Cited by 136Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceAntioxidants, Aging, Portulaca oleracea

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Aging Research Using Mouse Models

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Ackert‐Bicknell, Cheryl L., Anderson, Laura C., Sheehan, Susan, Hill, Warren G., Chang, Bo, Churchill, Gary A., Chesler, Elissa J., Korstanje, Ron, Peters, Luanne L.·2015·Current Protocols in Mouse Biology

DOI 10.1002/9780470942390.mo140195PMC PMC4590775

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Abstract

Despite the dramatic increase in human lifespan over the past century, there remains pronounced variability in “health‐span,” or the period of time in which one is generally healthy and free of disease. Much of the variability in health‐span and lifespan is thought to be genetic in origin. Understanding the genetic mechanisms of aging and identifying ways to boost longevity is a primary goal in aging research. Here, we describe a pipeline of phenotypic assays for assessing mouse models of aging. This pipeline includes behavior/cognition testing, body composition analysis, and tests of kidney function, hematopoiesis, and immune function, as well as physical parameters. We also describe study design methods for assessing lifespan and health‐span, and other important considerations when conducting aging research in the laboratory mouse. The tools and assays provided can assist researchers with understanding the correlative relationships between age‐associated phenotypes and, ultimately, the role of specific genes in the aging process. © 2015 by John Wiley & Sons, Inc.

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Authors: Ackert‐Bicknell, C. L., Anderson, L. C., Sheehan, S., Hill, W. G., Chang, B., Churchill, G. A., Chesler, E. J., Korstanje, R., & Peters, L. L.
Affiliations: University of Rochester Medicine (US)
Jackson Laboratory (US)
Beth Israel Deaconess Medical Center (US)
ORCID: Ackert‐Bicknell, Cheryl L.
Anderson, Laura C.
Sheehan, Susan
Hill, Warren G.
Chang, Bo
Churchill, Gary A.
Chesler, Elissa J.
Korstanje, Ron
Peters, Luanne L.
Venue: Current Protocols in Mouse Biology
Publisher: Wiley
Published: 2015-06
Volume: 5
Issue: 2
Pages: 95-133
ISSN: 2161-2617 (ISSN-L)
DOI: 10.1002/9780470942390.mo140195
PMC: PMC4590775
OpenAlex: W1519109490
Cited by: 135
References: 41
Citations by year: 2026: 13 · 2025: 13 · 2024: 19 · 2023: 20 · 2022: 18 · 2021: 23 · 2020: 8 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 3
FWCI: 1.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Current Protocols in Mouse Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders: National Institutes of Health (5p20dk097818-02, 5r01ey019943-13)
National Institute on Aging (AG-038070, P30AG038070)
National Eye Institute (EY019943, R01-EY019943)
National Cancer Institute (P30CA034196)
National Institute of Diabetes and Digestive and Kidney Diseases (DK097818, DK083299, P20-DK-097818, R01DK083299)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords: aging, mouse models of aging, healthspan, lifespan, longevity, phenotypic assays, body composition, renal function, hematopoiesis, immune function, research design
MeSH terms: Aging, Animals, Animal Structures, Behavior, Animal, Disease Models, Animal, Humans, Laboratory Animal Science, Longevity, Research Design, Mice

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