βA4 deposits are constant in the brain of the oldest old: An immunocytochemical study of 20 french centenarians
Abstract
beta A4 deposits occur in the brain of some individuals over 50 years of age. It could be a part of the aging process or indicate a disease found frequently in the elderly. To address this question, beta A4 immunocytochemistry was performed on the brain of 15 nondemented and 5 demented centenarians, some of whom were affected by Alzheimer's disease. We found beta A4 deposits in the parahippocampal and the superior temporal gyri of all the cases, whatever the clinical state. The hippocampus was frequently spared. The lesion density was not correlated with the severity of the mental deterioration. The constant deposition of beta A4 protein in the brain of very old people indicates that this process does not spare a large proportion of this population. This result favors beta A4 accumulation in the brain being an ineluctable age-related process.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Autopsy studies reveal at the time of death, brains from cognitively normal individuals frequently contain plaques.
“Autopsy studies reveal at the time of death, brains from cognitively normal individuals frequently contain plaques [77, 234-237].”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [236]
Since most young individuals will develop Aβ deposits if they live long enough, almost the entire population that doesn't already have AD is on their way to developing AD.
“Also, since most young individuals will develop Aβ deposits if they live long enough [9, 54, 79], almost the entire population that doesn’t already have AD is on their way to developing AD [3].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [79]
Brains from individuals surviving to age 85 and beyond have at least some degree of plaque and tangle pathology.
“Brain histology surveys suggest that brains from individuals surviving to age 85 and beyond have at least some degree of plaque and tangle pathology [9, 54, 79].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [79]
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Diagnostic and Statistical Manual of Mental Disorders, 3rd ed
Cooper, A. M., & Michels, R. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.1.128 · Cited by 7,417 · see citing works
Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659 · see citing works
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499 · see citing works
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084 · see citing works
Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus
Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L. (1987) · Science · doi:10.1126/science.2949367 · Cited by 1,611 · see citing works
Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U., & Gajdusek, D. C. (1987) · Science · doi:10.1126/science.3810169 · Cited by 1,333 · see citing works
Chartier-Harlin, M.-C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., Roques, P., Hardy, J., et al. (1991) · Nature · doi:10.1038/353844a0 · Cited by 1,214 · see citing works
Observations on the brains of non-demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1968) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(68)90154-8 · Cited by 681 · see citing works
Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease
Rumble, B. A., Retallack, R. W., Hilbich, C., Simms, G., Multhaup, G., Martins, R. N., Hockey, A., Montgomery, P., Beyreuther, K. T., & Masters, C. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906013202203 · Cited by 652 · see citing works
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643 · see citing works
Crystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Masdeu, J., Kawas, C., Aronson, M., & Wolfson, L. (1988) · Neurology · doi:10.1212/wnl.38.11.1682 · Cited by 586 · see citing works
Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.
Selkoe, D. J., Bell, D., Podlisny, M., Price, D. L., & Cork, L. (1987) · Science · doi:10.1126/science.3544219 · Cited by 471 · see citing works
βA4 amyloid protein deposition in brain after head trauma
