·, RSOO·, RSO2·, and RSO2OO· from the Reaction of Cysteine, Glutathione and Penicillamine Thiyl Radicals with Molecular Oxygen

Sevilla, M. D., Becker, D. A., & Yan, M. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014550351 · Cited by 120 · see citing works

Potential Repair of Free Radical Adducts of dGMP and dG by a Series of Reductants. A Pulse Radiolytic Study

O'Neill, P., & Chapman, P. W. (1985) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008514550101 · Cited by 118 · see citing works

Interactions of Thiyl Free Radicals with Oxygen: A Pulse Radiolysis Study

Tamba, M., Simone, G. D., & Quintiliani, M. (1986) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008614550991 · Cited by 114 · see citing works

Substituent effects on the stability of three-electron-bonded radicals and radical ions from organic sulfur compounds

Goebl, M., Bonifacic, M., & Asmus, K. D. (1984) · Journal of the American Chemical Society · doi:10.1021/ja00332a039 · Cited by 110 · see citing works

Reactivity of Thiols with Superoxide Radicals

Asada, K., & Kanematsu, S. (1976) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1976.10862321 · Cited by 101 · see citing works

Pulse Radiolysis of 2-Mercaptoethanol in Oxygenated Aqueous Solution. Generation and Reactions of the Thiylperoxyl Radical

Zhang, X., Zhang, N., Schuchmann, H., & von Sonntag, C. (1994) · The Journal of Physical Chemistry · doi:10.1021/j100077a020 · Cited by 97 · see citing works

S∴N and S∴O three-electron-bonded radicals and radical cations in aqueous solutions

Asmus, K., Goebl, M., HILLER, K. ‐., Mahling, S., & Mönig, J. (1985) · Journal of the Chemical Society Perkin Transactions 2 · doi:10.1039/p29850000641 · Cited by 96 · see citing works

The radiolysis of oxygenated cysteine solutions at neutral pH. The role of RSSR and O2−

Barton, J. P., & Packer, J. E. (1970) · International Journal for Radiation Physics and Chemistry · doi:10.1016/0020-7055(70)90029-x · Cited by 89 · see citing works

Lifetime of Peroxyl Radicals of Poly(U), Poly(A) and Single-and Double-Stranded DNA and the Rate of Their Reaction with Thiols

Schulte‐Frohlinde, D., Behrens, G., & Önal, A. M. (1986) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008614550481 · Cited by 79 · see citing works

Sodium selenite and N‐acetylcysteine in antiretroviral‐naive HIV‐1‐infected patients: a randomized, controlled pilot study

Look, Rockstroh, Rao, Barton, Lemoch, Kaiser, Kupfer, Sudhop, Spengler, & Sauerbruch (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00301.x · Cited by 75 · see citing works

Determination of Rate Constants of the Reactions of Thiols with Superoxide Radical by Electron Paramagnetic Resonance: Critical Remarks on Spectrophotometric Approaches

Dikalov, S., Khramtsov, V. V., & Zimmer, G. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0067 · Cited by 63 · see citing works

Reactivity of thiols with superoxide radicals.

Asada, K., & Kanematsu, S. (1976) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.40.1891 · Cited by 63 · see citing works

Antioxidant action of sodium diethyldithiocarbamate: Reaction with hydrogen peroxide and superoxide radical

Mankhetkorn, S., Abedinzadeh, Z., & Houée‐Levin, C. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90091-4 · Cited by 59 · see citing works

Reaction Rates of Superoxide Radicals with the Essential Amino Acids

Bielski, B. H. J., & Shiue, G. G. (2008) · Novartis Foundation Symposia · doi:10.1002/9780470715413.ch4 · Cited by 58 · see citing works

Electron spin resonance investigation of the structure and formation of sulfinyl radicals: reaction of peroxyl radicals with thiols

Swarts, S. G., Becker, D. A., DeBolt, S., & Sevilla, M. D. (1989) · The Journal of Physical Chemistry · doi:10.1021/j100338a034 · Cited by 54 · see citing works

The radiolysis of aqueous solutions of cysteine in the presence of oxygen

Al-Thannon, A., Barton, J. P., Packer, J. E., Sims, R. J., Trumbore, C. N., & Winchester, R. V. (1974) · International Journal for Radiation Physics and Chemistry · doi:10.1016/0020-7055(74)90024-2 · Cited by 53 · see citing works

The reaction of superoxide radical anion with dithiothreitol: A chain process

Zhang, N., Schuchmann, H. P., & Von Sonntag, C. (1991) · The Journal of Physical Chemistry · doi:10.1021/j100165a024 · Cited by 53 · see citing works

