The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Multifunctional Up‐Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual‐Responsive Drug Controlled Release
Abstract
Multifunctional nanocarriers based on the up‐conversion luminescent nanoparticles of NaYF 4:Yb 3+/Er 3+ core (UCNPs) and thermo/pH‐coupling sensitive polymer poly[(N‐isopropylacrylamide)‐co‐(methacrylic acid)] (P(NIPAm‐co‐MAA)) gated mesoporous silica shell are reported for cancer theranostics, including fluorescence imaging, and for controlled drug release for therapy. The as‐synthesized hybrid nanospheres UCNPs@mSiO 2‐P(NIPAm‐co‐MAA) show bright green up‐conversion fluorescence under 980 nm laser excitation and the thermo/pH‐sensitive polymer is active as a “valve” to moderate the diffusion of the embedded drugs in‐and‐out of the pore channels of the silica container. The anticancer drug doxorubicin hydrochloride (DOX) can be absorbed into UCNPs@mSiO 2‐P(NIPAm‐co‐MAA) nanospheres and the composite drug delivery system (DDS) shows a low level of leakage at low temperature/high pH values but significantly enhanced release at higher temperature/lower pH values, exhibiting an apparent thermo/pH controlled “on‐off” drug release pattern. The as‐prepared UCNPs@mSiO 2‐P(NIPAm‐co‐MAA) hybrid nanospheres can be used as bioimaging agents and biomonitors to track the extent of drug release. The reported multifunctional nanocarriers represent a novel and versatile class of platform for simultaneous imaging and stimuli‐responsive controlled drug delivery.
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Cites
Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
Multifunctional and stimuli-sensitive pharmaceutical nanocarriers
Torchilin, V. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.026 · Cited by 583
Xu, H., Cheng, L., Wang, C., Ma, X., Li, Y., & Liu, Z. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.053 · Cited by 301
Cited by
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,699
Zheng, W., Huang, P., Tu, D., Ma, E., Zhu, H., & Chen, X. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00178h · Cited by 894
Current advances in lanthanide ion (Ln3+)-based upconversion nanomaterials for drug delivery
Yang, D., Ma, P., Hou, Z., Cheng, Z., Li, C., & Lin, J. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00155a · Cited by 743
Self-citationWang, X.-G., Dong, Z.-Y., Cheng, H., Wan, S.-S., Chen, W.-H., Zou, M.-Z., Huo, J.-W., Deng, H.-X., & Zhang, X.-Z. (2015) · Nanoscale · doi:10.1039/c5nr04045k · Cited by 291
Self-citationBagheri, A., Arandiyan, H., Boyer, C., & Lim, M. (2016) · Advanced Science · doi:10.1002/advs.201500437 · Cited by 265
Metadata
- Authors
- Zhang, X., Yang, P., Dai, Y., Ma, P., Li, X., Cheng, Z., Hou, Z., Kang, X., Li, C., & Lin, J.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2013-03-27
- Volume
- 23
- Issue
- 33
- Pages
- 4067-4078
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2109850619
- Cited by
- 228
- References
- 4
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, X., Yang, P., Dai, Y., Ma, P., Li, X., Cheng, Z., Hou, Z., Kang, X., Li, C., & Lin, J. (2013). Multifunctional Up‐Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual‐Responsive Drug Controlled Release. Advanced Functional Materials. https://doi.org/10.1002/adfm.201300136
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