Antibody‐Modified Reduced Graphene Oxide Films with Extreme Sensitivity to Circulating Tumor Cells
Abstract
An antibody-modified reduced graphene oxide (rGO) film with unexpected -extreme sensitivity to circulating tumor cells (CTCs) is reported. The antibody--modified rGO films efficiently capture CTCs from billions of blood cells and minimize the background of white blood cells, without complex microfluidic operations.
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Anti-EpCAM antibody-modified reduced graphene oxide (rGO) films showed extreme sensitivity to CTC, and could efficiently capture CTC from fresh whole blood, with high specificity and low background.
“Li et al. used Anti-EpCAM antibody to modify reduced graphene oxide (rGO) films, which showed extreme sensitivity to CTC, and could efficiently capture CTC from fresh whole blood, with high specificity and low background.213”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [213]
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Smart nanoparticles for cancer therapy
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- Authors
- Li, Y., Lu, Q., Liu, H., Wang, J., Zhang, P., Liang, H., Jiang, L., & Wang, S.
- Affiliations
- Chinese Academy of Sciences (CN)
- Beihang University (CN)
- Wuhan Union Hospital (CN)
- Corresponding author
- Wang, Shutao
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2015-10
- Volume
- 27
- Issue
- 43
- Pages
- 6848-6854
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2155899969
- Cited by
- 143
- References
- 22
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 11 · 2023: 8 · 2022: 5 · 2021: 13 · 2020: 20 · 2019: 27 · 2018: 15 · 2017: 19 · 2016: 15 · 2015: 1
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Physical Sciences › Materials Science › Materials Chemistry › Graphene research and applications
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
- Keywords
- reduced graphene oxide, circulating tumor cells, CTC capture, blood cell separation, label-free detection, graphene oxide films
- MeSH terms
- Epithelial Cell Adhesion Molecule, Antigens, Neoplasm, Graphite, Humans, Microscopy, Fluorescence, Models, Molecular, Molecular Conformation, Neoplastic Cells, Circulating, Oxides, Cell Adhesion Molecules, Wettability, Mechanical Phenomena, Antibodies, Immobilized, MCF-7 Cells
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