APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer's disease?
Open accessAbstract
In Alzheimer's disease (AD), the distribution of the amyloid precursor protein (APP) and its fragments other than amyloid beta, has not been fully characterized. Here, we investigate the distribution of APP and its fragments in human AD brain samples and in mouse models of AD in reference to its proteases, synaptic proteins, and histopathological features characteristic of the AD brain, by combining an extensive set of histological and analytical tools. We report that the prominent somatic distribution of APP observed in control patients remarkably vanishes in human AD patients to the benefit of dense accumulations of extra‐somatic APP, which surround dense‐core amyloid plaques enriched in APP‐Nter. These features are accentuated in patients with familial forms of the disease. Importantly, APP accumulations are enriched in phosphorylated tau and presynaptic proteins whereas they are depleted of post‐synaptic proteins suggesting that the extra‐somatic accumulations of APP are of presynaptic origin. Ultrastructural analyses unveil that APP concentrates in autophagosomes and in multivesicular bodies together with presynaptic vesicle proteins. Altogether, alteration of APP distribution and its accumulation together with presynaptic proteins around dense‐core amyloid plaques is a key histopathological feature in AD, lending support to the notion that presynaptic failure is a strong physiopathological component of AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
APP is a marker of axonal degeneration and accumulates in presynaptic terminals, indicative of dystrophic neurons surrounding amyloid plaques.
“Previous studies have established APP as a marker of axonal degeneration54,55 and demonstrated its accumulation in presynaptic terminals, indicative of dystrophic neurons surrounding amyloid plaques.56”
From Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease (2025) · cites this paper as [56]
The Results report APP accumulations around amyloid plaques enriched in presynaptic proteins, and the study conclusions describe presynaptic APP within dystrophic axons (page numbers unavailable). However, the paper places the accumulations at axon terminals only presumptively; it does not demonstrate that they are in presynaptic terminals. The axonal-degeneration marker claim is attached to citations 54 and 55, not this citation. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works
A guided tour into subcellular colocalization analysis in light microscopy
Bolte, S., & Cordelières, F. (2006) · Journal of Microscopy · doi:10.1111/j.1365-2818.2006.01706.x · Cited by 5,238 · see citing works
Self-citationGoate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659 · see citing works
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works
A new method for gray-level picture thresholding using the entropy of the histogram
Kapur, J. N., Sahoo, P. K., & Wong, A. K. C. (1985) · Computer Vision Graphics and Image Processing · doi:10.1016/0734-189x(85)90125-2 · Cited by 3,692 · see citing works
Protein aggregation and neurodegenerative disease
Ross, C. A., & Poirier, M. A. (2004) · Nature Medicine · doi:10.1038/nm1066 · Cited by 3,454 · see citing works
A protein factor essential for microtubule assembly
Weingarten, M. D., Lockwood, A. H., Hwo, S. Y., & Kirschner, M. W. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.5.1858 · Cited by 3,089 · see citing works
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works
Dendritic organization in the neurons of the visual and motor cortices of the cat.
Sholl, D. A. (1953) · Europe PMC (PubMed Central) · Cited by 2,204 · see citing works
A practical guide to evaluating colocalization in biological microscopy.
