The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Natural‐Based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review
Open accessAbstract
Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fillers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specific degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fibers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed.
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Cites
Hydrogels for tissue engineering: scaffold design variables and applications
Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136
Hydrogels for biomedical applications
Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan—a review
George, M., & Abraham, T. E. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.017 · Cited by 2,012
Nucleation and growth of mineralized bone matrix on silk-hydroxyapatite composite scaffolds
Bhumiratana, S., Grayson, W. L., Castaneda, A., Rockwood, D. N., Gil, E. S., Kaplan, D. L., & Vunjak-Novakovic, G. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.058 · Cited by 265
Tonsomboon, K., & Oyen, M. L. (2013) · Journal of the Mechanical Behavior of Biomedical Materials · doi:10.1016/j.jmbbm.2013.03.001 · Cited by 207
Cunniffe, G. M., Dickson, G. R., Partap, S., Stanton, K. T., & O’Brien, F. J. (2010) · Journal of Materials Science: Materials in Medicine · doi:10.1007/s10856-009-3964-1 · Cited by 199
Rodrigues, S. C., Salgado, C. L., Sahu, A., Garcia, M. P., Fernandes, M. H., & Monteiro, F. J. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34394 · Cited by 127
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Zhang, K., Feng, Q., Fang, Z., Gu, L., & Bian, L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00071 · Cited by 394
Chen, S., Tang, Y., Liu, Y., Zhang, P., Lv, L., Zhang, X., Jia, L., & Zhou, Y. (2019) · Cell Proliferation · doi:10.1111/cpr.12669 · Cited by 344
Nanostructured metal oxides and its hybrids for photocatalytic and biomedical applications
Kannan, K., Radhika, D., Sadasivuni, K. K., Reddy, K. R., & Raghu, A. V. (2020) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2020.102178 · Cited by 341
Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery
Janmohammadi, M., Nazemi, Z., Salehi, A. O. M., Seyfoori, A., John, J. V., Nourbakhsh, M. S., & Akbari, M. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.05.018 · Cited by 323
Xiong, Y., Mi, B.-B., Lin, Z., Hu, Y.-Q., Yu, L., Zha, K.-K., Panayi, A. C., Yu, T., Chen, L., Liu, Z.-P., et al. (2022) · Military Medical Research · doi:10.1186/s40779-022-00426-8 · Cited by 291
Metadata
- Authors
- Pina, S., Oliveira, J. M., & Reis, R. L.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2015-01-10
- Volume
- 27
- Issue
- 7
- Pages
- 1143-1169
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W1980751943
- Cited by
- 948
- References
- 8
- FWCI
- 38.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pina, S., Oliveira, J. M., & Reis, R. L. (2015). Natural‐Based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review. Advanced Materials. https://doi.org/10.1002/adma.201403354
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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