Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative
Abstract
An association has been observed in several independent data sets between late onset Alzheimer's Disease (AD) and the APOE locus on chromosome 19. We have examined the genotype in family history positive (FHP) and family history negative (FHN) cases and find a distortion of the APOE allele frequencies in accord with previous studies. However, when we examined the allele distribution of the at‐risk siblings of the FHP group we found an excess of the ϵ4 allele which also differs significantly from historic controls but not from the affected siblings. The age distribution of the affected and unaffected siblings was similar, suggesting that the allelic frequency distortion in the unaffected siblings was not due to their being below the mean age of onset. Lod score linkage analysis, with age dependent onset and non‐stringent specification of the genetic parameters, did not suggest linkage to the APOE locus. Furthermore, an analysis of variance of the age of disease free survival suggested that APOE genotype contributes a small fraction of the total variance indicating that the APOE locus is a poor predictor of disease free survival age within late onset families. One explanation for the age dependent association reported by other groups, and our results, is that the APOE locus enhances the rate of progression of the disease process in otherwise predisposed individuals and that variation at this locus is not able in and of itself to cause the disease. We suggest this hypothesis is compatible with the current literature regarding APOE and AD. © 1995 Wiley‐Liss, Inc.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
APOE remains the only locus repeatedly associated with AAO, but PICALM and BIN1 have also been reported to affect AAO.
“To date, APOE remains the only locus repeatedly associated with AAO8,9, but PICALM and BIN1 have also been reported to affect AAO6,10,11.”
From A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease (2017) · cites this paper as [8]
Genes linked to early-onset AD risk that are expressed primarily in microglia include TREM2, MS4A, ABCA7, ApoE4, CD33, PU.1, and BIN1.
“Genetic studies show that a number of genes that have been linked to early-onset AD risk are expressed primarily in microglia.”
From Microglial signatures and their role in health and disease (2018) · cites this paper as [129]
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works
Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981 · see citing works
Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., & Lannfelt, L. (1992) · Nature Genetics · doi:10.1038/ng0892-345 · Cited by 1,513 · see citing works
Self-citationApolipoprotein E polymorphism and Alzheimer's disease
Poirier, J., Bertrand, P., Poirier, J., Kogan, S., Gauthier, S., Poirier, J., Gauthier, S., Davignon, J., Bouthillier, D., & Davignon, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91705-q · Cited by 1,108 · see citing works
Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107 · see citing works
Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.
(1991) · Europe PMC (PubMed Central) · Cited by 758 · see citing works
APOLIPOPROTEIN-E GENOTYPE AND ALZHEIMERS-DISEASE
Hardy, J., Houlden, H., Collinge, J., Kennedy, A. M., Newman, S., Rossor, M. N., Lannfelt, L., Lilius, L., Winblad, B. G., Crook, R., et al. (1993) · UCL Discovery (University College London) · Cited by 286 · see citing works
Self-citationApolipoprotein E genotype and Alzheimer's disease
Noguchi, S., Murakami, K., Yamada, N., Payami, H., Kaye, J. A., Heston, L. L., Bird, T. D., & Schellenberg, G. D. (1993) · The Lancet · doi:10.1016/0140-6736(93)91728-5 · Cited by 285 · see citing works
Genetics and molecular advances in Alzheimer's disease
Mullan, M., & Crawford, F. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90007-9 · Cited by 181 · see citing works
Self-citationAlzheimer's Disease and Possible Gene Interaction
George‐Hyslop, P. S., McLachlan, D. C., Tsuda, T., Rogaev, E. I., Karlinsky, H., Lippa, C. F., & Pollen, D. A. (1994) · Science · doi:10.1126/science.8290965 · Cited by 132 · see citing works
Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type
Schellenberg, G. D., Deeb, S. S., Boehnke, M., Bryant, E. M., Martin, G. M., Lampe, T. H., & Bird, T. D. (1987) · Journal of Neurogenetics · doi:10.3109/01677068709102337 · Cited by 93 · see citing works
Kennedy, A. M., Newman, S., McCaddon, A., Ball, J. A., Roques, P. K., MULLAN, M. J., Hardy, J., Chartier‐Harlin, M., Frackowiak, R. S. J., Warrington, E. K., et al. (1993) · Brain · doi:10.1093/brain/116.2.309 · Cited by 72 · see citing works
Self-citationImmediate intracardiac adrenaline injection in asystole
Eldor, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91729-6 · Cited by 65 · see citing works
Age of onset in familial early onset Alzheimer's disease correlates with genetic aetiology
MULLAN, M. J., Houlden, H., Crawford, F., Kennedy, A. M., Rogues, P. K., & Rossor, M. N. (1993) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320480303 · Cited by 44 · see citing works
Self-citationApolipoprotein E Phenotyping: A Word of Caution
Wenham, P. R., Sedky, A., & Spooner, R. J. (1991) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329102800610 · Cited by 36 · see citing works
Molecular pathology of Alzheimer's disease
MULLAN, M. J. (1993) · International Review of Psychiatry · doi:10.3109/09540269309037798 · Cited by 16 · see citing works
Self-citation
Flagged first, then by citations
1 of the 21 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Microglial signatures and their role in health and disease
Butovsky, O., & Weiner, H. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0057-5 · Cited by 1,046 · see citing works
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
The International Genomics of Alzheimer's Project, Huang, K.-L., Initiative, T. A. D. N., Marcora, E., Pimenova, A. A., Di Narzo, A. F., Kapoor, M., Jin, S. C., Harari, O., Bertelsen, S., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4587 · Cited by 423 · see citing works
Arendt, T., Schindler, C., Brückner, M. K., Eschrich, K., Bigl, V., Zedlick, D., & Marcova, L. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00516.1997 · Cited by 319 · see citing works
The Number of Trait Loci in Late-Onset Alzheimer Disease
Daw, E. W., Payami, H., Nemens, E. J., Nochlin, D., Bird, T. D., Schellenberg, G. D., & Wijsman, E. M. (2000) · The American Journal of Human Genetics · doi:10.1086/302710 · Cited by 295 · see citing works
A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia
Bullido, M. J., Artiga, M. J., Recuero, M., Sastre, I., García, M., Aldudo, J., Lendon, C. L., Han, S. W., Morris, J. C., Frank, A., et al. (1998) · Nature Genetics · doi:10.1038/ng0198-69 · Cited by 286 · see citing works
Payami, H., Zareparsi, S., Montee, K. R., Sexton, G. J., Kaye, J. A., Bird, T. D., Yu, C. E., Wijsman, E. M., Heston, L. L., Litt, M. J., et al. (1996) · PubMed Central · Cited by 248 · see citing works
Apolipoprotein E genotyping in Alzheimer's disease
Relkin, N. R. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90284-6 · Cited by 241 · see citing works
Wijsman, E. M., Pankratz, N., Choi, Y., Rothstein, J. H., Faber, K. M., Cheng, R., Lee, J. H., Bird, T. D., Bennett, D. A., Diaz-Arrastia, R. R., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001308 · Cited by 223 · see citing works
Pharmacogenomics in Alzheimer's Disease
Cacabelos, R. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-205-2_10 · Cited by 109 · see citing works
Evidence for a Novel Late-Onset Alzheimer Disease Locus on Chromosome 19p13.2
Wijsman, E. M., Daw, E. W., Yu, C. E., Payami, H., Steinbart, E. J., Nochlin, D., Conlon, E. M., Bird, T. D., & Schellenberg, G. D. (2004) · The American Journal of Human Genetics · doi:10.1086/423393 · Cited by 95 · see citing works
Grouselle, D., Winsky-Sommerer, R., David, J. P., Delacourte, A., Dournaud, P., & Epelbaum, J. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00698-3 · Cited by 92 · see citing works
A Unifying Hypothesis of Alzheimer's Disease. IV. Causation and Sequence of Events
