The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Polydopamine Decorated Microneedles with Fe‐MSC‐Derived Nanovesicles Encapsulation for Wound Healing
Open accessAbstract
Wound dressing with the capacities of antioxidation, antiinflammation, and efficient angiogenesis induction is expected for effectively promoting wound healing. Herein, a novel core‐shell hyaluronic acid (HA) microneedle (MN) patch with ferrum‐mesenchymal stem cell‐derived artificial nanovesicles (Fe‐MSC‐NVs) and polydopamine nanoparticles (PDA NPs) encapsulated in the needle tips is presented for wound healing. Fe‐MSC‐NVs containing multifunctional therapeutic cytokines are encapsulated in the inner HA core of the MN tips for accelerating angiogenesis. The PDA NPs are encapsulated in the outer methacrylated hyaluronic acid (HAMA) shell of the MN tips to overcome the adverse impacts from reactive oxygen species (ROS)‐derived oxidative stress. With the gradual degradation of HAMA patch tips in the skin, the PDA NPs are sustainably released at the lesion to suppress the ROS‐induced inflammation reaction, while the Fe‐MSC‐NVs significantly increase the migration, proliferation, and tube formation of human umbilical vein endothelial cells (HUVEC). More attractively, the combination of PDA NPs and Fe‐MSC‐NVs further promotes M2 macrophage polarization, thereby suppressing wound inflammation. Through in vivo experiment, the Fe‐MSC‐NVs/PDA MN patch shows an excellent effect for diabetic wound healing. These features of antioxidation, antiinflammation, and pro‐angiogenesis indicate the proposed composite core‐shell MN patch is valuable for clinical wound healing applications.
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Cites
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335
Polydopamine Surface Chemistry: A Decade of Discovery
Ryu, J. H., Messersmith, P. B., & Lee, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19865 · Cited by 1,843
Controlled Degradation and Mechanical Behavior of Photopolymerized Hyaluronic Acid Networks
Burdick, J. A., Chung, C., Jia, X., Randolph, M. A., & Langer, R. (2005) · Biomacromolecules · doi:10.1021/bm049508a · Cited by 777
Bao, X., Zhao, J., Sun, J., Hu, M., & Yang, X. (2018) · ACS Nano · doi:10.1021/acsnano.8b04022 · Cited by 722
Kim, H. Y., Kumar, H., Jo, M.-J., Kim, J., Yoon, J.-K., Lee, J.-R., Kang, M., Choo, Y. W., Song, S. Y., Kwon, S. P., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b01816 · Cited by 190
Cited by
Extracellular vesicle-loaded hydrogels for tissue repair and regeneration
Ju, Y., Hu, Y., Yang, P., Xie, X., & Fang, B. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100522 · Cited by 440
Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine
Huang, F., Lu, X., Yang, Y., Yang, Y., Li, Y., Kuai, L., Li, B., Dong, H., & Shi, J. (2023) · Advanced Science · doi:10.1002/advs.202203308 · Cited by 365
Liu, S., Yu, J.-M., Gan, Y.-C., Qiu, X.-Z., Gao, Z.-C., Wang, H., Chen, S.-X., Xiong, Y., Liu, G.-H., Lin, S.-E., et al. (2023) · Military Medical Research · doi:10.1186/s40779-023-00448-w · Cited by 357
Wu, M., Liu, H., Li, D., Zhu, Y., Wu, P., Chen, Z., Chen, F., Chen, Y., Deng, Z., & Cai, L. (2024) · Advanced Science · doi:10.1002/advs.202304641 · Cited by 257
Wu, M., Wang, Y., Liu, H., Chen, F., Zhang, Y., Wu, P., Deng, Z., & Cai, L. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.111705 · Cited by 28
Metadata
- Authors
- Ma, W., Zhang, X., Liu, Y., Fan, L., Gan, J., Liu, W., Zhao, Y., & Sun, L.
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2022-03-10
- Volume
- 9
- Issue
- 13
- Pages
- e2103317-e2103317
- ISSN
- 2198-3844 (ISSN-L)
- OpenAlex
- W4220724103
- Cited by
- 358
- References
- 5
- FWCI
- 27.61
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ma, W., Zhang, X., Liu, Y., Fan, L., Gan, J., Liu, W., Zhao, Y., & Sun, L. (2022). Polydopamine Decorated Microneedles with Fe‐MSC‐Derived Nanovesicles Encapsulation for Wound Healing. Advanced Science. https://doi.org/10.1002/advs.202103317
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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