Cited by 137Autophagy in Disease and TherapyAdenosine and Purinergic SignalingCalcium signaling and nucleotide metabolism

Autophagy-dependent ATP release from dying cells via lysosomal exocytosis

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Wang, Yidan, Martins, Isabelle, Ma, Yuting, Kepp, Oliver, Galluzzi, Lorenzo, Kroemer, Guido·2013·Autophagy

Abstract

ATP not only represents a key molecule for the intracellular storage and utilization of energy, but also plays a central role in the extracellular milieu, as it both recruits and activates immune cells. The secretion of ATP in the course of immunogenic cell death (ICD), a peculiar type of apoptosis that elicits adaptive immune responses, critically relies on the molecular machinery for autophagy. We have recently demonstrated that autophagy allows for the ICD-associated secretion of ATP as it contributes to the maintenance of lysosomal ATP stores. In addition, we found that ATP release in this setting is mediated by a molecular mechanism that involves lysosomal-associated membrane protein 1 (LAMP1)- and pannexin 1 (PANX1)-dependent lysosomal exocytosis.

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  • In ICD, ATP release occurs downstream of caspase activation and involves autolysosomal ATP accumulation, LAMP1 relocalization, ROCK1-dependent blebbing, and PANX1 opening.

    “In the context of ICD, ATP is released through a cascade of events occurring downstream of caspase activation and involving: (1) the autophagy-dependent accumulation of ATP within autolysosomes (the organelles forming by the fusion of autophagosomes or amphisomes with lysosomes), (2) the relocalization of lysosomal-associated membrane protein 1 (LAMP1) to the plasma membrane, (3) ROCK1-dependent”

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Authors
Wang, Y., Martins, I., Ma, Y., Kepp, O., Galluzzi, L., & Kroemer, G.
Affiliations
  • Université Paris-Sud (FR)
  • Institut Gustave Roussy (FR)
  • Délégation Paris 5 (FR)
Corresponding author
Kroemer, Guido
Venue
Autophagy
Published
2013-10-25
Volume
9
Issue
10
Pages
1624-1625
ISSN
  • 1554-8627 (ISSN-L)
  • 1554-8635
OpenAlex
W2093037778
Cited by
137
References
0
Citations by year
2026: 9 · 2025: 9 · 2024: 9 · 2023: 14 · 2022: 17 · 2021: 12 · 2020: 10 · 2019: 9 · 2018: 15 · 2017: 10 · 2016: 10 · 2015: 5 · 2014: 7 · 2013: 1
Type
journal article
Language
en
Open access
Locations
  • Autophagy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords
ATP release, immunogenic cell death, lysosomal exocytosis, LAMP1, pannexin 1, dying cells, extracellular ATP, adaptive immunity
MeSH terms
Adenosine Triphosphate, Animals, Autophagy, Exocytosis, Humans, Nerve Tissue Proteins, Apoptosis, Lysosomal-Associated Membrane Protein 1

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