Dunn, K., Kamocka, M., & McDonald, J. (2011) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00462.2010 · Cited by 1,998 · see citing works
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., & Van Leuven, F. (1998) · Nature · doi:10.1038/34910 · Cited by 1,818 · see citing works
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91209-9 · Cited by 1,693 · see citing works
Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study
Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588 · see citing works
Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575 · see citing works
Axonal damage in acute multiple sclerosis lesions
Ferguson, B. (1997) · Brain · doi:10.1093/brain/120.3.393 · Cited by 1,532 · see citing works
Single App knock-in mouse models of Alzheimer’s disease
Saito, T., Matsuba, Y., Mihira, N., Takano, J., Nilsson, P., Itohara, S., Iwata, N., & Saido, T. C. (2014) · Nature Neuroscience · doi:10.1038/nn.3697 · Cited by 1,447 · see citing works
Rovelet‐Lecrux, A., Hannequin, D., Raux, G., Meur, N. L., Laquerrière, A., Vital, A., Dumanchin‐Njock, C., Feuillette, S., Brice, A., Vercelletto, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1718 · Cited by 1,249 · see citing works
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
Alzheimer’s disease: Clinical trials and drug development
Mangialasche, F., Solomon, A., Winblad, B., Mecocci, P., & Kivipelto, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70119-8 · Cited by 1,217 · see citing works
Lee, J.-H., Yu, W. H., Kumar, A., Lee, S., Mohan, P. S., Peterhoff, C. M., Wolfe, D. M., Martinez-Vicente, M., Massey, A. C., Sovak, G., et al. (2010) · Cell · doi:10.1016/j.cell.2010.05.008 · Cited by 1,212 · see citing works
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
Soto, C., & Pritzkow, S. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0235-9 · Cited by 1,180 · see citing works
Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host
Meyer-Luehmann, M., Coomaraswamy, J., Bolmont, T., Kaeser, S., Schaefer, C., Kilger, E., Neuenschwander, A., Abramowski, D., Frey, P., Jaton, A. L., et al. (2006) · Science · doi:10.1126/science.1131864 · Cited by 971 · see citing works
A new criterion for automatic multilevel thresholding
Yen, J.-C., Chang, F., & Chang, S. (1995) · IEEE Transactions on Image Processing · doi:10.1109/83.366472 · Cited by 939 · see citing works
Kuhlmann, T., Lingfeld, G., Bitsch, A., Schuchardt, J., & Brück, W. (2002) · Brain : a journal of neurology · doi:10.1093/brain/awf235 · Cited by 851 · see citing works
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
Scheff, S. W., Price, D. A., Schmitt, F. A., DeKosky, S. T., & Mufson, E. J. (2007) · Neurology · doi:10.1212/01.wnl.0000260698.46517.8f · Cited by 824 · see citing works
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
Koo, E. H., Sisodia, S. S., Archer, D. R., Martin, L. J., Weidemann, A., Beyreuther, K., Fischer, P., Masters, C. L., & Price, D. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1561 · Cited by 733 · see citing works
Clinical trials of new drugs for Alzheimer disease
Huang, L.-K., Chao, S.-P., & Hu, C.-J. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-019-0609-7 · Cited by 702 · see citing works
Motter, R., Vigo‐Pelfrey, C., Kholodenko, D., Barbour, R., Johnson‐Wood, K., Galasko, D., Chang, L., Miller, B., Clark, C., Green, R., et al. (1995) · Annals of Neurology · doi:10.1002/ana.410380413 · Cited by 701 · see citing works
Pattern Discrimination and the Visual Cortex
Sholl, D. A., & Uttley, A. M. (1953) · Nature · doi:10.1038/171387a0 · Cited by 605 · see citing works
Lemere, C. A., Blusztajn, J. K., Yamaguchi, H., Wisniewski, T., Saido, T. C., & Selkoe, D. J. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0003 · Cited by 584 · see citing works
β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury
Gentleman, S. M., Nash, M. J., Sweeting, C. J., Graham, D. I., & Roberts, G. W. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90398-5 · Cited by 570 · see citing works
Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis
Eisele, Y. S., Obermüller, U., Heilbronner, G., Baumann, F., Kaeser, S. A., Wolburg, H., Walker, L. C., Staufenbiel, M., Heikenwalder, M., & Jucker, M. (2010) · Science · doi:10.1126/science.1194516 · Cited by 568 · see citing works
ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion
Huang, Y.-W. A., Zhou, B., Wernig, M., & Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2016.12.044 · Cited by 528 · see citing works
Knopman, D. S., Jones, D. T., & Greicius, M. D. (2021) · Alzheimer's & Dementia · doi:10.1002/alz.12213 · Cited by 524 · see citing works
Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H.-C., Xu, G., Koliatsos, V. E., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2766-05.2005 · Cited by 521 · see citing works
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
Bentahir, M., Nyabi, O., Verhamme, J., Tolia, A., Horré, K., Wiltfang, J., Esselmann, H., & Strooper, B. D. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03578.x · Cited by 412 · see citing works
Sleegers, K., Brouwers, N., Gijselinck, I., Theuns, J., Goossens, D., Wauters, J., Del‐Favero, J., Cruts, M., van Duijn, C. M., & Broeckhoven, C. V. (2006) · Brain · doi:10.1093/brain/awl203 · Cited by 406 · see citing works
Sun, L., Zhou, R., Yang, G., & Shi, Y. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618657114 · Cited by 382 · see citing works
Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease
Gouras, G. K., Almeida, C. G., & Takahashi, R. H. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.022 · Cited by 338 · see citing works
Jiang, Y., Mullaney, K. A., Peterhoff, C. M., Che, S., Schmidt, S. D., Boyer‐Boiteau, A., Ginsberg, S. D., Cataldo, A. M., Mathews, P. M., & Nixon, R. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908953107 · Cited by 288 · see citing works
de Wilde, M. C., Overk, C., Sijben, J., & Masliah, E. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.12.005 · Cited by 273 · see citing works
The Synaptic Vesicle Protein CSPα Prevents Presynaptic Degeneration
Fernández‐Chacón, R., Wölfel, M., Nishimune, H., Tabares, L., Schmitz, F., Castellano-Muñoz, M., Rosenmund, C., Montesinos, M. L., Sanes, J. R., Schneggenburger, R., et al. (2004) · Neuron · doi:10.1016/s0896-6273(04)00190-4 · Cited by 268 · see citing works
Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia
Mesulam, M. M., & Geula, C. (1994) · Annals of Neurology · doi:10.1002/ana.410360506 · Cited by 259 · see citing works
Alzheimer's disease and Down's syndrome
Mann, D. M. A. (1988) · Histopathology · doi:10.1111/j.1365-2559.1988.tb02018.x · Cited by 246 · see citing works
Ultrastructural Studies of the Cells Forming Amyloid Fibers in Classical Plaques
Wisniewski, H. M., Węgiel, J., WANG, K. C., Kujawa, M., & Lach, B. (1989) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100029887 · Cited by 244 · see citing works
Kandalepas, P. C., Sadleir, K. R., Eimer, W. A., Zhao, J., Nicholson, D. A., & Vassar, R. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1152-3 · Cited by 240 · see citing works
Sanchez-Varo, R., Trujillo-Estrada, L., Sanchez-Mejias, E., Torres, M., Baglietto-Vargas, D., Moreno-Gonzalez, I., De Castro, V., Jimenez, S., Ruano, D., Vizuete, M., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0896-x · Cited by 222 · see citing works
Woodruff, G., Young, J. E., Martinez, F. J., Buen, F., Gore, A., Kinaga, J., Li, Z., Yuan, S. H., Zhang, K., & Goldstein, L. S. B. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.018 · Cited by 177 · see citing works
Arai, H., Lee, V. M., Otvos, L. P., Greenberg, B., Lowery, D. E., Sharma, S., Schmidt, M. L., & Trojanowski, J. Q. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.6.2249 · Cited by 155 · see citing works
Delaère, P., He, Y., Fayet, G., Duyckaerts, C., & Hauw, J.-J. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90096-t · Cited by 149 · see citing works
CSPα knockout causes neurodegeneration by impairing SNAP‐25 function
Sharma, M., Burré, J., Bronk, P., Zhang, Y., Xu, W., & Südhof, T. C. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.467 · Cited by 143 · see citing works
Neely, K. M., Green, K. N., & LaFerla, F. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5156-10.2010 · Cited by 141 · see citing works
Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons
Yu, L., Tasaki, S., Schneider, J. A., Arfanakis, K., Duong, D. M., Wingo, A. P., Wingo, T. S., Kearns, N., Thatcher, G. R. J., Seyfried, N. T., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.1807 · Cited by 127 · see citing works
Zhang, X., Garbett, K., Veeraraghavalu, K., Wilburn, B., Gilmore, R., Mirnics, K., & Sisodia, S. S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0556-12.2012 · Cited by 122 · see citing works
