Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth
Open accessAbstract
The design of cancer-targeting particles with precisely tuned physicochemical properties may enhance the delivery of therapeutics and access to pharmacological targets. However, a molecular-level understanding of the interactions driving the fate of nanomedicine in biological systems remains elusive. Here, we show that ultrasmall (<10 nm in diameter) poly(ethylene glycol)-coated silica nanoparticles, functionalized with melanoma-targeting peptides, can induce a form of programmed cell death known as ferroptosis in starved cancer cells and cancer-bearing mice. Tumour xenografts in mice intravenously injected with nanoparticles using a high-dose multiple injection scheme exhibit reduced growth or regression, in a manner that is reversed by the pharmacological inhibitor of ferroptosis, liproxstatin-1. These data demonstrate that ferroptosis can be targeted by ultrasmall silica nanoparticles and may have therapeutic potential.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ferroptosis is potentially associated with a consistent release of immunostimulatory DAMPs.
“is potentially associated with a consistent release of immunostimulatory DAMPs [540, 541]”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [541]
Application of nanoparticles to tumor-bearing mice is sufficient to induce clinical remission.
“Two elegant studies have shown that the application of nanoparticles to tumor-bearing mice is sufficient to induce clinical remission.”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [112]
One paper implicated a direct tumoricidal effect of iron delivered by ultrasmall polyethylene glycol particles and attributed tumor regression to induction of ferroptosis in malignant cells.
“One of these papers implicated a direct tumoricidal effect of iron delivered by ultrasmall polyethylene glycol particles and attributed tumor regression to the induction of ferroptosis in malignant cells [112].”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [112]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713 · see citing works
Models for Longitudinal Data: A Generalized Estimating Equation Approach
Zeger, S. L., Liang, K., & Albert, P. S. (1988) · Biometrics · doi:10.2307/2531734 · Cited by 4,505 · see citing works
Methods in Mammalian Autophagy Research
Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497 · see citing works
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233 · see citing works
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732 · see citing works
Self-citationCepharanthine potently enhances the sensitivity of anticancer agents in K562 cells
Ikeda, R., Che, X., Yamaguchi, T., Ushiyama, M., Zheng, C., Okumura, H., Takeda, Y., Shibayama, Y., Nakamura, K. T., Jeung, H., et al. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00057.x · Cited by 2,268 · see citing works
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
He, S., Wang, L., Miao, L., Wang, T., Du, F., Zhao, L., & Wang, X. (2009) · Cell · doi:10.1016/j.cell.2009.05.021 · Cited by 2,214 · see citing works
Glutaminolysis and transferrin regulate ferroptosis
Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069 · see citing works
Self-citationSynchronized renal tubular cell death involves ferroptosis
Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415518111 · Cited by 1,126 · see citing works
Nanomedicine(s) under the Microscope
Duncan, R., & Gaspar, R. S. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200394t · Cited by 985 · see citing works
Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity
Stern, S. T., Adiseshaiah, P. P., & Crist, R. M. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-20 · Cited by 839 · see citing works
Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA
Jacobson, M. D., Burne, J. F., King, M. P., Miyashrta, T., Reed, J. C., & RAFF, M. C. (1993) · Nature · doi:10.1038/361365a0 · Cited by 751 · see citing works
Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe
Phillips, E. H., Medina, O. P., ZANZONICO, P. B., Carvajal, R. D., Pauliah, M., Ye, Y., Humm, J. L., Gönen, M., Kalaigian, H., Schöder, H. M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009524 · Cited by 716 · see citing works
Self-citationMultimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma
Benezra, M., Medina, O. P., ZANZONICO, P. B., Schaer, D., Ow, H., Burns, A., DeStanchina, E., Longo, V. A., Herz, E., Iyer, S. K., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45600 · Cited by 646 · see citing works
