Longitudinal white matter changes in frontotemporal dementia subtypes: Longitudinal White Matter Changes in FTD
Open accessAbstract
Frontotemporal dementia is a degenerative brain condition characterized by focal atrophy affecting the frontal and temporal lobes predominantly. Changes in white matter with disease progression and their relationship to grey matter atrophy remain unknown in FTD. This study aimed to establish longitudinal white matter changes and compare these changes to regional grey matter atrophy in the main FTD subtypes. Diffusion and T₁-weighted images were collected from behavioral-variant FTD (bvFTD: 12), progressive non-fluent aphasia (PNFA: 10), semantic dementia (SD: 11), and 15 controls at baseline and 12 months apart. Changes in white matter integrity were established by fractional anisotropy, mean, axial and radial diffusivity measurements using tract-based spatial statistics. Patterns of cortical grey matter atrophy were measured using voxel-based morphometry. At baseline, bvFTD showed severe cross-sectional changes in orbitofrontal and anterior temporal tracts, which progressed to involve posterior temporal and occipital white matter over the 12-month. In PNFA, cross-sectional changes occurred bilaterally in frontotemporal white matter (left > right), with longitudinal changes more prominent on the right. Initial white matter changes in SD were circumscribed to the left temporal lobe, with longitudinal changes extending to bilateral frontotemporal tracts. In contrast, progression of grey matter change over time was less pronounced in all FTD subtypes. Mean diffusivity was most sensitive in detecting baseline changes while fractional anisotropy and radial diffusivity revealed greatest changes over time, possibly reflecting different underlying pathological processes with disease progression. Our results indicate that investigations of white matter changes reveal important differences across FTD syndromes with disease progression.
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Progression of white matter microstructural disintegrity, as detected by DTI, showed fast rates in early bvFTD over 1 year.
“Progression of WM microstructural disintegrity, as detected by DTI, showed fast rates in early bvFTD (1 year) (Lam et al., 2014).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Lam et al., 2014
Whole brain atrophy and ventricular volume increased in both genetic and sporadic bvFTD, in several one-year follow-up studies and one six-month follow-up.
“Whole brain atrophy and ventricular volume increased in both genetic and sporadic bvFTD, in several one-year follow-up studies and one six-month follow-up (Knopman et al., 2009; Gordon et al., 2010; Lam et al., 2014; Floeter et al., 2016; Sheelakumari et al., 2018; Manera et al., 2019; Gordon et al., 2021).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Lam et al., 2014
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Diagnosing, monitoring and managing behavioural variant frontotemporal dementia
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Self-citationCorrelates of anomia in non-semantic variants of primary progressive aphasia converge over time
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Anhedonia in Semantic Dementia—Exploring Right Hemispheric Contributions to the Loss of Pleasure
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A review of the recent advances in neuroimaging of frontotemporal lobar degeneration
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- Authors
- Lam, B. Y. K., Halliday, G. M., Irish, M., Hodges, J. R., & Piguet, O.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Piguet, Olivier
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2013-11-25
- Volume
- 35
- Issue
- 7
- Pages
- 3547-3557
- ISSN
- 1065-9471 (ISSN-L)
- PMC
- PMC6869363
- OpenAlex
- W2161762785
- Cited by
- 90
- References
- 64
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 7 · 2018: 9 · 2017: 12 · 2016: 10 · 2015: 9 · 2014: 3
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
- Funders
- National Health and Medical Research Council of Australia (NHMRC) (APP1003139, 630489)
- Australian Research Council (ARC) Discovery Early Career Research Award (DE130100463)
- NHMRC Senior Principal Research Fellowship (APP630434)
- ARC Federation Fellowship (FF0776229)
- NHMRC Career Development Fellowship (APP1022684)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal dementia, white matter changes, gray matter atrophy, disease progression, behavioral variant frontotemporal dementia, progressive nonfluent aphasia, semantic dementia, fractional anisotropy, mean diffusivity, radial diffusivity, tract-based spatial statistics, voxel-based morphometry
- MeSH terms
- Aged, Atrophy, Brain Mapping, Cross-Sectional Studies, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Anisotropy, Disease Progression, Diffusion Tensor Imaging, Leukoencephalopathies, Frontotemporal Dementia
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