Cited by 199Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMedical Imaging Techniques and Applications

Assessment of β-Amyloid in a Frontal Cortical Brain Biopsy Specimen and by Positron Emission Tomography With Carbon 11–Labeled Pittsburgh Compound B

Leinonen, Ville·2008·Archives of Neurology

Abstract

Objective To compare carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) findings in patients with and without Alzheimer disease lesions in frontal cortical biopsy specimens. Design Cross-sectional study of [11C]PiB PET findings in patients with or without beta-amyloid (Abeta) aggregates in frontal cortical biopsy specimens. Setting Two university hospitals in Finland. Patients Ten patients who had undergone intraventricular pressure monitoring with a frontal cortical biopsy (evaluated for Abeta aggregates and hyperphosphorylated tau) for suspected normal-pressure hydrocephalus. Interventions [11C]PiB PET and evaluation for cognitive impairment using a battery of neuropsychological tests. Main outcome measures Immunohistochemical evaluation for Abeta aggregates and hyperphosphorylated tau in the frontal cortical biopsy specimen and [11C]PiB PET. Results In patients with Abeta aggregates in the frontal cortical biopsy specimen, PET imaging revealed higher [11C]PiB uptake (P Conclusions Our study supports the use of noninvasive [11C]PiB PET in the assessment of Abeta deposition in the brain. Large prospective studies are required to verify whether [11C]PiB PET will be a diagnostic aid, particularly in early Alzheimer disease.

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Crossref · 10.1001/archneur.65.10.noc80013

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  • PIB and other tracers can bind to fibrillar Aβ plaques, allowing for visualization of brain amyloid in individuals during PET.

    “the [11C]-benzothiazole radiotracer, Pittsburgh Compound B (PIB), as well as other tracers, can bind to fibrillar Aβ plaques, allowing for visualization of brain amyloid in individuals during positron emission tomography (PET) (23-25).”

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Authors
Leinonen, V.
Affiliations
Kuopio University Hospital (FI)
Corresponding author
Leinonen, Ville
Venue
Archives of Neurology
Published
2008-10-01
Volume
65
Issue
10
Pages
1304
ISSN
0003-9942 (ISSN-L)
OpenAlex
W2136040838
Cited by
199
References
19
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 15 · 2015: 10 · 2014: 17 · 2013: 17 · 2012: 27
FWCI
16.61
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords
amyloid-beta, 11C-Pittsburgh compound B, positron emission tomography, Alzheimer's disease, amyloid imaging, hyperphosphorylated tau, normal pressure hydrocephalus, cognitive impairment
MeSH terms
Aged, Alzheimer Disease, Aniline Compounds, Biopsy, Brain, Brain Mapping, Cross-Sectional Studies, Diagnosis, Differential, Female, Frontal Lobe, Humans, Hydrocephalus, Normal Pressure, Image Processing, Computer-Assisted, Male, Neuropsychological Tests, Predictive Value of Tests, Thiazoles, Amyloid beta-Peptides, Neurofibrillary Tangles, tau Proteins, Disease Progression, Intracranial Hypertension, Early Diagnosis, Positron-Emission Tomography, Plaque, Amyloid

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