Self-citationMa, X., Wu, Y., Jin, S., Tian, Y., Zhang, X., Zhao, Y., Yu, L., & Liang, X. (2011) · ACS Nano · doi:10.1021/nn202155y · Cited by 629 · see citing works
Liu, Y., Shoji-Kawata, S., Sumpter, R. M., Wei, Y., Ginet, V., Zhang, L., Posner, B., Tran, K. A., Green, D. R., Xavier, R. J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319661110 · Cited by 607 · see citing works
Self-citationGuiducci, C., Vicari, A. P., Sangaletti, S., Trinchieri, G., & Colombo, M. P. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4262 · Cited by 549 · see citing works
Autophagy and oxidative stress associated with gold nanoparticles
Li, J. J., Hartono, D., Ong, C. N., Bay, B.-H., & Yung, L. L. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.014 · Cited by 543 · see citing works
Duncan, R., & Richardson, S. C. W. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300293n · Cited by 333 · see citing works
Hypoxia and defective apoptosis drive genomic instability and tumorigenesisPreprint
Nelson, D. A., Tan, T.-T., Rabson, A. B., Anderson, D., Degenhardt, K., & White, E. (2004) · Genes & Development · doi:10.1101/gad.1204904 · Cited by 281 · see citing works
Li, C., Liu, H., Sun, Y., Wang, H., Guo, F., Rao, S., Deng, J., Zhang, Y., Miao, Y., Guo, C., et al. (2009) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjp002 · Cited by 260 · see citing works
Kandasamy, K., Srinivasula, S. M., Alnemri, E. S., Thompson, C. B., Korsmeyer, S. J., Bryant, J., & Srivastava, R. K. (2003) · PubMed · Cited by 195 · see citing works
Bradbury, M. S., Phillips, E. H., Montero, P. H., Cheal, S. M., Stambuk, H. E., Durack, J. C., Sofocleous, C. T., Meester, R. J. C., Wiesner, U. B., & Patel, S. G. (2012) · Integrative Biology · doi:10.1039/c2ib20174g · Cited by 175 · see citing works
Self-citationRoveri, A., Maiorino, M., & Ursini, F. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33023-9 · Cited by 169 · see citing works
Ma, K., Mendoza, C., Hanson, M. A., Werner‐Zwanziger, U., Zwanziger, J. W., & Wiesner, U. B. (2015) · Chemistry of Materials · doi:10.1021/acs.chemmater.5b01222 · Cited by 126 · see citing works
Self-citationMiao, Y., Benwell, K., & Quinn, T. P. (2007) · PubMed · Cited by 93 · see citing works
Self-citationMa, K., Zhang, D., Cong, Y., & Wiesner, U. B. (2016) · Chemistry of Materials · doi:10.1021/acs.chemmater.6b00030 · Cited by 92 · see citing works
Self-citationLong‐Term Effects of Nanoparticles on Nutrition and Metabolism
Chen, N., Wang, H., Huang, Q., Li, J., Yan, J., He, D., Fan, C., & Song, H. (2014) · Small · doi:10.1002/smll.201303635 · Cited by 74 · see citing works
Cancer nanomedicines: closing the translational gap
Gabizón, A., Bradbury, M. S., Prabhakar, U., Zamboni, W. C., Libutti, S. K., & Grodzinski, P. A. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61457-4 · Cited by 69 · see citing works
Self-citationA double agent in cancer: Deciphering macrophage roles in human tumors
Ruhrberg, C., & Palma, M. D. (2010) · Nature Medicine · doi:10.1038/nm0810-861 · Cited by 29 · see citing works
Yoo, B., Ma, K., Zhang, L., Burns, A., Sequeira, S. M., Mellinghoff, I. K., Brennan, C. W., Wiesner, U. B., & Bradbury, M. S. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.09.050 · Cited by 28 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695 · see citing works
Self-citationGalluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Self-citationFerroptosis: past, present and future
Li, J., Cao, F., Yin, H.-L., Huang, Z.-J., Lin, Z.-T., Mao, N., Sun, B., & Wang, G. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2298-2 · Cited by 4,171 · see citing works
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
Wang, W., Green, M., Choi, J. E., Gijón, M., Kennedy, P. D., Johnson, J. K., Liao, P., Lang, X., Kryczek, I., Sell, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1170-y · Cited by 2,880 · see citing works
Broadening horizons: the role of ferroptosis in cancer
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00462-0 · Cited by 2,942 · see citing works
Targeting apoptosis in cancer therapy
Carneiro, B. A., & El‐Deiry, W. S. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0341-y · Cited by 2,594 · see citing works
Targeting Ferroptosis to Iron Out Cancer
Hassannia, B., Vandenabeele, P., & Berghe, T. V. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.04.002 · Cited by 2,483 · see citing works