Roberts, G., Gentleman, S., Lynch, A., & Graham, D. I. (1991) · The Lancet · doi:10.1016/0140-6736(91)92724-g · Cited by 440 · see citing works
Alzheimer's disease in Down's syndrome: Clinicopathologic studies
Wisniewski, K. E., Dalton, A. J., McLachlan, D. R. C., Wen, G. Y., & Wisniewski, H. M. (1985) · Neurology · doi:10.1212/wnl.35.7.957 · Cited by 417 · see citing works
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease
Davies, L., Wolska, B., Hilbich, C., Multhaup, G., Martins, R. N., Simms, G., Beyreuther, K. T., & Masters, C. L. (1988) · Neurology · doi:10.1212/wnl.38.11.1688 · Cited by 369 · see citing works
Robakis, N., Wisniewski, H., Jenkins, E. C., Devine-Gage, E. A., Houck, G. E., Yao, X., Ramakrishna, N., Wolfe, G. C., Silverman, W., & Brown, W. T. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91754-5 · Cited by 268 · see citing works
Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease
Palmert, M. R., Golde, T. E., Cohen, M. L., Kovacs, D. M., Tanzi, R. E., Gusella, J. F., Usiak, M., Younkin, L. H., & Younkin, S. G. (1988) · Science · doi:10.1126/science.2457949 · Cited by 256 · see citing works
Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques
Giaccone, G., Tagliavini, F., Linoli, G., Bouras, C., Frigerio, L., Frangione, B., & Bugiani, O. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90169-9 · Cited by 231 · see citing works
Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease
Wisniewski, H. M., Bancher, C., Barcikowska, M., Wen, G. Y., & Currie, J. (1989) · Acta Neuropathologica · doi:10.1007/bf00688170 · Cited by 221 · see citing works
Beyreuther, K., & Masters, C. L. (1991) · Brain Pathology · doi:10.1111/j.1750-3639.1991.tb00667.x · Cited by 221 · see citing works
Zimmerman, H. M. (1986) · Surgical Neurology · doi:10.1016/0090-3019(86)90249-1 · Cited by 194 · see citing works
Delaère, P., Duyckaerts, C., Masters, C., Beyreuther, K., Piette, F., & Hauw, J.-J. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90391-l · Cited by 186 · see citing works
Self-citationDelaère, P., Duyckaerts, C. J., He, Y., Piette, F., & Hauw, J. (1991) · Acta Neuropathologica · doi:10.1007/bf00305876 · Cited by 173 · see citing works
Self-citationSenile Dementia of the Alzheimer Type
Traber, J., & Gispen, W. H. (1985) · Advances in applied neurological sciences · doi:10.1007/978-3-642-70644-8 · Cited by 170 · see citing works
Laminar distribution of neocortical senile plaques in senile dementia of the alzheimer type
Duyckaerts, C. J., Hauw, J., Bastenaire, F., Piette, F., Poulain, C., Rainsard, V., Javoy-Agid, F., & Berthaux, P. (1986) · Acta Neuropathologica · doi:10.1007/bf00686079 · Cited by 151 · see citing works
Self-citationAbsence of Duplication of Chromosome 21 Genes in Familial and Sporadic Alzheimer's Disease
George‐Hyslop, P. S., Tanzi, R. E., Polinsky, R. J., Neve, R. L., Pollen, D. A., Drachman, D. A., Growdon, J. H., Cupples, L. A., Nee, L. E., Myers, R. H., et al. (1987) · Science · doi:10.1126/science.2890206 · Cited by 142 · see citing works
The Amyloid β Protein Gene Is Not Duplicated in Brains from Patients with Alzheimer's Disease
Tanzi, R. E., Bird, E. D., Latt, S. A., & Neve, R. L. (1987) · Science · doi:10.1126/science.2890207 · Cited by 139 · see citing works
D�laere, P., Duyckaerts, C. J., Brion, J., Poulain, V., & Hauw, J. (1989) · Acta Neuropathologica · doi:10.1007/bf00687893 · Cited by 135 · see citing works
Self-citationBrion, J., Hanger, D. P., Couck, A. M., & Anderton, B. H. (1991) · Biochemical Journal · doi:10.1042/bj2790831 · Cited by 109 · see citing works
Duyckaerts, C. J., Delaère, P., Hauw, J., Abbamondi-Pinto, A. L., Sorbi, S., Allen, I. E., Brion, J., Flament-Durand, J., Duchen, L. W., Kauss, J., et al. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90226-d · Cited by 99 · see citing works
Self-citationDuyckaerts, C., Delaère, P., Poulain, V., Brion, J.-P., & Hauw, J.-J. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90706-9 · Cited by 65 · see citing works
Self-citationThe Pathology of the Aging Human Nervous System.
