The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation
Open accessAbstract
Individuals with Down syndrome over age 40 years are at risk for developing dementia of the Alzheimer type and have evidence for chronic oxidative stress. There is a paucity of treatment trials for dementia in Down syndrome in comparison to Alzheimer disease in the general (non‐Down syndrome) population. This 2‐year randomized, double‐blind, placebo‐controlled trial assessed whether daily oral antioxidant supplementation (900 IU of alpha‐tocopherol, 200 mg of ascorbic acid and 600 mg of alpha‐lipoic acid) was effective, safe and tolerable for 53 individuals with Down syndrome and dementia. The outcome measures comprised a battery of neuropsychological assessments administered at baseline and every 6 months. Compared to the placebo group, those individuals receiving the antioxidant supplement showed neither an improvement in cognitive functioning nor a stabilization of cognitive decline. Mean plasma levels of alpha‐tocopherol increased ∼2‐fold in the treatment group and were consistently higher than the placebo group over the treatment period. Pill counts indicated good compliance with the regimen. No serious adverse events attributed to the treatment were noted. We conclude that antioxidant supplementation is safe, though ineffective as a treatment for dementia in individuals with Down syndrome and Alzheimer type dementia. Our findings are similar to studies of antioxidant supplementation in Alzheimer disease in the general population. The feasibility of carrying out a clinical trial for dementia in Down syndrome is demonstrated. © 2011 Wiley‐Liss, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In one of the trials lasting 2 years, antioxidant supplementation with vitamin C, vitamin E, and α-lipoic acid in subjects with Down syndrome did not prevent cognitive decline nor improved cognitive function (Lott et al. 2011).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Lott et al. 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Longitudinal data analysis using generalized linear models
LIANG, K.-Y., & ZEGER, S. L. (1986) · Biometrika · doi:10.1093/biomet/73.1.13 · Cited by 18,550
(1967) · Project Euclid (Cornell University) · Cited by 4,720
Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability; Vol. IV
Roy, H. L. L., LeCam, L. M., & Neyman, J. (1969) · Revue de l Institut International de Statistique / Review of the International Statistical Institute · doi:10.2307/1402306 · Cited by 2,878
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380
Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., Galasko, D., Jin, S., Kaye, J., Levey, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050151 · Cited by 1,844
Dietary Intake of Antioxidants and Risk of Alzheimer Disease
Engelhart, M. J. (2002) · JAMA · doi:10.1001/jama.287.24.3223 · Cited by 1,080
Oxidative Alterations in Alzheimer's Disease
Markesbery, W. R., & Carney, J. M. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00215.x · Cited by 789
Bucks, R. S., Ashworth, D. L., Wilcock, G. K., & Siegfried, K. (1996) · Age and Ageing · doi:10.1093/ageing/25.2.113 · Cited by 581
Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant
Bowry, V. W., Ingold, K. U., & Stocker, R. (1992) · Biochemical Journal · doi:10.1042/bj2880341 · Cited by 511
Action of ascorbic acid as a scavenger of active and stable oxygen radicals
Niki, E. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1119s · Cited by 489
Cognitive deficits and associated neurological complications in individuals with Down's syndrome
Lott, I. T., & Dierssen, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70112-5 · Cited by 484
Self-citationNeuroanatomy of Down’s Syndrome: A High-Resolution MRI Study
Pinter, J. D., Eliez, S., Schmitt, J. E., Capone, G. T., & Reiss, A. L. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.10.1659 · Cited by 452
Ribosome Dysfunction Is an Early Event in Alzheimer's Disease
Ding, Q., Markesbery, W. R., Chen, Q., Li, F., & Keller, J. N. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3040-05.2005 · Cited by 433
Vitamin E for Alzheimer's dementia and mild cognitive impairment
Farina, N., Llewellyn, D. J., Isaac, M. G. E. K. N., & Tabet, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub5 · Cited by 424
Antioxidant Vitamin Intake and Risk of Alzheimer Disease
Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.203 · Cited by 414
Butterfield, D. A., Poon, H. F., St. Clair, D., Keller, J. N., Pierce, W. M., Klein, J. B., & Markesbery, W. R. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.002 · Cited by 377
Suarna, C., Dean, R. T., May, J. M., & Stocker, R. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.10.1616 · Cited by 356
Vitamin E and Cognitive Decline in Older Persons
Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., & Wilson, R. S. (2002) · Archives of Neurology · doi:10.1001/archneur.59.7.1125 · Cited by 346
Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage.
