The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Myeloid‐Derived Suppressor Cell Membrane‐Coated Magnetic Nanoparticles for Cancer Theranostics by Inducing Macrophage Polarization and Synergizing Immunogenic Cell Death
Abstract
A major challenge for traditional cancer therapy, including surgical resection, chemoradiotherapy, and immunotherapy, is how to induce tumor cell death and leverage the host immune system at the same time. Here, a myeloid‐derived suppressor cell (MDSC) membrane‐coated iron oxide magnetic nanoparticle (MNP@MDSC) to overcome this conundrum for cancer therapy is developed. In this study, MNP@MDSC demonstrates its superior performance in immune evasion, active tumor‐targeting, magnetic resonance imaging, and photothermal therapy (PTT)‐induced tumor killing. Compared with red blood cell membrane‐coated nanoparticles (MNPs@RBC) or naked MNPs, MNP@MDSCs are much more effective in active tumor‐targeting, a beneficial property afforded by coating MNP with membranes from naturally occurring MDSC, thus converting the MNP into “smart” agents that like to accumulate in tumors as the source MDSCs. Once targeted to the tumor microenvironment, MNPs@MDSC can act as a PTT agents for enhanced antitumor response by inducing immunogenic cell death, reprogramming the tumor infiltrating macrophages, and reducing the tumor's metabolic activity. These benefits, in combination with the excellent biocompatibility and pharmacological kinetics characteristics, make MNP@MDSC a promising, multimodal agent for cancer theranostics.
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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
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Autophagy-dependent ATP release from dying cells via lysosomal exocytosis
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Ma, Y., Zhang, Y., Li, X., Zhao, Y., Li, M., Jiang, W., Tang, X., Dou, J., Lu, L., Wang, F., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b06040 · Cited by 355
Ligand-installed nanocarriers toward precision therapy
Mi, P., Cabral, H., & Kataoka, K. (2020) · Advanced Materials · doi:10.1002/adma.201902604 · Cited by 350
Biomimetic Nanotechnology toward Personalized Vaccines
Zhou, J., Kroll, A. V., Holay, M., Fang, R. H., & Zhang, L. (2020) · Advanced Materials · doi:10.1002/adma.201901255 · Cited by 328
Tailoring Nanomaterials for Targeting Tumor‐Associated Macrophages
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Metadata
- Authors
- Yu, G., Rao, L., Wu, H., Yang, L., Bu, L., Deng, W., Wu, L., Nan, X., Zhang, W., Zhao, X., Liu, W., & Sun, Z.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2018-07-24
- Volume
- 28
- Issue
- 37
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2884188691
- Cited by
- 189
- References
- 7
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, G., Rao, L., Wu, H., Yang, L., Bu, L., Deng, W., Wu, L., Nan, X., Zhang, W., Zhao, X., Liu, W., & Sun, Z. (2018). Myeloid‐Derived Suppressor Cell Membrane‐Coated Magnetic Nanoparticles for Cancer Theranostics by Inducing Macrophage Polarization and Synergizing Immunogenic Cell Death. Advanced Functional Materials. https://doi.org/10.1002/adfm.201801389
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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