Hulette, C. M. (1991) · American Journal of Clinical Pathology · doi:10.1093/ajcp/96.6.778a · Cited by 62 · see citing works
Hauw, J., Vignolo, P., Duyckaerts, C. J., Beck, H., Forette, F., Henry, J. F., Laurent, M., Piette, F., Sachet, A., & Berthaux, P. (1986) · PubMed · Cited by 48 · see citing works
Self-citationProcessing of the Alzheimer's Disease ΒZA4 Amyloid Protein Precursor (APP)
Younkin, S. G. (1991) · Brain Pathology · doi:10.1111/j.1750-3639.1991.tb00668.x · Cited by 36 · see citing works
Neuronal loss and neuronal atrophy. Computer simulation in connection with Alzheimer's disease
Duyckaerts, C. J., Llamas, E., Delaère, P., Miele, P., & Hauw, J. (1989) · Brain Research · doi:10.1016/0006-8993(89)91602-8 · Cited by 17 · see citing works
Self-citationOgomori, K., Kitamoto, T., Tateishi, J., Sato, Y., & Tashima, T. (1988) · Journal of Gerontology · doi:10.1093/geronj/43.6.b157 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Preclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria
Dubois, B., Hampel, H., Feldman, H. H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Benali, H., Bertram, L., Blennow, K., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.002 · Cited by 1,925 · see citing works
Self-citationLife and Death of Neurons in the Aging Brain
Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344 · see citing works
The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786 · see citing works
Alzheimer's Disease: From Pathology to Therapeutic Approaches
Jakob‐Roetne, R., & Jacobsen, H. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802808 · Cited by 626 · see citing works
Morris, J. C., & Price, J. L. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:101 · Cited by 513 · see citing works
Alzheimer disease models and human neuropathology: similarities and differences
Duyckaerts, C. J., Potier, M., & Delatour, B. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0312-8 · Cited by 441 · see citing works
Self-citationSaura, J., Luque, J. M., Cesura, A. M., Prada, M. D., Chan‐Palay, V., Huber, G., Löffler, J., & Richards, J. G. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90311-5 · Cited by 385 · see citing works
Are reactive oxygen species involved in Alzheimer's disease?
Benzi, G. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00066-n · Cited by 365 · see citing works
PART is part of Alzheimer disease
Duyckaerts, C. J., Braak, H., Brion, J., Buée, L., Tredici, K. D., Goedert, M., Halliday, G. M., Neumann, M., Spillantini, M. G., Tolnay, M., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1390-7 · Cited by 316 · see citing works
Self-citationImaging the default mode network in aging and dementia
Hafkemeijer, A., van der Grond, J., & Rombouts, S. A. R. B. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.07.008 · Cited by 310 · see citing works
Jeremic, D., Jiménez-Díaz, L., & Navarro-López, J. D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101496 · Cited by 306 · see citing works
Brain aging, Alzheimer's disease, and mitochondria
Swerdlow, R. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.012 · Cited by 306 · see citing works
A walk through tau therapeutic strategies
Jadhav, S., Ávila, J., Schöll, M., Kovács, G. G., Kövari, E., Škrabana, R., Evans, L., Kontseková, E., Malawska, B., de Silva, R., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0664-z · Cited by 286 · see citing works
Prevalence of dementia disorders in the oldest-old: an autopsy study
Jellinger, K. A., & Attems, J. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0654-5 · Cited by 276 · see citing works
Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review
Minati, L., Edginton, T. L., Bruzzone, M. G., & Giaccone, G. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317508328602 · Cited by 266 · see citing works
Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia
Mesulam, M. M., & Geula, C. (1994) · Annals of Neurology · doi:10.1002/ana.410360506 · Cited by 259 · see citing works
The cause of neuronal degeneration in Alzheimer’s disease
Vickers, J. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00023-4 · Cited by 254 · see citing works
King, D. L., Arendash, G. W., Crawford, F., Sterk, T., Menendez, J., & MULLAN, M. J. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00037-6 · Cited by 227 · see citing works
Review article What causes alzheimer’s disease?
Armstrong, R. A. (2013) · Folia Neuropathologica · doi:10.5114/fn.2013.37702 · Cited by 220 · see citing works
The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms☆
Finch, C. E., & Sapolsky, R. M. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00053-6 · Cited by 204 · see citing works
Altered Proteins in the Aging Brain
Elobeid, A., Libard, S., Leino, M., Popova, S. N., & Alafuzoff, I. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw002 · Cited by 202 · see citing works
Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice
Gordon, M. N., King, D. L., Diamond, D. M., Jantzen, P. T., Boyett, K. W., Hope, C. E., Hatcher-Martin, J. M., DiCarlo, G., Gottschall, W. P. E., Morgan, D., et al. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00249-9 · Cited by 199 · see citing works
Giannakopoulos, P., Hof, P. R., Michel, J., Guimón, J., & Bouras, C. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00023-4 · Cited by 173 · see citing works
(1994) · PubMed Central · Cited by 169 · see citing works
Dickson, D. W. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00065-1 · Cited by 168 · see citing works
Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease
Jellinger, K. A., & Attems, J. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0156-7 · Cited by 157 · see citing works
Darvesh, S., Cash, M. K., Reid, G. A., Martin, E. V., Mitnitski, A., & Geula, C. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31823cc7a6 · Cited by 151 · see citing works
Senile Dementia with Tangles (Tangle Predominant Form of Senile Dementia)
Jellinger, K. A., & Bancher, C. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00160.x · Cited by 148 · see citing works
Overlap between neurodegenerative disorders
Armstrong, R. A., Lantos, P. L., & Cairns, N. J. (2005) · Neuropathology · doi:10.1111/j.1440-1789.2005.00605.x · Cited by 146 · see citing works
Barelli, H., Lebeau, A., Vizzavona, J., Delaère, P., Chevallier, N., Drouot, C., Marambaud, P., Ancolio, K., Buxbaum, J. D., Khorkova, O., et al. (1997) · Molecular Medicine · doi:10.1007/bf03401708 · Cited by 139 · see citing works
Self-citationImpact of Alzheimer's pathology on cognitive trajectories in nondemented elderly
Driscoll, I., Resnick, S. M., Troncoso, J. C., An, Y., O'Brien, R., & Zonderman, A. B. (2006) · Annals of Neurology · doi:10.1002/ana.21031 · Cited by 132 · see citing works
Asymptomatic Alzheimers Disease: A Prodrome or a State of Resilience?
