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Noncompressible Hemostasis and Bone Regeneration Induced by an Absorbable Bioadhesive Self‐Healing Hydrogel
Abstract
Bone bleeding and bone defects arising from trauma or bone tumor resection pose a great threat to patients and they are challenging problems to orthopedic surgeons. Traditional hemostatic materials are not suitable for bone fractures where compression cannot be applied, neither are they effective during surgeries where large amounts of body fluids prevent them from adhering to the large and irregular bone wound sites. This research introduces a catechol‐conjugated chitosan (CHI‐C) multi‐functional hydrogel with adhesion, self‐healing, cytocompatibility, hemocompatibility, and blood cell coagulation capacity. The hydrogel can be injected into internal and irregular bleeding sites and bone defective areas, and then rapidly self‐heals (within 2 min) to an integrated hydrogel that fully fills the defective sites and strongly sticks to bleeding areas in the presence of body fluids during surgery. In vivo experiments using a rabbit ilium bone defect model demonstrate quick hemostasis after the hydrogel is applied and the blood loss is only ¼ compared to the untreated injuries. In addition, the bone regeneration is not interfered by the hydrogel and the bone defect is no longer visible with disappearance of the hydrogel after 4 weeks. This multi‐functional hydrogel is potentially valuable for clinical applications towards tissue adhesion, hemostasis, and bone regeneration.
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“hydrogels can be functionalized to achieve specific properties and structures”
From Functionalized Hydrogel-Based Wearable Gas and Humidity Sensors. (2023) · cites this paper as [64]
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Metadata
- Authors
- Huang, W., Cheng, S., Wang, X., Zhang, Y., Chen, L., & Zhang, L.
- Affiliations
- South China Agricultural University (CN)
- Guangdong Academy of Medical Sciences (CN)
- University of Alberta (CA)
- Wuhan University (CN)
- Corresponding author
- Zhang, Yu
- Chen, Lingyun
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2021-02-28
- Volume
- 31
- Issue
- 22
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W3133980713
- Cited by
- 272
- References
- 51
- Citations by year
- 2026: 26 · 2025: 57 · 2024: 72 · 2023: 50 · 2022: 58 · 2021: 9
- FWCI
- 30.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Functional Materials (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- National Natural Science Foundation of China (31700880, 31771038)
- Topics
- Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- hemostasis, bone regeneration, self-healing hydrogels, bioadhesive hydrogel, bone defects, injectable hydrogel, hemocompatibility, tissue adhesion, bone tumor resection
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