Frei, B. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1113s · Cited by 326
Panisset, M. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540130067012 · Cited by 325
Selective neuroanatornic abnormalities in Down's syndrome and their cognitive correlates
Raz, N., Torres, I. J., Briggs, S. D., Spencer, W. D., Thornton, A. E., Loken, W. J., Gunning, F. M., McQuain, J., Driesen, N. R., & Acker, J. D. (1995) · Neurology · doi:10.1212/wnl.45.2.356 · Cited by 297
Alzheimer's disease in Down syndrome: Neurobiology and risk
Zigman, W. B., & Lott, I. T. (2007) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20163 · Cited by 290
Self-citationHess, D., Keller, H., Oberlin, B., Bonfanti, R., & Schüep, W. (1991) · PubMed · Cited by 283
Guidi, S., Bonasoni, P., Ceccarelli, C., Santini, D., Gualtieri, F., Ciani, E., & Bartesaghi, R. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00113.x · Cited by 276
Neužil, J., Thomas, S. R., & Stocker, R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00224-9 · Cited by 263
Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment
Wang, J., Markesbery, W. R., & Lovell, M. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03615.x · Cited by 260
Dementia and mortality in persons with Down’s syndrome
Coppus, A. M. W., Evenhuis, H. M., Verberne, G., Visser, F. E., van Gool, W. A., Eikelenboom, P., & van Duijn, C. M. (2006) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2006.00842.x · Cited by 260
Oral α-Tocopherol Supplements Decrease Plasma γ-Tocopherol Levels in Humans
Handelman, G. J., Machlin, L. J., Fitch, K., Weiter, J. J., & Dratz, E. A. (1985) · The Journal of Nutrition · doi:10.1093/jn/115.6.807 · Cited by 260
A Randomized Trial of Vitamin E Supplementation and Cognitive Function in Women
Kang, J. H. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.22.2462 · Cited by 227
Lloret, A., Badía, M.-C., Mora, N. J., Pallardó, F. V., Alonso, M.-D., & Viña, J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1033 · Cited by 225
Milgram, N. W., Head, E., Zicker, S. C., Ikeda-Douglas, C. J., Murphey, H. L., Muggenburg, B. A., Siwak, C. T., Tapp, D., & Cotman, C. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.014 · Cited by 218
Self-citationDevaraj, S., Leonard, S., Traber, M. G., & Jialal, I. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.018 · Cited by 214
Prevention of Tocopherol-mediated Peroxidation in Ubiquinol-10-free Human Low Density Lipoprotein
Bowry, V. W., Mohr, D., Cleary, J., & Stocker, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.11.5756 · Cited by 212
Opii, W. O., Joshi, G., Head, E., Milgram, N. W., Muggenburg, B. A., Klein, J. B., Pierce, W. M., Cotman, C. W., & Butterfield, D. A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.012 · Cited by 202
Self-citationCotman, C. W., & Head, E. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15413 · Cited by 197
Self-citationHuang, H.-Y., & Appel, L. J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3137 · Cited by 187
Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction
Cotman, C. W., Head, E., Muggenburg, B. A., Zicker, S. C., & Milgram, N. W. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00073-8 · Cited by 186
Self-citationFaster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation
Bruno, R. S., Leonard, S. W., Atkinson, J., Montine, T. J., Ramakrishnan, R., Bray, T. Μ., & Traber, M. G. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.10.051 · Cited by 185
Prevalence of dementia in intellectual disability using different diagnostic criteria
Strydom, A., Livingston, G., King, M., & Hassiotis, A. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.028845 · Cited by 171
Dementia in people with Down's syndrome