Driscoll, I., & Troncoso, J. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745348 · Cited by 130 · see citing works
Bancher, C., & Jellinger, K. A. (1994) · Acta Neuropathologica · doi:10.1007/bf00296494 · Cited by 115 · see citing works
Poon, L. W., Jazwinski, S. M., Green, R. C., Woodard, J. L., Martin, P., Rodgers, W. L., Johnson, M. A., Hausman, D. B., Arnold, J., Davey, A., et al. (2007) · PubMed · Cited by 113 · see citing works
Prevalence, incidence and duration of Braak's stages in the general population: can we know?
Duyckaerts, C., & Hauw, J.-J. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00047-x · Cited by 109 · see citing works
Self-citationMorphological substrates of cognitive decline in nonagenarians and centenarians: A new paradigm?
Imhof, A., Kövari, E., von Gunten, A., Gold, G., Rivara, C.-B., Herrmann, F. R., Hof, P. R., Bouras, C., & Giannakopoulos, P. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.025 · Cited by 106 · see citing works
Giannakopoulos, P., Gold, G., Kövari, E., von Gunten, A., Imhof, A., Bouras, C., & Hof, P. R. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0144-y · Cited by 95 · see citing works
The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease
Boon, B. D. C., Bulk, M., Jonker, A. J., Morrema, T. H. J., van den Berg, E., Popovic, M. M., Walter, J., Kumar, S., van der Lee, S. J., Holstege, H. H., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02198-8 · Cited by 93 · see citing works
Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old
Polvikoski, T. M., van Straaten, E. C. W., Barkhof, F., Sulkava, R., Aronen, H. J., Niinistö, L., Oinas, M., Scheltens, P., Erkinjuntti, T., & Kalaria, R. N. (2010) · Neurology · doi:10.1212/wnl.0b013e318200d6f9 · Cited by 88 · see citing works
Brain Ageing in the New Millennium
Trollor, J. N., & Valenzuela, M. (2001) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2001.00969.x · Cited by 88 · see citing works
Decreased Neprilysin Immunoreactivity in Alzheimer Disease, but Not in Pathological Aging
Wang, D.-S., Lipton, R. B., Katz, M. J., Davies, P. J., Herman Buschke, L., Kuslansky, G., Verghese, J., Younkin, S. G., Eckman, C., & Dickson, D. W. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.5.378 · Cited by 85 · see citing works
Giannakopoulos, P., Hof, P. R., Giannakopoulos, A.-S., Herrmann, F. R., Michel, J.-P., & Bouras, C. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540360028012 · Cited by 78 · see citing works
Chapter 26 Reduced neuronal activity and reactivation in Alzheimer's disease
Swaab, D. F., Lucassen, P. J., Salehi, A., Scherder, E., Someren, E. J. W. V., & Verwer, R. W. H. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)64027-3 · Cited by 73 · see citing works
García‐Sierra, F., Hauw, J. J., Duyckaerts, C. J., Wischik, C. M., Luna‐Muñoz, J., & Mena, R. (2000) · Acta Neuropathologica · doi:10.1007/s004010051189 · Cited by 69 · see citing works
Self-citationBerr, C., Hauw, J., Delaère, P., Duyckaerts, C. J., & Amouyel, P. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90763-3 · Cited by 69 · see citing works
Self-citationCentenarian Studies: Important Contributors to Our Understanding of the Aging Process and Longevity
Willcox, D., Willcox, B., & Poon, L. (2011) · Current Gerontology and Geriatrics Research · doi:10.1155/2010/484529 · Cited by 62 · see citing works
Jordà‐Siquier, T., Petrel, M., Kouskoff, V., Smailovic, U., Cordelières, F., Frykman, S., Müller, U., Mulle, C., & Barthet, G. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12546 · Cited by 63 · see citing works
von Gunten, A., Ebbing, K., Imhof, A., Giannakopoulos, P., & Kövari, E. (2010) · Current Gerontology and Geriatrics Research · doi:10.1155/2010/358531 · Cited by 62 · see citing works
Criteria for the neuropathological diagnosis of dementing disorders: routes out of the swamp?
