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Maleimide Cross‐Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross‐Linking for Cell Encapsulation and In Situ Delivery
Open accessAbstract
Engineered polyethylene glycol-maleimide matrices for regenerative medicine exhibit improved reaction efficiency and a wider range of Young's moduli by utilizing maleimide cross-linking chemistry. This hydrogel chemistry is advantageous for cell delivery due to the mild reaction that occurs rapidly enough for in situ delivery, while easily lending itself to “plug-and-play” design variations such as incorporation of enzyme-cleavable cross-links and cell-adhesion peptides.
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Cites
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology
Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., & Zhang, J. (2000) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.2.1.9 · Cited by 1,016
Cited by
A practical guide to hydrogels for cell culture
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Progress and potential in organoid research
Rossi, G., Manfrin, A., & Lutolf, M. P. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0051-9 · Cited by 1,182
Designing degradable hydrogels for orthogonal control of cell microenvironments
Kharkar, P. M., Kiick, K. L., & Kloxin, A. M. (2013) · Chem. Soc. Rev. · doi:10.1039/c3cs60040h · Cited by 717
Synthetic hydrogels for human intestinal organoid generation and colonic wound repair
Cruz-Acuña, R., Quirós, M., Farkas, A. E., Dedhia, P. H., Huang, S., Siuda, D., García-Hernández, V., Miller, A. J., Spence, J. R., Nusrat, A., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3632 · Cited by 558
Self-citationMcKinnon, D. D., Domaille, D. W., Cha, J. N., & Anseth, K. S. (2014) · Advanced Materials · doi:10.1002/adma.201303680 · Cited by 414
Metadata
- Authors
- Phelps, E. A., Enemchukwu, N. O., Fiore, V. F., Sy, J. C., Murthy, N., Sulchek, T. A., Barker, T. H., & García, A. J.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2011-12-16
- Volume
- 24
- Issue
- 1
- Pages
- 64-70
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2020809165
- Cited by
- 539
- References
- 2
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Phelps, E. A., Enemchukwu, N. O., Fiore, V. F., Sy, J. C., Murthy, N., Sulchek, T. A., Barker, T. H., & García, A. J. (2012). Maleimide Cross‐Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross‐Linking for Cell Encapsulation and In Situ Delivery. Advanced Materials. https://doi.org/10.1002/adma.201103574
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