The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Emerging Targets in Type 2 Diabetes and Diabetic Complications
Open accessAbstract
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and elevated blood glucose levels. Although a large drug portfolio exists to keep the blood glucose levels under control, these medications are not without side effects. More importantly, once diagnosed diabetes is rarely reversible. Dysfunctions in the kidney, retina, cardiovascular system, neurons, and liver represent the common complications of diabetes, which again lack effective therapies that can reverse organ injury. Overall, the molecular mechanisms of how type 2 diabetes develops and leads to irreparable organ damage remain elusive. This review particularly focuses on novel targets that may play role in pathogenesis of type 2 diabetes. Further research on these targets may eventually pave the way to novel therapies for the treatment—or even the prevention—of type 2 diabetes along with its complications.
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Cites
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Trends in insulin resistance: insights into mechanisms and therapeutic strategy
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Antar, S. A., Ashour, N. A., Sharaky, M., Khattab, M., Ashour, N. A., Zaid, R. T., Roh, E. J., Elkamhawy, A., & Al-Karmalawy, A. A. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115734 · Cited by 622
Tegegne, B. A., Adugna, A., Yenet, A., Yihunie Belay, W., Yibeltal, Y., Dagne, A., Hibstu Teffera, Z., Amare, G. A., Abebaw, D., Tewabe, H., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1440456 · Cited by 61
“There was a signi fi cant knowledge gap that has to be fi lled regarding the neurological, hepatic, ophthalmic, or renal issues related to DM (39, 40).”
BackgroundSusilawati, E., Levita, J., Susilawati, Y., & Sumiwi, S. A. (2023) · Medical Sciences · doi:10.3390/medsci11030050 · Cited by 38
From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration
Li, S., Du, J., Huang, Y., Gao, S., Zhao, Z., Chang, Z., Zhang, X., & He, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1355503 · Cited by 32
Metadata
- Authors
- Demir, S., Nawroth, P. P., Herzig, S., & Ekim Üstünel, B.
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2021-07-28
- Volume
- 8
- Issue
- 18
- Pages
- e2100275-e2100275
- ISSN
- 2198-3844 (ISSN-L)
- OpenAlex
- W3183548861
- Cited by
- 525
- References
- 44
- FWCI
- 45.80
- Type
- journal article
- Language
- en
- Open access
- gold
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- Demir, S., Nawroth, P. P., Herzig, S., & Ekim Üstünel, B. (2021). Emerging Targets in Type 2 Diabetes and Diabetic Complications. Advanced Science. https://doi.org/10.1002/advs.202100275
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