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Bioadaptable 3D Printed Scaffold for Microenvironment‐Activatable Visualization and Osteogenesis in Diabetic Bone Defect
Open accessAbstract
The regeneration of diabetic bone defects faces significant challenges due to glycemic fluctuations, reactive oxygen species (ROS), and chronic inflammation. A combined diagnostic and therapeutic strategy utilizing advanced visualization techniques enables monitoring of bone inflammation and implant degradation, facilitating timely and precise interventions to enhance bone repair. This study developed a multifunctional diagnostic and therapeutic scaffold (SrHA/IH/GOx@G) using 3D printing technology. The scaffold incorporates an “all‐in‐one” nanofluorescent probe (ICG@HMnO₂), Sr‐doped hydroxyapatite (SrHA), methacrylated gelatin (GelMA), and glucose oxidase (GOx). GOx catalyzes glucose and oxygen into gluconic acid and H₂O₂, while H₂O₂ is scavenged by ICG@HMnO₂, releasing Mn 2⁺ for magnetic resonance imaging (MRI) and ICG for near‐infrared (NIR) imaging. The scaffold tracks inflammation at bone defect sites for 14 days and monitors scaffold degradation in situ for up to 8 weeks. Moreover, releasing Sr and Ca ions from the scaffold promotes osteogenic differentiation and angiogenesis, significantly accelerating diabetic bone repair. This scaffold combines advanced diagnostic imaging, real‐time visualization, and therapeutic effects, offering a promising integrated strategy for treating diabetic bone defects with diagnostic and therapeutic applications.
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H2O2 promotes oxidative stress, exacerbates bone tissue degradation, and hinders bone regeneration.
“As a reactive oxygen species (ROS), H2O2 promotes oxidative stress, exacerbates bone tissue degradation, and hinders bone regeneration, counteracting GOx’s potential benefits16.”
From Microenvironment-responsive multifunctional enzyme-linked hydrogel for diabetic bone defect regeneration. (2025) · cites this paper as [16]
The Introduction identifies H2O2 as elevated in diabetic bone defects and says excess ROS exacerbate inflammation and delay bone repair. Section 2.3 links H2O2 clearance to reduced oxidative stress and a better osteogenic microenvironment. The paper does not specifically say that H2O2 exacerbates bone tissue degradation; its discussion of compromised bone microstructure attributes that effect to prolonged hyperglycemia. (LLM, conf=0.84)
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“16).”
Metadata
- Authors
- Feng, Q., Che, L., Li, C., Zhan, J., Li, B., Wang, L., Chen, S., Zhou, X., Song, D., & He, C.
- Affiliations
- Donghua University (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Zhou, Xiaojun
- Song, Dianwen
- He, Chuanglong
- ORCID
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2025-02-21
- Volume
- 35
- Issue
- 29
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W4407808999
- Cited by
- 16
- References
- 82
- Citations by year
- 2026: 12 · 2025: 4
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Advanced Functional Materials (publishedVersion)
- Funders
- National Natural Science Foundation of China (32271412, 32171404, 32071350, 82202675)
- Shanghai Rising-Star Program (22QA1400100)
- Fundamental Research Funds for the Central Universities (2232019A3‐06)
- Science and Technology Commission of Shanghai Municipality (19440741600, 20DZ2254900)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- diabetic bone defects, 3D-printed scaffolds, glucose oxidase, gelatin methacryloyl, near-infrared fluorescence imaging, reactive oxygen species, osteogenic differentiation, angiogenesis, bone regeneration
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