The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
18F‐flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial
Abstract
Objective: The most widely studied positron emission tomography ligand for in vivo β‐amyloid imaging is 11 C‐Pittsburgh compound B (11 C‐PIB). Its availability, however, is limited by the need for an on‐site cyclotron. Validation of the 18 F‐labeled PIB derivative 18 F‐flutemetamol could significantly enhance access to this novel technology. Methods: Twenty‐seven patients with early‐stage clinically probable Alzheimer disease (AD), 20 with amnestic mild cognitive impairment (MCI), and 15 cognitively intact healthy volunteers (HVs) above and 10 HVs below 55 years of age participated. The primary endpoint was the efficacy of blinded visual assessments of 18 F‐flutemetamol scans in assigning subjects to a raised versus normal uptake category, with clinical diagnosis as the standard of truth (SOT). As secondary objectives, we determined the correlation between the regional standardized uptake value ratios (SUVRs) for 18 F‐flutemetamol and its parent molecule 11 C‐PIB in 20 of the AD subjects and 20 of the MCI patients. We also determined test‐retest variability of 18 F‐flutemetamol SUVRs in 5 of the AD subjects. Results: Blinded visual assessments of 18 F‐flutemetamol scans assigned 25 of 27 scans from AD subjects and 1 of 15 scans from the elderly HVs to the raised category, corresponding to a sensitivity of 93.1% and a specificity of 93.3% against the SOT. Correlation coefficients between cortical 18 F‐flutemetamol SUVRs and 11 C‐PIB SUVRs ranged from 0.89 to 0.92. Test‐retest variabilities of regional SUVRs were 1 to 4%. Interpretation: 18 F‐Flutemetamol performs similarly to the 11 C‐PIB parent molecule within the same subjects and provides high test‐retest replicability and potentially much wider accessibility for clinical and research use. ANN NEUROL 2010
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Cites
Mild Cognitive Impairment: Clinical Characterization and Outcome
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Imaging β-amyloid burden in aging and dementia
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Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
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APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging
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Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
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PIB is a non-specific imaging marker of amyloid-beta (A ) peptide-related cerebral amyloidosis
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Nakamura, A., Kaneko, N., Villemagne, V. L., Kato, T., Doecke, J., Doré, V., Fowler, C., Li, Q.-X., Martins, R., Rowe, C., et al. (2018) · Nature · doi:10.1038/nature25456 · Cited by 1,681
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease
Ossenkoppele, R., Schonhaut, D. R., Schöll, M., Lockhart, S. N., Ayakta, N., Baker, S. L., O’Neil, J. P., Janabi, M., Lazaris, A., Cantwell, A., et al. (2016) · Brain · doi:10.1093/brain/aww027 · Cited by 1,185
Plasma phospholipids identify antecedent memory impairment in older adults
Mapstone, M., Cheema, A. K., Fiandaca, M. S., Zhong, X., Mhyre, T. R., MacArthur, L. H., Hall, W. J., Fisher, S. G., Peterson, D. R., Haley, J. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3466 · Cited by 1,043
β-Amyloid accumulation in the human brain after one night of sleep deprivation
Shokri-Kojori, E., Wang, G.-J., Wiers, C. E., Demiral, S. B., Guo, M., Kim, S. W., Lindgren, E., Ramirez, V., Zehra, A., Freeman, C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721694115 · Cited by 893
Brain Imaging in Alzheimer Disease
Johnson, K. A., Fox, N. C., Sperling, R. A., & Klunk, W. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006213 · Cited by 875
Metadata
- Authors
- Vandenberghe, R., Van Laere, K., Ivanoiu, A., Salmon, E., Bastin, C., Triau, E., Hasselbalch, S., Law, I., Andersen, A., Korner, A., Minthon, L., Garraux, G., Nelissen, N., Bormans, G., Buckley, C., Owenius, R., Thurfjell, L., Farrar, G., & Brooks, D. J.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2010-08-30
- Volume
- 68
- Issue
- 3
- Pages
- 319-329
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2074427084
- Cited by
- 646
- References
- 11
- FWCI
- 28.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vandenberghe, R., Van Laere, K., Ivanoiu, A., Salmon, E., Bastin, C., Triau, E., Hasselbalch, S., Law, I., Andersen, A., Korner, A., Minthon, L., Garraux, G., Nelissen, N., Bormans, G., Buckley, C., Owenius, R., Thurfjell, L., Farrar, G., & Brooks, D. J. (2010). 18F‐flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial. Annals of Neurology. https://doi.org/10.1002/ana.22068
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