Synthesis of Size‐Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single‐Layer Microchannels
Open accessAbstract
A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that this new method enables robust nanoprecipitation without polymer aggregation, regardless of the polymer molecular weight or precursor concentration implemented, where the size of the resulting polymeric NPs is tunable.
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Several new methods for manufacturing PLGA or PLA particles have been reported, including ultrasonic atomization, electrospray, microfluidic, pore-closing/thermoreversible-gel, and microfabrication.
“Recently, several new methods to manufacture PLGA or PLA particles have been reported, such as the ultrasonic atomization method [14,15], the electrospray method [16], the microfluidic method [17,18], the pore-closing and thermoreversible-gel method [19,20], and the microfabrication method [21].”
From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [18]
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710 · see citing works
Self-citationNanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233 · see citing works
Biodegradable polymeric nanoparticles as drug delivery devices
Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549 · see citing works
Impact of Nanotechnology on Drug Delivery
Farokhzad, O. C., & Langer, R. (2009) · ACS Nano · doi:10.1021/nn900002m · Cited by 3,364 · see citing works
Self-citationBiodegradable Long-Circulating Polymeric Nanospheres
Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,924 · see citing works
Self-citationNanoparticle-mediated cellular response is size-dependent
Jiang, W., Kim, B. Y. S., Rutka, J. T., & Chan, W. C. W. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.30 · Cited by 2,781 · see citing works
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
Farokhzad, O. C., Cheng, J., Teply, B. A., Sherifi, I., Jon, S., Kantoff, P. W., Richie, J. P., & Langer, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601755103 · Cited by 1,667 · see citing works
Self-citationNanomedicine—Challenge and Perspectives
Riehemann, K., Schneider, S. W., Luger, T. A., Godin, B., Mauro Ferrari, B., & Fuchs, H. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802585 · Cited by 1,310 · see citing works
Formulation of functionalized PLGA-PEG Nanoparticles for in vivo targeted drug delivery
Cheng, J., Teply, B. A., Sherifi, I., Sung, J., Luther, G., Gu, F. X., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Langer, R., & Farokhzad, O. C. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.047 · Cited by 1,273 · see citing works
Self-citationNanoparticle-Aptamer Bioconjugates
Farokhzad, O. C., Jon, S., Khademhosseini, A., Tran, T.-N., LaVan, D. A., & Langer, R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2550 · Cited by 897 · see citing works
Self-citationMicrofluidic Platform for Controlled Synthesis of Polymeric Nanoparticles
Karnik, R., Gu, F., Basto, P., Cannizzaro, C., Dean, L., Kyei-Manu, W., Langer, R., & Farokhzad, O. C. (2008) · Nano Letters · doi:10.1021/nl801736q · Cited by 887 · see citing works
Self-citationPrecise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
Gu, F., Zhang, L., Teply, B. A., Mann, N., Wang, A. Z., Radovic‐Moreno, A. F., Langer, R., & Farokhzad, O. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711714105 · Cited by 714 · see citing works
Self-citationSubcellular positioning of small molecules
Takayama, S., Ostuni, E., LeDuc, P. R., Naruse, K., Ingber, D. E., & Whitesides, G. M. (2001) · Nature · doi:10.1038/35082637 · Cited by 546 · see citing works
Wong, I., & Ho, C. (2009) · Microfluidics and Nanofluidics · doi:10.1007/s10404-009-0443-4 · Cited by 528 · see citing works
Solvent-Resistant Photocurable “Liquid Teflon” for Microfluidic Device Fabrication
Rolland, J. P., van Dam, R. M., Schorzman, D. A., Quake, S. R., & DeSimone, J. M. (2004) · Journal of the American Chemical Society · doi:10.1021/ja031657y · Cited by 440 · see citing works
Mechanism for Rapid Self-Assembly of Block Copolymer Nanoparticles
Johnson, B. K., & Prud’homme, R. K. (2003) · Physical Review Letters · doi:10.1103/physrevlett.91.118302 · Cited by 428 · see citing works
Avgoustakis, K. (2004) · Current Drug Delivery · doi:10.2174/1567201043334605 · Cited by 382 · see citing works
High-Temperature Microfluidic Synthesis of CdSe Nanocrystals in Nanoliter Droplets
Chan, E. M., Alivisatos, A. P., & Mathies, R. A. (2005) · Journal of the American Chemical Society · doi:10.1021/ja051381p · Cited by 377 · see citing works
Wolff, A., Perch-Nielsen, I. R., Larsen, U., et al. (2003) · Lab on a Chip · doi:10.1039/b209333b · Cited by 357 · see citing works
Valencia, P. M., Basto, P. A., Zhang, L., et al. (2010) · ACS Nano · doi:10.1021/nn901433u · Cited by 337 · see citing works
Self-citationRiley, T., Stolnik, S., Heald, C. R., Xiong, C. D., Garnett, M. C., Illum, L., Davis, S. S., Purkiss, S. C., Barlow, R. J., & Gellert, P. R. (2001) · Langmuir · doi:10.1021/la001226i · Cited by 303 · see citing works