The antioxidative activity of the mucoregulatory agents: Ambroxol, bromhexine and N-acetyl-L-cysteine. A pulse radiolysis study

Felix, K., Pairet, M., & Zimmermann, R. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00431-6 · Cited by 49 · see citing works

Pulse- and X-radiolysis of 2-mercaptoethanol in Aqueous Solution

Jayson, G. G., Stirling, D. A., & Swallow, A. J. (1971) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553007114550191 · Cited by 43 · see citing works

Radical-Induced Oxidation of Dithiothreitol in Acidic Oxygenated Aqueous Solution: A Chain Reaction

Lal, M., Rao, R., Fang, X., Schuchmann, H., & von Sonntag, C. (1997) · Journal of the American Chemical Society · doi:10.1021/ja970744l · Cited by 36 · see citing works

Structure and reactivity of peroxyl and sulphoxyl radicals from measurement of oxygen-17 hyperfine couplings: relationship with taft substituent parameters

Sevilla, M. D., Becker, D. A., & Yan, M. (1990) · Journal of the Chemical Society Faraday Transactions · doi:10.1039/ft9908603279 · Cited by 35 · see citing works

Redox reactions of thiol free radicals with the antioxidants ascorbate and chlorpromazine: role in radioprotection

Tamba, M., & O’Neill, P. (1991) · Journal of the Chemical Society Perkin Transactions 2 · doi:10.1039/p29910001681 · Cited by 32 · see citing works

Spectroscopic study of N-acetylcysteine and N-acetylcystine/hydrogen peroxide complexation

Picquart, M., Abedinzadeh, Z., Grajcar, L., & Baron, M. H. (1998) · Chemical Physics · doi:10.1016/s0301-0104(97)00337-6 · Cited by 28 · see citing works

Free-radical-induced elimination of hydrogen sulfide from dithiothreitol. A chain reaction

Akhlaq, M. S., & von Sonntag, C. (1986) · Journal of the American Chemical Society · doi:10.1021/ja00272a079 · Cited by 25 · see citing works

Radiation induced oxidation of sulphydryl molecules in aqueous solutions. A comprehensive review

Lal, M. (1994) · Radiation Physics and Chemistry · doi:10.1016/0969-806x(94)90174-0 · Cited by 21 · see citing works

On N-acetylcysteine. Part II. Oxidation of N-acetylcysteine by hydrogen peroxide: kinetic study of the overall process

Abedinzadeh, Z., Arroub, J., & Gardès-Albert, M. (1994) · Canadian Journal of Chemistry · doi:10.1139/v94-267 · Cited by 16 · see citing works

ChemInform Abstract: Free‐Radical‐Induced Elimination of H2S from Dithiothreitol. A Chain Reaction.

Akhlaq, M. S., & von Sonntag, C. (1986) · ChemInform · doi:10.1002/chin.198642121 · Cited by 8 · see citing works

Alkanethiylperoxyl Radicals

Chatgilialoglu, C., & Guerra, M. (1990) · Springer eBooks · doi:10.1007/978-1-4684-5874-9_5 · Cited by 8 · see citing works

On N-acetylcysteine. Part I. Experimental and theoretical approaches of the N-acetylcysteine/H2O2complexation

Arroub, J., Bergès, J., Abedinzadeh, Z., Langlet, J., & Gardès-Albert, M. (1994) · Canadian Journal of Chemistry · doi:10.1139/v94-266 · Cited by 7 · see citing works

Alpha-lipoic acid and N-acetylcysteine: New concepts for old drugs.

Bast, A., Haenen, G. R. M. M., Packer, L., & Cadenas, E. (1995) · Data Archiving and Networked Services (DANS) · Cited by 2 · see citing works

Action des radicaux OH• ou [math] sur la N-acétylcystéine

Charif, A., Abedinzadeh, Z., Gardès-Albert, M., & Ferradini, C. (1993) · Journal de Chimie Physique · doi:10.1051/jcp/1993900907 · Cited by 1 · see citing works

Thiol chemistry and specificity in redox signaling

Winterbourn, C. C., & Hampton, M. B. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.004 · Cited by 1,226 · see citing works

The chemistry and biological activities of N-acetylcysteine

Samuni, Y., Goldstein, S., Dean, O. M., & Berk, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.04.016 · Cited by 876 · see citing works

Hydroxyl Radical-Mediated Modification of Proteins as Probes for Structural Proteomics

