Age‐related rhesus macaque models of COVID‐19
Open accessAbstract
Background: Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need to explore the possible age‐related phenomena with non‐human primate models. Methods: Three 3‐5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS‐CoV‐2, and then analyzed by clinical signs, viral replication, chest X‐ray, histopathological changes and immune response. Results: Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS‐CoV‐2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages. Conclusion: SARS‐CoV‐2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS‐CoV‐2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS‐CoV‐2 infection.
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Rhesus macaques show a COVID-19-like disease caused by SARS-CoV-2 infection.
“rhesus macaques (Macaca mulatta), a non-human primate species that shows a COVID-19-like disease caused by SARS-CoV-2 infection (13).”
From Development of an inactivated vaccine candidate for SARS-CoV-2 (2020) · cites this paper as [13]
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- Authors
- Yu, P., Qi, F., Xu, Y., Li, F., Liu, P., Liu, J., Bao, L., Deng, W., Gao, H., Xiang, Z., Xiao, C., Lv, Q., Gong, S., Liu, J., Song, Z., Qu, Y., Xue, J., Wei, Q., Liu, M., Wang, G., Wang, S., Yu, H., Liu, X., Huang, B., Wang, W., Zhao, L., Wang, H., Ye, F., Zhou, W., Zhen, W., Han, J., Wu, G., Jin, Q., Wang, J., Tan, W., & Qin, C.
- Affiliations
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Capital Medical University (CN)
- Corresponding author
- Tan, Wenjie
- Qin, Chuan
- ORCID
- Qi, Feifei
- Xu, Yanfeng
- Liu, Peipei
- Liu, Jiayi
- Bao, Linlin
- Deng, Wei
- Gao, Hong
- Xiang, Zhiguang
- Xiao, Chong
- Lv, Qi
- Gong, Shuran
- Liu, Jiangning
- Song, Zhiqi
- Qu, Yajin
- Xue, Jing
- Wei, Qiang
- Liu, Mingya
- Wang, Guanpeng
- Wang, Shunyi
- Yu, Haisheng
- Liu, Xing
- Huang, Baoying
- Wang, Wenling
- Zhao, Li
- Wang, Huijuan
- Ye, Fei
- Zhou, Weimin
- Han, Jun
- Wu, Guizhen
- Jin, Qi
- Wang, Jianwei
- Tan, Wenjie
- Qin, Chuan
- Venue
- Animal Models and Experimental Medicine
- Publisher
- Wiley
- Published
- 2020-03
- Volume
- 3
- Issue
- 1
- Pages
- 93-97
- ISSN
- 2096-5451 (ISSN-L)
- 2576-2095
- PMC
- PMC7167234
- OpenAlex
- W3013070728
- Cited by
- 275
- References
- 2
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 18 · 2023: 26 · 2022: 39 · 2021: 79 · 2020: 100
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Animal Models and Experimental Medicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by-nc)
- Funders
- CAMS initiative for Innovative Medicine of China (2016-I2M-2-006)
- the National Research and Development Project of China (2020YFC0841100)
- National Key Research and Development Project of China (2016YFD0500304)
- National Key Research and Development Programme of China (2016YFD0500301, 2020YFC0840800, 2020YFC0840900)
- National Mega projects of China for Major Infectious Diseases (2017ZX10304402)
- Fundamental Research Funds for CAMS of China (2020HY320001)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- COVID-19 pandemic, SARS-CoV-2, rhesus monkeys, age-related susceptibility, interstitial lung disease, viral replication, alveolar epithelial cells, macrophages, immune response, nonhuman primate model, lung histopathology
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