APOE alleles’ association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos‐investigation of neurocognitive aging (HCHS/SOL)
Open accessAbstract
Introduction: Apolipoprotein E ( APOE ) alleles are associated with cognitive decline, mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and inconsistent effects reported in Latinos. We hypothesized that this heterogeneity is due to ancestry‐specific genetic effects. Methods: We investigated the associations of the APOE alleles with significant cognitive decline and MCI in 4183 Latinos, stratified by six Latino backgrounds, and explored whether the proportion of continental genetic ancestry (European, African, and Amerindian) modifies these associations. Results: APOE ε4 was associated with an increased risk of significant cognitive decline (odds ratio [OR] = 1.15, P ‐value = 0.03), with the strongest association in Cubans (OR = 1.46, P ‐value = 0.007). APOE‐ ε2 was associated with decreased risk of MCI (OR = 0.37, P ‐value = 0.04) in Puerto Ricans. Amerindian genetic ancestry was found to protect from the risk conferred by APOE ε4 on significant cognitive decline. Discussion: Results suggest that APOE alleles' effects on cognitive outcomes differ across six Latino backgrounds and are modified by continental genetic ancestry.
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In a study of 4,183 individuals from six Latino backgrounds, the effect of APOE-e4 on cognitive decline differed among groups.
“They found that the effect of APOE‐e4 on cognitive decline differed among groups, suggesting that factors related to geographic background and genetic ancestry may alter the extent to which APOE‐e4 contributes to cognitive decline.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [96]
The Methods (Study population) report 4,183 participants, and the Results examine six Latino background groups. The Results find a significant APOE ε4 association with cognitive decline only among Cubans, and an ancestry interaction, but tests of differences between groups were not significant. The Discussion treats a true difference in effect among groups as a possibility, so saying the study found such a difference overstates its evidence. (LLM, conf=0.85)
Experimental — accuracy not yet measuredFactors related to geographic background and genetic ancestry may alter the extent to which APOE-e4 contributes to cognitive decline.
“They found that the effect of APOE‐e4 on cognitive decline differed among groups, suggesting that factors related to geographic background and genetic ancestry may alter the extent to which APOE‐e4 contributes to cognitive decline.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [96]
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- Authors
- Granot‐Hershkovitz, E., Tarraf, W., Kurniansyah, N., Daviglus, M., Isasi, C. R., Kaplan, R., Lamar, M., Perreira, K. M., Wassertheil‐Smoller, S., Stickel, A., Thyagarajan, B., Zeng, D., Fornage, M., DeCarli, C. S., González, H. M., & Sofer, T.
- Affiliations
- Brigham and Women's Hospital (US)
- Wayne State University (US)
- University of Illinois Chicago (US)
- Albert Einstein College of Medicine (US)
- Rush University Medical Center (US)
- University of North Carolina at Chapel Hill (US)
- Department of Epidemiology & Population Health Department of Pediatrics Albert Einstein College of Medicine Bronx New York USA
- University of California San Diego (US)
- University of Minnesota (US)
- The University of Texas Health Science Center at Houston (US)
- University of California, Davis (US)
- Corresponding author
- Sofer, Tamar
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2020-11-06
- Volume
- 17
- Issue
- 3
- Pages
- 466-474
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC8016734
- OpenAlex
- W3095885963
- Cited by
- 71
- References
- 45
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 9 · 2023: 17 · 2022: 14 · 2021: 1 · 2020: 1
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (R01AG048642, RF1AG054548, RF1AG061022, R21AG056952)
- National Heart, Lung, and Blood Institute (HHSN268201300001I/N01‐HC‐65233)
- University of Miami (HHSN268201300004I/N01‐HC‐65234)
- Albert Einstein College of Medicine, Yeshiva University (HHSN268201300002I/N01‐HC‐65235)
- University of Illinois at Chicago (HHSN268201300003I/N01‐HC‐65236)
- San Diego State University (HHSN268201300005I/N01‐HC‐65237)
- National Institute on Minority Health and Health Disparities
- National Institute on Deafness and Other Communication Disorders
- National Institute of Dental and Craniofacial Research (HHSN268201300005C AM03, MOD03)
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Neurological Disorders and Stroke
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- APOE alleles, APOE ε4
- MeSH terms
- Aged, Aging, Alleles, Alzheimer Disease, Cognition, Female, Genotype, Hispanic or Latino, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, South America, United States, Caribbean Region, Apolipoprotein E4, Cognitive Dysfunction
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