Cited by 1,016Hydrogels: synthesis, properties, applicationsCollagen: Extraction and CharacterizationPolysaccharides Composition and Applications

Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology

Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., Zhang, J.·2000·Annual Review of Biomedical Engineering

Abstract

▪ Abstract Hydrogels are cross-linked hydrophilic polymers that can imbibe water or biological fluids. Their biomedical and pharmaceutical applications include a very wide range of systems and processes that utilize several molecular design characteristics. This review discusses the molecular structure, dynamic behavior, and structural modifications of hydrogels as well as the various applications of these biohydrogels. Recent advances in the preparation of three-dimensional structures with exact chain conformations, as well as tethering of functional groups, allow for the preparation of promising new hydrogels. Meanwhile, intelligent biohydrogels with pH- or temperature-sensitivity continue to be important materials in medical applications.

Integrity signals

Registry

Crossref · 10.1146/annurev.bioeng.2.1.9

Cites

79 of 79 references verified0 citation errors · 0 not checkable

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Authors
Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., & Zhang, J.
Affiliations
  • Purdue University West Lafayette (US)
  • Program on Therapeutic and Diagnostic Devices, Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907-1283;
Venue
Annual Review of Biomedical Engineering
Published
2000-08
Volume
2
Issue
1
Pages
9-29
ISSN
  • 1523-9829 (ISSN-L)
  • 1545-4274
OpenAlex
W2157220384
Cited by
1,016
References
81
Citations by year
2026: 17 · 2025: 24 · 2024: 23 · 2023: 26 · 2022: 28 · 2021: 41 · 2020: 42 · 2019: 36 · 2018: 61 · 2017: 53 · 2016: 57 · 2015: 56 · 2014: 56 · 2013: 65 · 2012: 65
FWCI
1.11
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Keywords
hydrogels, biohydrogel, chain conformation, pH-responsive hydrogels, thermosensitive hydrogel, stimuli-responsive hydrogels
MeSH terms
Biomedical Engineering, Chemistry, Physical, Diffusion, Surface Properties, Molecular Structure, Hydrogels, Chemical Phenomena

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