Cummings, B. J., Su, J. H., Geddes, J. W., Van Nostrand, W. E., Wagner, S. L., Cunningham, D. D., & Cotman, C. W. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90265-4 · Cited by 120 · see citing works
Zhang, X., Cai, Y., Xiong, K., Cai, H., Luo, X., Feng, J., Clough, R. W., Struble, R. G., Patrylo, P. R., & Yan, X. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07017.x · Cited by 117 · see citing works
Su, J. H., Cummings, B. J., & Cotman, C. W. (1994) · Neuroreport · doi:10.1097/00001756-199411000-00037 · Cited by 110 · see citing works
Peng, L., Liu, H., Ruan, H., Tepp, W. H., Stoothoff, W. H., Brown, R. H., Johnson, E. A., Yao, W., Zhang, S., & Dong, M. (2013) · Nature Communications · doi:10.1038/ncomms2462 · Cited by 108 · see citing works
Masliah, E., Mallory, M. E., Hansen, L. A., Alford, M. F., DeTeresa, R. M., & Terry, R. D. (1993) · PubMed Central · Cited by 107 · see citing works
Cognitive reserve, presynaptic proteins, and dementia in the elderly
Honer, W. G., Barr, A. M., Sawada, K., Thornton, A. E., Morris, M. C., Leurgans, S. E., Schneider, J. A., & Bennett, D. A. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.38 · Cited by 100 · see citing works
Sequential formation of different layers of dystrophic neurites in Alzheimer’s brains
Sharoar, M. G., Hu, X., Ma, X.-M., Zhu, X., & Yan, R. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0396-2 · Cited by 87 · see citing works
BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology
Peters, F., Salihoglu, H., Rodrigues, E. F., Herzog, É., Blume, T., Filser, S., Dorostkar, M. M., Shimshek, D. R., Brose, N., Neumann, U., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1804-9 · Cited by 86 · see citing works
ENGAGE and EMERGE: Truth and consequences?
Kuller, L. H., & López, O. L. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12286 · Cited by 85 · see citing works
Cacquevel, M., Aeschbach, L., Houacine, J., & Fraering, P. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035133 · Cited by 75 · see citing works
Kohli, B. M., Pflieger, D., Mueller, L. N., Carbonetti, G., Aebersold, R. H., Nitsch, R. M., & Konietzko, U. (2012) · Journal of Proteome Research · doi:10.1021/pr300123g · Cited by 74 · see citing works
Presynaptic failure in Alzheimer's disease
Barthet, G., & Mulle, C. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101801 · Cited by 74 · see citing works
Self-citationHeeroma, J. H., Roelandse, M., Wierda, K. D. B., van Aerde, K. I., Toonen, R. F. G., Hensbroek, R. A., Brussaard, A. B., Matus, A. I., & Verhage, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03503.x · Cited by 71 · see citing works
Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
Barthet, G., Jordá-Siquier, T., Rumi, J., Bernadou, F., Müller, U. C., & Mulle, C. (2018) · Nature Communications · doi:10.1038/s41467-018-06813-x · Cited by 66 · see citing works
Self-citationPresenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo
Gunawardena, S., Yang, G., & Goldstein, L. S. B. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt237 · Cited by 66 · see citing works
Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
Checler, F., Afram, E., Pardossi‐Piquard, R., & Lauritzen, I. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100489 · Cited by 61 · see citing works
High-Resolution Electron Microscopic Analysis of the Amyloid Fibril in Alzheimerʼs Disease
Narang, H. K. (1980) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198011000-00001 · Cited by 56 · see citing works
Peters, F., Salihoglu, H., Pratsch, K., Herzog, É., Pigoni, M., Sgobio, C., Lichtenthaler, S. F., Neumann, U., & Herms, J. W. (2019) · The EMBO Journal · doi:10.15252/embj.2019102345 · Cited by 43 · see citing works
Cellular mechanisms of γ-secretase substrate selection, processing and toxicity
Barthet, G., Georgakopoulos, A., & Robakis, N. K. R. K. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.006 · Cited by 42 · see citing works
Self-citationUmehara, F., Abé, M., Koreeda, Y., Izumo, S., & Osame, M. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00324-5 · Cited by 41 · see citing works
Loss of presenilin function is associated with a selective gain of APP function
Deyts, C., Clutter, M., Herrera, S., Jovanovic, N., GODDI, A. A., & Parent, A. (2016) · eLife · doi:10.7554/elife.15645 · Cited by 40 · see citing works
Barthet, G., Shioi, J., Shao, Z., Ren, Y., Georgakopoulos, A., & Robakis, N. K. R. K. (2011) · The FASEB Journal · doi:10.1096/fj.11-183806 · Cited by 33 · see citing works