Ferroptosis, a new form of cell death: opportunities and challenges in cancer
Mou, Y., Wang, J., Wu, J., He, D., Zhang, C., Duan, C., & Li, B. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0720-y · Cited by 1,943 · see citing works
Recent Progress in Ferroptosis Inducers for Cancer Therapy
Liang, C., Zhang, X., Yang, M., & Dong, X. (2019) · Advanced Materials · doi:10.1002/adma.201904197 · Cited by 1,569 · see citing works
Role of GPX4 in ferroptosis and its pharmacological implication
Seibt, T. M., Proneth, B., & Conrad, M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.014 · Cited by 1,520 · see citing works
Self-citationLin, L., Song, J., Song, L., Ke, K., Liu, Y., Zhou, Z., Shen, Z., Li, J., Yáng, Z., Tang, W., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201712027 · Cited by 1,472 · see citing works
Ferroptosis: Mechanisms and links with diseases
Yan, H.-F., Zou, T., Tuo, Q.-Z., Xu, S., Li, H., Belaidi, A. A., & Lei, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00428-9 · Cited by 1,471 · see citing works
The Metabolic Underpinnings of Ferroptosis
Zheng, J., & Conrad, M. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.011 · Cited by 1,338 · see citing works
Self-citationFerroptosis, necroptosis, and pyroptosis in anticancer immunity
Tang, R., Xu, J., Zhang, B., Liu, J., Liang, C., Hua, J., Meng, Q., Yu, X., & Shi, S. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00946-7 · Cited by 1,280 · see citing works
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
Angeli, J. P. F., Krysko, D. V., & Conrad, M. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0149-1 · Cited by 1,262 · see citing works
Self-citationRethinking cancer nanotheranostics
Chen, H., Zhang, W., Zhu, G., Xie, J., & Chen, X. S. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.24 · Cited by 1,107 · see citing works
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
Fang, X., Ardehali, H., Min, J., & Wang, F. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00735-4 · Cited by 1,094 · see citing works
GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis
Forcina, G. C., & Dixon, S. J. (2019) · PROTEOMICS · doi:10.1002/pmic.201800311 · Cited by 1,080 · see citing works
The chemical basis of ferroptosis
Conrad, M., & Pratt, D. A. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0408-1 · Cited by 1,027 · see citing works
Self-citationFerroptosis in infection, inflammation, and immunity
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210518 · Cited by 828 · see citing works
Emerging Strategies of Cancer Therapy Based on Ferroptosis
Shen, Z., Song, J., Yung, B. C., Zhou, Z., Wu, A., & Chen, X. S. (2018) · Advanced Materials · doi:10.1002/adma.201704007 · Cited by 740 · see citing works
Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model
Zhang, Y., Tan, H., Daniels, J. D., Zandkarimi, F., Liu, H., Brown, L. M., Uchida, K., O’Connor, O. A., & Stockwell, B. R. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.01.008 · Cited by 729 · see citing works
RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer
Sui, X., Zhang, R., Liu, S., Duan, T., Zhai, L., Zhang, M., Han, X., Xiang, Y., Huang, X., Lin, H., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01371 · Cited by 703 · see citing works
Targeting ROS in cancer: rationale and strategies
Glorieux, C., Liu, S., Trachootham, D., & Huang, P. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-00979-4 · Cited by 700 · see citing works
Yang, F., Xiao, Y., Ding, J.-H., Jin, X., Ma, D., Li, D., Shi, J., Huang, W. C., Wang, Y.-P., Jiang, Y., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.021 · Cited by 639 · see citing works
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
Hassannia, B., Wiernicki, B., Ingold, I., Qu, F., Herck, S. V., Tyurina, Y. Y., Bayır, H., Abhari, B. A., Angeli, J. P. F., Choi, S. M., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99032 · Cited by 626 · see citing works
Self-citationTargeting ferroptosis opens new avenues for the development of novel therapeutics
Sun, S., Shen, J., Jiang, J., Wang, F., & Min, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01606-1 · Cited by 632 · see citing works
Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics
Tang, W., Fan, W., Lau, J., Deng, L., Shen, Z., & Chen, X. S. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00805a · Cited by 606 · see citing works
Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetic for Biomedical Applications