Dittrich, P. S., & Schwille, P. (2003) · Analytical Chemistry · doi:10.1021/ac034568c · Cited by 232 · see citing works
Defining the drug incorporation properties of PLA–PEG nanoparticles
Govender, T. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00375-6 · Cited by 225 · see citing works
Mao, X., Waldeisen, J. R., & Huang, T. J. (2007) · Lab on a Chip · doi:10.1039/b711155j · Cited by 186 · see citing works
Translational nanomedicine: status assessment and opportunities
Murday, J. S., Siegel, R. W., Stein, J. A., & Wright, J. F. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.06.001 · Cited by 146 · see citing works
Wu, D., Luo, Y., Zhou, X., et al. (2004) · Electrophoresis · doi:10.1002/elps.200406157 · Cited by 140 · see citing works
Three-dimensional hydrodynamic focusing in two-layer polydimethylsiloxane (PDMS) microchannels
Chang, C., Huang, Z., & Yang, R. (2007) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/17/8/009 · Cited by 138 · see citing works
Two-dimensional hydrodynamic focusing in a simple microfluidic device
Simonnet, C., & Groisman, A. (2005) · Applied Physics Letters · doi:10.1063/1.2046729 · Cited by 134 · see citing works
Beletsi, A., Panagi, Z., & Avgoustakis, K. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.03.024 · Cited by 128 · see citing works
Polymeric nanoparticles, micelles and polymersomes from amphiphilic block copolymer
Cho, H. K., Cheong, I. W., Lee, J. M., & Kim, J. H. (2010) · Korean Journal of Chemical Engineering · doi:10.1007/s11814-010-0216-5 · Cited by 106 · see citing works
Ren, Y., Feeback, D. L., & Wang, W. (2004) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2004.09.001 · Cited by 94 · see citing works
Three-dimensional hydrodynamic focusing in a microfluidic Coulter counter
Scott, R., Sethu, P., & Harnett, C. K. (2008) · Review of Scientific Instruments · doi:10.1063/1.2900010 · Cited by 89 · see citing works
Huang, S., Tan, W.-H., Tseng, F., et al. (2006) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/16/11/013 · Cited by 85 · see citing works
Hydrodynamic Focusing Lithography
Bong, K. W., Bong, K. T., Pregibon, D. C., et al. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200905229 · Cited by 84 · see citing works
de Mello, A. J., & Edel, J. B. (2007) · Journal of Applied Physics · doi:10.1063/1.2721752 · Cited by 28 · see citing works
Kim, D. S., Kim, D. S., Kim, D. S., et al. (2009) · Microelectronic Engineering · doi:10.1016/j.mee.2009.01.017 · Cited by 27 · see citing works
Liquid–liquid fluorescent waveguides using microfluidic-drifting-induced hydrodynamic focusing
Lim, J., Kim, S., & Yang, S. (2010) · Microfluidics and Nanofluidics · doi:10.1007/s10404-010-0649-5 · Cited by 17 · see citing works
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Research works printed but not linked: 1
- [1]Soppimatha KS Aminabhavi TM Kulkarnia AR Rudzinski WE J. Controlled Release 2001 70 1 11166403
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Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works
Self-citationKamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070 · see citing works
Self-citationApplication of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles
Tao, J., Chow, S. F., & Zheng, Y. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.11.001 · Cited by 232 · see citing works
Use of lectin-functionalized particles for oral immunotherapy
Diesner, S. C., Wang, X.-Y., Jensen-Jarolim, E., Untersmayr, E., & Gabor, F. (2012) · Therapeutic Delivery · doi:10.4155/tde.11.146 · Cited by 40 · see citing works
- Authors
- Rhee, M., Valencia, P. M., Rodriguez, M. I., Langer, R., Farokhzad, O. C., & Karnik, R.
- Affiliations
- Brigham and Women's Hospital (US)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Farokhzad, Omid C.
- Karnik, Rohit
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2011-02-22
- Volume
- 23
- Issue
- 12
- Pages
- H79-83
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- PMC
- PMC3123733
- OpenAlex
- W2166797582
- Cited by
- 236
- References
- 37
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 12 · 2023: 9 · 2022: 21 · 2021: 24 · 2020: 9 · 2019: 19 · 2018: 15 · 2017: 18 · 2016: 27 · 2015: 16 · 2014: 15 · 2013: 19 · 2012: 21
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- PubMed Central
- Funders
- National Institutes of Health (5u54ca119349-05)
- National Cancer Institute (P50CA090381, L30 CA103793, CA 119349, U54 CA-119349)
- National Institute of Biomedical Imaging and Bioengineering (K08EB003647, EB003647)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Innovative Microfluidic and Catalytic Techniques Innovation
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Materials Science › Materials Chemistry › Pickering emulsions and particle stabilization
- Keywords
- polymeric nanoparticles, nanoprecipitation, microfluidic synthesis, size-tunable nanoparticles, polymer aggregation, polymer molecular weight
- MeSH terms
- Polymers, Nanoparticles, Microtechnology, Hydrodynamics
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