The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Size‐Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting
Open accessAbstract
Passive targeting of large nanoparticles by the enhanced permeability and retention (EPR) effect is a crucial concept for solid tumor targeting in cancer nanomedicine. There is, however, a trade‐off between the long‐term blood circulation of nanoparticles and their nonspecific background tissue uptake. To define this size‐dependent EPR effect, near‐infrared fluorophore‐conjugated polyethylene glycols (PEG‐ZW800s; 1–60 kDa) are designed and their biodistribution, pharmacokinetics, and renal clearance are evaluated in tumor‐bearing mice. The targeting efficiency of size‐variant PEG‐ZW800s is investigated in terms of tumor‐to‐background ratio (TBR). Interestingly, smaller sized PEGs (≤20 kDa, 12 nm) exhibit significant tumor targeting with minimum to no nonspecific uptakes, while larger sized PEGs (>20 kDa, 13 nm) accumulate highly in major organs, including the lungs, liver, and pancreas. Among those tested, 20 kDa PEG‐ZW800 exhibits the highest TBR, while excreting unbound molecules to the urinary bladder. This result lays a foundation for engineering tumor‐targeted nanoparticles and therapeutics based on the size‐dependent EPR effect.
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Cites
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Cited by
Polymeric Nanoparticles for Drug Delivery
Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,155
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Polymeric Delivery of Therapeutic Nucleic Acids
Kumar, R., Santa Chalarca, C. F., Bockman, M. R., Bruggen, C. V., Grimme, C. J., Dalal, R. J., Hanson, M. G., Hexum, J. K., & Reineke, T. M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00997 · Cited by 365
Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
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Metadata
- Authors
- Kang, H., Rho, S., Stiles, W. R., Hu, S., Baek, Y., Hwang, D. W., Kashiwagi, S., Kim, M. S., & Choi, H. S.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2019-12-03
- Volume
- 9
- Issue
- 1
- Pages
- e1901223-e1901223
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2992584767
- Cited by
- 480
- References
- 8
- FWCI
- 11.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Kang, H., Rho, S., Stiles, W. R., Hu, S., Baek, Y., Hwang, D. W., Kashiwagi, S., Kim, M. S., & Choi, H. S. (2020). Size‐Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201901223
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