Tyrrell, J., Cosgrave, M., McCarron, M., McPherson, J., Calvert, J., Kelly, A., McLaughlin, M., Gill, M., & LAWLOR, B. A. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.502 · Cited by 169
Coskun, P. E., Wyrembak, J., Derbereva, O., Melkonian, G., Doran, E. W., Lott, I. T., Head, E., Cotman, C. W., & Wallace, D. C. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100351 · Cited by 161
Self-citationα-Lipoic acid as a new treatment option for Alzheimer’s disease — a 48 months follow-up analysis
Häger, K., Kenklies, M., McAfoose, J., Engel, J., & Münch, G. W. (2007) · Springer eBooks · doi:10.1007/978-3-211-73574-9_24 · Cited by 155
Impact of antioxidants, zinc, and copper on cognition in the elderly
Age-Related Eye Disease Study Research Group (2004) · Neurology · doi:10.1212/01.wnl.0000142969.19465.8f · Cited by 149
Further evaluation of the Dementia Questionnaire for Persons with Mental Retardation (DMR)
Evenhuis, H. M. (1996) · Journal of Intellectual Disability Research · doi:10.1046/j.1365-2788.1996.786786.x · Cited by 148
Evaluation of a screening instrument for dementia in ageing mentally retarded persons
Evenhuis, H. M. (1992) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1992.tb00532.x · Cited by 138
Polidori, M. C., Mattioli, P., Aldred, S., Cecchetti, R., Stahl, W., Griffiths, H. R., Senin, U., Sies, H., & Mecocci, P. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000080027 · Cited by 135
Vitamin E for Alzheimer's disease and mild cognitive impairment
Isaac, M. G. E. K. N., Quinn, R., & Tabet, N. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub2 · Cited by 133
Antioxidant Vitamin Supplement Use and Risk of Dementia or Alzheimer's Disease in Older Adults
Gray, S. L., Anderson, M. L., Crane, P. K., Breitner, J. C. S., McCormick, W., Bowen, J. D., Teri, L., & Larson, E. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01531.x · Cited by 127
Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model
Lockrow, J. P., Prakasam, A., Huang, P., Bimonte‐Nelson, H. A., Sambamurti, K., & Granholm, A. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.11.021 · Cited by 126
Down's syndrome: A pathology involving the lack of balance of reactive oxygen species
Kȩdziora, J., & Bartosz, G. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90052-4 · Cited by 119
Early Glycoxidation Damage in Brains from Down's Syndrome
Odetti, P. R., Angelini, G., Dapino, D., Zaccheo, D., Garibaldi, S., Dagna-Bricarelli, F., Piombo, G., Perry, G. L., Smith, M. A., Traverso, N., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8186 · Cited by 118
Slonim, D. K., Koide, K., Johnson, K. L., Tantravahi, U., Cowan, J. M., Jarrah, Z., & Bianchi, D. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903909106 · Cited by 117
Molecular basis of pharmacotherapies for cognition in Down syndrome
Gardiner, K. (2009) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.10.010 · Cited by 113
Ishihara, K., Amano, K., Takaki, E., Shimohata, A., Sago, H., Epstein, C. J., & Yamakawa, K. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp176 · Cited by 113
Dementia and Alzheimer's Disease in Community-Dwelling Elders Taking Vitamin C and/or Vitamin E
Fillenbaum, G. G., Kuchibhatla, M. N., Hanlon, J. T., Artz, M. B., Pieper, C. F., Schmader, K. E., Dysken, M. W., & Gray, S. L. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1g280 · Cited by 113 · cited 3×
“…beenmixedwith some studies showing beneficial effects [Sano et al., 1997; Engelhart et al., 2002;Morris et al., 2002;Maxwell et al., 2005] and others absence of therapeutic efficacy [Luchsinger et al., 2003; Yaffe et al., 2004; Fillenbaum et al., 2005; Petersen et al., 2005; Kang et al., 2006].”
