Application of an iPSC‐Derived Organoid Model for Localized Scleroderma Therapy
Open accessAbstract
Localized scleroderma (LoS) is a rare chronic disease with extensive tissue fibrosis, inflammatory infiltration, microvascular alterations, and epidermal appendage lesions. However, a deeper understanding of the pathogenesis and treatment strategies of LoS is currently limited. In the present work, a proteome map of LoS skin is established, and the pathological features of LoS skin are characterized. Most importantly, a human‐induced pluripotent stem cell‐derived epithelial and mesenchymal (EM) organoids model in a 3D culture system for LoS therapy is established. According to the findings, the application of EM organoids on scleroderma skin can significantly reduce the degree of skin fibrosis. In particular, EM organoids enhance the activity of epidermal stem cells in the LoS skin and promotes the regeneration of sweat glands and blood vessels. These results highlight the potential application of organoids for promoting the recovery of scleroderma associated phenotypes and skin‐associated functions. Furthermore, it can provide a new therapeutic alternative for patients suffering from disfigurement and skin function defects caused by LoS.
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PSOs are already being adopted for various applications including disease modeling and regenerative therapy.
“Despite their recent discovery, PSOs are already being adopted for various applications including disease modeling and regenerative therapy [5,7–9], yet several considerations remain, such as their limited maturation and efficiency, and non-anatomical organization of dermal and epidermal compartments.”
From Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle‐Shaped Microfluidic Device (2024) · cites this paper as [7]
The Introduction and Discussion (page unavailable) describe iPSC-derived skin organoids used to treat localized scleroderma in mice, supporting regenerative therapy as an application. The Results identify the disease model as a bleomycin-induced mouse model; the copy does not show the organoids being used for disease modeling. (LLM, conf=0.85)
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- Authors
- Ma, J., Li, W., Cao, R., Gao, D., Zhang, Q., Li, X., Li, B., Lv, L., Li, M., Jiang, J., Wang, Y., Li, J., Wu, Z., Zhu, Y., Zhong, W., Zhang, S., & Leng, L.
- Affiliations
- Beijing Proteome Research Center (CN)
- National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and Toxicology Beijing 100850 China
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Anhui Medical University (CN)
- Institute of NBC Defense Beijing 102205 China
- Corresponding author
- Zhong, Wu
- Zhang, Shuyang
- Leng, Ling
- ORCID
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2022-03-22
- Volume
- 9
- Issue
- 16
- Pages
- e2106075-e2106075
- ISSN
- 2198-3844 (ISSN-L)
- PMC
- PMC9165518
- OpenAlex
- W4220920669
- Cited by
- 38
- References
- 31
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 12 · 2023: 6 · 2022: 4 · 2012: 1
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Advanced Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Key Research and Development Program of China (2021YFA1301603)
- National Science and Technology Major Project (2018ZX09711003)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- morphea, skin fibrosis, skin proteome, epidermal stem cells, sweat gland regeneration, 3D skin model
- MeSH terms
- Cell Differentiation, Fibrosis, Humans, Organoids, Scleroderma, Localized, Induced Pluripotent Stem Cells
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