Tissue adhesive catechol-modified hyaluronic acid hydrogel for effective, minimally invasive cell therapy
Abstract
Current hyaluronic acid (HA) hydrogel systems often cause cytotoxicity to encapsulated cells and lack the adhesive property required for effective localization of transplanted cells in vivo. In addition, the injection of hydrogel into certain organs (e.g., liver, heart) induces tissue damage and hemorrhage. In this study, we describe a bioinspired, tissue‐adhesive hydrogel that overcomes the limitations of current HA hydrogels through its improved biocompatibility and potential for minimally invasive cell transplantation. HA functionalized with an adhesive catecholamine motif of mussel foot protein forms HA‐catechol (HA‐CA) hydrogel via oxidative crosslinking. HA‐CA hydrogel increases viability, reduces apoptosis, and enhances the function of two types of cells (human adipose‐derived stem cells and hepatocytes) compared with a typical HA hydrogel crosslinked by photopolymerization. Due to the strong tissue adhesiveness of the HA‐CA hydrogel, cells are easily and efficiently transplanted onto various tissues (e.g., liver and heart) without the need for injection. Stem cell therapy using the HA‐CA hydrogel increases angiogenesis in vivo, leading to improved treatment of ischemic diseases. HA‐CA hydrogel also improved hepatic functions of transplanted hepatocytes in vivo. Thus, this bioinspired, tissue‐adhesive HA hydrogel can enhance the efficacy of minimally invasive cell therapy.
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Shin and coworkers showed that HA-CA can form a hydrogel after the addition of NaIO4; gelation was considered to be induced by the formation of catechol-catechol adducts due to the oxidation of catechol.
“For example, Shin and coworkers synthesized catechol-modified hyaluronic acid (HA-CA) and showed that HA-CA can form a hydrogel after the addition of NaIO4. Gelation was considered to be induced by the formation of catechol–catechol adducts due to the oxidation of catechol [67].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [67]
Cites
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“Gelation was considered to be induced by the formation of catechol–catechol adducts due to the oxidation of catechol [67].”
BackgroundEnzymatically cross-linked poly(γ-glutamic acid) hydrogel with enhanced tissue adhesive property
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Self-citationEnvironment-dependent adhesive behaviors of mussel-inspired coordinate-crosslinked bioadhesives
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- Authors
- Shin, J., Lee, J. S., Lee, C., Park, H., Yang, K., Jin, Y., Ryu, J. H., Hong, K. S., Moon, S., Chung, H., Yang, H. S., Um, S. H., Oh, J., Kim, D., Lee, H., & Cho, S.
- Affiliations
- Yonsei University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Konkuk University (KR)
- Dankook University (KR)
- Sungkyunkwan University (KR)
- Samsung Medical Center (KR)
- Corresponding author
- Cho, Seung‐Woo
- ORCID
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2015-05-15
- Volume
- 25
- Issue
- 25
- Pages
- 3814-3824
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W1588312047
- Cited by
- 432
- References
- 1
- Citations by year
- 2026: 22 · 2025: 34 · 2024: 29 · 2023: 46 · 2022: 56 · 2021: 62 · 2020: 61 · 2019: 51 · 2018: 27 · 2017: 29 · 2016: 13 · 2015: 2
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Functional Materials (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- hyaluronic acid hydrogel, catechol functionalization, mussel foot proteins, tissue adhesion, oxidative cross-linking, adipose-derived stem cells, hepatocyte transplantation, angiogenesis, ischemic diseases, bioinspired biomaterials, biocompatibility, hepatocyte function
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