Heininger, K. (2000) · Reviews in the Neurosciences · doi:10.1515/revneuro.2000.11.s1.213 · Cited by 138 · see citing works
Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease
Payami, H., Schellenberg, G. D., Zareparsi, S., Kaye, J. A., Sexton, G. J., Head, M. A., Matsuyama, S. S., Jarvik, L. F., Miller, B. L., McManus, D. Q., et al. (1997) · Neurology · doi:10.1212/wnl.49.2.512 · Cited by 84 · see citing works
Variability of Familial Risk of Alzheimer Disease Across the Late Life Span
Silverman, J. M., Ciresi, G., Smith, C. J., Marin, D. B., & Beeri, M. S. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.565 · Cited by 80 · see citing works
APOE and other loci affect age‐at‐onset in Alzheimer's disease families with PS2 mutation
Wijsman, E. M., Daw, E. W., Yu, X., Steinbart, E. J., Nochlin, D., Bird, T. D., & Schellenberg, G. D. (2005) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30087 · Cited by 79 · see citing works
APOA1 polymorphism influences risk for early-onset nonfamiliar AD
Vollbach, H., Heun, R., Morris, C. M., Edwardson, J. A., McKeith, I. G., Jessen, F., Schulz, A., Maier, W., & Kölsch, H. (2005) · Annals of Neurology · doi:10.1002/ana.20593 · Cited by 75 · see citing works
Relkin, N. R., Kwon, Y. J., Tsai, J., & Gandy, S. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32608.x · Cited by 69 · see citing works
Payami, H., Grimslid, H., Oken, B., Camicioli, R. M., Sexton, G. J., Dame, A., Howieson, D. B., & Kaye, J. A. (1997) · PubMed · Cited by 66 · see citing works
Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementia
Cutler, R. G., Haughey, N. J., Tammara, A., McArthur, J. C., Nath, A., Reid, R., Vargas, D. L., Pardo, C. A., & Mattson, M. P. (2004) · Neurology · doi:10.1212/01.wnl.0000134662.19883.06 · Cited by 67 · see citing works
Evidence for parent of origin effect in late-onset Alzheimer disease
Bassett, S. S., Avramopoulos, D., & Fallin, D. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10648 · Cited by 66 · see citing works
Nilsson, E. C., Long, Y. C., Martinsson, S., Glund, S., García-Rovés, P. M., Svensson, T., Andersson, L., Zierath, J. R., & Mahlapuu, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510461200 · Cited by 58 · see citing works
Burke, S. L., Maramaldi, P., Cadet, T. J., & Kukull, W. A. (2016) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2016.04.006 · Cited by 49 · see citing works
Pharmacogenomics for the treatment of dementia
Cacabelos, R. (2002) · Annals of Medicine · doi:10.1080/078538902320772115 · Cited by 40 · see citing works
Confirmation of association between D10S583 and Alzheimer's disease in a case–control sample
Ait‐Ghezala, G., Abdullah, L. I., Crescentini, R. M., Crawford, F., Town, T., Singh, S., Richards, D., Duara, R., & MULLAN, M. J. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00243-4 · Cited by 37 · see citing works
Self-citationCharacterization of lectin-mediated brain uptake of HIV-1 GP120
Banks, W. A., & Kastin, A. J. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19981115)54:4 · Cited by 49 · see citing works
Wierenga, C. E., Stricker, N. H., McCauley, A., Simmons, A. N., Jak, A. J., Chang, Y., Delano‐Wood, L., Bangen, K. J., Salmon, D. P., & Bondi, M. W. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.03.021 · Cited by 34 · see citing works
Engström, C., Åström, M., Nordqvist-Karlsson, B., Adolfsson, R., & Nylander, P. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00374-5 · Cited by 33 · see citing works
The molecular genetics of Alzheimer's disease
MULLAN, M. J., & Crawford, F. (1994) · Molecular Neurobiology · doi:10.1007/bf02816100 · Cited by 31 · see citing works
Self-citationMarchani, E. E., Bird, T. D., Steinbart, E. J., Rosenthal, E., Yu, C., Schellenberg, G. D., & Wijsman, E. M. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31072 · Cited by 29 · see citing works
Loring, J. F., Pászty, C., Rose, A., McIntosh, T. K., Murai, H., Pierce, J. E. S., Schramm, S. R., Wymore, K., Lee, V. M. ‐., Trojanowski, J. Q., et al. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02076-4 · Cited by 29 · see citing works
