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Cited by 675

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

An evidence‐based causative classification system for acute ischemic stroke

Ay, Hakan, Furie, Karen L., Singhal, Aneesh, Smith, Wade S., Sorensen, A. Gregory, Koroshetz, Walter J.·2005·Annals of Neurology

Abstract

Regular, evidence‐based assignment of patients to etiologic stroke categories is essential to enable valid comparison among studies. We designed an algorithm (SSS‐TOAST) that incorporated recent advances in stroke imaging and epidemiology to identify the most probable TOAST category in the presence of evidence for multiple mechanisms. Based on the weight of evidence, each TOAST subtype was subdivided into 3 subcategories as “evident”, “probable”, or “possible”. Classification into the subcategories was determined via predefined specific clinical and imaging criteria. These criteria included published risks of ischemic stroke from various mechanisms and published reports of the strength of associations between clinical and imaging features and particular stroke mechanisms. Two neurologists independently assessed 50 consecutively admitted patients with acute ischemic stroke through reviews of abstracted data from medical records. The number of patients classified as “undetermined‐unclassified” per the original TOAST system decreased from 38–40% to 4% using the SSS‐TOAST system. The kappa value for interexaminer reliability was 0.78 and 0.90 for the original TOAST and SSS‐TOAST respectively. The SSS‐TOAST system successfully classifies patients with acute ischemic stroke into determined etiologic categories without sacrificing reliabilty. The SSS‐TOAST is a dynamic algorithm that can accommodate modifications as new epidemiological data accumulate and diagnostic techniques advance. Ann Neurol 2005;58:688–697

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Metadata

Authors
Ay, H., Furie, K. L., Singhal, A., Smith, W. S., Sorensen, A. G., & Koroshetz, W. J.
Venue
Annals of Neurology
Publisher
Wiley
Published
2005-10-20
Volume
58
Issue
5
Pages
688-697
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2075389937
Cited by
675
References
5
FWCI
7.20
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: An evidence‐based causative classification system for acute ischemic stroke. https://app.cochat.ai/papers/10.1002/ana.20617
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Ay, H., Furie, K. L., Singhal, A., Smith, W. S., Sorensen, A. G., & Koroshetz, W. J. (2005). An evidence‐based causative classification system for acute ischemic stroke. Annals of Neurology. https://doi.org/10.1002/ana.20617

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