Xu, G., & Chance, M. R. (2007) · Chemical Reviews · doi:10.1021/cr0682047 · Cited by 685 · see citing works

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

Yang, W., & Hekimi, S. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000556 · Cited by 630 · see citing works

Mitochondria as a Pharmacological Target

Szewczyk, A. M., & Wojtczak, L. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.101 · Cited by 541 · see citing works

N-Acetylcysteine (NAC): Impacts on Human Health

Tenório, M. C. D. S., Graciliano, N. G., Moura, F. A., Oliveira, A. C. M. D., & Goulart, M. O. F. (2021) · Antioxidants · doi:10.3390/antiox10060967 · Cited by 526 · see citing works

N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production

Ezeriņa, D., Takano, Y., Hanaoka, K., Urano, Y., & Dick, T. P. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.01.011 · Cited by 405 · see citing works

Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity

Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031841 · Cited by 342 · see citing works

Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo dose-effects: A review

Sadowska, A. M., Manuel‐y‐Keenoy, B., & Backer, W. A. D. (2006) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2005.12.007 · Cited by 327 · see citing works

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

Lamprecht, D. A., Finin, P. M., Rahman, M. A., Cumming, B. M., Russell, S., Jonnala, S. R., Adamson, J., & Steyn, A. J. C. (2016) · Nature Communications · doi:10.1038/ncomms12393 · Cited by 239 · see citing works

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

Runkel, E. D., Liu, S., Baumeister, R., & Schulze, E. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003346 · Cited by 192 · see citing works

High glucose-induced oxidative stress impairs proliferation and migration of human gingival fibroblasts

Buranasin, P., Mizutani, K., Iwasaki, K., Mahasarakham, C. P. N., Kido, D., Takeda, K., & Izumi, Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201855 · Cited by 191 · see citing works

Medical and Dietary Uses of N-Acetylcysteine

Šalamon, Š., Kramar, B., Marolt, T. P., Poljšak, B., & Milisav, I. (2019) · Antioxidants · doi:10.3390/antiox8050111 · Cited by 188 · see citing works

High-Dose N-Acetylcysteine in Stable COPD

Tse, H. N., Raiteri, L., Wong, K. Y., Yee, K. S., Ng, L. Y., Wai, K. Y., Loo, C. K., & Chan, M. (2013) · CHEST Journal · doi:10.1378/chest.12-2357 · Cited by 189 · see citing works

Mitochondrial dysfunction in bipolar disorder: Evidence, pathophysiology and translational implications

Scaini, G., Rezin, G. T., Carvalho, A. F., STRECK, E. L., Berk, M., & Quevedo, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.040 · Cited by 184 · see citing works

Biological Activities and Potential Oral Applications of N‐Acetylcysteine: Progress and Prospects

Pei, Y., Liu, H., Yang, Y., Yang, Y., Jiao, Y., Tay, F. R., & Chen, J. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2835787 · Cited by 167 · see citing works

Oxidative Stress and Respiratory System: Pharmacological and Clinical Reappraisal of N-Acetylcysteine

Santus, P., Corsico, A., Solidoro, P., Braido, F., di Marco, F., & Scichilone, N. (2014) · COPD · doi:10.3109/15412555.2014.898040 · Cited by 138 · see citing works

The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment

Giménez-Palomo, A., Dodd, S., Anmella, G., Carvalho, A. F., Scaini, G., Quevedo, J., Pacchiarotti, I., Vieta, E., & Berk, M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.546801 · Cited by 140 · see citing works

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

Wang, B., Veldhoven, P. P. V., Brees, C., Rubio, N., Nordgren, M., Apanasets, O., Kunze, M., Baes, M. I., Agostinis, P., & Fransen, M. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.173 · Cited by 141 · see citing works

Role of N-acetylcysteine in the management of COPD

Sadowska, A. M., Verbraecken, J. A., Darquennes, K., & Backer, W. D. (2006) · International Journal of COPD · doi:10.2147/copd.2006.1.4.425 · Cited by 139 · see citing works

NAC, NAC, Knockin’ on Heaven's door: Interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells

Kalyanaraman, B. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102497 · Cited by 118 · see citing works

Redox Chemistry of Biological Thiols

Nagy, P., & Winterbourn, C. C. (2010) · Advances in molecular toxicology · doi:10.1016/s1872-0854(10)04006-3 · Cited by 125 · see citing works

N-acetylcysteine infusion alters blood redox status but not time to fatigue during intense exercise in humans