Harry, G. J., d’Hellencourt, C. L., Bruccoleri, A., & Schmechel, D. E. (2000) · Brain Behavior and Immunity · doi:10.1006/brbi.2000.0606 · Cited by 25 · see citing works
Apolipoprotein E ɛ4 Genotype and Gender: Effects on Memory
Sundermann, E. E., Gilbert, P. E., & Murphy, C. (2007) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318065415f · Cited by 25 · see citing works
Familial and Population‐Based Studies of Apolipoprotein E and Alzheimer's Diseasea
MULLAN, M. J., Scibelli, P., Duara, R., Fallin, D., Gold, M. R., Schinka, J. A., Hoyne, J. B., Osborne, A. R., Sevush, S., & Crawford, F. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32594.x · Cited by 25 · see citing works
Self-citationGenetic analysis of mechanisms of aging
Rose, M. R., & Archer, M. A. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80016-5 · Cited by 23 · see citing works
A mitochondrial bottleneck hypothesis of Alzheimer's disease
Davis, J. N., Hunnicutt, E. J., & Chisholm, J. C. (1995) · Molecular Medicine Today · doi:10.1016/s1357-4310(95)91532-x · Cited by 22 · see citing works
Comings, D., Wu, S., Chiu, C., Ring, R., Gade, R., Ahn, C., MacMurray, J. P., Dietz, G., & Muhleman, D. (1996) · American journal of medical genetics · doi:10.1002/(sici)1096-8628(19960531)67:3 · Cited by 283 · see citing works
Heritability of factors of the insulin resistance syndrome in women twins
Edwards, K. L., Newman, B. M., Mayer, E. J., Selby, J. V., Krauss, R. M., & Austin, M. A. (1997) · Genetic Epidemiology · doi:10.1002/(sici)1098-2272(1997)14:3 · Cited by 101 · see citing works
Self-citationInfluence of APOE genotype on familial aggregation of AD in an urban population
Devi, G., Ottman, R., Tang, M. ‐., Marder, K. S., Stern, Y., Tycko, B., & Mayeux, R. P. (1999) · Neurology · doi:10.1212/wnl.53.4.789 · Cited by 22 · see citing works
Editorial: Pragmatics and statistics in psychiatric genetics
Levinson, D. F. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970418)74:2 · Cited by 6 · see citing works
Self-citationA genealogical study of Alzheimer disease in the Saguenay region of Quebec
V�zina, H., Heyer, É., Fortier, I., Ouellette, G., Robitaille, Y., & Gauvreau, D. (1999) · Genetic Epidemiology · doi:10.1002/(sici)1098-2272(1999)16:4 · Cited by 23 · see citing works
Apolipoprotein-E ɛ4 Allele Frequency and Conferred Risk for Cuban Americans With Alzheimer's Disease
Sevush, S., Peruyera, G., Crawford, F., & MULLAN, M. J. (2000) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200008000-00013 · Cited by 17 · see citing works
Self-citationApolipoprotein E-Related Neurotoxicity as a Therapeutic Target for Alzheimer's Disease
Marques, M. A., & Crutcher, K. A. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:3:327 · Cited by 17 · see citing works
Effect of heterogeneity on the chromosome 10 risk in late-onset Alzheimer disease
Liang, X. S., Martin, E. R., Schnetz‐Boutaud, N. C., Bartlett, J., Anderson, B. C., Zuchner, S. L., Gwirtsman, H. E., Schmechel, D. E., Carney, R. M., Gilbert, J. R., et al. (2007) · Human Mutation · doi:10.1002/humu.20567 · Cited by 16 · see citing works
Variants regulating ZBTB4 are associated with age‐at‐onset of Alzheimer's disease
Blue, E., Yu, C., Thornton, T. A., Chapman, N. H., Kernfeld, E. M., Jiang, N., Shively, K. M., Buckingham, K. J., Marvin, C. T., Bamshad, M. J., et al. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12429 · Cited by 13 · see citing works
Bernardi, L., Gallo, M., Anfossi, M., Conidi, M. E., Colao, R., Puccio, G., Curcio, S. A. M., Frangipane, F., Clodomiro, A., Mirabelli, M., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130119 · Cited by 13 · see citing works
Cluett, C., Brayne, C., Clarke, R., Evans, G., Matthews, F., Rubinsztein, D. C., Huppert, F., Llewellyn, D. J., Rice, N., Henley, W., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.020 · Cited by 12 · see citing works
Association of apolipoprotein E but not B with Alzheimer's disease
Poduslo, S. E., Riggs, D., Schwankhaus, J. D., Osborne, A. R., Crawford, F., & MULLAN, M. J. (1995) · Human Genetics · doi:10.1007/bf00197418 · Cited by 11 · see citing works