Self-citationHaytural, H., Mermelekas, G., Emre, C., Nigam, S. M., Carroll, S. L., Winblad, B. G., Bogdanović, N., Barthet, G., Granholm, A., Orre, L. M., et al. (2019) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra119.001737 · Cited by 29 · see citing works
Self-citationD’Andrea, M. R., & Nagele, R. G. (2002) · Biotechnic & Histochemistry · doi:10.1080/bih.77.2.95.103 · Cited by 25 · see citing works
Haytural, H., Jordá-Siquier, T., Winblad, B. G., Mulle, C., Tjernberg, L. O., Granholm, A., Frykman, S., & Barthet, G. (2021) · Brain Communications · doi:10.1093/braincomms/fcab079 · Cited by 24 · see citing works
Self-citationAxonal injury in experimental herpes simplex encephalitis
Mori, I., Goshima, F., Mizuno, T., Imai, Y., Kohsaka, S., Ito, H., Koide, N., Yoshida, T., Yokochi, T., Kimura, Y., et al. (2005) · Brain Research · doi:10.1016/j.brainres.2005.07.037 · Cited by 11 · see citing works
Neuropathology of Abusive Head Trauma
Rorke-Adams, L. B. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6393-3.00045-2 · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 85 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [57]Barthet G, Mulle C. Presynaptic failure in Alzheimer's disease. Prog Neurobiol. 2020; 194: 101801. 32428558
Cited by
Sorted by citations
Prakash, P., Manchanda, P., Paouri, E., Bisht, K., Sharma, K., Rajpoot, J., Wendt, V., Hossain, A., Wijewardhane, P. R., Randolph, C. E., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.029 · Cited by 104 · see citing works
Tian, C., Stewart, T., Hong, Z., Guo, Z., Aro, P., Soltys, D., Pan, C., Peskind, E. R., Zabetian, C. P., Shaw, L. M. J., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12723 · Cited by 80 · see citing works
Maniv, I., Sarji, M., Bdarneh, A., Feldman, A., Ankawa, R., Koren, E., Magid-Gold, I., Reis, N., Soteriou, D., Salomon‐Zimri, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41545-7 · Cited by 52 · see citing works
McMillan, I. O., Li, J., & Wang, L. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00247.2022 · Cited by 42 · see citing works
The paradigm and future value of the metaverse for the intervention of cognitive decline
Zhou, H., Gao, J.-Y., & Chen, Y. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1016680 · Cited by 35 · see citing works
Hou, X., Zhang, X., Zou, H., Guan, M., Fu, C., Wang, W., Zhang, Z.-R., Geng, Y., & Chen, Y. (2023) · Neuron · doi:10.1016/j.neuron.2023.03.024 · Cited by 22 · see citing works
Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01637-3 · Cited by 20 · see citing works
Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice
Lin, L., Petralia, R. S., Holtzclaw, L. A., Wang, Y., Abebe, D. T., & Hoffman, D. A. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105887 · Cited by 16 · see citing works
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05008-x · Cited by 18 · see citing works
Sadleir, K. R., Gómez, K., Edwards, A. E., Patel, A. J., Ley, M. L., Khatri, A. W., Guo, J., Mahesh, S., Watkins, E. A., Popović, J., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02888-1 · Cited by 15 · see citing works
The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses
Lenz, M., Eichler, A., Kruse, P., Galanis, C., Kleidonas, D., Andrieux, G., Boerries, M., Jedlička, P., Müller, U., Deller, T., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1824-22.2023 · Cited by 13 · see citing works
Self-citationAstrocytic Hevin/ SPARCL ‐1 Regulates Cognitive Decline in Pathological and Normal Brain Aging
Cabral‐Miranda, F., Araújo, A. P. B., Medinas, D. B., & Gomes, F. C. A. (2025) · Aging Cell · doi:10.1111/acel.14493 · Cited by 12 · see citing works
Feole, M., Devoto, V. M. P., Dragišić, N., Arnaiz, C., Bianchelli, J., Texlova, K., Kovačovicova, K. L., Novotný, J., Havas, D., Falzone, T. L., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107137 · Cited by 8 · see citing works
Harris, S., Rajani, R. M., Zünkler, J., Ellingford, R. A., Yang, M., Rowland, J. M., Schmidt, A., Lee, B. I., Kehring, M., Hellmuth, M., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115801 · Cited by 7 · see citing works
Self-citationZhou, Y., Jiang, L. H., Zhang, Y., Zhou, C., Yang, H., He, Q., Wang, Y., Xiao, Q., Huang, D., Luo, Y., et al. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.02.005 · Cited by 6 · see citing works
