The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics
Abstract
Optical imaging has played a pivotal role in biology and medicine, but it faces challenges of relatively low tissue penetration and poor signal‐to‐background ratio due to light scattering and tissue autofluorescence. To overcome these issues, second near‐infrared fluorescence, self‐luminescence, and photoacoustic imaging have recently emerged, which utilize an optical region with reduced light–tissue interactions, eliminate real‐time light excitation, and detect acoustic signals with negligible attenuation, respectively. Because there are only a few endogenous molecules absorbing or emitting above the visible region, development of contrast agents is essential for those deep‐tissue optical imaging modalities. Organic semiconducting agents with π‐conjugated frameworks can be synthesized to meet different optical imaging requirements due to their easy chemical modification and legible structure–property relation. Herein, the deep‐tissue optical imaging applications of organic semiconducting agents including small‐molecule agents and nanoparticle derivatives are summarized. In particular, the molecular engineering and nanoformulation approaches to further improve the tissue penetration and detection sensitivity of these optical imaging modalities are highlighted. Finally, current challenges and potential opportunities in this emerging subfield of biomedical imaging are discussed.
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Cites
Quantum dot bioconjugates for imaging, labelling and sensing
Medintz, I. L., Uyeda, H. T., Goldman, E. R., & Mattoussi, H. (2005) · Nature Materials · doi:10.1038/nmat1390 · Cited by 6,229
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Photoacoustic tomography: In vivo imaging from organelles to organs
Wang, L. V., & Hu, S. (2012) · Science · doi:10.1126/science.1216210 · Cited by 4,331
Can the pharmaceutical industry reduce attrition rates?
Kola, I., & Landis, J. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1470 · Cited by 4,167
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 2,985
Imaging in the era of molecular oncology
Weissleder, R., & Pittet, M. J. (2008) · Nature · doi:10.1038/nature06917 · Cited by 2,364
Dysregulated pH: a perfect storm for cancer progression
Webb, B. A., Chimenti, M., Jacobson, M. P., & Barber, D. L. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3110 · Cited by 2,237
Molecular imaging in living subjects: seeing fundamental biological processes in a new light
Massoud, T. F., & Gambhir, S. S. (2003) · Genes & Development · doi:10.1101/gad.1047403 · Cited by 2,216
New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
Kobayashi, H., Ogawa, M., Alford, R., Choyke, P. L., & Urano, Y. (2010) · Chemical Reviews · doi:10.1021/cr900263j · Cited by 2,200
Going deeper than microscopy: the optical imaging frontier in biology
Ntziachristos, V. (2010) · Nature Methods · doi:10.1038/nmeth.1483 · Cited by 1,896
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Optical nano-agents in the second near-infrared window for biomedical applications
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Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy
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Self-citationLi, Y., Cai, Z., Liu, S., Zhang, H., Wong, S. T. H., Lam, J. W. Y., Kwok, R. T. K., Qian, J., & Tang, B. Z. (2020) · Nature Communications · doi:10.1038/s41467-020-15095-1 · Cited by 464
Metadata
- Authors
- Miao, Q., & Pu, K.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-07-29
- Volume
- 30
- Issue
- 49
- Pages
- e1801778-e1801778
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2886166918
- Cited by
- 537
- References
- 170
- FWCI
- 27.47
- Type
- journal article
- Language
- en
- Open access
- closed
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