Self-citationApolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease
Bronzova, J., van Duijn, C. M., Havekes, L. M., de Knijff, P., Broeckhoven, C. V., & Albert Hofman, D. (1996) · Journal of Neurology · doi:10.1007/bf00900501 · Cited by 9 · see citing works
Bassett, S. S., Havstad, S. L., & Chase, G. A. (2004) · Genetic Testing · doi:10.1089/1090657041797383 · Cited by 8 · see citing works
Choi, Y., Blue, E., Bird, T. D., Steinbart, E. J., Blacker, D., & Wijsman, E. M. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31220 · Cited by 7 · see citing works
MULLAN, M. J., Grossberg, G. T., Anand, R., & Enz, A. (2000) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v61n0413 · Cited by 6 · see citing works
Self-citationLynch, C. A., Brazil, J. C., Cullen, B., Coakley, D., Gill, M., Lawlor, B. A., & Hawi, Z. (2007) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-007-0098-7 · Cited by 6 · see citing works
A Common Haplotype Lowers PU.1 Expression in Myeloid Cells and Delays Onset of Alzheimer's Disease
Huang, K.-L., Marcora, E., Pimenova, A. A., Di Narzo, A. F., Kapoor, M., Jin, S. C., Harari, O., Bertelsen, S., Fairfax, B. P., Czajkowski, J., et al. (2017) · doi:10.1101/110957 · Cited by 6 · see citing works
Zhao, W., Blue, E., Cheung, C. Y. K., Steinbart, E. J., Schellenberg, G. D., Bird, T. D., & Wijsman, E. M. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32133 · Cited by 5 · see citing works
APOE Genotype, Family History of Dementia, and Alzheimer Disease Risk
Huang, W., Qiu, C., Strauss, E. I. V., Winblad, B. G., & Fratiglioni, L. (2004) · Archives of Neurology · doi:10.1001/archneur.61.12.1930 · Cited by 4 · see citing works
Farias, F., Benítez, B. A., & Cruchaga, C. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105247 · Cited by 4 · see citing works
Physostigmine and Alzheimer's disease
Thal, L. J. (1997) · Neurology · doi:10.1212/wnl.49.2.643 · Cited by 2 · see citing works
Physostigmine and Alzheimer's disease
Gold, M. (1997) · Neurology · doi:10.1212/wnl.49.2.642-b · Cited by 1 · see citing works
Association of Apo-B gene Polymorphism with adiposity
Khatoon, F., Badawy, A.-E., Batool, S., Abdullah, F. E., Balouch, Z., & Omer, D. S. (2014) · IOSR Journal of Applied Chemistry · doi:10.9790/5736-07615863
Bibliography NIA/AlzA Conference on Apolipoprotein E Genotyping in Alzheimer's Disease
Kwon, Y. J., Tsai, J., & Relkin, N. R. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32609.x
Alzheimer’s Disease: A Complex Paradigm
Avramopoulos, D. (2007) · CRC Press eBooks · doi:10.3109/9781420019544-4
Current Problems of Complex Disease Genes Mapping
Bulayeva, K., Bulayev, O. A., & Glatt, S. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-31964-3_1
(2021) · Wiley eBooks · doi:10.1002/9781119836070.refs
Alzheimer's Disease: A Complex Paradigm
Avramopoulos, D. (2007) · Medical psychiatry · doi:10.3109/9781420019544.001
- Self-citation
- Authors
- Bennett, C., Crawford, F., Osborne, A., Diaz, P., Hoyne, J., Lopez, R., Roques, P., Duara, R., Rossor, M., & Mullan, M.
- Affiliations
- University of South Florida (US)
- Mount Sinai Medical Center (US)
- St Mary's Hospital (GB)
- Corresponding author
- Mullan, Mike
- Venue
- American Journal of Medical Genetics
- Publisher
- Wiley
- Published
- 1995-02-27
- Volume
- 60
- Issue
- 1
- Pages
- 1-6
- ISSN
- 0148-7299 (ISSN-L)
- 1096-8628
- OpenAlex
- W2151359455
- Cited by
- 67
- References
- 21
- Citations by year
- 2021: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2014: 1 · 2013: 2
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- late-onset Alzheimer's disease, familial Alzheimer's disease, APOE ε4, disease progression, age of onset, family history (medicine), genetic linkage, disease-free survival, genetic susceptibility
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Apolipoproteins E, Base Sequence, Chromosomes, Human, Pair 19, Female, Genotype, Humans, Genetic Linkage, Male, Models, Genetic, Molecular Sequence Data, Case-Control Studies, Age of Onset, DNA Primers, Apolipoprotein E4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
