The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Nanoscale Metal–Organic Frameworks for Therapeutic, Imaging, and Sensing Applications
Open accessAbstract
Nanotechnology has played an important role in drug delivery and biomedical imaging over the past two decades. In particular, nanoscale metal–organic frameworks (nMOFs) are emerging as an important class of biomedically relevant nanomaterials due to their high porosity, multifunctionality, and biocompatibility. The high porosity of nMOFs allows for the encapsulation of exceptionally high payloads of therapeutic and/or imaging cargoes while the building blocks—both ligands and the secondary building units (SBUs)—can be utilized to load drugs and/or imaging agents via covalent attachment. The ligands and SBUs of nMOFs can also be functionalized for surface passivation or active targeting at overexpressed biomarkers. The metal ions or metal clusters on nMOFs also render them viable candidates as contrast agents for magnetic resonance imaging, computed tomography, or other imaging modalities. This review article summarizes recent progress on nMOF designs and their exploration in biomedical areas. First, the therapeutic applications of nMOFs, based on four distinct drug loading strategies, are discussed, followed by a summary of nMOF designs for imaging and biosensing. The review is concluded by exploring the fundamental challenges facing nMOF‐based therapeutic, imaging, and biosensing agents. This review hopefully can stimulate interdisciplinary research at the intersection of MOFs and biomedicine.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Metal-organic framework materials as catalysts
Lee, J., Farha, O. K., Roberts, J., Scheidt, K. A., Nguyen, S. T., & Hupp, J. T. (2009) · Chemical Society Reviews · doi:10.1039/b807080f · Cited by 7,969
Analysis of nanoparticle delivery to tumours
Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
Self-citationNO-Releasing Zeolites and Their Antithrombotic Properties
Wheatley, P. S., Butler, A. R., Crane, M. S., Fox, S., Xiao, B., Rossi, A. G., Megson, I. L., & Morris, R. E. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0503579 · Cited by 235
Cited by
Metal-organic frameworks for advanced drug delivery
He, S., Wu, L., Li, X., Sun, H., Xiong, T., Liu, J., Huang, C., Xu, H., Sun, H., Chen, W., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.019 · Cited by 528
Min, H., Wang, J., Qi, Y., Zhang, Y., Han, X., Xu, Y., Xu, J., Li, Y., Chen, L., Cheng, K., et al. (2019) · Advanced Materials · doi:10.1002/adma.201808200 · Cited by 394
Molecularly Imprinted Nanoparticles for Biomedical Applications
Zhang, H. (2020) · Advanced Materials · doi:10.1002/adma.201806328 · Cited by 341
Mechanically interlocked materials. Rotaxanes and catenanes beyond the small molecule
Mena-Hernando, S., & Pérez, E. M. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00888d · Cited by 303
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
Liu, J., Huang, J., Zhang, L., & Lei, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00178c · Cited by 285
Metadata
- Authors
- Lu, K., Aung, T., Guo, N., Weichselbaum, R., & Lin, W.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-07-04
- Volume
- 30
- Issue
- 37
- Pages
- e1707634-e1707634
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2810505935
- Cited by
- 692
- References
- 6
- FWCI
- 28.79
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nanoscale Metal–Organic Frameworks for Therapeutic, Imaging, and Sensing Applications. https://app.cochat.ai/papers/10.1002/adma.201707634
- The paper
- Lu, K., Aung, T., Guo, N., Weichselbaum, R., & Lin, W. (2018). Nanoscale Metal–Organic Frameworks for Therapeutic, Imaging, and Sensing Applications. Advanced Materials. https://doi.org/10.1002/adma.201707634
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