Guo, Q., Wu, G., Huang, F., Wei, Z. C., Wang, J., Zhang, B., Liu, R., Yang, Y., Wang, X., & Li, H. (2022) · Aging · doi:10.18632/aging.204336 · Cited by 7 · see citing works
Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulation
Danhash, E., Verbeck, A. C., Western, D., Díaz‐Pacheco, A. S., Galasso, G., You, S., Huang, G., Starr, E., Miller, N., Nadarajah, C. J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70580 · Cited by 6 · see citing works
Pan, W., Teng, Y., Han, X., Liu, S., Pang, X., Wang, L., & Zhao, M. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100193 · Cited by 5 · see citing works
Alkhatabi, H. A., & Pushparaj, P. N. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41266 · Cited by 4 · see citing works
A synapse perspective on the function of the amyloid precursor protein
Kruse, P., Eichler, A., Klukas, L., & Lenz, M. (2025) · Science Progress · doi:10.1177/00368504251360728 · Cited by 3 · see citing works
Ahangaran, S., Pourgholaminejad, A., Nosrati, R., & Babaei, P. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115919 · Cited by 5 · see citing works
Ellingford, R. A., Harris, S., Kehring, M., Rajani, R. M., Lam, F. K. W., Graykowski, D. R., Böken, D., Welikovitch, L. A., Khasnavis, A., Laban, R., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.02.027 · Cited by 6 · see citing works
SPIN90 Deficiency Ameliorates Amyloid β Accumulation by Regulating APP Trafficking in AD Model Mice
Oh, Y., Lee, W., Kim, S. H., Lee, S., Kim, B. C., Lee, K., Kim, S. H., & Song, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810563 · Cited by 4 · see citing works
Ionic liquid-functionalized carbon dots for inhibiting amyloid aggregation and oxidative stress
Wang, C., Shao, X., Fan, T., Cao, X., Wang, X., Guan, P., & Hu, X. (2024) · Journal of Materials Science · doi:10.1007/s10853-024-09564-x · Cited by 3 · see citing works
Gerlikhman, L., Das, U., & Sarkar, D. K. (2023) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2023-0003 · Cited by 5 · see citing works
The Therapeutic Effects of Seven Lycopodium Compounds on Cell Models of Alzheimer’s Disease
Guo, Q., Cai, Q., Huang, F., Wei, Z. C., Wang, J., Zhang, B., Liu, R., Yang, Y., Wang, X., & Li, H. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220704 · Cited by 3 · see citing works
Wang, X., Liu, Y., Fu, J., Li, Y., Zhao, M., & Tian, Q. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100422 · Cited by 2 · see citing works
XIth Cajal Conference: New frontiers in neuron‐glial plasticity in health and disease
Louail, A., de Tena, I. B., Rojas, R., & Casals, N. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15960 · Cited by 2 · see citing works
Zhang, Q., Wang, Y., Coulibaly, S., Sun, Z.-P., Cai, X.-L., Tu, T., Liu, Y., Pan, A., Cui, M., Manavis, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.11.622955 · Cited by 2 · see citing works
Jordá-Siquier, T., Scholler, J., Gantar, I., Policet-Bétend, H., Batti, L., Pagès, S., Kövari, E., & Lamy, C. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.10.693496 · Cited by 2 · see citing works
Self-citationWang, Y., Sun, Z., Zhou, P., Tu, T., Zhang, X.-J., Tu, E., Chen, H., Cheng, H.-Y., Pan, A., Zhang, Q., et al. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.03.032 · Cited by 1 · see citing works
Presynaptic accumulation of APP-CTFβ may contribute to synaptic dysfunction in Alzheimer’s disease
Kapadia, A., Schuhmann, F., Daşkın, E., Walter, J., Lindahl, I., Rahmani, N., Morrema, T. H. J., Rozemüller, A. J. M., Boon, B. D. C., Pezeshkian, W., et al. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00899-6 · Cited by 1 · see citing works
Sharma, G., Krishnarjuna, B., Hiiuk, V. M., Ivanova, M. I., Nagorny, P., & Ramamoorthy, A. (2025) · Protein Science · doi:10.1002/pro.70276 · Cited by 1 · see citing works
Feole, M., & Stokin, G. B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.17.516829
Chiang, V. S., Lipkin, S., McCusker, C., & Park, J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.08.519640
Whole-exome sequencing detected a novel APP variant in a Han-Chinese family with Alzheimer’s disease
Zhaoxia, W., Chenyu, W., ZhuangZhuang, Y., Liangliang, F., Lin, X., & Tang, T. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08400-w
Nguyen, H. D., Vu, G. H., & Kim, W. (2024) · Gene Reports · doi:10.1016/j.genrep.2024.101920
Transmembrane and coiled‐coil 2 associates with Alzheimer's disease pathology in the human brain