Gao, L., Fan, K., & Yan, X. (2017) · Theranostics · doi:10.7150/thno.19738 · Cited by 590 · see citing works
Dixon, S. J., & Stockwell, B. R. (2018) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055844 · Cited by 589 · see citing works
Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death
Battaglia, A. M., Chirillo, R., Aversa, I., Sacco, A., Costanzo, F. S., & Biamonte, F. (2020) · Cells · doi:10.3390/cells9061505 · Cited by 574 · see citing works
Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications
Ding, B., Zheng, P., Ma, P., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.201905823 · Cited by 523 · see citing works
Ferroptosis, radiotherapy, and combination therapeutic strategies
Lei, G., Mao, C., Yan, Y., Zhuang, L., & Gan, B. (2021) · Protein & Cell · doi:10.1007/s13238-021-00841-y · Cited by 518 · see citing works
Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture
Riegman, M., Sagie, L., Galed, C., Levin, T., Steinberg, N. J., Dixon, S. J., Wiesner, U. B., Bradbury, M. S., Niethammer, P., Zaritsky, A., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0565-1 · Cited by 483 · see citing works
Self-citationSize‐Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting
Kang, H., Rho, S., Stiles, W. R., Hu, S., Baek, Y., Hwang, D. W., Kashiwagi, S., Kim, M. S., & Choi, H. S. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201901223 · Cited by 483 · see citing works
Iron and ferroptosis: A still ill‐defined liaison
Doll, S. G., & Conrad, M. (2017) · IUBMB Life · doi:10.1002/iub.1616 · Cited by 472 · see citing works
Self-citationFerroptosis and Its Role in Diverse Brain Diseases
Weiland, A., Wang, Y., Wu, W., Lan, X., Han, X., Li, Q., & Wang, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1403-3 · Cited by 469 · see citing works
Qin, X., Zhang, J., Wang, B., Xu, G., Yang, X., Zou, Z., & Yu, C. (2021) · Autophagy · doi:10.1080/15548627.2021.1911016 · Cited by 436 · see citing works
Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity
Wiernicki, B., Maschalidi, S., Pinney, J. J., Adjemian, S., Berghe, T. V., Ravichandran, K. S., & Vandenabeele, P. (2022) · Nature Communications · doi:10.1038/s41467-022-31218-2 · Cited by 441 · see citing works
Molecular imaging and disease theranostics with renal-clearable optical agents
Cheng, P., & Pu, K. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00328-6 · Cited by 418 · see citing works
Wang, S., Li, F., Qiao, R., Hu, X., Liao, H., Chen, L., Wu, J., Wu, H., Zhao, M. L., Liu, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b06399 · Cited by 384 · see citing works
Ferroptosis and necroinflammation, a yet poorly explored link
Proneth, B., & Conrad, M. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0173-9 · Cited by 378 · see citing works
Self-citationNanocatalytic Tumor Therapy by Single-Atom Catalysts
Huo, M., Wang, L., Wang, Y., Chen, Y., & Shi, J. (2019) · ACS Nano · doi:10.1021/acsnano.9b00457 · Cited by 371 · see citing works
Nanoparticle Size Effects in Biomedical Applications
Dolai, J., Mandal, K., & Jana, N. R. (2021) · ACS Applied Nano Materials · doi:10.1021/acsanm.1c00987 · Cited by 365 · see citing works
Transferrin receptor 1 in cancer: a new sight for cancer therapy.
Shen, Y., Li, X., Dong, D., Zhang, B., Xue, Y., & Shang, P. (2018) · Europe PMC (PubMed Central) · Cited by 357 · see citing works
Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer
Zhang, F., Li, F., Lu, G., Nie, W., Zhang, L., Lv, Y., Bao, W., Gao, X., Wei, W., Pu, K., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b00892 · Cited by 358 · see citing works
Self-citationFerroptosis in health and disease
Berndt, C., Alborzinia, H., Skafar, V., Ayton, S., Barayeu, U., Bartelt, A., Bayır, H., Bebber, C. M., Birsoy, K., Böttcher, J. P., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103211 · Cited by 354 · see citing works
Self-citationNanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy
Qian, X., Zhang, J., Gu, Z., & Chen, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.04.023 · Cited by 331 · see citing works
Recent progress in ferroptosis: inducers and inhibitors
Du, Y., & Guo, Z. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01297-7 · Cited by 333 · see citing works
Colloidal capsules: nano- and microcapsules with colloidal particle shells
Bollhorst, T., Rezwan, K., & Maas, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00632a · Cited by 324 · see citing works
Cell death pathways: intricate connections and disease implications
