The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Encapsulation of Plasmid DNA by Nanoscale Metal–Organic Frameworks for Efficient Gene Transportation and Expression
Open accessAbstract
The intracellular delivery and functionalization of genetic molecules play critical roles in gene‐based theranostics. In particular, the delivery of plasmid DNA (pDNA) with safe nonviral vectors for efficient intracellular gene expression has received increasing attention; however, it still has some limitations. A facile one‐pot method is employed to encapsulate pDNA into zeolitic imidazole framework‐8 (ZIF‐8) and ZIF‐8‐polymer vectors via biomimetic mineralization and coprecipitation. The pDNA molecules are found to be well distributed inside both nanostructures and benefit from their protection against enzymatic degradation. Moreover, through the use of a polyethyleneimine (PEI) 25 kD capping agent, the nanostructures exhibit enhanced loading capacity, better pH responsive release, and stronger binding affinity to pDNA. From in vitro experiments, the cellular uptake and endosomal escape of the protected pDNA are greatly improved with the superior ZIF‐8‐PEI 25 kD vector, leading to successful gene expression with high transfection efficacy, comparable to expensive commercial agents. New cost‐effective avenues to develop metal–organic‐framework‐based nonviral vectors for efficient gene delivery and expression are provided.
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Cites
Non-viral vectors for gene-based therapy
Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123
Nonviral vectors for gene delivery
Mintzer, M. A., & Simanek, E. E. (2009) · Chemical Reviews · doi:10.1021/cr800409e · Cited by 2,366
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Tailoring nanocarriers for intracellular protein delivery
Gu, Z., Biswas, A., Zhao, M., & Tang, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00227e · Cited by 543
Alsaiari, S. K., Patil, S., Alyami, M., Alamoudi, K. O., Aleisa, F. A., Merzaban, J. S., Li, M., & Khashab, N. M. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11754 · Cited by 517
Cited by
Metal–Organic Frameworks for Drug Delivery: A Design Perspective
Lawson, H. D., Walton, S. P., & Chan, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01089 · Cited by 916
Zhou, Z., Vázquez-González, M., & Willner, I. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01030h · Cited by 308
Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy
He, X., Jiang, Z., Akakuru, O. U., Li, J., & Wu, A. (2021) · Chemical Communications · doi:10.1039/d1cc04846e · Cited by 303
Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts
Ma, L., Jiang, F., Fan, X., Wang, L., He, C., Zhou, M., Li, S., Luo, H., Cheng, C., & Qiu, L. (2020) · Advanced Materials · doi:10.1002/adma.202003065 · Cited by 298
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
Liu, J., Huang, J., Zhang, L., & Lei, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00178c · Cited by 285
Metadata
- Authors
- Li, Y., Zhang, K., Liu, P., Chen, M., Zhong, Y., Ye, Q., Wei, M. Q., Zhao, H., & Tang, Z.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-06-03
- Volume
- 31
- Issue
- 29
- Pages
- e1901570-e1901570
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2948364137
- Cited by
- 207
- References
- 6
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, Y., Zhang, K., Liu, P., Chen, M., Zhong, Y., Ye, Q., Wei, M. Q., Zhao, H., & Tang, Z. (2019). Encapsulation of Plasmid DNA by Nanoscale Metal–Organic Frameworks for Efficient Gene Transportation and Expression. Advanced Materials. https://doi.org/10.1002/adma.201901570
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