Jellinger, K. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-008-0466-z · Cited by 60 · see citing works
Prevalence and Pathology of Vascular Dementia in the Oldest-Old1
Jellinger, K. A., & Attems, J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100603 · Cited by 61 · see citing works
Hypertension and Related Factors in the Etiology of Alzheimer's Disease
Skoog, I. G., & Gustafson, D. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04796.x · Cited by 57 · see citing works
Stable Size Distribution of Amyloid Plaques Over the Course of Alzheimer Disease
Serrano‐Pozo, A., Mielke, M. L., Muzitansky, A., Gómez‐Isla, T., Growdon, J. H., Bacskai, B. J., Betensky, R. A., Frosch, M. P., & Hyman, B. T. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825e77de · Cited by 56 · see citing works
Behavioural and cellular effects of exogenous amyloid-β peptides in rodents.
Chambon, C., Wegener, N., Gravius, A., & Danysz, W. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.024 · Cited by 64 · see citing works
Armstrong, R. A. (2003) · Histopathology · doi:10.1046/j.1365-2559.2003.01601.x · Cited by 52 · see citing works
Foster, C. M., Kennedy, K. M., Horn, M. M., Hoagey, D. A., & Rodrigue, K. M. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.10.068 · Cited by 50 · see citing works
Is there a neuropathology difference between mild cognitive impairment and dementia?
Haroutunian, V. H., Hoffman, L. B., & Been, M. S. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/vharoutunian · Cited by 49 · see citing works
A grading system of Alzheimer disease lesions in neocortical areas
Metsaars, W. P., Hauw, J., Welsem, M. E. V., & Duyckaerts, C. J. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00134-3 · Cited by 50 · see citing works
Self-citationPontecorvo, M. J., & Mintun, M. A. (2011) · Alzheimer s Research & Therapy · doi:10.1186/alzrt70 · Cited by 49 · see citing works
Gandy, S., & Greengard, P. (1994) · International review of neurobiology · doi:10.1016/s0074-7742(08)60302-5 · Cited by 46 · see citing works
The neurochemistry of Alzheimer's disease
Blennow, K., & Cowburn, R. F. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb00378.x · Cited by 46 · see citing works
An immunohistochemical study of centenarian brains: a comparison
Itoh, Y., Yamada, M., Suematsu, N., Matsushita, M., & Otomo, E. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00050-1 · Cited by 45 · see citing works
Of Energy and Entropy: The Ineluctable Impact of Aging in Old Age Dementia
Boccardi, V., Comanducci, C., Baroni, M., & Mecocci, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122672 · Cited by 45 · see citing works
Centenarians: Human longevity outliers
Smith, D. W. E. (1997) · The Gerontologist · doi:10.1093/geront/37.2.200 · Cited by 40 · see citing works
Die Alzheimer‐Demenz: von der Pathologie zu therapeutischen Ansätzen
Jakob‐Roetne, R., & Jacobsen, H. (2009) · Angewandte Chemie · doi:10.1002/ange.200802808 · Cited by 40 · see citing works
On the ‘classification’ of neurodegenerative disorders: discrete entities, overlap or continuum?