Kist, M., & Vucic, D. (2021) · The EMBO Journal · doi:10.15252/embj.2020106700 · Cited by 328 · see citing works
Dixon, S. J. (2017) · Immunological Reviews · doi:10.1111/imr.12533 · Cited by 314 · see citing works
Silica Nanoparticles—A Versatile Tool for the Treatment of Bacterial Infections
Selvarajan, V., Obuobi, S. A. O., & Ee, P. L. R. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00602 · Cited by 323 · see citing works
Emerging mechanisms and targeted therapy of ferroptosis in cancer
Wang, H., Cheng, Y., Mao, C., Liu, S., Xiao, D., Huang, J. X., & Tao, Y. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.03.022 · Cited by 320 · see citing works
Jiang, Y., Mao, C., Yang, R., Yan, B., Shi, Y., Liu, X., Lai, W., Liu, Y., Wang, X., Xiao, D., et al. (2017) · Theranostics · doi:10.7150/thno.19988 · Cited by 293 · see citing works
A pyroptosis nanotuner for cancer therapy
Chen, B., Yan, Y., Yang, Y., Cao, G., Wang, X., Wang, Y., Wan, F., Yin, Q., Wang, Z., Li, Y., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01125-0 · Cited by 291 · see citing works
Evolution and clinical translation of drug delivery nanomaterials
Hassan, S., Prakash, G., Bal‐Öztürk, A., Saghazadeh, S., Sohail, M. F., Seo, J., Dokmeci, M. R., Zhang, Y. S., & Khademhosseini, A. (2017) · Nano Today · doi:10.1016/j.nantod.2017.06.008 · Cited by 288 · see citing works
Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook
Wang, C., Ye, Y., Hu, Q., Bellotti, A., & Gu, Z. (2017) · Advanced Materials · doi:10.1002/adma.201606036 · Cited by 288 · see citing works
Inorganic nanoparticles in clinical trials and translations
Huang, H., Feng, W., Chen, Y., & Shi, J. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100972 · Cited by 285 · see citing works
Ferroptosis and Necroptosis in the Kidney
Belavgeni, A., Meyer, C., Stumpf, J., Hugo, C., & Linkermann, A. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.03.016 · Cited by 279 · see citing works
Ferroptosis and Its Potential Role in Human Diseases
Han, C., Liu, Y., Dai, R., Ismail, N., Su, W., & Li, B. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00239 · Cited by 274 · see citing works
Nishizawa, H., Matsumoto, M., Shindo, T., Saigusa, D., Kato, H., Suzuki, K., Sato, M., Ishii, Y., Shimokawa, H., & Igarashi, K. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009548 · Cited by 273 · see citing works
Tonnus, W., Meyer, C., Steinebach, C., Belavgeni, A., von Mäßenhausen, A., Gonzalez, N. Z., Maremonti, F., Gembardt, F., Himmerkus, N., Latk, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24712-6 · Cited by 273 · see citing works
Self-citationPersister cancer cells: Iron addiction and vulnerability to ferroptosis
Rodriguez, R., Schreiber, S. L., & Conrad, M. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.12.001 · Cited by 271 · see citing works
Self-citationLin, L., Song, J., Song, L., Ke, K., Liu, Y., Zhou, Z., Shen, Z., Li, J., Yáng, Z., Tang, W., et al. (2018) · Angewandte Chemie · doi:10.1002/ange.201712027 · Cited by 262 · see citing works
Nanotechnology Strategies To Advance Outcomes in Clinical Cancer Care
Hartshorn, C. M., Bradbury, M. S., Lanza, G. M., Nel, A. E., Rao, J., Wang, A. Z., Wiesner, U. B., Yang, L. P. H., & Grodzinski, P. A. (2017) · ACS Nano · doi:10.1021/acsnano.7b05108 · Cited by 263 · see citing works
Self-citationDar, H. H., Tyurina, Y. Y., Mikulska-Ruminska, K., Shrivastava, I., Ting, H.-C., Tyurin, V. A., Krieger, J., St. Croix, C. M., Watkins, S., Bayir, E., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99490 · Cited by 251 · see citing works
Metallodrugs in cancer nanomedicine
Peña, Q., Wang, A., Zaremba, O., Shi, Y., Scheeren, H. W., Metselaar, J. M., Kiessling, F., Pallares, R. M., Wuttke, S., & Lammers, T. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00468a · Cited by 259 · see citing works
The ancillary effects of nanoparticles and their implications for nanomedicine
Stater, E. P., Sonay, A. Y., Hart, C., & Grimm, J. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-01017-9 · Cited by 252 · see citing works
Guidelines for evaluating myocardial cell death
Mishra, P. K., Adameová, A., Hill, J. A., Baines, C. P., Kang, P. M., Downey, J. M., Narula, J., Takahashi, M., Abbate, A., Piristine, H. C., et al. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00259.2019 · Cited by 238 · see citing works
Wang, Z., Ju, Y., Ali, Z., Yin, H. Y., Sheng, F., Lin, J., Wang, B., & Hou, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-12142-4 · Cited by 232 · see citing works
Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death
Li, Y., Du, Y., Zhou, Y., Chen, Q., Luo, Z., Ren, Y., Chen, X., & Chen, G. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01267-1 · Cited by 220 · see citing works
Cao, Y., Li, Y., He, C., Yan, F., Li, J., Xu, H., Zhuang, J., Zhou, H., Peng, Y., Fu, X., et al. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-020-00620-5 · Cited by 211 · see citing works
Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management
Huo, D., Jiang, X., & Hu, Y. (2019) · Advanced Materials · doi:10.1002/adma.201904337 · Cited by 206 · see citing works
Self-citationMechanisms and Models of Kidney Tubular Necrosis and Nephron Loss
Maremonti, F., Meyer, C., & Linkermann, A. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2021101293 · Cited by 208 · see citing works
Targeting ferroptosis in breast cancer
Li, Z., Chen, L., Chen, C., Zhou, Y., Hu, D., Yang, J., Chen, Y., Zhuo, W., Mao, M., Zhang, X., et al. (2020) · Biomarker Research · doi:10.1186/s40364-020-00230-3 · Cited by 204 · see citing works
Ferroptosis as a potential target for cancer therapy
Chen, Z., Wang, W., Razak, S. R. A., Han, T., Ahmad, N. H., & Li, X. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05930-w · Cited by 208 · see citing works
Du, X. C., Kleitz, F., Li, X., Huang, H., Zhang, X., & Qiao, S. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201707325 · Cited by 197 · see citing works
The α6β4 integrin promotes resistance to ferroptosis
Brown, C. W., Amante, J. J., Goel, H. L., & Mercurio, A. M. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201701136 · Cited by 196 · see citing works
Coordinatively Unsaturated Fe 3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors
Zhang, P., Hou, Y., Zeng, J., Li, Y., Wang, Z., Zhu, R., Ma, T., & Gao, M. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201904880 · Cited by 191 · see citing works
Self-citationCell-in-cell phenomena in cancer
Fais, S., & Overholtzer, M. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0073-9 · Cited by 192 · see citing works
Self-citationMetal–Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH
Ploetz, E., Zimpel, A., Cauda, V., Bauer, D., Lamb, D. C., Haisch, C., Stefan Zahler, A., Vollmar, A. M., Wuttke, S., & Engelke, H. (2020) · Advanced Materials · doi:10.1002/adma.201907267 · Cited by 191 · see citing works
Yang, C., Zhang, Y., Lin, S., Liu, Y., & Li, W. (2021) · Aging · doi:10.18632/aging.202774 · Cited by 174 · see citing works
Alves, F. M., Lane, D. J. R., Nguyen, T. P. M., Bush, A. I., & Ayton, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02088-5 · Cited by 197 · see citing works
“Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels
Nairz, M., Theurl, I., Swirski, F. K., & Weiss, G. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1944-8 · Cited by 178 · see citing works
Chen, F., Ma, K., Madajewski, B., Zhuang, L., Zhang, L., Rickert, K. W., Marelli, M., Yoo, B., Turker, M. Z., Overholtzer, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06271-5 · Cited by 185 · see citing works
Self-citationLiu, X., Yan, B., Li, Y., Ma, X., Jiao, W., Shi, K., Zhang, T., Chen, S., He, Y., Liang, X., et al. (2020) · ACS Nano · doi:10.1021/acsnano.9b08320 · Cited by 185 · see citing works
Nanomaterial-induced ferroptosis for cancer specific therapy
Liu, M., Liu, B., Liu, Q., Du, K., Wang, Z., & He, N. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.12.015 · Cited by 180 · see citing works
Sol-Gel Silica Nanoparticles in Medicine: A Natural Choice. Design, Synthesis and Products
Gonçalves, M. C. (2018) · Molecules · doi:10.3390/molecules23082021 · Cited by 180 · see citing works
Tang, H., Zhang, Y., Yang, T., Wang, C., Zhu, Y., Qiu, L., Liu, J., Song, Y., Zhou, L., Zhang, J., et al. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01455-7 · Cited by 179 · see citing works
Jin, X., Tang, J., Qiu, X., Nie, X., Ou, S., Wu, G., Zhang, R., & Zhu, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01825-7 · Cited by 182 · see citing works
Ten Things You Might Not Know about Iron Oxide Nanoparticles
Daldrup-Link, H. E. (2017) · Radiology · doi:10.1148/radiol.2017162759 · Cited by 176 · see citing works
Ferroptosis in Cancer Treatment: Another Way to Rome
Wu, Y., Yu, C., Luo, M., Chen, C., Qiu, J., Zhang, S., & Hu, K. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.571127 · Cited by 176 · see citing works
Molecular transport in articular cartilage — what have we learned from the past 50 years?
