Cited by 186Gold and Silver Nanoparticles Synthesis and ApplicationsPlasmonic and Surface Plasmon ResearchAdvanced Sensor and Energy Harvesting Materials

Flexible Plasmonic Biosensors for Healthcare Monitoring: Progress and Prospects

Song, Liping, Chen, Jing, Xu, Ben Bin, Huang, Youju·2021·ACS Nano

Abstract

The noble metal nanoparticle has been widely utilized as a plasmonic unit to enhance biosensors, by leveraging its electric and/or optical properties. Integrated with the “flexible” feature, it further enables opportunities in developing healthcare products in a conformal and adaptive fashion, such as wrist pulse tracers, body temperature trackers, blood glucose monitors, etc . In this work, we present a holistic review of the recent advance of flexible plasmonic biosensors for the healthcare sector. The technical spectrum broadly covers the design and selection of a flexible substrate, the process to integrate flexible and plasmonic units, the exploration of different types of flexible plasmonic biosensors to monitor human temperature, blood glucose, ions, gas, and motion indicators, as well as their applications for surface-enhanced Raman scattering (SERS) and colorimetric detections. Their fundamental working principles and structural innovations are scoped and summarized. The challenges and prospects are articulated regarding the critical importance for continued progress of flexible plasmonic biosensors to improve living quality.

Integrity signals

Registry

Crossref · 10.1021/acsnano.1c07176

Cites

287 of 287 references verified0 citation errors · 0 not checkable

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  • Gas-selective-capturing materials are critical in SERS-based VOC gas detection because they enhance the concentration of target gas molecules, improving the signal-to-noise ratio of the SERS measurement.

    “Gas-selective-capturing materials are critical in SERS-based VOC gas detection due to their benefits (Ly et al. 2021; Song et al. 2021). Firstly, these materials enhance the concentration of the target gas molecules, leading to an improved signal-to-noise ratio of the SERS measurement.”
  • Gas-selective-capturing materials improve the selectivity of SERS-based VOC detection by designing specific binding sites that selectively recognize target gas molecules based on their chemical properties.

    “Secondly, these materials improve the selectivity of the detection system by designing specific binding sites that can selectively recognize the target gas molecules based on their chemical properties, such as size, shape, and functional groups.”

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Authors
Song, L., Chen, J., Xu, B. B., & Huang, Y.
Affiliations
  • University of Science and Technology of China (CN)
  • Chinese Academy of Sciences (CN)
  • Northumbria University (GB)
  • Hangzhou Normal University (CN)
Corresponding author
  • Xu, Ben Bin
  • Huang, Youju
Venue
ACS Nano
Published
2021-11-29
Volume
15
Issue
12
Pages
18822-18847
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
OpenAlex
W3217205856
Cited by
186
References
288
Citations by year
2026: 26 · 2025: 44 · 2024: 45 · 2023: 44 · 2022: 27
FWCI
7.07
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Nano (publishedVersion)
  • PubMed (publishedVersion)
  • Northumbria Research Link (Northumbria University) (acceptedVersion)
Funders
  • Engineering and Physical Sciences Research Council (EP/N007921/1)
  • National Natural Science Foundation of China (51873222, 52103325, 52111530128)
  • the start-up funding from Hangzhou Normal University (4095C5021920452)
  • Key Research and Development Projects of Anhui Province (202004g01020016, 202104g01020009)
  • Zhejiang Provincial Natural Science Foundation of China (Z22B055324)
Topics
  • Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
  • Physical Sciences › Engineering › Biomedical Engineering › Plasmonic and Surface Plasmon Research
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
Keywords
noble metal nanoparticles, flexible substrates, wearable health monitoring, body temperature monitoring, blood glucose monitoring, ion detection, gas sensing, motion sensing, surface-enhanced Raman scattering, colorimetric sensing, conformal sensors
MeSH terms
Colorimetry, Delivery of Health Care, Humans, Spectrum Analysis, Raman, Biosensing Techniques, Metal Nanoparticles

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