Cited by 149Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

βA4 deposits are constant in the brain of the oldest old: An immunocytochemical study of 20 french centenarians

Delaère, Pia, He, Yi, Fayet, Guillemette, Duyckaerts, Charles, Hauw, Jean-Jacqes·1993·Neurobiology of Aging

Abstract

beta A4 deposits occur in the brain of some individuals over 50 years of age. It could be a part of the aging process or indicate a disease found frequently in the elderly. To address this question, beta A4 immunocytochemistry was performed on the brain of 15 nondemented and 5 demented centenarians, some of whom were affected by Alzheimer's disease. We found beta A4 deposits in the parahippocampal and the superior temporal gyri of all the cases, whatever the clinical state. The hippocampus was frequently spared. The lesion density was not correlated with the severity of the mental deterioration. The constant deposition of beta A4 protein in the brain of very old people indicates that this process does not spare a large proportion of this population. This result favors beta A4 accumulation in the brain being an ineluctable age-related process.

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Crossref · 10.1016/0197-4580(93)90096-t

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Autopsy studies reveal at the time of death, brains from cognitively normal individuals frequently contain plaques.

    “Autopsy studies reveal at the time of death, brains from cognitively normal individuals frequently contain plaques [77, 234-237].”
  • Since most young individuals will develop Aβ deposits if they live long enough, almost the entire population that doesn't already have AD is on their way to developing AD.

    “Also, since most young individuals will develop Aβ deposits if they live long enough [9, 54, 79], almost the entire population that doesn’t already have AD is on their way to developing AD [3].”

    From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [79]

  • Brains from individuals surviving to age 85 and beyond have at least some degree of plaque and tangle pathology.

    “Brain histology surveys suggest that brains from individuals surviving to age 85 and beyond have at least some degree of plaque and tangle pathology [9, 54, 79].”

    From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [79]

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Authors
Delaère, P., He, Y., Fayet, G., Duyckaerts, C., & Hauw, J.-J.
Affiliations
Inserm (FR)
Corresponding author
Delaère, Pia
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
1993-03
Volume
14
Issue
2
Pages
191-194
ISSN
0197-4580 (ISSN-L)
OpenAlex
W1974729491
Cited by
149
References
38
Citations by year
2026: 2 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 3
FWCI
7.11
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Funders
Association France Alzheimer
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
amyloid-beta, centenarians, brain aging, Alzheimer's disease, dementia, parahippocampal gyrus, superior temporal gyrus, hippocampus, lesion density, immunocytochemistry
MeSH terms
Aged, Aged, 80 and over, Brain, Brain Chemistry, Dementia, Female, France, Hippocampus, Humans, Immunohistochemistry, Male, Temporal Lobe, Amyloid beta-Peptides, Neurofibrillary Tangles

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