Armstrong, R. A. (2012) · Folia Neuropathologica · doi:10.5114/fn.2012.30521 · Cited by 40 · see citing works
Advances on the Understanding of the Origins of Synaptic Pathology in AD
Lacor, P. N. (2007) · Current Genomics · doi:10.2174/138920207783769530 · Cited by 38 · see citing works
Biochemistry of Alzheimer's disease amyloid plaques
Fraser, P. E., Lévesque, L., & McLachlan, D. R. C. (1993) · Clinical Biochemistry · doi:10.1016/0009-9120(93)90110-r · Cited by 37 · see citing works
Cortical Neuropathology in Aging and Dementing Disorders
Hof, P. R., Bouras, C., & Morrison, J. H. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_8 · Cited by 35 · see citing works
A History of Senile Plaques: From Alzheimer to Amyloid Imaging
Beach, T. G. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac030 · Cited by 35 · see citing works
Sugihara, S., Ogawa, A., Nakazato, Y., & Yamaguchi, H. (1995) · Acta Neuropathologica · doi:10.1007/bf00294312 · Cited by 34 · see citing works
Blennow, K., & Vanmechelen, E. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_20 · Cited by 34 · see citing works
Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains
Pirttilä, T., Soininen, H. S., Mehta, P. D., Heinonen, O., Lehtimäki, T. J., Bogdanović, N., Paljärvi, L., Kim, K. S., Kosunen, O., Winblad, B. G., et al. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00204-7 · Cited by 33 · see citing works
Clinico-Neuropathological Findings in the Oldest Old from the Georgia Centenarian Study
Tanprasertsuk, J., Johnson, E. J., Johnson, M. A., Poon, L. W., Nelson, P. T., Davey, A., Martin, P., Barbey, A. K., Barger, K., Wang, X.-D., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181110 · Cited by 30 · see citing works
Johnson, J. K., McCleary, R., Oshita, M. H., & Cotman, C. W. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00363-1 · Cited by 32 · see citing works
Molecular basis for anti-amyloid therapy in the prevention and treatment of Alzheimer’s disease
Gandy, S. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00125-2 · Cited by 32 · see citing works
Physiologic Origins of Age-Related β-Amyloid Deposition
Beach, T. G. (2008) · Neurodegenerative Diseases · doi:10.1159/000113685 · Cited by 31 · see citing works
Wildburger, N. C., Gyngard, F., Guillermier, C., Patterson, B., Elbert, D., Mawuenyega, K., Schneider, T., Green, K., Roth, R., Schmidt, R., et al. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00169 · Cited by 33 · see citing works
Scala, C. D., Armstrong, N., Chahinian, H., Chabrière, É., Fantini, J., & Yahi, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113383 · Cited by 31 · see citing works
Tolnay, M., Calhoun, Pham, Egensperger, & Probst (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00175.x · Cited by 30 · see citing works
Fentie, I. H., Greenwood, M. M., Wyss, J. M., & Clark, J. T. (2004) · Endocrine · doi:10.1385/endo:25:1:15 · Cited by 29 · see citing works
Besser, L. M., Alosco, M. L., Gomez, L. A. R., Zhou, X., McKee, A. C., Stern, R. A., Gunstad, J., Schneider, J. A., Chui, H. C., & Kukull, W. A. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw072 · Cited by 28 · see citing works
Uchihara, T., Duyckaerts, C., Lazarini, F., Mokhtari, K., Seilhean, D., Amouyel, P., & Hauw, J. (1996) · Acta Neuropathologica · doi:10.1007/s004010050506 · Cited by 25 · see citing works
Self-citationQuantitative analysis of neuropathologic changes in the cerebral cortex of centenarians
Giannakopoulos, P., Hof, P. R., Vallet, P. G., Giannakopoulos, A.-S., Charnay, Y., & Bouras, C. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(95)00103-3 · Cited by 23 · see citing works
β-Amyloid (Aβ) deposition in elderly non-demented patients and patients with Alzheimer's disease
Armstrong, R. A. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90289-5 · Cited by 24 · see citing works
Patterns of synaptic and nerve cell pathology in Alzheimer's disease
Lassmann, H. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00215-4 · Cited by 24 · see citing works
Duyckaerts, C. J., Colle, M.-A., Seilhean, D., & Hauw, J. (1998) · Acta Neuropathologica · doi:10.1007/s004010050818 · Cited by 23 · see citing works