Medved, I., Brown, M. J., Bjorksten, A. R., Leppik, J. A., Sostaric, S. M., & McKenna, M. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00884.2002 · Cited by 114 · see citing works

N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes

Moazzen, H., Lu, X., Ma, N. L., Velenosi, T. J., Urquhart, B. L., Wisse, L. J., Gittenberger-de Groot, A. C., & Feng, Q. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-46 · Cited by 111 · see citing works

Improvement by N-acetylcysteine of acute respiratory distress syndrome through increasing intracellular glutathione, and extracellular thiol molecules and anti-oxidant power: evidence for underlying toxicological mechanisms

Soltan-Sharifi, M. S., Mojtahedzadeh, M., Najafi, A., Khajavi, M. R., Rouini, M. R., Moradi, M., Mohammadirad, A., & Abdollahi, M. R. (2007) · Human & Experimental Toxicology · doi:10.1177/0960327107083452 · Cited by 104 · see citing works

Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity

Saito, Y., Uppal, A., Geisen, P., & Hartnett, M. E. (2020) · PubMed Central · doi:10.17615/fn4f-9z34 · Cited by 99 · see citing works

Understanding Reactive Oxygen Species in Bone Regeneration: A Glance at Potential Therapeutics and Bioengineering Applications

Sheppard, A. J., Barfield, A. M., Barton, R. S., & Dong, Y. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.836764 · Cited by 99 · see citing works

Secondary Reactions and Strategies To Improve Quantitative Protein Footprinting

Xu, G., Kiselar, J., He, Q., & Chance, M. R. (2005) · Analytical Chemistry · doi:10.1021/ac048282z · Cited by 96 · see citing works

Copper‐Catalyzed Aerobic Formation of Unstable Sulfinyl Radicals for the Synthesis of Sulfinates and Thiosulfonates

Shyam, P. K., Kim, Y. K., Lee, C., & Jang, H. (2015) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201500785 · Cited by 96 · see citing works

Oxidative stress in cardiomyocytes contributes to decreased SERCA2a activity in rats with metabolic syndrome

Balderas‐Villalobos, J., Molina-Muñoz, T., Mailloux‐Salinas, P., Bravo, G., Carvajal, K., & Gómez-Viquez, N. L. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00211.2013 · Cited by 92 · see citing works

Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders

STRECK, E. L., Gonçalves, C. L., Furlanetto, C. B., Scaini, G., Dal‐Pizzol, F., & Quevedo, J. (2014) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2013-1224 · Cited by 82 · see citing works

Effect of Chronic N-Acetyl Cysteine Administration on Oxidative Status in the Presence and Absence of Induced Oxidative Stress in Rat Striatum

Harvey, B. H., Joubert, C., du Preez, J. L., & Berk, M. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9466-y · Cited by 81 · see citing works

N-acetylcysteine improves redox status, mitochondrial dysfunction, mucin-depleted crypts and epithelial hyperplasia in dextran sulfate sodium-induced oxidative colitis in mice

Amrouche-Mekkioui, I., & Djerdjouri, B. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.06.014 · Cited by 81 · see citing works

Nanomedicine in the ROS-mediated pathophysiology: Applications and clinical advances

Nash, K. M., & Ahmed, S. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.07.003 · Cited by 80 · see citing works

Nutrient Metabolism, Subcellular Redox State, and Oxidative Stress in Pancreatic Islets and β-Cells

Roma, L. P., & Jonas, J. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.10.012 · Cited by 75 · see citing works

Revisiting the reactions of superoxide with glutathione and other thiols

Winterbourn, C. C. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.11.028 · Cited by 75 · see citing works

From hyperglycemia to AGE-RAGE interaction on the cell surface: A dangerous metabolic route for diabetic patients

Nogueira‐Machado, J. A., & Chaves, M. M. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.7.871 · Cited by 74 · see citing works

Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats.

Zhang, S., Chai, F.-Y., YAN, H. H., Guo, Y. G., & Harding, J. J. (2008) · PubMed Central · Cited by 70 · see citing works

Redox Control of GTPases: From Molecular Mechanisms to Functional Significance in Health and Disease

Heo, J. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2984 · Cited by 68 · see citing works

Benefits of High-Dose N-Acetylcysteine to Exacerbation-Prone Patients With COPD

Tse, H. N., Raiteri, L., Wong, K. Y., Ng, L. Y., Yee, K. S., & Tseng, C. Z. S. (2014) · CHEST Journal · doi:10.1378/chest.13-2784 · Cited by 67 · see citing works

Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress

Boldogh, I. R., Roy, G., Lee, M. S., Bácsi, A., Hazra, T. K., Bhakat, K. K., Das, G. C., & MITRA, S. P. (2003) · Toxicology · doi:10.1016/j.tox.2003.08.013 · Cited by 62 · see citing works

Activity of Megazol, a Trypanocidal Nitroimidazole, Is Associated with DNA Damage

Enanga, B., Ariyanayagam, M. R., Stewart, M. L., & Barrett, M. P. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.10.3368-3370.2003 · Cited by 61 · see citing works

Effects of pyrogallic acid on Microcystis aeruginosa: oxidative stress related toxicity

Lu, Z., Zhang, Y., Gao, Y., Liu, B., Sun, X., He, F., Zhou, Q., & Wu, Z. (2016) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2016.06.039 · Cited by 60 · see citing works

Reactive Oxygen Species and Nrf2: Functional and Transcriptional Regulators of Hematopoiesis

Hu, L., Zhang, Y., Miao, W., & Cheng, T. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5153268 · Cited by 59 · see citing works

Treatment of oxidative stress, apoptosis, and DNA injury with N-acetylcysteine at simulative pesticide toxicity in fish

Atamanalp, M., Parlak, V., Özgeriş, F. B., Yeltekin, A. Ç., Uçar, A., Keleş, M. S., & Alak, G. (2021) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2021.1871794 · Cited by 57 · see citing works

Effect of High/Low Dose N-Acetylcysteine on Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

Shen, Y., Cai, W., Lei, S., & Zhang, Z. (2013) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.3109/15412555.2013.858315 · Cited by 56 · see citing works

N-Acetylcysteine and Hydrogen Sulfide in Coronavirus Disease 2019

Bourgonje, A. R., Offringa, A. K., van Eijk, L. E., Abdulle, A. E., Hillebrands, J., van der Voort, P. H. J., van Goor, H., & Hezik, E. J. V. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8247 · Cited by 58 · see citing works

Effect of antioxidants on the incidence of wound infection in burn patients.

Sahib, A. S., Al‐Jawad, F. H., & Al-Kaisy, A. A. (2010) · PubMed Central · Cited by 53 · see citing works

Enhanced ROS production leads to excessive fat accumulation through DAF-16 in Caenorhabditis elegans

Wang, K., Chen, S., Zhang, C., Huang, J., Wu, J., Zhou, H., Jin, L., Xu, Q., Jin, J., & Lyu, J. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.07.017 · Cited by 50 · see citing works

The effect of N-acetylcysteine on epistaxis and quality of life in patients with HHT: a pilot study.

de Gussem, E. M., Snijder, R. J., Disch, F. J. M., Zanen, P., Westermann, C. J. J., & Mager, J. J. (2009) · PubMed · Cited by 49 · see citing works

Role of antioxidants in the treatment of burn lesions.

Al‐Jawad, F. H., Sahib, A. S., & Al-Kaisy, A. A. (2008) · PubMed Central · Cited by 49 · see citing works

tert-Butylhydroquinone as a Spectroscopic Probe for the Superoxide Radical Scavenging Activity Assay of Biological Samples

Bekdeşer, B., Özyürek, M., Güçlü, K., & Apak, R. (2011) · Analytical Chemistry · doi:10.1021/ac200788m · Cited by 49 · see citing works

N-Acetyl-L-Cysteine Protects Liver and Kidney Against Chromium(VI)-Induced Oxidative Stress in Mice

Boşgelmez, İ. İ., & Güvendik, G. (2016) · Biological Trace Element Research · doi:10.1007/s12011-016-0901-2 · Cited by 49 · see citing works

Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans

Rieckher, M., Markaki, M., Princz, A., Schumacher, B., & Tavernarakis, N. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.009 · Cited by 46 · see citing works

The oxidative stress induced in vivo by Shiga toxin-2 contributes to the pathogenicity of haemolytic uraemic syndrome

Gomez, S. A., Abrey-Recalde, M. J., Panek, C. A., Ferrarotti, N., Repetto, M. G., Mejías, M. P., Fernández, G. C., Vanzulli, S. I., Isturiz, M. A., & Palermo, M. S. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12124 · Cited by 45 · see citing works

Preparation of an 18F‐Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species

Al-Karmi, S. A., Albu, S. A., Vito, A., Janzen, N., Czorny, S. K., Banevicius, L., Nanao, M., Zubieta, J. A., Capretta, A. A., & Valliant, J. F. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201604473 · Cited by 45 · see citing works

Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans

Sasakura, H., Moribe, H., Nakano, M., Ikemoto, K., Takeuchi, K., & Mori, I. (2017) · Journal of Cell Science · doi:10.1242/jcs.202119 · Cited by 45 · see citing works

Blue light irradiation-induced oxidative stress in vivo via ROS generation in rat gingival tissue

Yoshida, A., Shiotsu-Ogura, Y., Wada-Takahashi, S., Takahashi, S., Toyama, T., & Yoshino, F. (2015) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2015.07.001 · Cited by 45 · see citing works

Estresse oxidativo: revisão da sinalização metabólica no diabetes tipo 1

Reis, J. S., Veloso, C. A., de Mattos, R. T., Purisch, S., & Nogueira‐Machado, J. A. (2008) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302008000700005 · Cited by 42 · see citing works

Highly cytotoxic gold( i )-phosphane dithiocarbamate complexes trigger an ER stress-dependent immune response in ovarian cancer cells

Le, H. V., Babak, M. V., Ehsan, M. A., Altaf, M., Reichert, L., Gushchin, A. L., Ang, W. H., & Isab, A. A. (2020) · Dalton Transactions · doi:10.1039/d0dt01411g · Cited by 40 · see citing works

A Mutation in Caenorhabditis elegans NDUF-7 Activates the Mitochondrial Stress Response and Prolongs Lifespan via ROS and CED-4

Rauthan, M., Ranji, P., Abukar, R., & Pilon, M. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.018598 · Cited by 39 · see citing works

N-Acetylcysteine protects against trichloroethene-mediated autoimmunity by attenuating oxidative stress

Wang, G., Wang, J., Ma, H., Ansari, G. A. S., & Khan, M. F. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.08.020 · Cited by 39 · see citing works

N-acetylcysteine alleviated bisphenol A-induced testicular DNA hypermethylation of rare minnow (Gobiocypris rarus) by increasing cysteine contents

Yuan, C., Wang, L., Zhu, L., Ran, B., Xue, X., & Wang, Z. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.02.035 · Cited by 38 · see citing works

Formulation and Characterization of Injectable Poly(dl-lactide-co-glycolide) Implants Loaded with N-Acetylcysteine, a MMP Inhibitor

Desai, K. G. H., Mallery, S. R., & Schwendeman, S. P. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9430-1 · Cited by 38 · see citing works

The administration of N-acetylcysteine reduces oxidative stress and regulates glutathione metabolism in the blood cells of workers exposed to lead

Kasperczyk, S., Dobrakowski, M., Kasperczyk, A., Ostałowska, A., & Birkner, E. (2013) · Clinical Toxicology · doi:10.3109/15563650.2013.802797 · Cited by 36 · see citing works

Effect of N-acetylcysteine administration on the expression and activities of antioxidant enzymes and the malondialdehyde level in the blood of lead-exposed workers

Kasperczyk, S., Dobrakowski, M., Kasperczyk, A., Machnik, G., & Birkner, E. (2014) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2014.01.024 · Cited by 36 · see citing works

Mechanism of Thiol Oxidation by the Superoxide Radical

Cardey, B., Foley, S., & Enescu, M. (2007) · The Journal of Physical Chemistry A · doi:10.1021/jp0731102 · Cited by 35 · see citing works

Oxidative Stress: A Potential Therapeutic Target in Placental Malaria

Sarr, D., Cooper, C. A., Bracken, T. C., Martinez-Uribe, O., Nagy, T., & Moore, J. M. (2017) · ImmunoHorizons · doi:10.4049/immunohorizons.1700002 · Cited by 34 · see citing works

An in vivo and in vitro study on the protective effects of N-acetylcysteine on mitochondrial dysfunction in isoproterenol treated myocardial infarcted rats

Basha, R. H., & Priscilla, D. H. (2011) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2011.05.002 · Cited by 33 · see citing works

Evaluation of N-acetyl-cysteine against tetrachlorobenzoquinone-induced genotoxicity and oxidative stress in HepG2 cells

Dong, H. F., Xu, D., Hu, L., Li, L., Song, E., & Song, Y. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.11.036 · Cited by 33 · see citing works

The Protein Deacetylase SIRT3 Prevents Oxidative Stress-induced Keratinocyte Differentiation

Bause, A. S., Matsui, M. S., & Haigis, M. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.472324 · Cited by 32 · see citing works

Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax

Blatt, N. B., Boitano, A. E., Lyssiotis, C. A., Opipari, A. W., & Glick, G. D. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.07.022 · Cited by 29 · see citing works

Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs

Lyakhovich, A., & Graifer, D. M. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666150729114036 · Cited by 28 · see citing works

Influence of N-acetylcysteine administration on pulmonary O2 uptake kinetics and exercise tolerance in humans

Bailey, S. J., Winyard, P. G., Blackwell, J. R., Vanhatalo, A., Lansley, K. E., DiMenna, F. J., Wilkerson, D. P., Campbell, I. T., & JONES, A. M. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.10.002 · Cited by 28 · see citing works

Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats.