BackgroundVitamins in human arteriosclerosis with emphasis on vitamin C and vitamin E
Abudu, N., Miller, J. J., Attaelmannan, M., & Levinson, S. S. (2003) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.09.018 · Cited by 111
Supplemental Use of Antioxidant Vitamins and Subsequent Risk of Cognitive Decline and Dementia
Maxwell, C. J., Hicks, M. S., Hogan, D. B., Basran, J., & Ebly, E. M. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000085074 · Cited by 105
Antioxidant approaches for the treatment of Alzheimer’s disease
Lee, H. P., Zhu, X., Casadesús, G., Castellani, R. J., Nunomura, A., Smith, M. A., Lee, H., & Perry, G. L. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.74 · Cited by 104
Ellis, J., Tan, H. K., Gilbert, R. E., Muller, D. P. R., Henley, W., Moy, R. J., Pumphrey, R., Ani, C. C., Davies, S., Edwards, V., et al. (2008) · BMJ · doi:10.1136/bmj.39465.544028.ae · Cited by 102
Vitamin E for Alzheimer's disease and mild cognitive impairment
Isaac, M. G. E. K. N., Quinn, R., & Tabet, N. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854 · Cited by 96
ets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons
Helguera, P., Pelsman, A., Pigino, G., Wolvetang, E., Head, E., & Busciglio, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5107-04.2005 · Cited by 88
Self-citationChronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease
Siedlak, S. L., Casadesús, G., Webber, K. M., Pappolla, M. A., Atwood, C., Smith, M. A., & Perry, G. L. (2009) · Free Radical Research · doi:10.1080/10715760802644694 · Cited by 79
Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients
Pappert, E. J., Tangney, C., Goetz, C. G., Ling, Z. D., Lipton, J. W., Stebbins, G. T., & Carvey, P. M. (1996) · Neurology · doi:10.1212/wnl.47.4.1037 · Cited by 77
Dhitavat, S., Ortiz, D., Rogers, E. J., Rivera, E. R., & Shea, T. B. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.074 · Cited by 71
Pop, V., Head, E., Hill, M., Gillen, D. L., Berchtold, N. C., Muggenburg, B. A., Milgram, N. W., Murphy, M. P., & Cotman, C. W. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6194-09.2010 · Cited by 70
Self-citationOxidative stress and cognitive ability in adults with Down syndrome
Strydom, A., Dickinson, M. J., Shende, S., Praticò, D., & Walker, Z. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.10.006 · Cited by 62
Coenzyme Q10 (Ubiquinol-10) Supplementation Improves Oxidative Imbalance in Children With Trisomy 21
Miles, M. V., Patterson, B. J., Chalfonte-Evans, M., Horn, P. S., Hickey, F. J., Schapiro, M. B., Steele, P. E., Tang, P., & Hotze, S. L. (2007) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2007.08.003 · Cited by 52
Roat, E., Prada, N., Ferraresi, R., Giovenzana, C., Nasi, M., Troiano, L., Pinti, M., Nemes, E., Lugli, E., Biagioni, O., et al. (2007) · FEBS Letters · doi:10.1016/j.febslet.2006.12.058 · Cited by 51
Mitochondrial dysfunction in mouse trisomy 16 brain
Bambrick, L. L., & Fiskum, G. M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.045 · Cited by 51
Bléhaut, H., Mircher, C., Ravel, A., Conte, M., de Portzamparc, V., Poret, G., de Kermadec, F. H., Rethoré, M. O., & Sturtz, F. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008394 · Cited by 51
Stress, Aging, and Neurodegenerative Disorders: Molecular Mechanismsa
Busciglio, J. A., Andersen, J. K., Schipper, H. M., Gilad, G. M., McCarty, R. C., Marzatico, F., & Toussaint, O. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09021.x · Cited by 45
The response of γ vitamin E to varying dosages of α vitamin E plus vitamin C
Gutierrez, A., de Serna, D. G., Robinson, I., & Schade, D. S. (2009) · Metabolism · doi:10.1016/j.metabol.2008.11.003 · Cited by 37
Sparrow, S. S., & Cicchetti, D. V. (1984) · Applied Research in Mental Retardation · doi:10.1016/s0270-3092(84)80003-x · Cited by 35
Aguiar, A. S., Tuon, T., Albuquerque, M. M., Rocha, G. S., Speck, A. E., Araújo, J. C., Dafré, A. L., Prediger, R. D., & Pinho, R. A. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0120-x · Cited by 34
