The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Self‐Assembled Semiconducting Polymer Nanoparticles for Ultrasensitive Near‐Infrared Afterglow Imaging of Metastatic Tumors
Open accessAbstract
Detection of metastatic tumor tissues is crucial for cancer therapy; however, fluorescence agents that allow to do share the disadvantage of low signal‐to‐background ratio due to tissue autofluorescence. The development of amphiphilic poly(p‐phenylenevinylene) derivatives that can self‐assemble into the nanoagent (SPPVN) in biological solutions and emit near‐infrared afterglow luminescence after cessation of light irradiation for ultrasensitive imaging of metastatic tumors in living mice is herein reported. As compared with the counterpart nanoparticle (PPVP) prepared from the hydrophobic PPV derivate, SPPVN has smaller size, higher energy transfer efficiency, and brighter afterglow luminescence. Moreover, due to the higher PEG density of SPPVN relative to PPVP poly(ethylene glycol), SPPVN has a better accumulation in tumor. Such a high sensitivity and ideal biodistribution allow SPPVN to rapidly detect xenograft tumors with the size as small as 1 mm 3 and tiny peritoneal metastatic tumors that are almost invisible to naked eye, which is not possible for PPVP. Moreover, the oxygen‐sensitive afterglow makes SPPVN potentially useful for in vivo imaging of oxygen levels. By virtue of enzymatic biodegradability and ideal in vivo clearance, these organic agents can serve as a platform for the construction of advanced afterglow imaging tools.
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Second window for in vivo imaging
Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848
Hong, G., Zou, Y., Antaris, A. L., Diao, S., Wu, D., Cheng, K., Zhang, X., Chen, C., Liu, B., He, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms5206 · Cited by 563
Male Reproductive Health and Environmental Xenoestrogens
Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L. J., Jegou, B., Jensen, T. K., Jouannet, P., Keiding, N., et al. (1996) · Environmental Health Perspectives · doi:10.2307/3432709 · Cited by 348
Cited by
Miao, Q., & Pu, K. (2018) · Advanced Materials · doi:10.1002/adma.201801778 · Cited by 537
Self-citationRecent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy
Zhen, X., Cheng, P., & Pu, K. (2019) · Small · doi:10.1002/smll.201804105 · Cited by 483
Self-citationMultimodal Biophotonics of Semiconducting Polymer Nanoparticles
Jiang, Y., & Pu, K. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.8b00242 · Cited by 478
Self-citationMolecular Probes for Autofluorescence-Free Optical Imaging
Jiang, Y., & Pu, K. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00506 · Cited by 426
Self-citationSemiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer
Li, J., & Pu, K. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00569 · Cited by 412
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Metadata
- Authors
- Xie, C., Zhen, X., Miao, Q., Lyu, Y., & Pu, K.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-04-02
- Volume
- 30
- Issue
- 21
- Pages
- e1801331-e1801331
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2795980237
- Cited by
- 214
- References
- 3
- FWCI
- 10.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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