Hopkins, P. C. R., Troakes, C., King, A., & Tear, G. (2024) · Brain Pathology · doi:10.1111/bpa.13290
Yu, G., Xu, S., Wang, Q., Li, J., Li, J., Wang, R., Zhang, L., Xie, W., Wen, S., Li, M., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-5965581/v1
Wang, Y., Zhang, Q.-L., Zhou, P., Tu, T., Sun, Z.-P., Zhang, X.-J., Tu, E., Chen, H., Cheng, H., Pan, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.16.670658
Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614915
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694843
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694840
Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614924
Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614909
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694825
Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614918
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694849
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694861
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694837
Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614921
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694834
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694846
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694858
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694852
Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614927
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694831
Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614906
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694828
Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614912
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Figshare · doi:10.6084/m9.figshare.26694855
Ackley, C., Liau, Z., Arya, S., Antee, T., Cheang, E. S., Knudsen, G. M., Lane‐Donovan, C., Sampognaro, P. J., & Kao, A. W. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-025-00017-6
Zhao, Z., Yang, L., Zhang, Z., Song, J., Zhang, C., & Duan, X. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031599
Moreira-de-Sá, A. (2024) · theses.fr (ABES) · doi:10.70675/3e418ab2ze9a3z43e4z9d87ze5870aefddac
Neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD Alzheimer’s disease model mice
Sadleir, K. R., Gomez, K. P., Chandra, S., Ley, M. L., Khatri, A. W., Guo, J., Xue, Y., Cepko, C. L., & Vassar, R. J. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-026-02097-2
Untiveros, G., Germain, R. S., Barrington, B., Kujawa, S. A., Prakapenka, A. V., & Strizzi, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27135885
APP-CTFβ/C99 Oligomers Drive Synaptic Vesicle Tethering through C-Terminal InteractionsPreprint
Kapadia, A., Cijffers, E., Van, S., & Hafner, A. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7162192 · Cited by 1 · see citing works
The Genetics and Mechanisms of Alzheimer's Disease in Down Syndrome
Bourin, M. (2026) · Journal of Mental Health Disorders · doi:10.33696/mentalhealth.6.069
Tu, T., Zhang, Q., Sun, Z., Kang, C., Li, D., Huo, X., Zhang, X.-J., Zhang, Y., Cui, M., Pan, A., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71778
Sadleir, K. R. (2025) · Galter Health Sciences Library, Northwestern University · doi:10.18131/0m0ef-phj22
- Authors
- Jordà‐Siquier, T., Petrel, M., Kouskoff, V., Smailovic, U., Cordelières, F., Frykman, S., Müller, U., Mulle, C., & Barthet, G.
- Affiliations
- University Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297 Bordeaux France
- University Bordeaux, CNRS, INSERM, Bordeaux Imaging Center, BIC, UMS 3420, US 4 Bordeaux France
- Centre National de la Recherche Scientifique (FR)
- Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society Karolinska Institutet Solna Sweden
- Karolinska Institutet (SE)
- Heidelberg University (DE)
- Corresponding author
- Barthet, Gaël
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2022-01-25
- Volume
- 18
- Issue
- 11
- Pages
- 2099-2116
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC9786597
- OpenAlex
- W4210588922
- Cited by
- 63
- References
- 85
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 22 · 2023: 9 · 2022: 9
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Fondation pour la Recherche Médicale (#DEQ20160334900)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid precursor protein, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Animals, Brain, Humans, Mice, Transgenic, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Mice, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review