Gardette, V., Andrieu, S., Lapeyre‐Mestre, M., Coley, N., Cantet, C., Ousset, P., Grand, A., Monstastruc, J.-L., & Vellas, B. J. (2010) · CNS Drugs · doi:10.2165/11318010-000000000-00000 · Cited by 31
Assessment of Aging Individuals with Down Syndrome in Clinical Trials: Results of Baseline Measures
Sano, M. C., Aisen, P. S. S., Dalton, A. J., Andrews, H., & Tsai, W. (2005) · Journal of Policy and Practice in Intellectual Disabilities · doi:10.1111/j.1741-1130.2005.00021.x · Cited by 28
Complementary and alternative medicine in developmental disabilities
Brown, K., & Patel, D. R. (2005) · The Indian Journal of Pediatrics · doi:10.1007/bf02731671 · Cited by 27
Tiano, L., Carnevali, P., Padella, L., Santoro, L., Principi, F., Brugè, F., Carle, F., Gesuita, R., Gabrielli, O., & Littarru, G. P. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.11.016 · Cited by 27
Bialowas‐McGoey, L. A., Lesicka, A., & Whitaker‐Azmitia, P. M. (2008) · Glia · doi:10.1002/glia.20727 · Cited by 25
β-Amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome
Head, E., Lott, I. T., Cribbs, D. H., Cotman, C. W., & Rohn, T. T. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00705-x · Cited by 23
Self-citationEdland, S. D., Emond, J. A., Aisen, P. S. S., & Petersen, R. C. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181c9983f · Cited by 22
Retana-Ugalde, R., Casanueva, E., Altamirano-Lozano, M. A., González-Torres, C., & Mendoza-Núñez, V. M. (2008) · Annals of Nutrition and Metabolism · doi:10.1159/000129652 · Cited by 21
(2010) · Nature Neuroscience · doi:10.1038/nn0610-651 · Cited by 19
The Dyspraxia Scale for adults with Down syndrome
Dalton, A. J. (2008) · Springer eBooks · doi:10.1007/978-1-84800-249-4_5 · Cited by 14
Christie, L., Opii, W. O., & Head, E. (2008) · AGE · doi:10.1007/s11357-008-9063-2 · Cited by 10
Self-citation
Cited by
Sorted by citations
The role of antioxidants in the chemistry of oxidative stress: A review
Pisoschi, A. M., & Pop, A. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.04.040 · Cited by 2,963
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
Wiseman, F. K., Al-Janabi, T., Hardy, J., Karmiloff-Smith, A., Nizetic, D., Tybulewicz, V. L. J., Fisher, E. M. C., & Strydom, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3983 · Cited by 562
Vitamin E for Alzheimer's dementia and mild cognitive impairment
Farina, N., Llewellyn, D. J., Isaac, M. G. E. K. N., & Tabet, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub5 · Cited by 424
Gomes, M. B., & Negrato, C. A. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-80 · Cited by 275
Metadata
- Authors
- Lott, I. T., Doran, E., Nguyen, V. Q., Tournay, A., Head, E., & Gillen, D. L.
- Affiliations
- University of California, Irvine (US)
- University of Kentucky (US)
- Corresponding author
- Lott, Ira T.
- Venue
- American Journal of Medical Genetics Part A
- Publisher
- Wiley
- Published
- 2011-07-07
- Volume
- 155
- Issue
- 8
- Pages
- 1939-1948
- ISSN
- 1552-4825 (ISSN-L)
- 1552-4833
- PMC
- PMC3410645
- OpenAlex
- W2027752708
- Cited by
- 136
- References
- 85
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 14 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 15 · 2013: 5 · 2012: 22
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Medical Genetics Part A (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of California, Irvine
- National Institute on Aging (AG 21912, AG 16573, P50AG016573, R01AG021912, P50-AG-21912)
- National Center for Research Resources (UL1RR031985)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065160)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Down syndrome, dementia, Alzheimer-type dementia, antioxidant supplementation, alpha-tocopherol, vitamin C, alpha-lipoic acid, oxidative stress, cognitive decline, plasma vitamin E, treatment efficacy, trial feasibility
- MeSH terms
- Alzheimer Disease, Antioxidants, Ascorbic Acid, Down Syndrome, Drug Combinations, Feasibility Studies, Female, Humans, Thioctic Acid, Male, Middle Aged, Pilot Projects, Treatment Outcome, alpha-Tocopherol
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