Shi, Q., YAN, H. H., Li, M.-Y., & Harding, J. J. (2009) · PubMed Central · Cited by 28 · see citing works

Warburg-like effect is a hallmark of complex I assembly defects

Desquiret‐Dumas, V., Leman, G., Wetterwald, C., Chupin, S., Lebert, A., Khiati, S., Mao, M. L., Geffroy, G., Kane, M. S., Chevrollier, A., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.05.011 · Cited by 27 · see citing works

Metabolic ROS Signaling: To Immunity and Beyond

Andreyev, A. Y., Kushnareva, Y. E., Starkova, N. N., & Starkov, A. A. (2020) · Biochemistry (Moscow) · doi:10.1134/s0006297920120160 · Cited by 28 · see citing works

Burns, endothelial dysfunction, and oxidative stress: the role of antioxidants.

Sahib, A. S., Al‐Jawad, F. H., & Al-Kaisy, A. A. (2009) · PubMed Central · Cited by 26 · see citing works

Flow Injection Spectrophotometric Determination of N-Acetylcysteine and Captopril Employing Prussian Blue Generation Reaction

Suarez, W. T., Pessoa-Neto, O. D., Janegitz, B. C., Vieira, H. J., Faria, R. C., & Fatibello‐Filho, O. (2011) · Analytical Letters · doi:10.1080/00032719.2010.551696 · Cited by 26 · see citing works

Acute exposure of the aquatic macrophyte Callitriche obtusangula to the herbicide oxadiazon: The protective role of N-acetylcysteine

Iriti, M., Castorina, G., Picchi, V., Faoro, F., & Gomarasca, S. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.11.025 · Cited by 25 · see citing works

Deliberate ROS production and auxin synergistically trigger the asymmetrical division generating the subsidiary cells in Zea mays stomatal complexes

Livanos, P., Galatis, B., & Apostolakos, P. (2015) · PROTOPLASMA · doi:10.1007/s00709-015-0866-6 · Cited by 25 · see citing works

Effect of thiol redox state modulators on oxidative stress and sclerotial differentiation of the phytopathogenic fungus Rhizoctonia solani

Patsoukis, N., & Georgiou, C. D. (2007) · Archives of Microbiology · doi:10.1007/s00203-007-0237-6 · Cited by 24 · see citing works

N-Acetylcysteine inhalation improves pulmonary function in patients received liver transplantation

Li, X., Wei, X., Chen, C., Zhang, Z., Liu, D., Hei, Z., & Yao, W. (2018) · Bioscience Reports · doi:10.1042/bsr20180858 · Cited by 24 · see citing works

Emerging Pharmacotherapies in Alcohol-Associated Hepatitis

Wakil, A., Niazi, M. A., Meybodi, M. A., & Pyrsopoulos, N. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.06.012 · Cited by 21 · see citing works

Cysteine Oxidation by the Superoxide Radical: A Theoretical Study

Cardey, B., & Enescu, M. (2009) · ChemPhysChem · doi:10.1002/cphc.200900010 · Cited by 21 · see citing works

1 H and 13 C NMR spectroscopic study of oxidation of D , L ‐cystine and 3,3′‐dithiobis(propionic acid) with hydrogen peroxide in aqueous solution

KATRITZKY, A. R., Akhmedov, N. G., & Denisko, O. V. (2002) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.1110 · Cited by 21 · see citing works

Insulin signaling alters antioxidant capacity in the diabetic heart

Matsuzaki, S., Eyster, C. A., Newhardt, M. F., Giorgione, J. R., Kinter, C. S., Young, Z. T., Kinter, M. T., & Humphries, K. M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102140 · Cited by 20 · see citing works

Effect of glutathione biosynthesis-related modulators on the thiol redox state enzymes and on sclerotial differentiation of filamentous phytopathogenic fungi

Patsoukis, N., & Georgiou, C. D. (2007) · Mycopathologia · doi:10.1007/s11046-007-9008-9 · Cited by 20 · see citing works

Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner

Samandari-Bahraseman, M. R., Khorsand, B., Zareei, S., Amanlou, M., & Rostamabadi, H. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110642 · Cited by 19 · see citing works

Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels

Guinan, A. F., Rochfort, K. D., Fitzpatrick, P. A., Walsh, T. G., Pierotti, A. R., Phelan, S., Murphy, R. P., & Cummins, P. M. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt127 · Cited by 18 · see citing works

N-Acetylcysteine provides dose-dependent protection against fenthion toxicity in the brain of Cyprinus carpio L

Üner, N., Sevgiler, Y., Durmaz, H., Benli, P. P., & Çınkıloğlu, E. (2009) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2009.02.001 · Cited by 18 · see citing works

The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson’s disease

Kobayashi, H., Fukuhara, K., Tada‐Oikawa, S., Yada, Y., Hiraku, Y., Murata, M., & Oikawa, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05774.x · Cited by 18 · see citing works

H2S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?

Gorini, F., Turco, S. D., Sabatino, L., Gaggini, M., & Vassalle, C. (2021) · Biomedicines · doi:10.3390/biomedicines9091107 · Cited by 17 · see citing works

Thiol redox state and oxidative stress affect sclerotial differentiation of the phytopathogenic fungi Sclerotium rolfsii and Sclerotinia sclerotiorum

Patsoukis, N., & Georgiou, C. D. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03527.x · Cited by 17 · see citing works

Influence of N -acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats

Priya, S., Paramasivan, V., Vivekanandan, P., & Karthikeyan, S. (2011) · Toxicology and Industrial Health · doi:10.1177/0748233711399323 · Cited by 17 · see citing works

Phosphorylation of a p38‐like MAPK is involved in sensing cellular redox state and drives atypical tubulin polymer assembly in angiosperms

Livanos, P., Galatis, B., Gaitanaki, C., & Apostolakos, P. (2013) · Plant Cell & Environment · doi:10.1111/pce.12222 · Cited by 17 · see citing works

Oxidative post-translational modification of catalase confers salt stress acclimatization by regulating H2O2 homeostasis in Malus hupehensis

Yang, F., Liu, Y., Zhang, X., Liu, X., Wang, G., Jing, X., Wang, X., Zhang, Z., Hao, G., Zhang, S., et al. (2023) · Journal of Plant Physiology · doi:10.1016/j.jplph.2023.154037 · Cited by 14 · see citing works

N-Acetylcysteine prevents baker’s-yeast-induced inflammation and fever

Ferreira, A. P. O., Pasin, J. S. M., Saraiva, A. L., Ratzlaff, V., Rossato, M. F., Andrighetto, R., Rubin, M. A., Ferreira, J., & Mello, C. F. (2011) · Inflammation Research · doi:10.1007/s00011-011-0392-8 · Cited by 14 · see citing works

Highly selective and sensitive fluorescent sensing of N-acetylcysteine: Effective discrimination of N-acetylcysteine from cysteine

Dong, W., Wen, H., Yang, X., & Li, H. (2012) · Dyes and Pigments · doi:10.1016/j.dyepig.2012.10.014 · Cited by 14 · see citing works

Radical Scavenging by Thiols and the Fate of Thiyl Radicals

Winterbourn, C. C. (2013) · Springer eBooks · doi:10.1007/978-94-007-5787-5_2 · Cited by 14 · see citing works

Action des radicaux superoxyde sur la N-acétylcystéine

Benrahmoune, M., Ghassah, M., & Abedinzadeh, Z. (1997) · Journal de Chimie Physique · doi:10.1051/jcp/1997940257 · Cited by 1 · see citing works

Etude de l'action du radical superoxyde vis-a-vis de la n-acetylcysteine par radiolyse

Benrahmoune, M. (1998) · Cited by 1 · see citing works

On N-acetylcysteine. Part II. Oxidation of N-acetylcysteine by hydrogen peroxide: kinetic study of the overall process

Abedinzadeh, Z., Arroub, J., & Gardès-Albert, M. (1994) · Canadian Journal of Chemistry · doi:10.1139/v94-267 · Cited by 16 · see citing works

60Co γ-radiolysis of oxygenated aqueous solutions of cysteine at pH 7

Packer, J. E., & Winchester, R. V. (1970) · Canadian Journal of Chemistry · doi:10.1139/v70-068 · Cited by 22 · see citing works

The radiolysis of aqueous solutions of cysteine

Winchester, R. V. (1968) · ResearchSpace (University of Auckland)