The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
A Bioprinted Cardiac Patch Composed of Cardiac‐Specific Extracellular Matrix and Progenitor Cells for Heart Repair
Open accessAbstract
Congenital heart defects are present in 8 of 1000 newborns and palliative surgical therapy has increased survival. Despite improved outcomes, many children develop reduced cardiac function and heart failure requiring transplantation. Human cardiac progenitor cell (hCPC) therapy has potential to repair the pediatric myocardium through release of reparative factors, but therapy suffers from limited hCPC retention and functionality. Decellularized cardiac extracellular matrix hydrogel (cECM) improves heart function in animals, and human trials are ongoing. In the present study, a 3D‐bioprinted patch containing cECM for delivery of pediatric hCPCs is developed. Cardiac patches are printed with bioinks composed of cECM, hCPCs, and gelatin methacrylate (GelMA). GelMA‐cECM bioinks print uniformly with a homogeneous distribution of cECM and hCPCs. hCPCs maintain >75% viability and incorporation of cECM within patches results in a 30‐fold increase in cardiogenic gene expression of hCPCs compared to hCPCs grown in pure GelMA patches. Conditioned media from GelMA‐cECM patches show increased angiogenic potential (>2‐fold) over GelMA alone, as seen by improved endothelial cell tube formation. Finally, patches are retained on rat hearts and show vascularization over 14 d in vivo. This work shows the successful bioprinting and implementation of cECM‐hCPC patches for potential use in repairing damaged myocardium.
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“The concept is gaining traction, as the ability to print tissues composed entirely of native proteins, cells and/or biocompatible synthetic components is possible and accessible to many laboratories9–17.”
From In situ expansion, differentiation, and electromechanical coupling of human cardiac muscle in a 3D bioprinted, chambered organoid (2020) · cites this paper as [10]
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“Models that replicate the geometrically complex structure of the heart, harboring chambers and large vessels with soft biomaterials, can be achieved using 3D bioprinting.”
From In situ expansion, differentiation, and electromechanical coupling of human cardiac muscle in a 3D bioprinted, chambered organoid (2020) · cites this paper as [10]
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1 retracted
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Metadata
- Authors
- Bejleri, D., Streeter, B. W., Nachlas, A. L. Y., Brown, M. E., Gaetani, R., Christman, K. L., & Davis, M. E.
- Affiliations
- Georgia Institute of Technology (US)
- University of California San Diego (US)
- Corresponding author
- Davis, Michael E.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2018-10-31
- Volume
- 7
- Issue
- 23
- Pages
- e1800672-e1800672
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- PMC
- PMC6521871
- OpenAlex
- W2899402424
- Cited by
- 255
- References
- 60
- Citations by year
- 2026: 14 · 2025: 28 · 2024: 29 · 2023: 46 · 2022: 36 · 2021: 41 · 2020: 41 · 2019: 17 · 2018: 3
- FWCI
- 26.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- Funders
- National Heart, Lung, and Blood Institute (R01HL113468)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Keywords
- 3D bioprinting, cardiac patch, congenital heart disease, pediatric heart failure, gelatin methacryloyl, bioinks, cardiomyocyte differentiation, angiogenesis, endothelial tube formation, vascularization, myocardial repair, cell retention
- MeSH terms
- Animals, Cells, Cultured, Extracellular Matrix, Gelatin, Heart Diseases, Humans, Myocardium, Stem Cells, Rats, Sprague-Dawley, Hydrogels, Tissue Engineering, Myocytes, Cardiac, Stem Cell Transplantation, Rats, Tissue Scaffolds, Elastic Modulus, Bioprinting, Printing, Three-Dimensional
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