DiDomenico, C. D., Lintz, M., & Bonassar, L. J. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0033-5 · Cited by 171 · see citing works
Gonzalez‐Carter, D., Leo, B. F., Ruenraroengsak, P., Chen, S., Goode, A. E., Theodorou, I. G., Chung, K. F., Carzaniga, R., Shaffer, M. S. P., Dexter, D. T., et al. (2017) · Scientific Reports · doi:10.1038/srep42871 · Cited by 170 · see citing works
Exploiting ferroptosis vulnerabilities in cancer
Nakamura, T., & Conrad, M. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01425-8 · Cited by 169 · see citing works
Self-citationAutophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis
Lin, L., Zhang, M.-X., Zhang, L., Zhang, D., Li, C., & Li, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.809955 · Cited by 165 · see citing works
Self-citationSong, J., Lin, L., Yáng, Z., Zhu, R., Zhou, Z., Li, Z., Wang, F., Chen, J., Yang, H., & Chen, X. S. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b13902 · Cited by 163 · see citing works
Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications
Zheng, H., Jiang, J., Xu, S., Liu, W., Xie, Q., Cai, X., Zhang, J., Liu, S., & Li, R. (2021) · Nanoscale · doi:10.1039/d0nr08478f · Cited by 164 · see citing works
The Relationship between Ferroptosis and Tumors: A Novel Landscape for Therapeutic Approach
Xia, X., Fan, X., Zhao, M., & Zhu, P. (2019) · Current Gene Therapy · doi:10.2174/1566523219666190628152137 · Cited by 159 · see citing works
- Authors
- Kim, S. E., Zhang, L., Ma, K., Riegman, M., Chen, F., Ingold, I., Conrad, M., Turker, M. Z., Gao, M., Jiang, X., Monette, S., Pauliah, M., Gonen, M., Zanzonico, P., Quinn, T., Wiesner, U., Bradbury, M. S., & Overholtzer, M.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
- Helmholtz Munich (DE)
- University of Missouri (US)
- Corresponding author
- Bradbury, Michelle S.
- Overholtzer, Michael
- ORCID
- Venue
- Nature Nanotechnology
- Published
- 2016-09-26
- Volume
- 11
- Issue
- 11
- Pages
- 977-985
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- PMC
- PMC5108575
- OpenAlex
- W2527636586
- Cited by
- 622
- References
- 33
- Citations by year
- 2026: 27 · 2025: 52 · 2024: 72 · 2023: 67 · 2022: 89 · 2021: 83 · 2020: 85 · 2019: 56 · 2018: 49 · 2017: 38 · 2016: 2
- FWCI
- 43.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Site cant be reached (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- National Institutes of Health (5u54ca199081-05)
- National Cancer Institute (R01CA161280, R01CA166413, U54-CA199081, P30CA008748)
- National Institute of General Medical Sciences (R01GM111350, R01GM113013)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- ferroptosis, ultrasmall nanoparticles, silica nanoparticles, polyethylene glycol coating, nutrient deprivation, cancer cell death, liproxstatin-1, tumor growth inhibition, nanomedicine, tumor xenografts, nanoparticle biodistribution
- MeSH terms
- alpha-MSH, Amino Acids, Animals, Antineoplastic Agents, Humans, Iron, Lysosomes, Melanoma, Particle Size, Polyethylene Glycols, Quinoxalines, Silicon Dioxide, Spiro Compounds, Mice, SCID, Cell Death, Xenograft Model Antitumor Assays, Cell Line, Tumor, Mice, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