Self-citationAlzheimer's Disease Pathology in Non-Demented Elderly
Kazee, A. M., & Johnson, E. M. (1998) · Journal of Alzheimer s Disease · doi:10.3233/jad-1998-1202 · Cited by 21 · see citing works
βAP deposition and head trauma
Adle‐Biassette, H., Duyckaerts, C. J., Wasowicz, M., He, Y., Fornés, P., Foncin, J. F., Lecomte, D., & Hauw, J. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00029-2 · Cited by 19 · see citing works
Self-citationInteraction Mechanism Between the HSV-1 Glycoprotein B and the Antimicrobial Peptide Amyloid-β
Bourgade, K., Frost, E. H., Dupuis, G., Witkowski, J. M., Laurent, B., Calmettes, C., Ramassamy, C., Desroches, M., Rodrigues, S., & Fülöp, T. (2022) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220061 · Cited by 18 · see citing works
Kreutzer, A. G., Parrocha, C. M. T., Haerianardakani, S., Guaglianone, G., Nguyen, J. T., Diab, M. N., Yong, W. H., Perez-Rosendahl, M. A., Head, E., & Nowick, J. S. (2023) · ACS Central Science · doi:10.1021/acscentsci.3c00592 · Cited by 18 · see citing works
Węgiel, J., Flory, M. J., Kuchna, I., Nowicki, K., Ma, S. Y., Wegiel, J., Badmajew, E., Silverman, W. P., de Leon, M. J., Reisberg, ., et al. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx027 · Cited by 18 · see citing works
MAGNETIC RESONANCE SPECTROSCOPY AND ITS APPLICATION TO AGING AND ALZHEIMER'S DISEASE
McClure, R. J., Kanfer, J. N., Panchalingam, K., Klunk, W. E., & Pettegrew, J. W. (1995) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(25)00277-1 · Cited by 17 · see citing works
Centenarians and the Genetics of Longevity
Perls, T. T., Terry, D. F., Silver, M. H., Shea-Drinkwater, M., Bowen, J., Joyce, E., Ridge, S. B., Fretts, R. C., Daly, M. J., Brewster, S. J., et al. (2000) · Results and problems in cell differentiation · doi:10.1007/978-3-540-48003-7_1 · Cited by 17 · see citing works
Biomarkers for Early Diagnosis of Alzheimer’s Disease in the Oldest Old: Yes or No?
Paolacci, L., Giannandrea, D., Mecocci, P., & Parnetti, L. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161127 · Cited by 15 · see citing works
Probiotic supplement as a promising strategy in early tau pathology prevention: Focusing on GSK-3β?
Flynn, C. M., & Yuan, Q. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1159314 · Cited by 14 · see citing works
Cen, S., Wang, L., Qiu, M., Xu, Z., Xu, L., Bao, R., Tang, X., Gong, J., Wu, J., Shao, Z., et al. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100315 · Cited by 12 · see citing works
Detecting bioactive amyloid β peptide species in Alzheimer's disease
Liu, Y., Dargusch, R., Banh, C., Miller, C. A., & Schubert, D. A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02751.x · Cited by 12 · see citing works
Coexistence of reactive plasticity and neurodegeneration in Alzheimer diseased brains.
Guevara, J., Dilhuydy, H., Espinosa, B., Delacourte, A., Quirion, R., Mena, R., Joanette, Y., Zenteno, E., & Robitaille, Y. (2004) · Histology and Histopathology · doi:10.14670/hh-19.1075 · Cited by 14 · see citing works
Centenarians: Health and Frailty
Forette, B. (1997) · Springer eBooks · doi:10.1007/978-3-642-60813-1_7 · Cited by 12 · see citing works
Inhibitors of the Maillard Reaction
Colaco, C. A. L. S., & Harrington, C. R. (1996) · CNS Drugs · doi:10.2165/00023210-199606030-00001 · Cited by 11 · see citing works
- Authors
- Delaère, P., He, Y., Fayet, G., Duyckaerts, C., & Hauw, J.-J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Delaère, Pia
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1993-03
- Volume
- 14
- Issue
- 2
- Pages
- 191-194
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1974729491
- Cited by
- 149
- References
- 38
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association France Alzheimer
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta, centenarians, brain aging, Alzheimer's disease, dementia, parahippocampal gyrus, superior temporal gyrus, hippocampus, lesion density, immunocytochemistry
- MeSH terms
- Aged, Aged, 80 and over, Brain, Brain Chemistry, Dementia, Female, France, Hippocampus, Humans, Immunohistochemistry, Male, Temporal Lobe, Amyloid beta-Peptides, Neurofibrillary Tangles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review